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Park, Minhwa,Woo, So-Youn 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.4
Obesity that caused by high-fat diet, heredity, drinking, or lack of exercise is related to metabolic syndrome, insulin resistance, type 2 diabetes and cardiovascular disease and it becomes a serious social problem. Although obesity shows low-grade chronic inflammation which induces from immune response in adipose tissue, relation between inflammation and pathogenesis of obesity has not been incompletely understood. Therefore, study for immune response in obesity is essential to design effective therapeutic strategy.
Park, Minhwa,Kim, Yu-Hee,Ryu, Jung-Hwa,Woo, So-Youn,Ryu, Kyung-Ha Hindawi Publishing Corporation 2015 Stem cells international Vol.2015 No.-
<P>Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4<SUP>+</SUP> T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.</P>
Development of Landslide Detection Algorithm Using Fully Polarimetric ALOS-2 SAR Data
( Minhwa Kim ),( Keunhoo Cho ),( Yoontaek Jung ),( Yeji Lee ),( Sangeun Park ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
SAR data is useful in a variety of applications such as disaster monitoring, target detection, and land cover classification. Especially, Polarimetric SAR data contains more information compared to conventional single-or dual- polarization SAR data. The objective of this study is to propose a novel landslide detection algorithm based on the polarimetric parameters providing better discriminability of landslide affected areas from undamaged backgrounds, such as the polarimetric entropy, radar vegetation index, and HH- and VV-polarization coherence. Since the estimation of polarimetric parameters can be affected by the number of look, another objective of this study is to evaluate the effect of speckle filtering on the landslide detection using polarimetric SAR data. On the other hand, it is important to correct geometric distortions in polarimetric SAR image because the landslide usually occurs in highly sloping terrain. In this study, we also investigate the effect of orthorectification on the estimation of polarimetric parameters. In order to develop the landslide detection algorithm, several deep seated landslides in Japan caused by Typhoon Talas in September 2011 were investigated using the L-band PALSAR-2 data.
Gahye Kim,Minhwa Hwang,Seonghyeon Lee,Yeon-Hwan Park 한국성인간호학회 2021 성인간호학회 학술대회 Vol.2021 No.8
Aim(s): Malnutrition is common among older adults and is associated with increased risks of many adverse health outcomes including frailty and poor quality of life. Older men living alone are a vulnerable social group who have a higher risk of poor nutrition than those living with others or women living alone. However, little is known about factors related to malnutrition in older men living alone. This study aimed to investigate the nutritional status and identify risk factors related to malnutrition in Korean older men living alone. Method(s): We analyzed the secondary data of 230 older men aged 65 years and over without severe cognitive impairment in the prospective cohort study of Korean elderly living alone conducted in 2019. Nutritional status was measured using the Mini Nutritional Assessment-Short Form (MNA-SF). Analyzed data included demographic factors (age, income), health condition (comorbidity, polypharmacy), physical (instrumental activities of daily living), cognitive (Mini-Mental Stated Examination), psychological function (depression), and lifestyle (smoking, drinking, exercise, meal frequency). Binary logistic regression analyses were performed. Result(s): Participant's mean age was 74.23±5.70 years. Of the participants 32.2% had malnutrition and 67.8% normal nutritional status. Factors related to malnutrition in older men living alone were income (Odds Ratio [OR]=.37, 95% confidence Interval[CI] = 15-.89), polypharmacy (OR=2.47, 95% CI=1.28-4.77), depression (OR=2.20, 95% CI=1.14-4.24), smoking (OR=2.51, 95% CI=1.27-4.97), low meal frequency (OR=4.13, 95% CI=2.11-8.07). Conclusion(s): It is important for the elderly men living alone to take a comprehensive nutritional assessment including socioeconomic status, health condition, psychological function, and lifestyle to prevent malnutrition. Strategies to improve healthy lifestyles and reduce depression are needed for effective nutritional management of older men living alone.