Heme oxygenase-1 induced by desoxo-narchinol-A attenuated the severity of acute pancreatitis via blockade of neutrophil infiltration

Bae, Gi-Sang,Kim, Dong-Goo,Jo, Il-Joo,Choi, Sun-Bok,Kim, Myoung-Jin,Shin, Joon Yeon,Kim, Dong-Uk,Song, Ho-Joon,Joo, Myungsoo,Park, Sung-Joo ELSEVIER 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.69 No.-

<P><B>Abstract</B></P> <P>Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Female C57/BL6 Mice were intraperitoneally injected with supramaximal concentrations of cerulein (50 μg/kg) hourly for 6 h to induce AP. DMSO or DN was administered intraperitoneally, then mice were sacrificed 6 h after the final cerulein injection. Administration of DN increased pancreatic HO-1 expression through activation of activating protein-1, mediated by mitogen-activated protein kinases. Furthermore, DN treatment reduced the pancreatic weight-to-body weight ratio as well as production of digestive enzymes and pro-inflammatory cytokines. Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage. Additionally, DN treatment inhibited neutrophil infiltration into the pancreas via regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) by HO-1. Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Desoxo-narchinol-A (DN) is a natural compound of HO-1 inducer in pancreas. </LI> <LI> Mechanism of DN-induced HO-1 is mediated by MAPK/Activator Protein-1/HO-1 signaling. </LI> <LI> DN-induced HO-1 blocks neutrophil infiltration into pancreas via inhibition of CXCL2. </LI> <LI> DN inhibits cerulein-induced acute pancreatitis (AP) and AP-associated lung injury. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

SVD 알고리즘 및 HMM을 이용한 얼굴 및 눈 패턴 검출

진경찬,김명남,신장규,손병기,조진호 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The studies about automatic pattern detection of the eye and face from the human image acquired by the CCD image sensor have good applicabilities in the industry, home automation, and data communication field. In general, pattern detection method consists of feature based matching and template matching. In feature based matching, the feature vector is extracted with DLM(dynamic linking matching), EBGM(elastic bunch graph matching), HMM(hidden markov model) matching and knowledge based matching using statistical characteristics. In template matching, in general, the template vector is extracted with PCA(principal component analysis). When these method applied in the face and eye detection, each method has its own merits and some disadvantage. Therefore, by combined utilization of SVD(singular value decomposition) and HMM algorithm, is expected that we can selectively make use of each methods advantage and it result in improved detection accuracy. In this paper, we proposed the method for face and eye detection, which was combined by the two algorithms, to be suitable for the high speed image processing using DSP chip or microprocessor. In the beginning, template matching was followed by a template extraction using batch SVD algorithm and then face pattern was classified and recognized by HMM algorithm which is one of feature based matching technique. Finally, eye pattern detection was performed by pattern search neural network utilizing eigeneye image.

생활습관요인과 자가인식 건강상태의 관련도 포지셔닝

김명선,손미란,전진호,유병철 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : This study purposed to propose the fundamental data to develop the proper health promotion program through observation about the current status, lifestyle behaviors and results of health examinations of public personnel in Busan Metropolitan City. Methods : Subjects were 988 public services (683 male, 305 female) who were employed in City Hall of Busan Metropolitan City. We investigated the relation between lifestyle behaviors and self recognized health status using health examination in 2006. Data analysis on multiple logistic regression and multi-dimensional scaling were done using SPSS win(ver 12.0k) program. Results : The proportion of above 50 years old age are 47.1% in male and 59.7% in female. There are 10.2% in male and 15.8% in female with family history of hypertension, and 8.5% in male and 14.5% in female with family history of diabetes mellitus. There are 37.7% in male and 12.1% in female with obesity, and 10.6% in male and 7.7% in female with abnormal liver function. The disease suspicion rate for male was 1.8%, and 4.6% for female. Risk of hypertension in male was 3.7 times greater than in female and risk of diabetes mellitus in males was 5.0 times greater than in female. By questionnaire 71.8% in male and 78.3% in female had been thought themselves to have disease. Both male and female participants were more likely to think themselves with disease according to disease history of diabetes mellitus, liver dysfunction and hypercholesterolemia. Also aging is interfered that self-recognized health status. Conclusion : Self recognized health status was associated with diabetes mellitus, liver dysfunction, hypercholesterolemia, family history of chronic disease and aging in public employee of Busan Metropolitan City. This association point that there is need for continuous education and effort to modify their life style.

비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

Cyclic 활성슬러지 공정을 이용한 돈사폐수의 영양소 제거특성

조용진,임재명,이호식 江原大學校 附設 環境硏究所 1999 環境硏究 Vol.16 No.-

The cyclic activated sludge process is a modified activated sludge using the sequencing batch reactor(SBR) operation that can achieve the combination of carbon oxidation and nutrient removal. The operational characteristics of cyclic activated sludge process include a time-sequenced operation of anaerobic/aerobic/anoxic condition in a single reactor to achieve a maximum efficiency. The application of cyclic activated sludge process is, however, usually focused on the low strength wastewater including domestic sewage. As a result, limited attention has given to the high strength wastewater, especially for the piggery wastewater. The primary objective of this study is to evaluate an optimum operational cyclic to achieve combination of organic and nutrient removal using the piggery wastewater. The factors affecting inhibitory effects on nitrification during the cyclic operation is further determined. The result of this study, optimum operational cyclic of activated sludge process is 1hr : 2hr A/O(anoxic/oxic) ratio. Also, It was efficient that the SRT is operated more than 10 days and the specific nitrification rates were 0.04~0.24 ㎎N/gMv/hr at 20℃. Nitrification inhibition of piggery wastewater was found to occur at an influent volumetric loading over 0.3 NH₄-N ㎏/㎥/d. After a biological treatment, remaining phosphorus removal experiments were executed in oxidized ferrous column. As a result, the experiment showed the high density of variation in concentration by contact time on air. As for column aeration, completely phosphorus removal time was 25 minutes in contact time on air(20 hr) with aeration and 400 minutes(w/aeration) and 580 minutes(w/o aeration) in contact time on air(0 hr) respectively.

하악골 골절후의 골치유과정에 있어서 방사선학적 추적조사

최진영,김명호,허경희,서병무,이종호,정필훈,김명진 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The results of radiographic study of healing of fractured mandible are often inconsistent with clinical evaluation of bone healing pattern of it. In addition, there is inconsistency between radiographic studies. We think if such inconsistency is resolved, clinical assessment combined with radiologic evidence can be used to guide to more accurate clinical management. The purpose of this study is to evaluate radiological healing pattern of mandible, and to apply its result to clinical use. Panoramic view was used to analyze the change of radiographic finding in 35 patients (27 male, 8 female, ranging 17 to 53 years old) treated for mandibular fracture at the department of oral & maxillofacial surgery, SNUH in the period 1991 to 1998, Patients are all treated by rigid internal fixation using monocortical miniplate. Within 9 weeks, no change is observed at fracture site. Osteogenic change is observed at various time interval (3 to 21 weeks). We have found radiographic change of healing is observed 4 to 6 weeks later to clinical healing, According to this result, we recommend radiographic follow-up at 4 week, 10 week, 10 month.

연소반응 합성된 TiC 분말 소결체의 미세구조에 미치는 금속 Binder 영향

김명진,박민우,전재호,한유동 慶星大學校 1998 論文集 Vol.19 No.2

TiC cermets werefabricated by sintering of TiC and metal powders produced by self propagating high temperature systhesis (SHS). A total of five different cermet systems were studied. These are TiC-Ni, TiC-Co, TiC-Fe, TiC-Al and TiC-Cu. Powders of Ti, C, and metals (Ni, Co, Fe, Cu, Al) were first reacted to form TiC carbide in the matrix of each metal by SHS. The reaction products were crushed into fine powders, which were subsequently sintered at high temperatures either in hydrogen atmosphere or in vacuum for over 1 hours. The mocrosturctural evolution of the cermets was studied including carbide particle size and shape, growth of particles, and density of sintered body. The effects of different binder metals on the mocrosturctures of the cermets are discussed.

폴리에스테르 섬유 감량시스템용 프로세서 타이트레이터 개발

조진호,이흥락,이종현,김명남,구성모,김무영,진경찬,유병희,강민수,김국진 경북대학교 센서기술연구소 1993 연차보고서 Vol.1993 No.-

폴리에스테르 섬유 감량시스템의 제어를 위해서는 처리조 내에서 감량되는 섬유가 목표 감량치에 도달했는지를 판단해 주는 장치가 필요하다. 본 연구에서는 가성소다용액의 초농도 및 섬유 감량 정도의 정확한 측정과 감량 종료시간의 산출 및 이에 따른 종료신호를 발생할 수 있는 폴리에스테르 섬유 감량기 전용의 자동적정장치를 개발하였다. To control caustic soda treatment system for the polyester fabric reduction, we need the device to determine that the fabric has been arrived target reduction value. In this study, we develope an automatic process titrator for the caustic soda treatment system. Major functions of the target titrating system are accurate measurements of the caustic soda concentration and then producing the end point signal for caustic soda treatment system.

현장계측에 의한 해안매립지반 침하 연구 : 목표 해안 매립지를 중심으로

권호진,김영명 광주대학교 1996 産業技術硏究 Vol.7 No.-

본 연구에서는 목포신도심 2단계 조성공사에서 계측한 해안매립지반의 침하량을 Terzaghi의 1차원 압밀이론과 비교하였고, 또 실측치에 의한 장래침하량 추정방법인 쌍곡선방법, Hoshino 방법 및 Asaoka 방법과 비교 분석하였으며, 그 결과는 다음과 같다. 1. 지반의 침하는 성토높이의 영향을 받는다는 것을 침하계측으로부터 확인하였다. 2. Terzaghi의 1차원 압밀이론에 근거한 전산 프로그램으로부터 산정한 이론침하량은 계측침하량에 비해 큰 값을 나타내었다. 3. 단기간의 실측치에 의한 장래침하량 추정방법 중 쌍곡선방법이 다른 추정방법보다 상대적으로 신뢰성이 크게 나타났다. 4. 단기간의 계측값으로부터 추정한 장래침하량은 실제 계측침하량보다 전반적으로 큰 값을 나타내었다. 5. 쌍곡선 방법을 이용하여, 현재까지의 성토하중으로 인한 500일까지의 장래침하량을 예측하였다. In this study, the reliability of consolidation settlement calculation method was analyzed by using in-situ measurement at reclamation area in Mokpo seaside district. Based on the results obtained from the relations between theoretical settlement and in-situ settlement, it was found that the theoretical settlement by the Terzaghi's one dimensional consolidation theory was overestimated. Of all the methods to predict the final settlement by using the previously measured data, the hyperbolic method was relatively more reliable than the others such as Hoshino's method and Asaoka's method.