http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Alu-Derived Old World Monkeys Exonization Event and Experimental Validation of the LEPR Gene
Huh, Jae-Won,Kim, Young-Hyun,Kim, Dae-Soo,Park, Sang-Je,Lee, Sang-Rae,Kim, Sang-Hyun,Kim, Ek-Yune,Kim, Sun-Uk,Kim, Myeong-Su,Kim, Heui-Soo,Chang, Kyu-Tae Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.3
The leptin receptor (LEPR) is a crucial regulatory protein that interacts with Leptin. In our analysis of LEPR, novel AluJb-derived alternative transcripts were identified in the genome of the rhesus monkey. In order to investigate the occurrence of AluJb-derived alternative transcripts and the mechanism underlying exonization events, we conducted analyses using a number of primate genomic DNAs and adipose RNAs of tissue and primary cells derived from the crab-eating monkey. Our results demonstrate that the AluJb element has been integrated into our common ancestor genome prior to the divergence of simians and prosimians. The lineage-specific exonization event of the LEPR gene in chimpanzees, orangutans, and Old World monkeys appear to have been accomplished via transition mutations of the 5' splicing site (second position of C to T). However, in New World monkeys and prosimians, the AluJb-related LEPR transcript should be silenced by the additional transversion mutation (fourth position of T to G). The AluJb-related transcript of human LEPR should also be silenced by a mutation of the 5' splicing site (first position of G to A) and the insertion of one nucleotide sequence (minus fourth position of A). Our data suggests that lineage-specific exonization events should be determined by the combination event of the formation of splicing sites and protection against site-specific mutation pressures. These evolutionary mechanisms could be major sources for primate diversification.
( Sung Pil Hong ),( Tae Il Kim ),( Hyun Gun Kim ),( Hyun Soo Kim ),( Seong Eun Kim ),( Kyu Chan Huh ),( Jeong Eun Shin ),( Jae Myung Cha ),( Suck Ho Lee ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Background/Aims: Recent guidelines strongly recommend that the interval of surveillance colonoscopy be determined according to the risk stratification obtained at index colonoscopy. However, because of the differences in perception of the classification of colorectal intraepithelial neoplasia between Asian and Western countries, there is some confusion about surveillance colonoscopy. The aim of the present study was to evaluate the clinicopathological characteristics and the interval of surveillance colonoscopy between patients with high-grade dysplasia/carcinoma in situ and those with intramucosal carcinoma. Methods: From January 2003 to June 2010, 727 patients were included from 8 tertiary centers. Four hundred fifteen patients (57.1%) had high-grade dysplasia /carcinoma in situ (group A), and 312 (43.9%) had intramucosal carcinoma (group B). Clinicopathological data were reviewed retrospectively. Results: Group A had a significantly more frequent family history of colorectal cancer (3.1% vs. 0.6%, P<0.001), smaller polyp size (12 mm vs. 15 mm, P=0.001), and more proximal location (31.1% vs. 21.8%, P=0.005) than did group B. Among 727 patients, surveillance colonoscopy was performed within 6 months in 55.8% of patients and within 12 months in 77.8%. Group B had a significantly shorter interval of surveillance colonoscopy than did group A (P<0.001). There was no difference in detection of advanced neoplasia at surveillance colonoscopy between the 2 groups (6.6% vs. 5.4%, P=0.638). Conclusions: The recommended interval of surveillance colonoscopy is not followed in Korea. More education about post-polypectomy surveillance guidelines is required. (Intest Res 2013;11:276-282)
Uncertainty Observer using the Radial Basis Function Networks for Induction Motor Control
Sung-Hoe Huh,Kuo-Beum Lee,Ick Choy,Gwi-Tae,Park,Ji-Yoon Yoo 전력전자학회 2004 JOURNAL OF POWER ELECTRONICS Vol.4 No.1
A stable adaptive sensorless speed controller for three-level inverter fed induction motor direct torque control (DTC) system using the radial-basis function network (RBFN) is presented in this paper Torque ripple in the DTC system for high power induction motor could he drastically reduced with the foregoing researches of switching voltage selection andtorque ripple reduction algorithms However, speed control performance is still influenced by the inherent uncertainty of the system such as parametric uncertainty, external load disturbances and unmodeled dynamics, and its exact mathematical model is much difficult to be obtained due to their strong nonlinearity. in this paper, the mherent uncertainty is approximated on-line by the RBFN, and an additional robust control tenn is introduced to compensate for the reconstruction error of the RBFN instead of the rich number of rules and additional updated parameters. Control law for stabilizing the system and adaptive laws for updating both of weights in the RBFN and a bounding constant are established so that the whole closed-loop system is stable in the sense of Lyapunov, and the stability proof of the whole control system is presented Computer simulations as well as experimental results are presented to show the validity and effectiveness of the proposed system
A simple and effective treatment for nasal telangiectasia: Needle-assisted electrocoagulation
( Sang Young Byun ),( Bo Ri Kim ),( Jung Tae Park ),( Je Byeong Chae ),( Kyoung Chan Park ),( Sang Woong Youn ),( Changhun Huh ),( Jung Im Na ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Nasal telangiectasia is a common phenomenon in elderly and can cause significant cosmetic and psychological problem. Although there are various lasers and chemical treatment for nasal telangiectasia, insufficient effect and side effects such as purpura and postinflammatory hyperpigmentation are common. We used needle-assisted electrocoagulation for the treatment of nasal telangiectasia with success. A male aged 72 years visited dermatologic department complaining of heavy nasal telangiectasia occurred about 10 years ago. After local anesthesia with EMLA® cream, 30G needle tip was placed in the telangiectactic vessel lumen and electric current was delivered through it. Immediate disappearance of blood vessels was observed. Downtime was minimal because only needle marks exist after procedure. There was no purpura. He showed dramatic improvement of telangiectasia after one session, and after four sessions, almost complete clearance was obtained. Needle-assisted electrocoagulation is a simple and effective treatment for nasal telangiectasia with minimal downtime and minimal adverse effects.
Huh, Tae-Sung,Lee, Hee-Jong,Han ,In-Sup,Kim, Tae-Rin Korean Chemical Society 1986 Bulletin of the Korean Chemical Society Vol.7 No.1
Reaction of ${\alpha}-cyano-{\beta}-phenylacrylic$ acid derivatives (Ⅰ) with thioglycolic acid in the molar ratio of 1:2 in saturated sodium bicarbonate solution yielded 3-(4'-oxo-2'-thiazolin-2'-yl)-2-phenyl-4-oxotetrahydrothiophene derivatives (V). Thioglycolic acid was found to be added not only to carbon-carbon double bond but also to carbon-nitrogen triple bond and those adducts were cyclized to V.
Huh, Tae-Sung,Han, Hae-Sook,Han, In-Sup,Kim, Tae-Rin Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.1
The addition reactions of thioglycolic acid to ${\omega}$, ${\omega}$-diacetylstyrene derivatives were investigated. ${\omega}$, ${\omega}$-Diacetylstyrene derivatives easily undergo addition reactions with thioglycolic acid to form s-(2, 2-diacetyl-1-phenylethyl)-thiogycolic acid, s-[2,2-diacetyl-1-(methyl) phenylethyl]-thioglycolic acid, s-[2,2-diacetyl-1-(p-methoxy) phenylethyl]-thioglycolic acid and s-[2,2-diacetyl-1-(p-chloro) phenylethyl]-thioglycolic acid, respectively. The structures of these compounds were identified by neutralization equivalent, UV, IR, and NMR spectral data.
A Neuro Fuzzy Controller for DC-DC Converters
Sung-hoe Huh,Yong-Ha Hwang,Gwi-Tae Park,Ick Choy 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-
A new type of controller for DC-DC converters is presented The proposed neuro-fuzzy controller combines fuzzy logic with neural networks to adjust parameters of the fuzzy controller to the most appropriate. Neither the exact mathematical models of the DC-DC converters nor the tuning process of the parameters of the fuzzy controller are needed in the proposed scheme Simulation results are presented to show the above process and transient, steady state responses, and load regulation of the given system.
Huh, Tae-Sung 가톨릭대학교 자연과학연구소 1999 자연과학논문집 Vol.20 No.-
In certain favourable cases, cross-ozonides 4 could undergo acid-catalyzed intramolecular rearangement to the corresponding 1,2,4,6-tetroxepanes 5 and monoozonides 6. All of the tetroxepanes 5 and monoozonides 6 have been isolated as pure substances and characterized by their ¹H NMR and ^(13)C NMR spectra.
Case Reports : Spontaneous rupture of the Lateral thoracic artery in patients with Liver cirrhosis
Tae Hee Lee,Yong Sung Park,Dong Jin Chung,Ji Hyung Kim,Sun Moon Kim,Euyi Hyeog Im,Kyu Chan Huh 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3
Bleeding in patients with liver cirrhosis is primarily caused by gastroesophageal varix in association with extensive collateral circulation, portal hypertensive gastropathy, a Mallory-Weiss tear and peptic ulcer disease. The spontaneous rupture of an artery, as a result of coagulopathy, is extremely rare in patients with liver cirrhosis; however, we recently observed a case of a spontaneous rupture of the lateral thoracic artery in a 47 year-old male patient with alcoholic liver cirrhosis. The patient expired despite repeated transcatheter arterial embolization of the lateral thoracic artery and best supportive care. This is, to our knowledge, the first documented case of the spontaneous rupture of the lateral thoracic artery in a patient with liver cirrhosis.