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miRNAs-dependent regulation of synapse formation and function
Minseok Song 한국유전학회 2020 Genes & Genomics Vol.42 No.8
Background A synapse is a fundamental signaling component that facilitates neuronal connectivity and information processing in the brain. Dynamic changes in the number, size, and functionality of synapse are induced by extensive signaling networks and structural proteins, which are stimulated on various neuronal activities. Changes in the expression level of synaptic proteins depend upon the physiological and pathological conditions at transcriptional, post-transcriptional, and post-translational levels. MicroRNAs (miRNAs) have not only emerged as pivotal gene expression regulators in neurons, but also in diverse cell types. miRNAs are evolutionarily conserved small non-coding RNAs that modulate mRNA stability and protein synthesis by interacting with 3′-untranslated region (3′-UTR) of mRNAs. Often, miRNA expression is limited to specific neuronal compartments such as axons, dendrites, and cell body to locally regulate protein synthesis in response to various stimuli. Objective Increasing evidences suggest that miRNAs are involved in the regulation of neuronal proliferation, differentiation, migration, development, and many other processes. This article reviews recent findings on the role of miRNAs in synapse formation and function. Conclusions Many studies have elucidated the role of miRNAs in diverse neuronal physiological and pathological processes. A better understanding of the mechanisms involved in miRNA functioning at the synapse will be beneficial in formulating novel therapeutic strategies.
Song, Minseok,Oh, Joseph,Choi, Seokhwan,Kim, Yeonho,Kim, Hyunsoo The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.4
In this paper, a motor control algorithm for performing a mode change without an integrated starter generator (ISG) is suggested for the automatic transmission-based hybrid electric vehicle (HEV). Dynamic models of the HEV powertrains such as engine, motor, and mode clutch are derived for the transient state during the mode change, and the HEV performance simulator is developed. Using the HEV performance bench tester, the characteristics of the mode clutch torque are measured and the motor torque required for the mode clutch synchronization is determined. Based on the dynamic models and the mode clutch torque, a motor torque control algorithm is presented for mode changes, and motor control without the ISG is investigated and compared with the existing ISG control.
Song, Minseok,Oh, Joseph,Kim, Jonghyun,Kim, Youngchul,Yi, Jaeshin,Kim, Yeonho,Kim, Hyunsoo SAGE Publications 2014 Proceedings of the Institution of Mechanical Engin Vol.228 No.1
<P>In this paper, an electric oil pump control algorithm for an automatic-transmission-based hybrid electric vehicle was proposed. Dynamic models of the hybrid electric vehicle powertrain and hydraulic control system, including a mechanical oil pump and an electric oil pump, were obtained, and a hybrid electric vehicle performance simulator was developed. Also, a flow consumption model of the hydraulic control system was constructed. To represent the characteristics of the hydraulic control system according to the change in the temperature of the automatic transmission fluid, a viscosity index concept was introduced. Based on the simulation and test results, a viscosity index–line pressure–electric oil pump power map was proposed to describe the power supply requirement according to the viscosity index and the required line pressure. Using the viscosity index–line pressure–electric oil pump power map, an electric oil pump control algorithm was suggested to control the electric oil pump by using multi-stage power for a given viscosity index. The mechanical oil pump speed at which the electric oil pump is turned off was obtained on the basis of the flow consumption model. The electric oil pump control algorithm was evaluated by experiments and simulations. The proposed electric oil pump control algorithm satisfied the target line pressure requirement according to the viscosity index. In addition, an electric oil pump control strategy during an automatic transmission gear shift was suggested for the situation in which the maximum line pressure required for the gear shift cannot be achieved by only the mechanical oil pump. The electric-oil-pump-assisted power was determined from the flow consumption model and the mechanical oil pump speed considering the gear shift. The simulation results confirmed that the electric oil pump control strategy satisfied the maximum line pressure during a gear shift.</P>
Minseok Song,Joseph Oh,Seokhwan Choi,Yeonho Kim,Hyunsoo Kim 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.4
In this paper, a motor control algorithm for performing a mode change without an integrated starter generator (ISG) is suggested for the automatic transmission-based hybrid electric vehicle (HEV). Dynamic models of the HEV powertrains such as engine, motor, and mode clutch are derived for the transient state during the mode change, and the HEV performance simulator is developed. Using the HEV performance bench tester, the characteristics of the mode clutch torque are measured and the motor torque required for the mode clutch synchronization is determined. Based on the dynamic models and the mode clutch torque, a motor torque control algorithm is presented for mode changes, and motor control without the ISG is investigated and compared with the existing ISG control.
비 뇌영상 데이터와 기계학습을 이용한 알츠하이머병 분류
송민석(Minseok Song),정혜윰(Hyeyoom Jung),이승용(Seungyong Lee),이종원(Jongwon Lee),김동현(Donghyeon Kim),안민규(Minkyu Ahn) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
치매 진단을 위해, 의사들은 여러 수기 검사를 먼저 진행한 후 확실한 진단을 위해 의료 영상(Magnetic Resonance Image: MRI) 등을 이용한다. 비용과 시간이 많이 소요되는 MRI 영상을 제외한 수기 검사만으로도 치매를 정확히 진단할 수 있다는 통계적 유의성을 얻고자 본 연구를 진행하였다. Open MRI database 인 ADNI 에서 제공하는 환자의 MRI 영상 이외의 메타데이터를 활용하여 치매를 진단하는 모델을 구성하였다. 진단하는 모델로는 Random Forest Regression 과 Multinomial Logistic Regression 을 사용하여 최대 78%의 정확도를 얻었으며, 각각의 모델로부터 Feature Importance 를 추출하여 치매를 진단함에 있어서 중요한 요소들을 정리해 보았다.