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Lim, WonBong,Kim, OkSu,Jung, JinAn,Ko, YoungJong,Ha, JooWon,Oh, HeeKyun,Lim, HoiSoon,Kwon, HyukIl,Kim, InAe,Kim, Jisun,Kim, MiSook,Kim, SeoYune,Kim, Byung-kuk,Kim, SunMi,Kang, Byung-Cheol,Choi, HongRa Informa Healthcare 2010 PHARMACEUTICAL BIOLOGY Vol.48 No.12
<P><I>Context:</I> A growing body of evidence shows that compounds of plant origin have the ability to prevent cancer. The fruit of gardenia, <I>Gardenia jasminoides</I> Ellis (Rubiaceae), has long been used as a food additive and herbal medicine, and its pharmacological actions, such as protective activity against oxidative damage, cytotoxic effect, and anti-inflammatory and anti-tumor activity, have already been reported.</P><P><I>Objective:</I> The purpose of the present study was to investigate the presence of DNA topoisomerase 1 inhibitor in various solvent fractions of <I>Gardenia</I> extract and examine the induction of oral cancer cell death upon treatment with <I>Gardenia</I> extract.</P><P><I>Materials and methods:</I> The methanol extract of <I>Gardenia</I> was partitioned with <I>n-</I>hexane, dichloromethane, ethyl acetate, <I>n-</I>butanol, and water.</P><P><I>Results:</I> In the DNA topoisomerase 1 assay, <I>n-</I>hexane and dichloromethane fractions inhibited topoisomerase 1 and led to a decrease in the cell viability of KB cells. The dichloromethane fraction (0.1 mg/mL) also showed 77% inhibition of cell viability in KB cells compared with HaCaT cells. Treatment with dichloromethane fraction led to apoptotic cell death as evidenced by flow cytometric analysis and morphological changes. In addition, treatment with <I>Gardenia</I> extract dichloromethane fraction led to the partial increase of caspase-3, caspase-8 and caspase-9 activities and the cleavage of poly (ADP-ribose) polymerase.</P><P><I>Conclusion:</I> Taken together, these results suggest that the dichloromethane fraction from <I>Gardenia</I> extract induces apoptotic cell death by DNA topoisomerase 1 inhibition in KB cells. These findings suggest the possibility that <I>Gardenia</I> extract could be developed as an anticancer modality.</P>
Efficacy of Caffeine in Promoting Hair Growth by Enhancing Intracellular Activity of Hair Follicles
Kim, Sehyun,Kim, Su Na,Jeong, Gyusang,Hong, Min Jung,Lee, Yonghee,Shin, Seung Hyun,Park, Hyeokgon,Jung, Yu Chul,Kim, Eun Joo,Park, Byung Cheol,Kim, Hyoung-June Society of Cosmetic Scientists of Korea 2019 Korean journal of cosmetic science Vol.1 No.1
Caffeine is widely used in cosmetics and hair care products. Although its efficacy in stimulating hair growth has been confirmed in recent studies, its mechanism of action remains unelucidated. The present study aimed to determine the effects of caffeine on hair growth, with a focus on intracellular hair follicle activity. Experiments included in vitro and ex vivo tests, and a clinical study. Caffeine enhanced the cellular activity and potassium channel opening. It also promoted human hair follicle elongation. Immunohistochemical staining showed that the Ki-67 signal was significantly higher in cells treated with caffeine. These efficacies of caffeine were comprehensively demonstrated in clinical results, wherein caffeine-containing shampoo improved hair density after 24 weeks of testing. Collectively, the results of this study demonstrated that caffeine promoted hair growth and inhibited the progression of hair loss by enhancing intracellular activity of hair follicles.
Kim, Sehyun,Lee, Hyunjae,Kim, Heejin,Jang, Dong-Hwan,Kim, Hyun-Jin,Hur, Jin,Cho, Yoon-Sung,Hur, Kyeon Elsevier 2018 RENEWABLE & SUSTAINABLE ENERGY REVIEWS Vol.98 No.-
<P><B>Abstract</B></P> <P>This paper presents the steps taken by the Korea Electric Power Corporation (KEPCO), the nation's only utility, to overcome limitations involved in increasing renewable energy penetration in an effort to support the government's movement for renewable energy expansion. While the government proposes reducing carbon dioxide emissions by 37% of the Business As Usual (BAU) value by 2030, which is about 315 million tonnes, it has improved energy policies for developing and deploying renewable energy technologies. To facilitate the integration of renewable energy into the future Korean power system, the government has announced a guaranteed interconnection policy for renewable energy sources under 1 MW. Based on this movement, the following measures have been enacted. First, examination of the hosting capacity of the current power system has been initiated to streamline the interconnection process for the distributed renewable energy sources and to reinforce the transmission and distribution network in a proactive manner. Second, to comply with reliability performance standards, an efficient planning procedure has been established for determining the optimal location and size of a renewable complex. To proceed with interconnection requests without delay, a prototype of a Renewable Energy Map (REM) based on PSS/e and Python has been developed. This tool facilitates more practical impact studies by incorporating capacity factors of renewable sources. In addition, it automates the screening process for determining suitable interconnection buses and feasible options for grid reinforcement. This tool is a step toward realizing the twin visions of “G-Platform” and “Carbon Zero” projects in Jeju Island.” These efforts, which have been initiated in response to the Paris Climate Change Accord of 2015 and the 23rd Conference of the Parties 2017, aim to increase renewable energy from 7% to 20% of the total generated energy in Korea by 2030.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The movement of the Korea government in improving support policy, interconnection procedure, and investments for renewable energy expansion. </LI> <LI> The movement of Korea Electric Power Corporation (KEPCO) in fully understanding current hosting capacity of the power system for enabling ‘Guaranteed interconnection of renewable energy sources under 1 MW’. </LI> <LI> The movement of KEPCO and associated universities for developing renewable energy map (REM) for establishing foundation of predicting efficient installation of renewable energy aggregation without violating reliability standard. </LI> <LI> Current projects regarding renewable energy expansion. </LI> </UL> </P>
Kim, Young-Joon,Park, Jin Mo,Kim, Taeil,Kim, Senyun,Kim, Jung Mo 이화여자대학교 세포신호전달연구센터 2003 고사리 세포신호전달 심포지움 Vol. No.5
The Mediator complex is generally required for transcriptional regulation in species ranging from yeast to human. Throughout evolution, the functional diversity of the Mediator complex has been enhanced to meet the increasing requirement for sophisticated gene regulation. We took systematic biochemical and genomics approaches to examine various types of Mediator proteins in Drosophila melanogaster. Such efforts led to the identification of three distinct forms of Mediator complexes. In exploring their compositional and functional heterogeneity, we found that different cell types may require distinct Mediator complexes, some of which may participate in nuclear processes other than the previously identified functions. On the top of the complex heterogeneity, several Mediator genes show distinct mutant phenotype thus were suggested to mediate transcriptional regulation of distinct group of genes via activator-specific interactions. However, their physiological relevance and activator-specificities in cell have not been addressed. Using biochemical analysis coupled with RNAi-mutational analysis, we confirmed that physical interaction between specific activator proteins and dTRAP80 is required for transcriptional activation of distinct group of genes in vivo. We extended this study to other Mediator genes by generating mutant Mediator cells and examining their defect on transcriptional regulation with the use of micro array analysis.