심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한국 아동의 기본운동기술 평가 시스템 개발: 평가 기준 설정 및 소프트웨어 프로그램 개발

박승하 ( Seung Ha Park ),최재남 ( Chae Nam Choe ),김미예 ( Mi Ye Kim ) 한국스포츠과학원 2009 체육과학연구 Vol.20 No.3

The purpose of the study was to establish the contents for fundamental movement skill test and the evaluation standards, and to develop the computer-based software program for assessment. For setting up locomotor skill test, we made up items and performance criterions for five skills (run, hop, gallop, slide, horizontal jump), based on TGMD-II and the developmental stage from previous research (Seedfeldt et al., 1982; Roberton et al., 1984). These contents were investigated by the group of experts in field of motor learning and development. The validity was identified through verifying mean difference among three raters over skill levels, and the reliability was tested through agreement statistics (over 83%) and correlation analysis (over .86) among three raters. All items for object-control skill test were referred from Park`s (Park, 2008). For establishing the evaluation standard, the fundamental movement skills (five locomotor & six object-control skills) of total 944 children (male 522, female 422) were recorded and analyzed. Raw score was transformed to T-score, and then five grades were established based on percentile for grading in 2007 National Physical Fitness Surveillance (Ministry of Curture, Sports, and Tourism, 2008). Computer-based software program was developed through processing of the design of a picture, database establishment, program logic design, software manufacture, bug test, & revision. The software program was comprised of the main manu and the functional manu, which included item assessment, data administration, and inquiry of results. Main picture was made up windows for selecting school/student, editing the image, managing the region and key-position, selecting contents for evaluating, and assessing. In conclusions, our results mean that the program establishes items and standard to assess the fundamental movement skills for pre- and post school aged children in korea, and systematically constructs the computerized organization for managing the rating results. Also, we think that it will be contributed to building up on-line system for sharing various feedback information and images easily with parents and children.

초등 고학년 주의력결핍 과잉행동장애아동의 설명글 쓰기 능력

박진희ㆍ김승미ㆍ이은주(Park Jin HeeㆍKim Seung MiㆍLee Eun Ju) 한국특수교육학회 2016 특수교육학연구 Vol.50 No.4

The purpose of this study is to identify the qualitative characteristics appeared in the expository writings of children with ADHD. A total of 30 students living in Seoul and Gyeonggi-do area were selected as subjects for the study. Fifteen of them were elementary school children with ADHD in grade 5 or grade 6, and the remaining 15 were normal children whose chronological age matched with those with ADHD. According to the study results, significant differences were not found between the two groups in terms of objectivity of content, unity of content, method of content development, and appropriate use of vocabulary. However, there were significant differences between the two groups in terms of the structure of writings and sentence accuracy. The results indicate that children with ADHD can properly generate contents related to the subject/topic, but have difficulty in organizing logically and expressing in accurate sentences. Therefore, it is necessary to develop a variety of approaches that will improve expository writing skills of children with ADHD based on the characteristics appeared in their writings.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

Aspergillus sp. ISR 균주를 통한 콜레스테롤 합성저해제 lovastain의 생산

박상은,조미현,신동화,황승환,박천석 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-

본 연구에서 한국 토양에서 분리된 lovastatin 생산 균주인 Aspergillus sp. ISR 균주를 이용하여 여러 배지 조성 성분이 lovastatin의 생산에 미치는 영향을 관찰하였다. 탄소원으로는 lactose보다 glycerol 5%가 가장 효과적이었으며 질소원과 인산염의 경우는 기본 RPM배지 조성과 농도에서 보다 효과적인 것을 발견하지 못하였다. 복합영양원으로 rapeseed meal 보다는 대두박이 보다 효과적이어서 저렴한 배지원으로 사용이 가능할 것으로 사료된다. 최종적으로 최적화된 배지를 사용하여 52 mg·L^(-1)의 lovastatin을 생산할 수 있었고 이는 기존의 RPM 배지보다 수율이 4.5배 증가한 것이다. 좀 더 효과적인 lovastatin의 생산을 위하여 회분식 발효에 대한 연구와 분자유전학적인 연구를 통한 고생산 균주의 제조에 대한 연구가 진행중이다. Effects of various nutritional components on the production of lovastatin were investigated in the Aspergillus sp. ISR. Among various carbon (C) sources, glycerol was determined to be the most effective C source at the concentration of 5% (v/v). In case of nitrogen sources, 0.2% (w/v) KNO_(3) efficiently induced the lovastatin production in Aspergillus sp. ISR. Interestingly, the addition of soybean meal into the production medium enhanced the lovastatin production compared to the rapeseed meal. Conclusively, Aspergillus sp. ISR produced 52 mg·L^(-1) of lovastatin in the optimized medium containing 5% (v/v) glycerol, 0.2% (w/v) KNO_(3), 0.3% (w/v) KH_(2)PO_(4), and 0.3% (w/v) soybean meal, which was 4.5 times higher than the amount produced using the standard RPM (rapeseedmeal production medium).

간호사의 통증관리에 대한 주관성 연구

박경숙,송미승,김경희 성인간호학회 2001 성인간호학회지 Vol.13 No.1

The purpose of this study is to analyze the structural pattern of nurses' pain management with patients who experience pain. As a research method, the Q methodology, which is useful for an objective view of a highly abstract concept, was applied. The data collecting activity of this study was from August, 21st, 2000 to November, 24th 2000 The Q-population. the previous thesis and a literature review were done. Questions about pain management by the nurse on the patients. caregivers, nursing students, doctors, nurses, and others were asked in documentary work and in-depth interviews. In all. 223 units of the Q-population were formed, and the last 35 units of the Q-population were extracted. The data on the P-sample was collected from 41 nurses who worked in the medical and surgical units of a hospital that belonges to C university in Seoul. The research results were constituted in 3 types. Type I was the 'pattern of judging by objectivity'. The statement on which most of the People highly agreed for those patterns was shown by 'If patients said that they are suffering from pain, we sufficiently performed an assessment about the etiology, location, duration and degree'. For type I, the same pain was found in different locations according to the patients. so the etiology of the pain should be identified first place Since ways of coping are different according to pain etiology, it was thought that it is important to assess sufficiently the pain etiology, location, duration, and degree Therefore. when patients complain of pain, the pain etiology should be identified and assessed; according to the result, pain management should be performed systematically. Tyre II was the 'pattern of accepting by subjectivity'. The statement on which most of the people highly agreed for those patterns was shown as 'If patients said that they are suffering from pain, the medical treatment should be performed rapidly and speedily. 'For type h. when the patient complains of pain. treatment should be performed quickly in order to prevent the condition getting worse. and it is thought that activity is a reasonable duty Further, by trying to show empathy after pain is admitted and by understanding and coping rapidly with the pain of patients, an attitude which matched the altruistic morals of nurses is being shown. Type III was the 'pattern of worrying about', and the statement on which most of the people highly agreed for those patterns was shown is 'When there is a pain. to help patients to tolerate the pain to the highest degree. 'In type III, the pain is a subjective expression, so there is a difference according to every individual. Therefore, actually if there is no measurement of pain, it could be exaggerated so nurses should help patients to tolerate it to the utmost. Even if there is a way to remove pain without an analgesic drug, nurses were reluctant to perform pain management as they possibly could. Through these research results, pain management of nurses was classified in 3 types, and structural characteristics in each type were discovered. Based upon the characteristics according to the type, an individualized pain management intervention strategy should be established and the follow up work performed

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

데이터베이스 품질 평가를 위한 품질 특성 정의 및 선정

박미영,승현우 서울여자대학교 컴퓨터과학연구소 2006 정보기술논문지 Vol.4 No.-

체계적인 데이터베이스 품질관리 방법론에 대한 중요성이 강조되고 있는 실정이며 데이터베이스 품질향상을 위한 인증제 도입도 적극적으로 추진되고 있다. Mynatt에 의하면 개발이 완료되어 사용자에게 납품되는 소프트웨어 시스템의 실행코드 1000줄당 예상되는 오류건수가 6-7개 정도이며, 소프트웨어 시스템을 유지보수하는데 드는 비용이 평균적으로 개발 비용의 200-300% 정도라고 한다. 소프트웨어뿐만 아니라 데이터베이스 품질 관리에서도 사용자의 품질 요구수준이 높아짐에 따라 데이터베이스 품질에 대한 중요성을 심각하게 고려해야 할 시기이다. 소프트웨어의 오류는 사용자가 요구한 항목들이 충실하게 반영되지 않아 일어나는 현상이 대부분이므로 데이터베이스 품질 관리에서도 역시 사용자의 요구사항이 빠짐없이 반영되었는지를 확인할 수 있는 방법이 강구되어야 한다. 본 연구에서는 데이터베이스의 품질을 정량적으로 측정할 수 있는 품질 특성을 데이터베이스 개발 단계별로 선정한다. 데이터베이스 품질은 품질 특성으로 구성되어 있는데 이러한 품질 특성은 기관과 학자에 따라 달리 정의되고 있으나 본 논문에서는 국제화 표준에 부응하기 위하여 ISO/IEC 9126-1에서 제시하고 있는 품질 특성을 이용한다. Today the importance of QC(qua1ity control) methodology in formulating DB is urged, and introducing certification system for DB quality improvement is also positively propelled. According to Mynatt's study it is appeared around 6-7 software errors per 1000 lines of software actuation codes after the development to users, and it is showed about 200-300% of average fixing cost for utility & operation. Not only software but also DB QC to meet users' increasing QC level the importance of DB QC is now seriously examined. The most of SW error comes as the user's demand is not carefully programed, and also for DB QC it is studied the confirm method whether or the user's demand is counted without fail. In this study it is to develop a quality measurement list for fixed quality as step as DB program process. DB quality is organized characteristically, and this characteristic definition changes based on a scalar and his study group. To meet International Standard this study adapts quality characteristic based on ISO/IEC 9126-1.