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성장호르몬 분비성 뇌하수체 선종에서 소마토스타틴 수용체 (제2아형, 제5아형), G_i2α 및 Pit-1 유전자 발현
류미숙,양인명,박철영,우정택,김성운,김진우,김영설,최영길,김은희,박승준,김국기 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2
Background: Mutation of Gs protein subunit (gsp oncogene), detected in about 30∼40% of growth hormone (GH)-secreting pituitary tumors, is associated with an increased long-acting somatostatin analog octreotide sensitivity. However, the mRNA expression of somatostatin receptor (sst) was not changed in the GH-secreting pituitary tumor, regardless of whether they were gsp oncogene positive or negative. This suggests that the expression of genes coding for G_i2α, Pit-1 and the other factors involved in the regulation of secretory activity in somatotrophs is likely to be altered in gsp oncogene positive tumors. We observed the impact of the gsp oncogene on the expression of the genes coding for Gi2, Pit-1 and sst (2&5) in GH-secreting pituitary tumors. Methods: The GH response to octreotide was examined in 13 acromegalic patients before transsphenoidal adenomectomy. Genomic DNA and RNA were extracted from fresh frozen tumor tissues. PCR was performed to amplify and sequence the region between codon 184 and 251 that includes exons 8 and 9 of the Gs gene. Sst2, sst5, G_i2α and Pit-1 mRNA levels were measured by semi-quantitative RT-PCR. Results: Sst2 and sst5 mRNA transcripts were detected in all tumors (7 gsp +, 6 gsp-). The amount of sst transcripts varied considerably varied between the tumors. There were no significant differences in sex, age, tumor size, grade or basal GH levels. Pit-1 and sst2 mRNA levels were not different. In contrast, G_i2 mRNA levels were significantly higher in gsp (+) while sst5 mRNA levels were higher in gsp (-). Conclusion: These data suggests that gsp oncogene may increase Gi2α levels but decrease sst5 mRNA levels. However, Pit-1 and sst2 mRNA expression may not be affected by gsp oncogene. The increased expression of the G_i2α gene might be an inhibitory compensatory response to the action of gsp oncogene
잔骨材의 粒度分布가 시멘트 모르터의 透水特性에 미치는 影響에 關한 實驗的 硏究
梁富弘,柳顯紀 忠州大學校 1991 한국교통대학교 논문집 Vol.25 No.-
This study originally was intended to evaluate the efficiency by standard sand in the method of waterproofing efficiency valuation, but actually, the case of natural sand used in practical construction much affect to the difference of grading range with standard sand as well. Therfore, this aimed to show a kind of reference material for practical construction of waterproofing resulted by comparing/analysing the affection for property of permeability with variety o grading range of fine aggregate.
Yang, You-Jung,Ryu, Jin-Sook,Kim, Seog-Young,Oh, Seung Jun,Im, Ki Chun,Lee, Heuiran,Lee, Sang-Wook,Cho, Kyung Ja,Cheon, Gi-Jeong,Moon, Dae Hyuk Springer-Verlag 2006 European Journal of Nuclear Medicine and Molecular Vol.33 No.4
<P>3'-Deoxy-3'-[(18)F]fluorothymidine (FLT) is a promising new radiopharmaceutical for imaging cell proliferation. We evaluated whether FLT PET can be used to monitor early responses to radiation treatment.</P>
기관지 동맥 색전술시 합병될 수 있는 척수 손상의 예측을 위한 펜토탈 소디움 유발검사의 임상 적용
김기현,심형진,유승훈,곽병국,나형일,송인섭,김양수,이종범 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.1
The evaluate the clinical significance of pentothal sodium provocative test for prediction of spinal cord complication in bronchial artery emobolization or chemotreatment(BAE or BACT),82 arteries of 31 patients were studies. thirty-one patients consists of twenty-two cases of pulmonary tuberculosis, senen cases of primary lung cancer,one case of merastatic lung cancer and a case of aspergilloma. 82 arteries consists of 56 bronchial arteries, 9 intercostobronchial trunks, 7 intercostal arteries, 5 intemal mammary arteries, 2 thyrocervical trunks, a inferior phrenic artery,a lateral thoracic artery and a superior thoracic artery. In allcases, selective arterial angiography was performed after arch aortography. Before infusion of embolic or chemotherapeutic agent, 2.5% water solution of pentothal sodium(ultra short-acting barbiturate) was injected. Neurologic examination was done to evaluate the spinal cord complication. There was no significant acute and delayed neurologic change in all cases. The complication and problem caused by pentothal sodium test itself were not found either. In conclusion, pentothal sodium test is easy, simple and method to prevent and predict spinal cord complication in BAE or BACT, but the accumulation of clinical experiences will be needed.
Shinhyuk Yang,Jun Yong Bak,Sung-Min Yoon,Min Ki Ryu,Himchan Oh,Chi-Sun Hwang,Gi Heon Kim,Sang-Hee Ko Park,Jin Jang IEEE 2011 IEEE electron device letters Vol.32 No.12
<P>In-Ga-Zn-O thin-film transistors processed at 150°C on laminated polyethylene naphthalate substrates exhibit ing high electrical performances such as a saturation mobility of 24.26 cm<SUP>2</SUP>/(V · s), a subthreshold slope of 140 mV/dec, a turn-on voltage V<SUB>on</SUB> of -0.41 V, and an on-off ratio of 1.8 × 10<SUP>9</SUP> were fabricated. Cool-off-type adhesive was adopted to easily detach the plastic substrate from the carrier holder. Devices also showed highly uniform characteristics with a variation of 0.09 V in turn-on voltage. Stability characteristics under the positive gate bias stress can be enhanced by increasing the annealing time at 150°C.</P>
간세포암에 대한 화학 색전 및 주입 요법 후에 발생한 발열과 감염성 합병증에 관한 전향적 연구
김양수,이상오,이미숙,정두련,김은옥,정영화,우준희,이영상,서동진,성규보,류지소,고기영 대한감염학회 1998 감염 Vol.30 No.3
목적 : 간동맥 화학 색전 및 주입 요법을 시행 받은 환자에서 시술 후 나타나는 발열 및 감염성 합병증의 빈도와 특성을 관찰하고, 이들 중 감염성 합병증이 발생한 환자들을 미래 예측할 수 있는 임상적 지표들이 있는 지 알고자 하였다. 방법 : 1997년 6월부터 8월까지 간세포암으로 간동맥 화학 색전 및 주입 요법을 시행받은 환자들을 대상으로 전향적으로 조사하였다. 화학 색전 및 주입 요법 시행 후 발열이 발생하였으나 감염 및 간 회 색전증의 증거 없이 자연히 소실된 경우에 한해 색전술 후 증후군이라고 정의하였다. 결과 : 284명에서 303예의 시술(화학 색전 요법 200예, 주입 요법 103예)이 시행되었다. 이중 108예(35.6%)에서 시술 후 발열이 있었다. 발열의 원인으로 감염성 합병증이 7예 (2.3%), 허혈성 담낭염이 5예(1.7%)였고 1예는 분류가 힘들어 나머지 95예(31.4%)를 색전술 후 증후군으로 분류하였다. 감염성 합병증은 배양 음성 중성구성 복수(culture-negative neutrocytic ascites)가 3예, 원발성 세균성 복막염이 2예(이중 1예는 패혈증 동반), 패혈송 쇽이 1예, 요로 감염증이 1예이었다. 색전술 후 증후군은 발열이 없었던 군에 비해 복수가 있거나(odds ratio [OR], 2.74; 95% contidence interval [CI], 1.30∼5.75) 종양이 클수록 (OR, 1/15; 95% CI, 1.06∼1.24), 도한 좌우 감동맥을 모두 막은 경우 (OR, 1.81; 95% CI, 1.00∼3.28) 빈번하게 발생하였다. 감염성 합병증일 때에는 색전술 후 발열이 있으면서 systemic inflammatory response syndrome(SIRS)의 기준을 만족하거나 (p<0.05) 시술 후 72시간 이후에 복부 동통이 발생하는 경우가 많았다.(p<0.01). 그러나 발열 시 감염을 미리 구별할 수 있는 검사실 소견은 없었다. 결론 : 간세포암에 대한 화학 색전 및 주입 요법 후 색전술 후 증후군은 31.4%, 감염성 합병증은 2.3%에서 발생하였다. 색전술 후 발열이 있으면서 SIRS의 기준을 만족하거나 시술 후 72시간 이 후에 복부 동통이 발생할 때에는 감염성 합병증을 반드시 고려해야 하겠다. Background : Transarterial chemoembolization(TACE) and chemoinfusion (TACI) are the methods used increasingly in hepatocelluar carcinoma patients. In this study, the incidence of fever and infectious complications after TACE or TACI in pateints with hepatocellular cacinoma was investigated and clinical parameters predicting such complications were evaluated. Methods : Prospective surveys were done in hepatocelluar carcinoma patients who had undergone TACE or TACI from June August, 1997. Three hundred three treatment cases with TACE (200) or TACI (103) in 284 patients were analyzed. The postembolization syndrome was defined as fever following TACE or TACI that spontaneously subsided without the evidence of infections or extrahepatic emboilizations. Results : One hundread eight (35.6%) out of 303 cases showed fever after the treatment. Regarding the etiology of the fever, after the treatment. Regarding the etiology of the fever, infections occurred in 7 cases (2.3%), and ischemic cholecystitis existed in 5 cases (1.7%). In one case the cause was not clear and 95 cases (31.4%) were classified as the postembolization syndrome. Out of the infections, three had culture-negative neutrocytic scites, two spontaneous bacterial peritonitis (one was accompanied with sepsis), one septic shock, and one urinary tract infection. The postembolization syndrome was more frequently found in the cases with ascites (odd ratio [OR], 2.74; 95% confidence interval[CI], 1.30∼5.75), with larger tumor (OR, 1.15; 95% CI, 1.06∼1.24) and with embolization both hepatic arteries (OR, 1.81; 95% CI, 1.00∼3.28). In the cases with infections, many satisfied the criteria for systemic inflammatory response syndrome (SIRS, P<0.05) or had abdominal pain 72 hours later (P<0.01) after the treatment. However, no other laboratory data predicted infection among the cases with fever. Conclusion : After TACE or TACI in hepatocellular carcinoma patients, 31.4% of cases showed the postembolization syndrome and 2.3% of cases showed infection. Infection should be considered as a cause of fever in patients satisfying the criteria for SIRS or with abdominal pain 72 hours later after the treatment.