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복합곡면 가공시 공구간섭의 탐지와 공구경로 수정에 관한 연구
서태일,조명우,조재형 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.6
In this paper we deal with interference problem in the case of compound surface machining. A new tool interference detection and correction method based on the envelope of the tool path is suggested to identify and correct the tool interference - not only within the local path of tool movement, but also outside of the tool path. Therefore, the developed strategy can be used to check the possible interference in any region of the surface. In order to analyze quantitatively the milled surface errors produced by the tool interference, improved surface prediction model is also suggested in cutting process by general cutters. The effectiveness of th proposed method is demonstrated through simulation study.
Jae Won Seo,Kyu Seong Park,Gwang Bin Lee,Sang-eun Park,Jae-Hoon Choi,Myeong Hee Moon 대한면역학회 2023 Immune Network Vol.23 No.4
Lipid accumulation in macrophages is a prominent phenomenon observed in atherosclerosis. Previously, intimal foamy macrophages (FM) showed decreased inflammatory gene expression compared to intimal non-foamy macrophages (NFM). Since reprogramming of lipid metabolism in macrophages affects immunological functions, lipid profiling of intimal macrophages appears to be important for understanding the phenotypic changes of macrophages in atherosclerotic lesions. While lipidomic analysis has been performed in atherosclerotic aortic tissues and cultured macrophages, direct lipid profiling has not been performed in primary aortic macrophages from atherosclerotic aortas. We utilized nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry to provide comprehensive lipid profiles of intimal non-foamy and foamy macrophages and adventitial macrophages from Ldlr−/− mouse aortas. We also analyzed the gene expression of each macrophage type related to lipid metabolism. FM showed increased levels of fatty acids, cholesterol esters, phosphatidylcholine, lysophosphatidylcholine, phosphatidylinositol, and sphingomyelin. However, phosphatidylethanolamine, phosphatidic acid, and ceramide levels were decreased in FM compared to those in NFM. Interestingly, FM showed decreased triacylglycerol (TG) levels. Expressions of lipolysis-related genes including Pnpla2 and Lpl were markedly increased but expressions of Lpin2 and Dgat1 related to TG synthesis were decreased in FM. Analysis of transcriptome and lipidome data revealed differences in the regulation of each lipid metabolic pathway in aortic macrophages. These comprehensive lipidomic data could clarify the phenotypes of macrophages in the atherosclerotic aorta.