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백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화
김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1
N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)
Kwon, Yong-Hyun,Choi, Ji-Young,Shin, Mi-Kyung,Lim, Woo-Sung,Lee, Sung-Keun,Kang, Ju-Hee,Park, Chang-Shin The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.4
Neuronal cell toxicity induced by decreased nitric oxide (NO) production may be caused by modulation of constitutive neuronal NO synthase (nNOS). We used lead acetate ($Pb^{2+}$) to modulate physiological NO release and the related pathways of protein kinases like PKC, CaM-KII, and PKA in CATH.a cells, a dopaminergic cell line that has constitutive nNOS activity. In the cells treated with $Pb^{2+}$, cell viability and modulation (phosphorylation) levels of nNOS were determined by MTT assay and Western blot analysis, respectively. nNOS reductase activity (cytochrome c) was also assessed to compare the phosphorylation site-specific nNOS activity. nNOS activity was also determined by NADPH consumption rates. $Pb^{2+}$ treatment alone increased the phosphorylation of nNOS with decreased reductase activity. The phosphorylation levels increased markedly with decreased nNOS reductase activity, when $Pb^{2+}$ was combined with inhibitors for two (PKC and CaM-KII) or three (PKA, PKC and CaM-KII) protein kinases. Interestingly, when the cells were exposed to $Pb^{2+}$ plus PKC or CaM-KII inhibitor, the nNOS was phosphorylated strongly with the lowest activity. However, the levels of phosphorylated nNOS following $Pb^{2+}$ treatment decreased significantly after combined treatment with the PKA inhibitor, and $Pb^{2+}$-induced suppression of reductase activity did not occur. These results demonstrate that physiological NO release in the neuronal cells exposed to $Pb^{2+}$ can be decreased by PKA-mediated nNOS phosphorylation that may be caused by interactions with PKC and/or CaM-KII.
Kwon, Mi-Sook,Lim, Shin Gwon,Park, Yuwon,Lee, Sang-Min,Chung, Kyung Yoon,Shin, Tae Joo,Lee, Kyu Tae American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.17
<P>P2-type manganese-based oxide materials have received attention as promising cathode materials for sodium ion batteries because of their low cost and high capacity, but their reaction and failure mechanisms are not yet fully understood. In this study, the reaction and failure mechanisms of beta-Na-0.7[Mn1-xLix]O2+y (x = 0.02, 0.04, 0.07, and 0.25), alpha-Na0.7MnO2+y, and, beta-Na0.7MnO2+z are compared to clarify the dominant factors influencing their electrochemical performances. Using a quenching process with various amounts of a Li dopant, the Mn oxidation state in beta-Na-0.7[Mn1-x.Li-x]O2+y is carefully controlled without the inclusion of impurities. Through various in situ and ex situ analyses including X-ray diffraction, X-ray absorption near-edge structure spectroscopy, and inductively coupled plasma mass spectrometry, we clarify the dependence of (i) reaction mechanisms on disordered Li distribution in the Mn layer, (ii)' reversible capacities on the initial Mn oxidation state, (iii) redox potentials on the Jahn Teller distortion, (iv) capacity fading on phase transitions during charging and discharging, and (v) electrochemical performance on Li dopant vs Mn vacancy. Finally, we demonstrate that the optimized beta-Na-0.7[Mn1-x.Li-x]O2+y (x = 0.07) exhibits excellent electrochemical performance including a high reversible capacity of similar to 183 mA h g(-1) and stable cycle performance over 120 cycles.</P>
Mi Sung Kim,Hyuk Jung Kim,Hae Won Park,Heon-Ju Kwon,So-Yeon Lee,Shin Ho Kook,Hee-Jin Park,Yoon Jung Choi 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.6
Purpose: To retrospectively assess the impact of high-grade obstructions identified on initial CT on outcomes of patients with appendiceal inflammatory masses managed by nonoperative treatment. Methods: Institutional Review Boards approved this retrospective study and informed consent was waived. Included were 52 consecutive patients diagnosed with appendiceal inflammatory masses by CT scan and managed by nonoperative treatment. The main outcome measure was treatment failure and secondary outcomes were complications and initial and total hospital stay. Patient demographics, inflammatory markers, and CT findings for presence of an appendiceal inflammatory mass and high-grade obstruction were assessed. Patients with and without high-grade obstruction were compared for patient characteristics and outcomes using Fisher exact test and Student t-test. Results: Among 52 patients, 14 (27%) had high-grade obstruction on CT examination at presentation. No significant differences were observed in patient characteristics (P > 0.05), treatment failure (P = 0.33), complications (P = 0.29), or initial (P = 0.73) or total (P = 0.72) hospitalization between patients with and without high-grade obstruction. Conclusion: For patients who were managed by nonoperative treatment for appendiceal inflammatory masses, the presence of high-grade obstruction identified on initial CT scan did not significantly affect outcomes of treatment failure, complications, and initial and total hospitalization.