뇌동맥류 수술환자의 정신신경학적 분석

정현태,박순필,김상진,도종웅 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.4

The mortality rate of aneurysmal surgery had recently been reduced remarkably due to mordern microsurgical technique and refinement of the timing of operation. Despite recovery without neurological deficits, many patients remain with emotional and psychological sequelae postoperatively. We evaluated 33 patients, operated on intracranial aneurysm for recent 2 years, about quality of life and degree of cognitive function. For proper evaluation of outcome of aneurysmal surgery, in addition to the neurological outcome, psychological aspects must be considered.

감마나이프수술 환자의 만족도 및 재원일수에 대한 고찰

정상순,정현태,백선하,김동규 한국의료QA학회 2001 한국의료질향상학회지 Vol.8 No.1

Background : Since a Gamma Knife had been installed on December 1997, 405 patients have been treated until December 1999 at department of neurosurgery of Seoul National University hospital. The authors analyzed results of a work to improve satisfaction of Gamma Knife surgery patients and to reduce hospital length of stay. Methods : To understand main discontent of patients, a pre-survey was performed from October 1998 to December 1999 using a questionnaire. By Analyzing 93 questionnaire received from 234 patients, pain on frame application, explanation before surgery, waiting time before surgery, waiting time before medical procedure were main discontent factor and overall satisfaction ratio was 71.0%. To improve satisfaction ratio, several quality improvement activity works were designed and applied to 123 patients during the period between January 2000 and September 2000. The same questionnaire were analyzed. Works to reduce the patient hospital LOS were devised and applied during the same period. Results : The overall satisfaction ratio of Gamma Knife radiosurgery patients was increased to 83,7%(P=0.10). The main factor to improve satisfaction ratio was to reduce waiting time(P=0.05) and improvement of discomfort during the surgery(P=0.06). The average LOS was reduced from 3.1 to 2.7 days(P=0.003). Conclusion : As a result of quality assurance activities, the overall satisfaction ratio of patients was improved and LOS was reduced. The pain during frame application was remained as a main discontent factor and a further study is required to reduce this pain.

니페디핀이 암피실린의 흡수에 미치는 영향

정현정,용철순,최윤수,오두만 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

Amino-β-lactam antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the Na^(+)/H^(+) exchanger and cakium ion is involved in control of this antiport. Interaction between ampicillin which is one of the amino-β-lactam antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of O₂/CO₂ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb's buffer at pH6.0 Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.

산업정책의 이론분석

정상현,이순호 又石大學校 1990 論文集 Vol.12 No.-

The idea of industrial policy calls into question many of the economic beliefs that Americans have popularly used since the end of World WarⅡ to explain their own economic preesminence such things as their commitment to market mechanism as the supreme arbiter of economic desions, their reliance on adversarial rather than cooperative public-private relations, and their greater devotion than other peoples to free trade. The purpose of this study puts its first place on the analysis of the idea of industrial policy, and secondly identifies the four approaches on the industial policy.

방사선작업종사자에게 발생한 암의 업무관련성 평가를 위한 선별선량의 활용

정미선,진영우,임현술,김종순 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3

방사선사진에서의 골질과 임상적으로 평가한 골질 분류의 상관관계

김현우,허경회,박관수,김정화,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined in each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and -0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites. (Korean J Oral Maxillofac Radiol 2006; 36 : 25-32)

일회통과 관류실험시 물의 수송 : 관류액의 종류와 삼투압의 영향 Effects of Some Perfusates and Their Osmolality

이정화,이현주,용철순,오두만 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-

The single pass perfusion experiments were performed in anesthetized rata to investigate the effects of perfusates and their osmolality on the water transport and to determine the correlation between the extent of water transport and the volume change of perfusate. Phenol red was used as a nonabsorbable marker. In normal rats, when perfused at a flow rate of 0.5 ml/min 2-(N-morpholino) ethanesulfonic acid (MES) aid Sorensen's phosphate hullers showed minimal net water transport as 0.125 and 0.173 %/cm of intestinal length, respecetively. Hypotonic perfusate of 200 mOsm㎏ of water and hypertonic perfusate of 400 mOsm/㎏ of water generated significant water transport compared with isotonic perfusate of 300 mOsn/㎏ of water. There was a linear correlation between the attent of water transport and the volume change of perfusate, suggesting that the volume change can be used as a measure of water transport.

항생제 혼합 시멘트 정을 이용한 장관골 감염성 불유합의 이단계 치료

조세현,정순택,박형빈,황선철,하용찬,황인환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 장관골 감염성 불유합의 치료 시 항생제 혼합 시멘트 정을 이용한 이단계 재건술의 결과를 분석하고자 한다. 대상 및 방법: 1998년 1월부터 2002년 9월까지 장관골 감염성 불유합으로 이단계 재건 수술을 받은 41예 (대퇴골 26예, 경골 15예)를 대상으로 하였다. 일단계 수술에서는 광범위한 변연 절제술, 부골 제거 및 세척술과 기존 고정 장치의 제거 또는 외고정 장치로의 교환을 시행한 후 시공 (dead space)과 불유합 주변 연부조직 내 항생제 혼합 시멘트 정을 삽입하였다. 임상적 감염 증상이 호전된 평균 8.7주 (3주~32주) 후 이단계 재건술로서 Ⅰ군은 내고정 장치 (금속판 5예, 골수강내 금속정 8예), Ⅱ군은 외고정 장치 (Ilizarov 25예, Monofixator 3예)로 각각 고정하고 17예에서는 골내 이동술이나 골 연장술을 시행하였다. 양군 모두 필요한 경우 골 이식과 시멘트 정의 교환을 추가하였다. 추시 기간은 16개월에서 최장 71개월로 평균 45개월 이었다. 치료 결과는 골유합 기간 및 Paley 방법에 의한 방사선상 골유합 상태와 하지 기능으로 평가하였다. 결과: Ⅰ군 13예 전부와 Ⅱ군 28예 중 26예에서 감염의 치료와 골유합을 얻었다. 이단계 재건술 후 골 이식술, 골 소파술, 외고정 핀 교환과 각변형 교정술, 피부 이식 또는 근육 피판 회전술 등의 보조적 시술이 Ⅰ군은 평균 2회, Ⅱ군은 평균 6.2회 추가되었다. 평균 골유합 기간은 Ⅰ군이 19.3주이고 Ⅱ군이 23.1주로 내고정군이 더 빨랐다. 방사선상 Paley 골유합 상태는 Ⅰ군이 우수 8예, 양호 5예이었고, Ⅱ군이 우수 18예, 양호 7예, 보통 1예, 불량 2예 이었다 (p=0.492). 기능적 결과는 Ⅰ군에서 우수 6예, 양호 6예, 보통 1예 이었고, Ⅱ군에서는 우수 10예, 양호 13예, 보통 3예, 불량 2예 이었다 (p=0.267). 결론: 항생제 혼합 시멘트 정의 골수염 치료 효과가 관찰되었으며, 감염이 호전된 후 내고정 장치로 교환해 준 군이 외고정을 유지한 군에 비하여 추가 수술 횟수가 적고, 골유합 기간도 빨랐다. Purpose: To evaluate treatment results between internal na external fixation groups in two-stage reconstruction of infected nonunion of long bones using antibiotics-impregnated cement beads. Materials and Methods: In the first stage, preexisting hardwares were removed and radical debridement was done. The dead space was filled with antibiotics -impregnated cement beads and the nonunion sits was immobilized by external fixation, cast or skeletal traction. In the second stage, all cases were divided into two groups; the nonunion was fixed by internal fixation in group Ⅰ versus external fixation in group Ⅱ. The intervening period between the first and second stage was average 8.7 weeks (range, 3~23 weeks). Results: The follow-up period was average 45 months (range, 16~71 months). Infection control and bone union were achieved in all 13 cases of group Ⅰ. Infection recurred in two of 28 cases in group Ⅱ, one underwent above-knee amputation and the other case was lost in follow-up. The mean number of supportive operations including repeated curettage, augmentation and change of infected pins, angular correction, and soft tissue flap was average 2 and 6.2 times respectively in group Ⅰ and group Ⅱ. Bony union period was average 19.3 and 23.1 weeks in each group. According to Paley's classification, group Ⅰ was similar to group Ⅱ in bony and functional result (p>0.05). Conclusion: Antibiotics-impregnated cement beads provided positive effect on infection control. Internal fixation group showed less number of additional operations and earlier bony union than external fixation group.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

대학 공시정보를 활용한 교육국제화역량 인증 여부 예측: 이산선택모형에 의한 대학알리미 공시정보 분석

이동현(Lee, Dong-hyun),조순정(Cho, Soon-jeong) 한국경영교육학회 2020 경영교육연구 Vol.35 No.3

[연구목적] 본 연구는 대학 공시정보를 활용하여 교육국제화역량 인증(IEQAS) 여부를 예측하며, 대학의 인증 유지를 위한 자가 점검에 적합한지 연구 모형을 검증하는데 목적이 있다. [연구방법] 동 연구는 IEQAS 인증․미인증 예측을 위해 2019년 대학알리미 웹사이트에 공개된 138개 사립 대학의 공시정보를 수집했다. 이어, 인증 대학 77개교 및 미인증 대학 61개교 두 집단 간 지표 차이를 검정 후, 5개의 대학경쟁력지표 및 9개의 재정회계지표를 독립 변수로, 2019년 3월에 발표된 IEQAS 인증 결과를 이산형 종속 변수로 설정하여 이산선택모형에 따라 로짓분석과 판별분석을 하였다. [연구결과] 본 연구자들은 t-검정으로 선별한 재학생충원율/신입생충원율/전임교원확보율(이상 대학경쟁력), 학생1인당교육비/교육비환원율/부채비율/법인전임급비율(이상 재정회계)을 연구 모형에 유의한 요인으로 투입했다. 그 결과, 대학경쟁력 지표를 통한 예측력은 로짓분석 71.7%, 판별분석 71.0%로, 재정회계 지표의 경우 로짓분석 70.3%, 판별분석 66.7%의 예측력을 보였다. 동 이산선택모형 내에 공통으로 관여한 유의미한 변수는 재학생충원율, 신입생충원율과 학생1인당교육비로 나타났다. [연구의 시사점] 동 연구는 조직의 부실 여부 예측에 유용한 로짓분석과 판별분석을, 정부의 대학별 공개 자료를 활용하여 IEQAS 인증․미인증 예측에 적용해 본 가치를 지닌다. 본 연구의 이산선택모형은 타당성과 신뢰성이 확인됨으로써, 대학이 손수 IEQAS 인증 유지 점검 시 활용할 수 있으며 대학 평가에 관한 경영교육 실무에 기여할 것이다. [Purpose] Based on a discrete choice model(DCM), this study aims to predict the ‘pass/fail’ of the International Education Quality Assurance (IEQAS) by analyzing publicly opened dataset. Thus, it will enable Korean universities to self-test their IEQAS-related capabilities in a productive manner. [Methodology] This work utilized disclosed data on academyinfo.go.kr in 2019, including a total of 138 private universities from My university competitiveness(MUC), Financial accounting index(FAI); relying on related literature, it proposed two hypotheses and 14 independent variables, followed by conducting logit analysis(LA) and discriminant analysis(DA). [Findings] First, t-tests identified three MUC variables(Levy with enrolled students; Levy with new students; Faculty in full service) and four FAI variables(Educational expenditure; Educational restitution rate; Liability ratio; Corporate transferred money) between 77 IEQAS ‘pass’ group and 61 IEQAS ‘fail’ group in 2019. This DCM presented the following predictive powers: 71.7%-LA vs 71.0%-DA in MUC and 70.3% -LA vs 66.7%-DA in FAI, while Levy with enrolled students, Levy with new students and Educational expenditure worked as keys to predicting the ‘pass/fail’. [Implications] The DCM combining LA/DA can be used for both scholars on the business education area and the IEQAS-related practitioners.