흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

Protein Methylase Ⅱ 活性 및 그 酵素力學에 미치는 金屬이온의 影響

姜龍淳,林圭,郭相太 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

Effects of metal ions on the kinetic properties of protein methylase II from various tissues were investigated. 1. Copper ion(Cu^2+) and zinc ion(Zn^2+) were potent inhibitors, the activity of the enzymes from heart, liver, brain and placenta being completely inhibited at 2 mM. The other ions did not almostly affect the activity of the enzyme. 2. The inhibition of copper and zinc ions were recovered 58%, 62% of the enzyme activities of heart and 68%, 67% of its activities of placenta by EDTA, respectively. And the inhibition of zinc ion was almostly recovered by adding histone after zinc ion and EDTA preincubation. 3. The inhibition of copper ion was completely recovered by adding of 10 mM of mercaptoetharnol, but zinc ion did not almost affect. 4. The inhibition of zinc ion was completely recovered by adding 50 mM of phosphate, but copper ion did not almost affect. 5. The apparent Km values for S-adenosyl-L-methionine were 4x10^-6 M in heart and 2x10^-6M in placenta. The kinetic analysis of the enzymes from heart and placenta in the presence of 50 uM of copper ion showed that the nature of the inhibition was noncomptitive, considering that Km was constant and Vmax was decreased, and 50 uM zinc ion showed that it was uncompetitive, considering that both Km and Vmax were decreased. These results suggest that the inhibitions of protein methylase II by copper and zinc ion are related to the other mechanisms, respectively.

家兎에 있어서 頭蓋內壓亢進이 Picrotoxin 痙攣에 미치는 영향

姜珍祥,鄭光現,丁相鍵,李順揆 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.1

After intravenous administration of picrotoxin, 4 steps of responses were observed, i. e. a) tremor and disturbance of righting reflex b) clonic convulsion c) tetanic convulsion and d) death. Picrotoxin (1㎎/㎏) elicited above responses 14.2 (a), 32.6 (b) and 38.8 (c) minutes after intravenous administration, exhibiting shortening of the duration with Increased doses. Jncreased intracranial pressure by intraventricular administration of saline or extradural balloon method facilitated picrotoxin convulsion. Phenobarbital and dilantin suppressed picrotoxin convulsion and facilitating effect of intracranial pressure on picrotoxin convulsion. Possible mechanism of the effect of increased intracranial pressure on picrotoxin convulsion was discussed.

소뇌에 발생한 Nocardiosis : 증례 보고 Case Report

성연상,김상진,박순필,강재규,도종웅 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.6

The authors report a extemely rare case of primary cerebellar nocardial abscess. Cerebral nocardiosis is rare disease and often fatal, and often fatal, and commonly spreaded from nocardiosis of lung or skin. Total excision of abscess and medication with sulfonamide is the treatment of choice. The patient was treated by continuous external dirainage with intermittent irrigation of abscess cavity by sulfonamide and given with sulfonamide for 10 months.

Speaker Verification System Using Hybrid Model

강현규,양성일,권영헌 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-

본 논문은 하이브리드 모델을 이용한 화자 식별시스템에 대한 연구이다. 화자 식별을 위하여 설계한 하이브리드 화자 인식기는 일반적으로 사용되고 있는 HMM과 DTW를 사용하여 구성하였다. 인식기의 성능을 판단하기 위한 실험은 다음의 세 가지에 대하여 수행하였다. 시스템에 등록되어 있는 화자의 식별과 비 등록 화자의 등록된 화자 키워드 도용에 대한 시스템 거부, 그리고 등록된 화자의 다른 등록 화자에 대한 키워드 도용에 따른 시스템 거부에 관하여 검토하였다. 키워드는 화자의 이름을 사용하였고, 시스템에 사용된 특징 파라메터는 15차 켑스트럼(CEP), 10차 line spectrum pairs (LSP), 10개 대역으로 나뉘어진 주파수 대역별 에너지값(FB)을 사용하였다. 이 세 가지의 특징 파라메터들과 두 개의 인식기를 조합, 무두 여섯 개의 인식 결과 값을 누적하여 인식 여부를 결정하도록 하였다. 개별적 시스템에서 발생되는 오인식을 Hybrid model을 이용하여 처리한 본 시스템에서는 좋은 결과를 얻을 수 있었다. This paper is a study on the speaker verification system(SVS) using hybrid model. For speaker verification, we design a hybried-recognizer composed of conventional methods (such as HMM, DTW), We verified the performance; system access for registered speaker using correct keyword, system deny-Ⅰfor non-registered speaker using arbitrary keyword, and system deny-Ⅱ forregistered speaker using keyword of another registered speaker. A name of speaker is used as keyword. We use three classes of feature vectors respectively; line spectrum pairs (LSP), cepstrum (CEP), and filter bank energy (FB). Hybridrecognizer using these three features will give rise to six results with respect to feature and recognizer. Though a single system makes some recognition error, this speaker verification system using hybridmodel shows a good results in this experiment.

시간-주파수 분포를 이용한 레이다 신호해석 및 처리에 관한 연구

강상만,김중규 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.2

본 논문에서는 Time Frequency Distribution(TFD)을 이용한 새로운 레이다 신호처리 알고리즘을 제시한다. 신호를 시간과 주파수 영역에 대해서 동시에 해석하는 방법입 TFD를 이용하여 레이다 신호처리의 궁극적인 목표인 time delay(range)와 frequency shift(velocity)를 찾아내는 것이 그 목적이다. 능동적 레이다의 경우, 레이다 신호의 특성상 송신신호에 대한 정확한 정보를 가지고 있다는 점에 착안하여 송·수신 신호간에 correlation을 취한 새로운 신호에 대해서 TFD를 취해 주는 Correlated TFD(CTFD) 알고리즘을 제안한다. CTFD알고리즘을 통해서 전파의 송·수신 경로에 더해지게 되는 잡음성분의 영향을 감소시키는 효과를 얻을 수 있다. 따라서 보다 정확한 detection이 가능하게 된다. 그러나 TFD는 많은 계산 과정을 필요로 하기 때문에 현재의 기술로는 실시간 처리가 어려운 상황이다. 그래서 실시간 처리를 위한 방법으로 correlation과 TFD를 병행하여 time delay와 frequency shift를 독립적으로 찾아내는 보다 빠른 알고리즘 또한 제시한다. 본 논문에서 제시한 알고리즘의 타당성을 보이기 위해 -30dB ∼ 30dB 까지의 SNR을 갖는 additive white Gaussian noise(AWGN) 상황을 가정하여 기존의 방법과의 비교를 통한 실험결과를 제시한다. We propose a new algorithm for radar signal analysis and processing using the Time Frequency Distribution(TFD) by which the radar signal can be analyzed both in time and frequency domains simultaneously. The objective is to estimate the time delay and frequency shift between the transmitted signal and. the received signal, which is the typical goal of a radar system. The proposed algorithm is a Correlated TFD(CTFD) in the sense that it computes the time -frequency distribution of the cross-correlation between the transmitted and the received signals. Here, we consider an active radar system for which the signal characteristics are completely known a priori. By taking the TFD of the cross -correlation function rather than the radar signal itself, the effect of channel noise could be reduced significantly. One of the drawbacks for TFD method is that it involves a lot of computations, and thus can hardly be implemented in real time. To achieve the desired goal, i.e. estimation of time delay and frequency shift, in less time than the conventional TFD method, we propose a modified processing scheme which independently implements the correlation and the TFD methods for estimating the time delay and the frequency shift respectively. Finally in order to show the feasibility of our proposed scheme, we give some numerical results for an additive white Gaussian noise(AWGN) environment where the signal to noise ranges from -30 dB to 30 dB, and compared the result with conventional TFD methods.

乳房 疾患의 病理組織學的 硏究

姜大榮,宋圭祥 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

A histopathologic study was made on 844 cases of the breast lesions of female, which were collected, from Jan. 1980 to July 1985, at the Department of Pathology, School of Medicine, Chungnam National University. The results were as follows 1. Among 844 cases of the breast lesions of female the age distribution shows the highest frequency in the third decade(317 cases, 37.6%), followed by the 4th decade(260 cases, 30.8%), the 5th decade(147 cases, 17.4%), the 6th decade(53 cases, 6.3%), and the second decade(42 cases, 5.0%) in decreasing order of frequency. 2. The most: frequent breast lesion was the nonneoplastic lesion(345 cases, 40.9%), followed by benign tumor(326 cases, (38.6%), malignant tumor(130 cases, 15.4%), and inflammatory disease(43 cases, 5.1%). 3. Among inflammatory disease, acute mastitis and abscess was 21 cases and chronic mastitis and plasma cell mastitis was 20 cases. Seventeen cases of inflammatory disease were present in the third decade. 4. The most prevalent nonneoplastic lesion was fibrocystic disease(297 cases, 86.1%), which reveals the highest frequency in the fourth decade(129 cases), followed by third decade(93 cases) and the fifth decade(54 cases). The mean age of fibrocystic disease was 32.9 years. 5. Among benign tumor fibroadenoma was 269 cases (82.5%), intraductal papilloma and lactating adenoma, 17 cases, respectively, lipoma 7 cases, and tubular adenoma, cystosarcoma phyllodes, fibroma, 4 cases, each. The most prevalent age of fibroadenoma was the third decade(the mean age; 27.7 years). 6. Among 130 cases of malignant tumor infiltrating duct carcinoma shows the highe incidence(112 cases, 86.1%), followed by noninfiltrating duct carcinoma 10 cases, lobula carcinoma 4 cases, and sarcoma 3 cases, in decreasing order of frequency. The most frequen subtype of infiltrating duct carcinoma was simple type, followed by scirrhous, medullary, papillary, colloid, and infiltrating comedocarcinoma. The malignant tumor shows highest incidence in the fifth decade and the mean age was 47.6 years.

삼랑진 지점의 수위-유량곡선식 개발에 관한 연구

강대석,민일규,이승휘,옥치율 東亞大學校 海洋資源硏究所 2003 硏究論文集 Vol.15 No.-

In this study, Development The Rating-Curve Formula through to enforce the discharge investigator on Samrangjin Point. As use the result, We earning rationality, Economical irrigation and establishment a water control project, the basic material of determines hydraulic capacity to design water resources structure. At the same time, We can use The Rating-curve for a high efficient Flood wamning forecast in Nak-Dong River. The result and opinion of the discharge investigator is as follow: 1. The Rating-Curve Formula is Q=(-1065.91941)+1137.237287H+4.671360913H³(1.27<H<9.57) 2. A periodical and continuously management make a routine check over a watermark. 3. When enforce the discharge inverstigator, it require many time, person and equipment. So we can get accuracy and safety working conditions by assist a new system equipment to amount of flowing water measurement. 4. We must sublate to prepare the river bed or collect aggregate as possible, for the upper and downstream section in the established point of a watermark .

준설수심에 따른 사천만의 해수유동 특성에 관한 연구

강대석,유상호,민일규,이동수,민병형 東亞大學校 海洋資源硏究所 2003 硏究論文集 Vol.15 No.-

This study on the characteristics of the tidal current at the half closed bay selected Sachoˇn Bay located in the western Kyung-nam area as the object location of the study. Then, I analyzed the current with the varying dredging depth after the depth integral of the three Dimensional continuous equation and Navier-stokes equation. The study would get the following results, and the results could be used meamingfully as the analysis material about the dredging depth's influnce on the surrounding ocean when developing the coastal port. 1. When measuring the tidal current, there is a bit dispersion in the current direction of the observed object, but it is the wind effect at the bay. Considering that the calculated result is the shallow-water equation integranted in depth, the results can be concluded to in accored with my expectancy. 2. In case of reclaiming and dredging, the flow velocity and direciton change constantly, compared with the present condition. 3. At the wide bay dredge depth does not arrect the level of the ocean, but in case of inflow from the flood, the increase of the inflow of the river water affects the level of the ocean. 4. As the dredge depth grows deep, the maximum flood tidal current and obb tidal current at the front coast of the reclaimed decreases a little. However, the wide area Pc-7~Pc-9 doesn't show any change. As we saw in the above result, feacturcs of the tidal current as the level of the ocean and the current velocity don't change in the aspect of the ocean engineering even if we increase the degree of the dredge depth up to 6m in Sachoˇn Bay

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.