특수형 방사성 동위원소 운반캡슐의 안정성 평가

이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.

Cell Selectivity of Arenicin-1 and Its Derivative with Two Disulfide Bonds

Lee, Ju-Un,Park, Ka-Hyon,Lee, Jee-Young,Kim, Jin-Kyoung,Shin, Song-Yub,Park, Yoon-Kyung,Hahm, Kyung-Soo,Kim, Yang-Mee Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.6

Resonance Frequency Analysis In Non-Submerged, Internal Type Implantwith Sinus Augmentation Using Deproteinized Bovine Bone Mineral

( Ju Hyon Lee ),( Hyung Gi Min ),( Jin Sook Lee ),( Myung Rae Kim ),( Na Ra Kang ) 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2S

Development of Two-way Plant Factory System for Seedling and Cultivation

Ju-hyun Park,Sang-Woo Lee,Tai Moon Ha,Kyu Hyon Hwang,Junghye Lee,Hae Kil Lee,Myeong-Whoon Seo 한국원예학회 2017 한국원예학회 학술발표요지 Vol.2017 No.5

Rethinking the History of Smallpox in the Early Twentieth Century: The SS Korea and Uncertainty Surrounding the Diagnosis of Smallpox

LEE Hyon Ju 대한의사학회 2020 醫史學 Vol.29 No.1

This research explores the case of the 1903 smallpox outbreak on the SS Korea , a transpacific carrier making runs between Southeast Asia, East Asia, Hawaii, and the United States. These regions were connected to a degree that no one had ever imagined through the SS Korea . Honolulu, Hawaii, was one of the most important territories in US maritime history and served as a waypoint between Asia and San Francisco on the mainland. As increasing numbers of people traveled by sea, various microbes were communicated across the Pacific Ocean. International tourists traveling across the ocean to Hawaii and the United States were alerted to infectious diseases, smallpox being one of the most significant of such diseases. The story of the SS Korea serves as an important lens through which to explore the early twentieth century transpacific world connected through Honolulu. Focusing on the spread of smallpox via international travelers, this research studies aspects of the public health system that were developed to contain smallpox infection on international ships and the application of smallpox vaccination as a method for infectious disease control. More importantly, in bringing attention to the uncertainty surrounding the diagnosis of smallpox, this research argues for the necessity of historians to build a more comprehensive medical historical context for disease control systems that includes the limits of medical science in making diagnoses of infectious diseases, the uncertainties arising from a lack of this component, and the implementation of health policies and preventative medical technologies.

A New Flavanone from the Wood of Amorpha fruticosa L.

Lee, Hyun-Jung,Lee, Oh-Kyu,Kwon, Yeong-Han,Choi, Don-Ha,Kang, Ha-Young,Lee, Hyeon-Yong,Paik, Ki-Hyon,Lee, Hak-Ju Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.3

Machine Learning Approaches for the Prediction of Prostate Cancer according to Age and the Prostate-Specific Antigen Level

Jaegeun Lee(이재근),Seung Woo Yang(양승우),Seunghee Lee(이승희),Yun Kyong Hyon(현윤경),Jinbum Kim(김진범),Long Jin(김용),Ji Yong Lee(이지용),Jong Mok Park(박종목),Taeyoung Ha(하태영),Ju Hyun Shin(신주현),Jae Sung Lim(임재성),Yong Gi 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.2

Purpose: The aim of this study was to evaluate the applicability of machine learning methods that combine data on age and prostate-specific antigen (PSA) levels for predicting prostate cancer. Materials and Methods: We analyzed 943 patients who underwent transrectal ultrasonography (TRUS)-guided prostate biopsy at Chungnam National University Hospital between 2014 and 2018 because of elevated PSA levels and/or abnormal digital rectal examination and/or TRUS findings. We retrospectively reviewed the patients’ medical records, analyzed the prediction rate of prostate cancer, and identified 20 feature importances that could be compared with biopsy results using 5 different algorithms, viz., logistic regression (LR), support vector machine, random forest (RF), extreme gradient boosting, and light gradient boosting machine. Results: Overall, the cancer detection rate was 41.8%. In patients younger than 75 years and with a PSA level less than 20 ng/mL, the best prediction model for prostate cancer detection was RF among the machine learning methods based on LR analysis. The PSA density was the highest scored feature importances in the same patient group. Conclusions: These results suggest that the prediction rate of prostate cancer using machine learning methods not inferior to that using LR and that these methods may increase the detection rate for prostate cancer and reduce unnecessary prostate biopsy, as they take into consideration feature importances affecting the prediction rate for prostate cancer.

미국에서의 백신 반대 운동

이현주 ( Hyon Ju Lee ) 한국미국사학회 2018 미국사연구 Vol.47 No.-

최근 미국에서 백신접종 거부의 증가와 반대 운동은 공중보건 분야에 있어 매우 우려되는 사안으로 떠오르고 있다. 본 논문은 백신 접종에 대한 이러한 논쟁이 역사적 기원을 가지고 있음을 보여주고자 한다. 더불어, 양자에 대한 더욱 명확한 이해를 위해 과거로부터 현재까지의 백신 정책과 백신 반대 운동이 통합적으로 연구되어야 함을 피력하려 한다. 그리하여, 본고에서는 18세기에서 21세기에 이르는 긴 시간 동안 미국의 백신접종 정책이 어떻게 발달되어 왔는지와 함께 미국에서 백신 반대 운동이 어떻게 태동하게 되었으며 진화해 왔는지 논의할 것이다. 면역 정책에 대한 논쟁은 18세기 초 해당 기술이 가능해 지게 되면서, “면역”이라는 단어 및 개념이 형성되기 이전, 그리고 인류역사상 첫 백신이 개발되기 전부터 존재해왔다. 본 연구는 면역 정책에 대한 초기 논쟁으로부터 현재까지 백신 접종에 있어 계속적으로 문제시 되는 이슈 및 백신 반대운동의 역사에 있어 중요한 순간들을 다룬다. 이를 통해 본고에서는 백신 접종 반대 운동이 복잡한 의학적, 사회적, 정치적 이슈들이 연계되어 있는 가운데, 지역사회, 주, 그리고 연방 차원의 백신 정책에 대응해 형성, 발달되어 왔으며, 백신 정책 또한 백신 반대운동의 영향으로 변화해 왔음에 주목한다. Vaccine objectors and the antivaccination movement have become one of the most concerning issues in public health in the United States. This paper argues that the controversy over vaccination is not an ahistorical phenomenon. It is important to discuss antivaccination movements as integrated with vaccination policies from the past to the present for a more complete understanding of both. This paper examines the origins and progress of the antivaccination movement, as well as the development of vaccination policies in the United States, over a long time span stretching from the eighteenth century to the twenty-first century. Controversy over immunization policy emerged even before the word immunization was coined and the first vaccine in human history was discovered, as similar medical technology had come to be available in the early eighteenth century. Tracing back from the present immunization controversy to its very early history, this study focuses on issues in vaccination (arguments for and against) that have continuously appeared and particular historical moments when the voices of vaccine objectors resurged. The study aims to explain that antivaccination movements have formed in reaction to community, state, and national vaccination policies, and that the policies in turn have been shaped by antivaccination movements amid a complex amalgam of medical, social, and political issues.

여성의사와 해외선교 ― 19세기 말에서 20세기 초 내한 미국인 선교사를 중심으로 ―

이현주 ( Hyon Ju Lee ) 이화여자대학교 이화사학연구소 2021 梨花史學硏究 Vol.- No.63

This research explores the rise and demise of American women’s overseas medical mission and various religious, social, and professional aspects of the American society, which contributed into the process lasting from the late nineteenth to the mid twentieth centuries. Using American women medical missionaries to Korea as a historical sample, this study provides quantitative and qualitative analyses of the proposed inquiry. Furthermore, it evaluates the relationship among the educational and professional developments of women medical professionals, women centered overseas mission, and other women’s issues emerging in the dawn to the twentieth century. In doing that this research provides a more comprehensive and larger historical context of the rise and fall of American women’s medical missionary work to Korea.

Oral Hormone replacement treatment and uterine volume in Korean adolescent with Turner syndrome : retrospective case- control study

( Yeon Ju Lee ),( Hye In Kim ),( Seok Kyo Seo ),( Young Sik Choi ),( Sihyun Cho ),( Byung Seok Lee ),( Bo Hyon Yun ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: In this study, we aimed to investigate uterine volume (UV) among pubertal induction (PI) versus natural menarche (NM) group in Turner syndrome (TS), and normal control group. In detail, we ought to elucidate the factors that affect uterine development during hormone replacement treatment (HRT). Methods: A retrospective case-controlled study was performed in patients diagnosed with TS from Apr 2004 to Aug 2018. Among TS, women who experienced menarche without HRT were defined as the NM group, and women who did or did not experience menarche after oral HRT were defined as the PI group. The control group included 16-year-old girls who underwent gynecological ultrasonography from Feb 2013 to Jun 2021, and excluded patients diagnosed with POI, hereditary disease, and Mullerian anomalies. UV, height, weight, BMI, FSH, LH, E2, HRT starting age, and duration of HRT were assessed. It was analyzed using the independent t-test, Mann-Whitney test, Kruskal-Wallis test, One-way ANOVA, Pearson correlation, partial correlation analysis. The study has been submitted for approval to IRB at Yonsei University College of Medicine(4-2021-1805). Results: Among TS patients, there was no significant difference in the diagnosis age, final height, weight, and pre-treatment hormone level between NM and PI. UV was significantly larger in the control group than in the TS group(Control vs NM, 40.22 vs 26.37, p-value =0.005), (control vs PI, 40.22 vs 18.08, p-value < 0.001). There was no significant difference between the NM group and the PI group, but the mean value was found to be high in the NM group (p-value = 0.098). The UV of the PI group showed a negative correlation with the pre-HRT LH level(r=-0.68, p-value = 0.030), and a positive correlation with the HRT onset age (r=0.715, p-value 0.020). Conclusion: UV is important in terms of pregnancy outcomes-smaller uteri may lead more pregnancy complications. LH level before PI and timing of HRT initiation may influence UV. The PI start timing should be carefully determined.