항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

자동봉합기르를 이용한 위전절제술에 대한 임상적 고찰

송선교(Sun Kyo Song),손수상(Soo Sang Sohn),강중신(Joong Shin Kang) 대한외과학회 1985 Annals of Surgical Treatment and Research Vol.28 No.2

진행 위암의 치료

송선교 ( Sun Kyo Song ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S

Curative surgery is the most common and desirable treatment for advanced gastric cancer (AGC), but macroscopically curative resection of AGC dose not always mean a curative outcome, For the tailored management of AGC, accurate preoperative stage are made by using abdominal CT, FDG PET and laparoscopy is necessary. In case of T3/T4 lesion, neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACR) are effective therapeutic approaches with acceptable toxicity without increasing surgical morbidity and mortality. I recommend the use of a multidisciplinary therapeutic strategy for treatment of AGC. Future applications of newer cytotoxic drugs such as oxaliplatin, capecitabine, irinotecan, and docetaxel or targeted therapies may help to improve the management of AGC.

자동봉합기를 이용한 위장관수술의 임상적 고찰

송선교(Sun Kyo Song),손수상(Soo Sang Sohn),강중신(Joong Shin Kang) 대한외과학회 1984 Annals of Surgical Treatment and Research Vol.27 No.1

Vertical capacitance aptasensors for real-time monitoring of bacterial growth and antibiotic susceptibility in blood

Song, Jun Ho,Lee, Sun-Mi,Park, In Ho,Yong, Dongeun,Lee, Kyo-Seok,Shin, Jeon-Soo,Yoo, Kyung-Hwa Elsevier 2019 Biosensors & bioelectronics Vol.143 No.-

<P><B>Abstract</B></P> <P>For the treatment of bacteremia, early diagnosis and rapid antibiotic susceptibility tests (ASTs) are necessary because survival chances decrease significantly if the proper antibiotic administration is delayed. However, conventional methods require several days from blood collection to AST as it requires three overnight cultures, including blood culture, subculture, and AST culture. Herein, we report a more rapid method of sensing bacterial growth and AST in blood based on a vertical capacitance sensor functionalized with aptamers. Owing to their vertical structure, the influence of blood cells sunk by gravity on capacitance measurements were minimized. Thus, bacterial growth in blood at 10<SUP>0</SUP>–10<SUP>3</SUP> CFU/mL was monitored in real-time by measuring changes in capacitance at <I>f</I> = 10 kHz. Moreover, real-time capacitance measurements at <I>f</I> = 0.5 kHz provided information on biofilm formation induced during blood cultures. Bacterial growth and biofilm formation are inhibited above the minimal inhibitory concentration of antibiotics; therefore, we also demonstrated that vertical capacitance aptasensors could be applied to rapid AST from positive blood cultures without a need for the subculture process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Our aptasensor can be used to monitor bacterial growth and antibiotic susceptibility in blood in real-time. </LI> <LI> Our aptasensor detects the bacterial growth directly rather than secondary CO<SUB>2</SUB> gas produced by metabolism, so it can be employed as an alternative method to CO<SUB>2</SUB> detection. </LI> <LI> Our aptasensor can be also used to perform a rapid antibiotic susceptibility tests using positive blood cultures without a subculture process. </LI> <LI> Therefore, the time needed to obtain the AST results from blood collection can be significantly reduced using our aptasensor. </LI> <LI> In addition, the bacteria growth and the biofilm formation can be simultaneously monitored during the blood culture by measuring the capacitance changes at different frequencies. </LI> </UL> </P>

重症 體表 火傷에 의한 心筋의 超微形態學的 變化

宋善敎,孫允卿,郭精植,孫泰重 慶北大學校 醫科大學 1986 慶北醫大誌 Vol.27 No.3

저자는 체표의 중증화상이 심근에 미치는 영향을 초미형태학적으로 규명하기 위해 체중 250gm 정도의 Sprague-Dawley계 흰쥐수컷에 Strenberg방법으로 30%의 3도화상을 입힌 뒤 6시간, 1일, 3일, 5일 및 7일에 각각 3마리씩 좌심실의 심근을 광학 및 전자현미경적으로 관찰하였다. 광학현미경적으로는 간질조직의 경한 부종과 울혈이 일어났다. 전자현미경적으로는 화상후 6시간부터 sarcoplas-mic reticulum의 확장, myelin figure의 출현, mitochondria의 경한종창이 일어나 3일까지 지속되었고, 5일후에는 mitochondria의 심한 종창, 핵막강의 확장, 공포형성과 FCD등이 출현하였다. 그러나 이와 같은 변화는 모두 가역적이었다. 이러한 소견으로 보아 화상후 6시간부터 3일까지 일어나는 비교적 경한 퇴행성 변화는 핍혈성 세포손상으로 보이며 5일이후 일어난 mitochondria의 심한 종창은 화상독에 의한 특징적인 손상으로 생각된다. This study was carried out to investigate ultrastructural changes of myocardium after severe skin burns, Sprague-Dawley rats weighing approximately 250 gm were given 30% third degree burns of the skin and were observed by means of light and electron microscope at 6 hours, 1 day, 3 days, 5 days, and 7 days after burns. On light microscopy, interstitial edema and congestion appeared after burns. On electron microscopy, dilatation of T-tubules, formation of myelin figures, and slight swelling of mitochondria appeared. These changes were persisted for 3 days after burns. At 5 days after skin burns severe dilatation of mitochondria, widening of perinuclear spaces, vacuolar changes, and formation of focal cytoplasmic degradation appeared. But these changes were reversible. By these changes, it would be considered tht slight degradation of myocardium occurring from 6 hours to 3 days after severe skin burns were caused by ischemia, and latent changes, such as marked swelling of mitochondria, were characteristic onew caused by burn toxin.

위암 절제조직에서 nm23 단백질 발현의 임상적 의의

송선교,김상운,김홍진 영남대학교 의과대학 1999 Yeungnam University Journal of Medicine Vol.16 No.1

위암환자에서 nm23 단백질이 예후인자로서의 영향을 규명하기 위해 위절제술로 얻어진 76명의 원발암 조직에 대해서 nm23 단백질의 단세포군 항체를 이용한 면역조직화학적 염색을 실시한 결과 nm23 단백질의 양성발현율은 53.9%(23/76)였다. 병리조직학적 소견들과의 비교에서 nm23 단백질의 양성발현율은조기암보다 진행암에서, 림프절 전이 양성군에서, 그리고 암세포의 림프관 침습이 있을 때 높게 나타났으며 유의한 차이가 있었다. nm23 단백질의 발현유무가 재발과 관련이 있는지에 대한 분석결과 재발율에서 차이가 없었다. nm23 단백질 발현 유무가 생존기간에 영향을 끼치는가에 대한 단변량 분석결과 생존과 관련이 없는 것으로 나타났다. 이상의 결과로 nm23 단백질의 양성발현 여부를 예후인자로 사용하기는 어려울 것으로 사료된다. The aim of present study was to elucidate whether the expression of nm23 protein might be of clinical value as a prognostic factor in gastric cancer. The expression of nm23 protein was analyzed using an immunohistochemical method with formalin-fixed and paraffin-embedded tissue samples from 76 gastric carcinoma patients. The cytoplasmic immunoreactivity of nm23 protein were detected in 53.9% of the sample tissues(41/76). When the immunoreactivity of nm23 protein with TNM status and other histopathologic findings were compared by using Chi-Square test, nm23 was found to have correlations with lymph node metastasis(p=0.04), a number of metastatic lymph node, and the invasion of lymphatic vessels(p=0.007): however, it had no correlation with TNM status. The conventional prognostic factors such as the depth of invasion, the degree of lymph node metastasis and the presence of distant metastasis, a Borrmann type, size of tumor, and the curability with operation were found to have a strong correlation with the survival time (p<0.003). However, the expression of nm23 protein was not significantly correlated with survival time in survival analysis. These results showed that the expression of nm23 protein is not a useful prognostic indicator in gastric cancer.

Improved Performance of Red Phosphorescent Organic Light Emitting Diodes Using Partial Mixed Host System

Sun, Yong,Lee, Ho Won,Lee, Song Eun,Yang, Hyung Jin,Yoo, Han Kyu,Hwang, Kyo Min,Kim, Chan Woo,Yoon, Seung Soo,Kim, Young Kwan American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.10

열처리에 따른 Cd₁-xZnxS/In 박막의 광학적 및 전기적 특성 분석

송우창,이경호,심상흥,이상교,심재선,박종국 三陟大學校 2002 論文集 Vol.35 No.-

In this thesis, effects of the thickness of indium films and the annealing temperature on optical and electrical properties of chemically deposited CdZnS films for the efficiency of the Cd1-xZnxS/CdTesolar cells were investigated. To improve the electrical conductivity of Cd1-xZnxs films, thin indium films(10-4Onm thickness)were evaporated on the suface of Cd1-rZnxs films. Experimental parameters such as indium film thickness, Zn mole fraction, and the annealing temperature in terms of structural and electrical properties of Cd1-xZnxs films were investigated. The diffusion process was carried out by heating the sample in air at 150-550℃ for 20 minute As the indium film thickness is increased, the resistivity decreases and the lowest value(0.3 O -cm)is obtained for Cd1-xZnxs films annealed at 450℃ with 40nm of the thickness.

The impact of aerosols on deep convective clouds in a double-moment microphysics scheme

Kyo-Sun Lim,Song-You Hong,Seong-Soo Yum,Jimy Dudhia 한국기상학회 2009 한국기상학회 학술대회 논문집 Vol.2009 No.4