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Sung Kwan Kim,Hee Chang Chae,Choong Beom Seo,Eun Hee Seo,Chang Min Dae,Tae Eun Kim 대한CT영상기술학회 2022 대한CT영상기술학회지 Vol.24 No.1
The purpose of this study was to increase accuracy and success rate of radiofrequency catheter ablation by analysis of left atrial volume change relative to left ventricular volume change and left atrial diameter change relative to left atrial volume change. 20 patients with normal heart rhythm were set as the control group, and 20 patients with diagnosed atrial fibrillation were set as the experimental group. The cardiac cycle was divided into 10 stages ranging from 0% to 90%, and left ventricular volume, left atrial volume, left atrial diameter, pulmonary vein diameter were measured for each group. the correlation between the left ventricular volume and the left atrial volume was analyzed, and the correlation between the left atrial volume and left atrial diameter was analyzed. The diameter of the pulmonary veins was measured. As a result of analyzing the correlation between left ventricular volume and left atrial volume through Spearman correlation, the control group showed a negative correlation.(P<0.001) The experimental group were not correlated.(P=0.075) As a result of analyzing the correlation between the left atrial volume and the left atrial diameter, both groups showed a positive correlation.(P<0.001) As a result of analyzing the diameter of the pulmonary vein by Wilcoxon signed-rank test, both groups showed a significant difference in the maximum diameter and the minimum diameter.(P<0.001) Because the volume and diameter of the left atrium in patients with atrial fibrillation change irregularly, the radiologist check all cardiac cycle and reconstruct to increase the accuracy and success rate of radiofrequency catheter ablation.
( Sang Jun Suh ),( Jong Eun Yeon ),( Sun Jae Lee ),( Hyun Jung Lee ),( Eileen L. Yoon ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Kwan Soo Byun ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Current guidelines suggest the criteria for discontinuation of nucleos(t)ide analogues (NA) in selected patients. However treatment induced virological response is not permanent. Aim of our study is to evaluate the clinical significance of HBsAg titer in predicting sustained virologic response after NA therapy discontinuation. Methods: From Jun 1998 to Dec 2010, medical record of 81 chronic hepatitis B patients who discontinued NA was analyzed retrospectively. Sustained virologic response (SVR) was arbitrarily defined as undetectable HBV DNA by real-time PCR(with lower limit of detection of 116 copies/mL, 20 IU/mL) persisted more than 12 months after treatment discontinuation. Results: Median age was 51 years, 54 (67%) patients were male, and 50 (62%)patients were HBeAg positive. Median baseline ALT, HBV DNA and HBsAg were 292 IU/mL, 7.1log10 IU/mL and 3.3log10 IU/mL. NA were lamivudine (n=53), adefovir (n=15), lamivudine combined with adefovir (n=4), and entecavir (n=9). Median treatment duration and follow-up period were 26 and 27 months. 11/81 (14%) patients had SVR. The cumulative relapse rates were 37/81 (46%) at 6 months and 42/81 (52%) 12 months after treatment discontinuation. The baseline ALT, HBV DNA and presence of HBeAg were not different between patients with or without SVR. In univariate analysis, age, treatment duration and HBsAg level at treatment discontinuation were different in patients with or without SVR; 51 vs. 43 years, p=0.033; 53 vs. 25 months, p=0.011; 2.1 vs. 3.3log10 IU/mL, p=0.003. In multivariate analysis, only HBsAg level at treatment discontinuation remained as an independent factor associated with SVR (p=0.019). The cutoff value of HBsAg level <2log10 IU/mL was predictive of SVR [(AUROC, 0.991; 95% confidence interval[CI], 0.000-1.000; p<0.05); sensitivity, 100%; specificity, 93%; positive predictive value, 69%; negative predictive value, 100%]. Conclusions: Large proportion of patients treated with oral antivirals relapsed after the treatment discontinuation. In the decision of the treatment discontinuation, HBsAg level <2log10 IU/mL at treatment discontinuation can predict sustained viral suppression in selected patients.
A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study
Sung Hoon Park,Myung Gu Lee,Kwan Ho Lee,Yong Bum Park,Kwang Ha Yoo,Jeong Woong Park,Chang Hwan Kim,Yong Chul Lee,Jae Seuk Park,Yong Soo Kwon,Ki Hyun Seo,Hui Jung Kim,Seung Min Kwak 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.5
Background: Limited data on the incidence and clinical characteristics of adult pertussis infections are available in Korea. Methods: Thirty-one hospitals and the Korean Centers for Disease Control and Prevention collaborated to investigate the incidence and clinical characteristics of pertussis infections among adults with a bothersome cough in non-outbreak, ordinary outpatient settings. Nasopharyngeal aspirates or nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and culture tests. Results: The study enrolled 934 patients between September 2009 and April 2011. Five patients were diagnosed as confirmed cases, satisfying both clinical and laboratory criteria (five positive PCR and one concurrent positive culture). Among 607 patients with cough duration of at least 2 weeks, 504 satisfied the clinical criteria of the US Centers for Disease Control and Prevention (i.e., probable case). The clinical pertussis cases (i.e., both probable and confirmed cases) had a wide age distribution (45.7±15.5 years) and cough duration (median, 30 days; interquartile range, 18.0~50.0 days). In addition, sputum, rhinorrhea, and myalgia were less common and dyspnea was more common in the clinical cases, compared to the others (p=0.037, p=0.006, p=0.005, and p=0.030, respectively). Conclusion: The positive rate of pertussis infection may be low in non-outbreak, ordinary clinical settings if a PCR-based method is used. However, further prospective, well-designed, multicenter studies are needed.
Anemia in Chronic Liver Disease
( Sang Jun Suh ),( Han Ah Lee ),( Tae Hyung Kim ),( Young Sun Lee ),( Jong Jin Hyun ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Soon 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The anemia in chronic liver disease is common. The causes can be bleeding, malnutrition, erythrocyte sequestration and underproduction, and medicine’s side effects. Many patients are just regarded as iron deficiency anemia (IDA) and described iron supplements. We investigated the patterns of anemia in chronic liver disease and triage the causes. Methods: The patients invited to Korea university ansan hospital from 2012 to 2016 were investigated retrospectively. 1632 patients were test for anemia lab. The definition of anemia is <13.0g/dl(men) or 8.1g/dl(women) according to WHO’s threshold. Reticulocyte production index (RPI) is calculated by [reticulocyte count (%)*hematocrit/ 45]/reticulocyte maturation time. If RPI ≥2.5, it is classified as hemolysis or hemorrhage. If RPI < 2.5, it was checked red cell morphology. Normocytic (MCV 80-100) is classified as hypo-proliferative disorder, and macrocytic (MCV >100) or microcytic (MCV <80) is classified as maturation disorder. In hypo-proliferative disorder, eGFR (using MDRD fomula) < 30ml/min/1.73 m2 is classified as renal disease. If CRP >3mg/dl, it is classified as inflammatory disorder. In maturation disorder, if transferrin saturation (Fe/TIBC) <15% or ferritin <18 ng/ml, it classified as IDA. In macrocytic morphology, if the patients diagnosed as alcoholic disease, it is classified as folate and/or vitamin B12 deficiency. Others are classified as undetermined. This classification is modified from ‘algorithm of the physiologic classification of anemia’ of Harrison’s Internal Medicine. Results: Total 441 patients were available for analysis. 11 patients were classified as hemolysis/hemorrhage according to RPI ≥2.5. 430 patients were divided as hypo-proliferative (n=275) and maturation disorder (n=155) according to RBC morphology. IDA 72, renal disease 9, inflammatory disease 30, and thiamine folate deficiency 61 patients were classified. 258 patients were undermined. In IDA 72 patients, 38 patients were treated with iron supplement. In other causes 111 patients, 16 patients were described iron. In undermined 258 patients, 75 patients described iron. The proportion who diagnosed and appropriately treated with iron supplement was 8.8%, and 3.7% were miss treated, and 17.5% needed further evaluation. Conclusions: A lot of patients with anemia in chronic liver disease are treated with undetermined diagnosis. Using algorithm, many patients could be classified and treated appropriately.
( Sung Eun Kim ),( Sang-ho Jo ),( Seung Hwan Han ),( Kwan Yong Lee ),( Sung Ho Her ),( Min-ho Lee ),( Won-woo Seo ),( Seong-sik Cho ),( Sang Hong Baek ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Calcium channel blockers (CCBs) are the most widely prescribed medication for patients with vasospastic angina (VA). However, few studies have compared the prognosis of VA patients who are prescribed different CCBs. Methods: We enrolled 2,960 patients who received provocation test prospectively in 11 university hospitals in Korea. We divided 1,586 patients received four major CCBs into two groups: a first generation CCB (diltiazem and nifedipine) group and a second generation CCB (amlodipine and benidipine) group. Primary outcome was time to events of composite of death from any cause, acute coronary syndrome (ACS) and symptomatic arrhythmia during 3-year follow-up. We also compared the effect of each CCB on the control of angina symptoms. Results: There was no difference of the primary outcome among the two groups with a cumulative incidence rate of 5.4%, 2.9%, and a person-month incidence rate of 2.33 and 1.26, respectively (hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.25 to 1.17; p = 0.120, as reference with the 1st generation CCBs). The incidence of ACS was significantly lower in 2nd generation CCBs group with a person-month incidence rate of 1.66 vs. 0.35 (HR, 0.22; 95% CI, 0.05 to 0.89; p = 0.034). Use of benidipine showed a significant better control of angina symptom compared with diltiazem for 3 years (odds ratio, 0.17; 95% CI, 0.09 to 0.32; p < 0.0001 at 3rd year). Conclusions: The first and second generation CCB groups did not differ in terms of composite outcome occurrence. However, the ACS incidence rate was significantly lower in the users of the 2nd generation CCBs.
Characteristics of energetically modified fly ash (EMFa) blended cement
Sung Kwan Seo 한양대학교 세라믹연구소 2017 Journal of Ceramic Processing Research Vol.18 No.3
Around 39% of domestic power is generated from coal-fired power plants, and coal ash is generated as a by-product. Whilethe amount of domestic coal fly ash is about 8.35 million tons/year, about 80% of which is reported as fly ash (6.84 milliontons) and 20% is bottom ash (1.51 million tons). Generally, fly ash is used for concrete admixture, subsidiary raw materialsof cement fabrication process, etc. However, it is not used in large scale because of its low early-term strength and the problemof lowering the alkaline of concrete. Therefore, this study aims to increase early-term reactivity of fly ash and to increasecement substitution amount by fabricating the energetically modified fly ash (EMFa) through grinding of fly ash. Experimental results show that the EMFa is more effective in accelerating early-term hydration than when mixed with nongrindingfly ash. Also, when 20% of EMFa was substituted, it showed compressive strength equal to or higher than that ofOPC, and the carbonation resistance was also increased in comparison with that of non-grinding fly ash.
Seo, Sung Kwan,Chu, Yong Sik,Shim, Kwang Bo,Jeong, Jae Hyun The Korean Ceramic Society 2016 한국세라믹학회지 Vol.53 No.4
Coal ash, a material generated from coal-fired power plants, can be classified as fly ash and bottom ash. The amount of domestic fly ash generation is almost 6.84 million tons per year, while the amount of bottom ash generation is 1.51 million tons. The fly ash is commonly used as a concrete admixture and a subsidiary raw material in cement fabrication process. And some amount of bottom ash is used as a material for embankment and block. However, the recyclable amount of the ash is limited since it could cause deterioration of physical properties. In Korea, the ashes are simply mixed and used as a replacement material for cement. In this study, an attempt was made to mechanically activate the ash by grinding process in order to increase recycling rates of the fly ash. Activated fly ash was prepared by controlling the mill types and the milling times and characteristics of the mortar containing the activated fly ash was analyzed. When the ash was ground by using a vibratory mill, physical properties of the mortar mixed with such fly ash were higher than the mortar mixed with fly ash ground by a planetary mill.