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경도변화에 따른 Al의 밀링가공시 가공 특성에 관한 연구
김성일,이상진,김민호,김태영,이위로 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-
The cutting tests of aluminum alloy for various hardnesses were carried out using CNC milling machine. The surface roughness(Ra, Rmax) of cut surface and cutting forces are measured at various cutting conditions such as spindle speed, feed speed and hardness. In the CNC end-milling, the surface roughness increases as feed speed increases and decreases as spindle speed increases. However, the bulit-up edge has occurred on in case of low hardness and low feed speed. In experimental conditions, as the hardness of aluminum alloy increases, the surface roughness(Ra, Rmax) decreases
Lee, Wi Hyoung,Lee, Seung Goo,Kwark, Young-Je,Lee, Dong Ryeol,Lee, Shichoon,Cho, Jeong Ho American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.24
<P>In organic field-effect transistors (OFETs), surface modification of the gate-dielectric is a critical technique for enhancing the electrical properties of the device. Here, we report a simple and versatile method for fabricating an ultrathin cross-linked interlayer (thickness ∼3 nm) on an oxide gate dielectric by using polymeric silsesquiazane (SSQZ). The fabricated siloxane film exhibited an ultrasmooth surface with minimal hydroxyl groups; the properties of the surface were chemically tuned by introducing phenyl and phenyl/fluorine pendent groups into the SSQZ. The growth characteristics of two semiconductorspentacene (p-type) and <I>N</I>,<I>N</I>′-ditridecyl-3,4,9,10-perylene tetracarboxylic diimide (PTCDI-C13, n-type)on this ultrathin film were systematically investigated according to the type of pendent groups in the SSQZ-treated gate dielectric. Pentacene films on phenyl/fluorine groups exhibited large grains and excellent crystalline homogeneity. By contrast, PTCDI-C13 films exhibited greater crystalline order and perfectness when deposited on phenyl groups rather than on phenyl/fluorine groups. These microstructural characteristics of the organic semiconductors, as well as the dipole moment of the pendent groups, determined the electrical properties of FETs based on pentacene or PTCDI-C13. Importantly, compared to FETs in which the gate dielectric was treated with a silane-coupling agent (a commonly used surface treatment), the FETs fabricated using the tunable SSQZ treatment showed much higher field-effect mobilities. Finally, surface treatment with an ultrathin SSQZ layer was also utilized to fabricate flexible OFETs on a plastic substrate. This was facilitated by the facile SSQZ deposition process and the compatibility of SSQZ with the plastic substrate.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-24/am507003n/production/images/medium/am-2014-07003n_0007.gif'></P>
Changes of Methyl trans-cinnamate Levels During Fruit-body Development in Tricholoma matsutake
Lee, Wi Young,Park, Youngki,Ahn, Jin Kwon,Ka, Kang Hyeon Korean Society of Forest Science 2005 한국산림과학회지 Vol.94 No.5
The relationship between the contents of methyl trans-cinnamate and the ratio of DP/DS (diameter of pileus / diameter of stalk) in the fruit-body of Tricholoma matsutake during its development was investigated. The stages of development were divided as follows: stage A is less than 1, stage B is from 1 to less than 2, stage C is from 2 to less than 3, and stage D is more than 3 of the values of DP/DS. The contents of methyl trans-cinnamate in pileus and stalk of pine mushroom ranged from $77{\mu}g/g$ to $824{\mu}g/g$ and from $7.6{\mu}g/g$ to $22.4{\mu}g/g$, respectively during its development. In the part of pileus, there is no relevance of the methyl trans-cinnamate content of pine mushroom between the stage A and B, but there was significantly different among the stage of B, C and D. In the case of stalk, the relevance of the methyl trans-cinnamate content of pine mushroom between stage D and other stages showed a low difference. In addition, as pileus of pine mushroom developed the level of the aroma compound increased as well and showed higher correlation relationship ($r^2=0.877$) between the contents of methyl trans-cinnamate in the pileus and the ratio of DP/DS. From the results of this study, we can conclude that the aromatic component of pine mushroom can be deduced from the value of DP/DS, which indicates the stage of the development appearance.
Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
Lee, Min-Young,Kang, Ju-Seong,Go, Ryeo-Eun,Byun, Yong-Sub,Wi, Young Jin,Hwang, Kyung-A,Choi, Jae-Hoon,Kim, Hyoung-Chin,Choi, Kyung-Chul,Nam, Ki-Hoan The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha ($TNF-{\alpha}$) converting enzyme, which is the molecule responsible for the release of $TNF-{\alpha}$. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of $TNF-{\alpha}$ release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative $TNF-{\alpha}$ related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II. The severity of the CIA was measured by traditional clinical scores and histopathological analysis of hind limb joints. A rota-rod test and grip strength test were employed to evaluate the severity of CIA based on losses of physical functions. The results indicated that Rhbdf2 mutant mice showed clear alleviation of the clinical severity of CIA as demonstrated by the significantly lower severity indexes. Moreover, a grip strength test was shown to be useful for the evaluation of physical functional losses by CIA. Overall, the results showed that the Rhbdf2 gene has a significant effect on the induction of CIA, which is related to $TNF-{\alpha}$.
Production of Anthraquinones of Polygonum multiflorum in Vivo and in Vitro
Wi Young Lee,Jin Kwon Ahn,Seung Taek Kim,Eung-Jun Park 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.4
Root growth and anthraquinones production of Polygonum multiflorum were investigated under various conditionsin vivo and in vitro treated with different concentrations of sucrose, MS salts and auxins (IBA, IAA and NAA). First we analyzed the anthraquinone levels in various tissues of the field-grown plants to find that the highest accumulation was found in the root tissues. In vitro root growth of nodal segments was significantly affected by the amount of sucrose (30 g?L-1) in the medium, but not by the concentration of MS salts. Among various auxins tested, IBA treatment (0.5 ㎎ㆍmL?¹) significantly stimulated the root growth, compared with the treatments of either IAA or NAA. Although the physcion contents (㎍ㆍg?¹ DW) were reduced 3.8-fold at the maximum as the IBA concentrations were increased from 0.1 to 1.0 ㎎ㆍmL?¹, total anthraquinone contents (㎍ㆍ100 mL?¹) of both rhein and emodin were not significantly lowered, due to the inhibitory effect of IBA. In the present study, we developed an efficient in vitro root culture system for Polygonum multiflorum, which provides further data for a large-scale bioprocessing of this plant.