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RISS 인기검색어
- 검색키워드
- 저자 : PB Tirupathi Pichiah (검색결과 3 건)
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PB Tirupathi Pichiah,조석호,한성규,차연수 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.4
Dietary fiber and proteins are individually known to decrease feeding, but could result greater weight management benefit when both are combined. We hypothesized that supplementing the diet with fermented barley, being rich in both dietary fiber and proteins, could lower energy intake by modulating the mRNA expression level of hypothalamic genes associated with the regulation of feeding behavior and satiety; thereby decreasing body weight gain. To test our hypothesis, four groups of Sprague Dawley rats were arranged in a 2 × 2 factorial design (n = 6), low-fat diet with either guar gum (LFD-G) or fermented barley (LFD-FB) and high-fat diet with either guar gum (HFD-G) or fermented barley (HFD-FB). Using oral gavage, fermented barley was given at a dosage of 1500 mg/kg body weight and guar gum was supplemented in an equivalent quantity to that of the fiber in the fermented barley. After 19 weeks, the fermented barley-supplemented groups showed a significant reduction in energy intake, triglyceride, body weight gain, and serum leptin, compared to the guar gum-supplemented groups in both the low- and high-fat diet groups. Likewise, the anorexigenic gene proopiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript (CART) mRNA level were significantly higher in the fermented barley-supplemented groups compared to the guar gum-supplemented groups in rats fed on both high- and low-fat diets. In conclusion, fermented barley supplementation upregulated hypothalamic POMC/CART, decreased energy intake in both low- and high-fat diet groups, and prevented excessive weight gain in rats.
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Pichiah, PB Tirupathi,Cha, Youn‐,Soo John Wiley Sons, Ltd 2015 Journal of the Science of Food and Agriculture Vol.95 No.15
<P><B>Abstract</B></P><P><B>BACKGROUND</B></P><P>Foods that are rich in fat and or sodium chloride promote obesity and associated diseases, whereas intake of dietary fiber averts obesity development. <I>Salicornia herbacea</I> (SH) is a rich source of dietary fiber and high in sodium chloride; therefore, we investigated whether replacing common salt with SH in a high‐fat diet could prevent obesity development.</P><P><B>RESULTS</B></P><P>Mice were divided into five groups: group ND was fed a normal diet, group HD was fed a high‐fat diet, group HD‐NaCl was fed a high fat diet with sodium chloride 10 g kg<SUP>−1</SUP>, group HD‐CL was fed a high‐fat diet with cellulose 30 g kg<SUP>−1</SUP> and group HD‐SH was fed a high‐fat diet with SH powder 50 g kg<SUP>−1</SUP>. The amount of sodium chloride and cellulose added in the respective diet was equivalent to their amount in SH. Data from our study showed that, SH supplementation significantly decreased body weight gain, liver weight, hepatic triglyceride, serum leptin and insulin, along with the mRNA level of key lipid anabolic genes such as SREBP‐1c, PPARγ and FAS compared to the HD group.</P><P><B>CONCLUSION</B></P><P>The results of this study demonstrated that SH is a potential natural anti‐obesity agent that can be used in place of sodium chloride. © 2014 Society of Chemical Industry</P>
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Duraisamy Kalpana,이양수,Krishnamoorthy Srikanth,PB Tirupathi Pichiah,차연수 한국고분자학회 2014 Macromolecular Research Vol.22 No.5
The cultural filtrates of Klebsiella pneumoniae cultured under normal gravity and low shear modeledmicrogravity were potentially used to biosynthesize gold nanoparticles using the precursor gold III chloride trihydrate. The gold nanoparticles produced were spherical, of size between 16-36 and 24-50 nm with the cultural filtratesof normal and low shear modeled microgravity respectively. The characteristic plasmon resonance of gold nanoparticlesoccurred between 535-550 nm in the spectral analysis. XRD reflections (1 1 1), (2 0 0), (2 2 0), (3 1 1) indicatethe face centered cubic and crystalline nature of the biosynthesized gold nanoparticles. The FTIR study proposesthat proteins excreted into the cultural filtrate were involved in the synthesis and stabilization of gold nanoparticles. The in vitro cytotoxicity on 3T3L1, H9c2 and HepG2 cell lines showed the nontoxic and biocompatible nature ofbiosynthesized gold nanoparticles.
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