유방암 환자의 말초혈액에서 역전사효소연쇄중합반응을 이용한 Human Mammaglobin 측정의 임상적 유용성

김재홍,강석윤,송정엽,최태영,임홍석,김선경,김영진,박준성,김현수,최진혁,임호영,김효철 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

Background: The mammaglobin gene encodes a novel protein that is secreted from the mammalian epithelium of normal breast tissue as well as malignant breast cancer tissues. In order to ascertain the prognostic value of mammaglobin gene in breast cancer patients, we measured the expression of human mammaglobin (hMAM) by RT-PCR method in various stages of breast cancer patients. Methods: Peripheral blood samples from forty healthy volunteers and 114 breast cancer patients were obtained. Peripheral blood stem cells (PBSC) collected for the purpose of autologous stem cell transplantation in five patients with metastatic breast cancer and ten patient with high risk for relapse and no evidence of disease were used for hMAM assay. Results: All samples from peripheral blood of forty healthy individuals (twenty males and twenty females) were negative for hMAM, whereas 43 of 114 samples (38%) from breast cancer patients were positive for hMAM mRNA. All the normal breast tissues were positive for hMAM mRNA. hMAM mRNA expression was detected in 11 of 42 (26%) in breast cancer patients who underwent for curative resection and had no evidence of disease, in 8 of 25 (34%) with chemo-sensitive relapsed disease, and in 16 of 32 (53%) with chemo-refractory progressive disease. Eight (53%) samples from peripheral blood of 15 breast cancer patients with metastatic disease at diagnosis were positive for hMAM. Three (20%) samples from peripheral blood stem cells of 15 breast cancer patients for high dose chemotherapy were positive for hMAM. Conclusion : In contrast to healthy volunteers, hMAM transcripts were detected in the peripheral blood of breast cancer patients. The frequency of hMAM expression in peripheral blood was correlated with the clinical stages of disease, but, was not significant. The contamination of hMAM expressing cells in the stem cell pool warrants additional effective purging method before the transplantation. The clinical relevance of hMAM RT-PCR-based tumor cell detection in the peripheral blood of breast cancer patients should be further evaluated in prospective studies.

K-SADS-PL을 사용하여 평가한 주의력결핍과잉행동장애 외래 환자의 공존질환에 대한 연구

김진용 ( Jin Yong Kim ),유한익 ( Han Ik K. Yoo ),고진경 ( Jin Kyung Goh ),전정원 ( Jeong Won Jeon ),홍진표 ( Jin Pyo Hong ),김성윤 ( Seong Yoon Kim ),김창윤 ( Chang Yoon Kim ) 한국정신병리진단분류학회 2005 精神病理學 Vol.14 No.1

Objectives: This study was performed to assess the comorbidity and associated emotional and behavioral manifestations in attention deficit hyperactivity disorder(ADHD) subjects, and the parenting stress and sense of competence in their mothers. Method: To investigate the comorbid conditions of ADHD, 102 ADHD patients(82 males, 9.58±2.65) and their caregivers visiting outpatient clinic were interviewed using the Korean version of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime. The Korean-Child Behavior Checklist, Children`s Depression Inventory, and Revised Children`s Manifest Anxiety Scale(RCMAS) were used to measure the psychopathologies in the subjects. The Parenting Stress Index/Short form and Parenting Sense of Competence Scale were also applied to the caregivers of ADHD patients. Results: Eighty-four(82.4%) of ADHD subjects had comordid psychiatric disorders. Comorbid oppositional defiant disorder, anxiety disorders, tic disorders, and elimination disorders were accompanied with ADHD in 54.9%, 24.9%, 19.6%, and 12.7%, respectively. Mean scores of Social Problems, Total Behavior Problems, and RCMAS were significantly higher in comorbid ADHD group than pure ADHD group. Parents of ADHD patients with comorbidity reported higher parenting stress and lower parenting sense of competence. Conclusion: Majority of ADHD patients had comorbid psychiatric conditions, and more psychopathologies and related parenting complications were associated with comorbidity.

시판 한우육과 한우육 판매점의 미생물 분포

김수민,이신호,성삼경,김순희,김대곤 한국축산학회 1997 한국축산학회지 Vol.39 No.3

The Bacteriological qualities of retailed Hanwoo beef and retail stores were studied to investigate hygienic status in marketing system of Hanwoo beef. Total bacterial counts of retailed Hanwoo beefs showed average 10³∼10⁴/㎠. Bacteriolgical quality of the retailed Hanwoo beefs was affected significantly by the sanitationary conditons of the individual retail store, not by the kind of retail stores. Total bacteria( counts of knives used in the retail stores showed from 10²/㎠ to 10^5/㎠ (average 10³∼10⁴/㎠). The level of contamination was increased as they were used frequently. Total bacterial counts of balance, cutting boards, slicing machine and chopper used in the retail Hanwoo beef stores were 10¹∼10⁴/㎠z, 10⁴∼10^5/㎠, 10³∼10^5/㎠ and 10³∼10^6/㎠, respectively. Chopper showed the highest contamiantion level among various materials used in the retail Hanwoo beef stores such as knife, cutting board, slicing machine and choppor.

Growth of Epitaxial MgB₂ Thick Films with Columnar Structures by Using HPCVD

Seong, W. K.,Huh, J. Y.,Kang, W. N.,Kim, J.-W.,Kwon, Y.-S.,Yang, N.-K.,Park, J.-G. Wiley - VCH 2007 CHEMICAL VAPOR DEPOSITION -WEINHEIM- Vol.13 No.12

<P>Epitaxial MgB<SUB>2</SUB> thick films are grown on Al<SUB>2</SUB>O<SUB>3</SUB> substrates at 600 °C by using the hybrid physical (HP)CVD technique. In order to obtain a high magnesium vapor pressure around the substrates, we use a special susceptor having a susceptor cap and achieve a very high growth rate of 0.17 &mgr;m min<SUP>–1</SUP>. Hexagonal-shaped columnar structures are observed by cross-sectional and planar-view transmission electron microscope (TEM) images. For the 1.7 &mgr;m thick film, the T<SUB>c</SUB> is observed to be 40.5 K with a J<SUB>c</SUB> of 1.5 × 10<SUP>6</SUP> A cm<SUP>–2</SUP> at 30 K. The vortex pinning mechanism by intercolumnar boundaries will be discussed.</P> <B>Graphic Abstract</B> <P>By using novel HPCVD technique with a special susceptor and a susceptor cap, epitaxial MgB<SUB>2</SUB> thick films with columnar structures are successfully fabricated at low temperatures (below 600 °C). The susceptor cap significantly enhances the local magnesium vapor pressure around the substrates so that a very high growth rate of 0.17 &mgr;m/min could be achieved. For the 1.7-&mgr;m-thick film, the T<SUB>c</SUB> was observed to be 40.5 K.</P>

Pilling-Bedworth Ratio Approach to Surface Oxidation of Al-Mg Alloys Containing Al₂Ca and Its Experimental Verification

Ha, Seong-Ho,Yoon, Young-Ok,Kim, Bong-Hwan,Lim, Hyun-Kyu,Lee, Taeg-Woo,Lim, Sung-Hwan,Kim, Shae K. American Scientific Publishers 2018 Science Of Advanced Materials Vol.10 No.5

<P>Pilling-Bedworth ratio (PBR) of metal/dissimilar metal oxide and metal/mixed metal oxide for Al-Mg alloys containing Al2Ca was experimentally examined. The Al-7.5mass%Mg alloy exhibits a thick oxide layer due to the formation of MgO, primarily during the initial stage of oxidation at 788 K. As oxidation continues, the oxide layer of Al-7.5mass%Mg alloy develops an MgAl2O4-spineI. With the addition of 0.3mass%Al2Ca, the surface of the alloy exhibits a passivation effect. The alloy containing Al2Ca additive displays a combination of CaO, MgO and Al2O3 on its surface, and results in a PBR of similar to 1.</P>

Yersinia enterocolitica의 조기진단법 개발에 관한 연구

민홍기,성원근,홍성화,김창민,이춘근,오호정,최규실,안현신,김성자,윤성식,원봉필 국립보건연구원 1994 국립보건원보 Vol.31 No.2

工業敎育大學 敎育改善에 關한 硏究(Ⅱ)

孟琦錫,洪元杓,任洪彬,李廷玟,朴萬植,李載元,金八圭,權五憲,成世鎭,朴東徹,金太均,李定根 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

Since the College of Industrial Education of Chungnam National University took charge of technical teacher preparation in 1977, much efforts have been concentrated on the activities for creating favorable educational environments in terms of curricula, pedagogic affairs, inner and outer facilities, etc. In this study some imposed barriers which are likely to hinder this college from achieving better education were identified and analysed. Considerably large scale of the student enrollment in comparison with the market demand is a prevailing issue which causes an adverse effect for clarification of the educational goal of the college and another problem is concerned with the student entry criteria which do not require the pre-experiences in the field. Under this circumstances, a guide line to improve the teacher education is recommended as follow; 1) The number of the student enrollment should be adjusted to meet the minimum range in the wave of the technical teacher demand projection and the shortage of teacher could be covered by the graduates from the shortterm courses in this college. 2) The current curriculum is accordingly recommended to be diversified taking into consideration the qualification of the student. The suggested consists of four-year regular course, one-year course, and six-month course and the short-term courses are provided to induce the experienced people from industries. 3) In order to have teachers adjust themselves to changing technology, education on sound and fundamental knowledges should be provided in the pre-service education course and education on advanced knowledges and applied theories deferred to the in-service training course. 4) In the four-year pre-service education, the general education and pedagogic subjects are to be drastically intensified from 18 credits and 22 credits up to 40 credits and 30 credits respectively.

마이크로 센서용 다채널 전해질 분석기의 샘플챔버 개선 및 샘플상호간의 간섭현상 보정

박준경,성기웅,배상곤,진경찬,김명남,손병기,조진호 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

In this paper, the sample chamber for multichannel electrolyte analyzing system was designed and the correction algorithm for interference among samples was proposed. The sample chamber was designed to replace the ISFET sensor more easier. The principles of design were the structural independency of each channel and the shield of sample solution from air contact. The correction algorithm could reject the interference effect of mixed sample solution and compensate the voltage difference between single electrolyte solution and mixed electrolyte solution. To approve the proposed algorithm, the several experiments were carried out under the condition of mixed samples. We acknowledged that with our proposed algorithm, the sensor output influenced by mixed electrolyte solution was improved with measurement accuracy.

Study of Cryogenic Conduction Cooling Systems for an HTS SMES

Yeom, H.K.,Hong, Y.J.,Park, S.J.,Seo, T.B.,Seong, K.C.,Kim, H.J. IEEE 2007 IEEE transactions on applied superconductivity Vol.17 No.2

<P>Superconducting magnetic energy storage (SMES) is more fast response, economical, and environment-friendly than uninterruptible power supply (UPS) using the battery. And the SMES not only has the ability to control active and reactive power simultaneously, but also has a long life time because the superconducting magnet does not have degradation problem which the battery has. Therefore, the SMES is a candidate for instead of the UPS using the battery. The SMES needs cryogenic system without exception. A conduction cooling system that has a simple, light and small structure is well adapted to high temperature superconducting (HTS) SMES. The cryogenic conduction cooling system is needed some technologies such as insulation, vacuum, and thermal analysis. Conduction heat is mainly transferred by cooler port, access port, support bar, etc., and radiation heat is transferred by vacuum chamber, thermal shield and HTS coil surface. The heat loads through the conduction and radiation of cryostat are calculated. Radiation shield heat load, temperature of HTS coil and conduction copper plate are estimated and measured. A cryopumping effect of cooled radiation shield was observed. A current lead and HTS coil heat load was evaluated to maintain HTS coil temperature was under 20 K.</P>

Design and Manufacturing of a Conduction-Cooled Sample Holder for a Superconducting Property Measurement System

Sohn, M. H.,Sim, K.,Kim, H. J.,Eom, B. Y.,Jeong, Y. W.,Baik, S. K.,Seong, K. C. Institute of Electrical and Electronics Engineers 2015 IEEE transactions on applied superconductivity Vol.25 No.3

<P>We had developed four years ago a superconducting property measurement system (SPMS) that can be used to acquire electrical and thermal properties of high-temperature superconductor (HTS) tape samples. The SPMS was composed of the sample holder for mounting an HTS tape and 3 T HTS magnet, both cooled individually by conduction using a cryocooler. The maximum dimension of the HTS tape sample that could be loaded on the sample holder was 15 mm in width and 250 mm in length. The conduction-cooled sample holder was again fabricated to increase the maximum test current up to 800 A. Maximum transport current was 763 A in magnetic field intensity 3 T. The measuring temperature range was 15-50 K.</P>