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Mi Na Gil,Du Ri Choi,Kwang Sik Yu,Ji Heun Jeong,Dong Ho Bak,Do Kyung Kim,Nam Seob Lee,Je Hun Lee,Young Gil Jeong,Chun Soo Na,Dae Seung Na,Ki Hyun Ryu,Seung Yun Han 대한해부학회 2016 Anatomy & Cell Biology Vol.49 No.3
Cholestatic liver cirrhosis (CLC) eventually proceeds to end-stage liver failure by mediating overwhelming deposition of collagen, which is produced by activated interstitial myofibroblasts. Although the beneficial effects of Rhus verniciflua Stokes (RVS) on various diseases are well-known, its therapeutic effect and possible underlying mechanism on interstitial fibrosis associated with CLC are not elucidated. This study was designed to assess the protective effects of RVS and its possible underlying mechanisms in rat models of CLC established by bile duct ligation (BDL). We demonstrated that BDL markedly elevated the serological parameters such as aspartate aminotransferase, alanine transaminase, total bilirubin, and direct bilirubin, all of which were significantly attenuated by the daily uptake of RVS (2 mg/kg/day) for 28 days (14 days before and after operation) via intragastric route. We observed that BDL drastically induced the deterioration of liver histoarchitecture and excessive deposition of extracellular matrix (ECM), both of which were significantly attenuated by RVS. In addition, we revealed that RVS inhibited BDL-induced proliferation and activation of interstitial myofibroblasts, a highly suggestive cell type for ECM production, as shown by immunohistochemical and semi-quantitative detection of a-smooth muscle actin and vimentin. Finally, we demonstrated that the anti-fibrotic effect of RVS was associated with the inactivation of Smad3, the key downstream target of a major fibrogenic cytokine, i.e., transforming growth factor b (TGF-b). Simultaneously, we also found that RVS reciprocally increased the expression of Smad7, a negative regulatory protein of the TGF-b/Smad3 pathway. Taken together, these results suggested that RVS has a therapeutic effect on CLC, and these effects are, at least partly, due to the inhibition of liver fibrosis by the downregulation of Smad3 and upregulation of Smad7.
Metabolic features of macrophages in inflammatory diseases and cancer
Na, Yi Rang,Je, Sungmo,Seok, Seung Hyeok Elsevier 2018 Cancer letters Vol.413 No.-
<P><B>Abstract</B></P> <P>Macrophages are now considered to be important players in various inflammatory diseases as well as tumor progression. Emerging evidence reveals that macrophage metabolic features are deeply associated with their immune functions. Understanding the interaction between cellular metabolism and immune signaling pathways in macrophages can help us to develop appropriate therapeutic approaches for inflammatory diseases. In this review, we briefly summarize key metabolic features of M1 and M2 macrophages as well as signaling interactions between major metabolic molecules with TLRs and NLRs. Current knowledges of cellular metabolism are focused on macrophages in various disease situations including sepsis, atherosclerosis, obesity, tuberculosis and cancer. Novel insights and present targets for regulating macrophage metabolism are also discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pre-established glycolytic capacity determines inflammatory functions of GM-CSF derived macrophages. </LI> <LI> LPS/IFNγ induces aerobic glycolysis but IL-4/IL-13 potentiates mitochondrial respiration in macrophages. </LI> <LI> AMPK, mTOR and mitochondrial ROS integrate with pattern recognition receptor signaling pathways. </LI> <LI> Key metabolic changes of macrophages were reviewed focused on the inflammatory diseases and cancer. </LI> </UL> </P>
Inflammatory myofibroblastic tumor occurs in an Africa Green Monkey (Chlorocebus aethiops)
Han-Na Kim,Seung-Min Ha,Hwal-Yong Lee,Bon-Sang Koo,Youngjeon Lee,Jung-Joo Hong,Seung Ho Baek,Chang-Yeop Jeon,Sang Je Park,Young-Hyun Kim,Kang Jin Jeong,Jae-Won Huh,Sang-Rae Lee,Yeung Bae Jin 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.1