http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Byung Woo Jhun ),( Kyeong Man Jeon ),( Jung Seop Eom ),( Ji Hyun Lee,),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Backgroud: Chronic pulmonary aspergillosis (CPA) is uncommon and there are few data on the clinical characteristics, optimal therapeutic strategies, and outcomes. Methods: We retrospectively reviewed the records of patients with newly diagnosed CPA and assessed the clinical, radiologic, and laboratory responses, and outcomes between January 2008 and January 2012. Results: A total of 70 CPA patients were included. Median age was 55 years and 51 patients (72.9% ) were men. Fifty-seven patients (81.4%) had a history of pulmonary tuberculosis and 32 patients (45.7%) had non-tuberculosis mycobacterium (NTM) lung disease, 17 of whom had a history of NTM treatment and 15 was under NTM treatment. Sixty-nine patients (98.6%) received oral itraconazole, except one with oral voriconazole for a median duration of 6.2 months. Symptomatic improvement occurred in 52 patients (74.3%), radiologic improvement occurred in 29 (41.4%), and laboratory tests improved more than 60% of all patients. Thirty-six patients (51.4%) achieved treatment success, defined as symptomatic improvement after at least 6 months of therapy regardless of radiological improvement, and 4 of whom needed retreatment after a median of 8.4 months. There was no difference in clinical characteristics and outcomes according to NTM status and 10 (14.3%) discontinued therapy due to adverse reactions. Death occurred in 10 (14.3%) and median follow-up duration was 11.2 months. Conclusion: Antifungal therapy for about 6 months and reassessment of disease might be feasible treatment strategy in managing patients with CPA.
Bronchoscopic Findings of Pulmonary Paragonimiasis
( Kyeong Man Jeon ),( Jae Uk Song ),( Sang Won Um ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Joung Ho Han ),( Ho Joong Kim ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6
Background: Pulmonary paragonimiasis is a subacute to chronic inflammatory disease of the lung caused by lung flukes that result in prolonged inflammation and mechanical injury to the bronchi. However, there are few reports on the bronchoscopic findings of pulmonary paragonimiasis. This report describes the bronchoscopic findings of pulmonary paragonimiasis. Methods: The bronchosocpic findings of 30 patients (20 males, median age 50 years) with pulmonary paragonimiasis between May 1995 and December 2007 were reviewed retrospectively. Results: The diagnoses were based on a positive serologic test results for Paragonimus-specific antibodies in 13 patients (43%), or the detection of Paragonimus eggs in the sputum, bronchial washing fluid, or lung biopsy specimens in 17 patients (57%). The bronchoscopic examinations revealed endobronchial lesions in 17 patients (57%), which were located within the segmental bronchi in 10 patients (59%), lobar bronchi in 6 patients (35%) and main bronchi in 1 patient (6%). The bronchoscopic characteristics of endobronchial lesions were edematous swelling of the mucosa (16/17, 94%) and mucosal nodularity (4/17, 24%), accompanied by bronchial stenosis in 16 patients (94%). Paragonimus eggs were detected in the bronchial washing fluid of 9 out of the 17 patients with endobronchial lesions. The bronchial mucosal biopsy specimens showed evidence of chronic inflammation with eosinophilic infiltration in 6 out of 11 patients (55%). However, no adult fluke or ova were found in the bronchial tissue. Conclusion: Bronchial stenosis with mucosal changes including edematous swelling and mucosal nodularity is the most common bronchoscopic finding of pulmonary paragonimiasis.
전경만 ( Kyeong Man Jeon ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.3
Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in the intensive care unit (ICU), with an incidence ranging from 8% to 38%. Patients who acquire VAP have higher mortality rates and longer ICU and hospital stays. Because there are other potential causes of fever, leukocytosis, and pulmonary infiltrates, clinical diagnosis of VAP is overly sensitive. The only alternative approach to the clinical diagnosis of VAP is the Clinical Pulmonary Infection Score (CPIS). Employing quantitative cultures of respiratory secretions in the diagnosis of VAP leads to less antibiotic use and probably to lower mortality. With respect to microbiologic diagnosis, however, it is not clear that the use of invasive sampling using bronchoscopy is associated with better outcomes. Delayed administration of antibiotic therapy is associated with an increased mortality, and inadequate antibiotic therapy is also associated with higher mortality. Therefore, prompt initiation of adequate antibiotic therapy is a cornerstone of the treatment of VAP. The initial antibiotic therapy should be based on the most common organisms in each hospital and the most likely pathogens for that specific patient. When final cultures and susceptibilities are available, de-escalation to less broad spectrum antibiotics should be done. Since clinical improvement usually takes 2 to 3 days, clinical responses to the initial empirical therapy should be evaluated by day 3. A short course of antibiotic therapy appears to be equivalent to a traditional course of more than 14 days, except when treating non-fermenting gram-negative organisms. If patients receive initially adequate antibiotic therapy, efforts should be made to shorten the duration of therapy to as short as 7 days, provided that the etiologic pathogen is not a non-fermenting gram-negative organism.
전경만 ( Kyeong Man Jeon ) 대한내과학회 2014 대한내과학회지 Vol.86 No.5
Pain, agitation and delirium (PAD) occur frequently in mechanically ventilated patients in the intensive care unit (ICU). Consequently, analgesics and sedatives are frequently administered to critically ill patients with the aim of treating PAD, decreasing the physiological stress response, and improving synchrony with mechanical ventilation. However, many of the analgesics and sedatives in current use can lead to adverse outcomes, including longer durations of mechanical ventilation, prolonged ICU stays, delirium, and an increased risk of death, particularly when these agents are administered at excessive doses for prolonged periods. The purpose of this review is to provide an overview of the initial evaluation and monitoring of, and the medications commonly prescribed for, PAD. Moreover, we highlight the major recommendations of the recent guidelines published by the Korean Society of Critical Care Medicine and American College of Critical Care Medicine. (Korean J Med 2014;86:546-556)
고요산혈증을 보이는 한국인 건강검진 내원자들에서의 통풍의 유병률과 관련 인자들에 관한 연구
김응호 ( Eung Ho Kim ),전경만 ( Kyeong Man Jeon ),박건우 ( Keon Woo Park ),김형진 ( Hyung Jin Kim ),안중경 ( Joong Kyong Ahn ),전찬홍 ( Chan Hong Jeon ),차훈석 ( Hoon Suk Cha ),고은미 ( Eun Mi Koh ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1
Objective: To investigate the prevalence of gout among hyperuricemic Korean people who visited Health Screening Center and to study related factors in the development of gout. Methods: The medical records of 6,461 people who visited Health Screening Center from March to May in 2002 were reviewed. Five hundred twenty one out of 603 hyperuricemic individuals were interviewed by telephone. Gout was diagnosed according to the clinical criteria of Wallace. Basic demographic and lifestyle variables as well as biochemical data were collected. Results: The prevalence of hyperuricemia was 14.3% in men and 2.2% in women. The prevalence of gout among hyperuricemic population was 16.6% for men and 6.7% for women. The mean age was higher in gout patients compared to the hyperuricemic people without gout, and serum uric acid and creatinine levels were increased in gout patients. The mean systolic blood pressure and the alcohol consumption amount were also increased in gout patients. In the multiple logistic regression analysis, statistically significant related factors for the development of gout among hyperuricemic population were age, uric acid level and alcohol consumption amount. Conclusion: The prevalence of gout among hyperuricemic Korean people who visited Health Screening Center was 16.6% for men and 6.7% for women. The possible related factors in the development of gout among hyperuricemic population were age, uric acid level and alcohol consumption amount.
Estimation of Timber Production Under Thinning Scenarios Using a Forest Stand Yield Model
( Jeon Eo Jin ),( Young Hwan Kim ),( Kyeong Hak Lee ),( Shin Man Yong ) 한국임학회 2012 한국임학회 학술발표논문집 Vol.2012 No.-
In this study, forest stand yield and its changes along with 10 thinning scenarios were estimated using a forest stand yield model for six major tree species in Korea (Pinus densiflora in Gangwon province, Pinus densiflora in other regions, Pinus koraiensis, Larix leptolepis, Quercus acutissima Carruth, Quercus mongolica). The 10 thinning scenarios were generated based on a number of management constraints and assumptions. Under the 10 scenarios, the overall stand yield volumes from thinning and final harvesting were estimated for each species. The results showed that highest yield volumes were obtained when 30% of basal areas were thinned at 20 and 40 years for Pinus densiflora in Gangwon province, Pinus koraiensis and Quercus mongolica, while highest yield volumes were obtained when 20% of basal areas were thinned at 20, 30 and 40 years for Pinus densiflora in other regions and Larix leptolepis. These two scenarios gave the same amount of highest yield volume for Quercus acutissima Carruth.
Jeon, Bu-Nam,Kim, Min-Kyeong,Yoon, Jae-Hyeon,Kim, Min-Young,An, Haemin,Noh, Hee-Jin,Choi, Won-Il,Koh, Dong-In,Hur, Man-Wook Oxford University Press 2014 Nucleic acids research Vol.42 No.18
<P>ZNF509 is unique among POK family proteins in that four isoforms are generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). Here, we investigated the functions of ZNF509 isoforms in response to DNA damage, showing isoforms to be induced by p53. Intriguingly, to inhibit proliferation of HCT116 and HEK293 cells, we found that ZNF509L activates <I>p21/CDKN1A</I> transcription, while ZNF509S1 induces <I>RB</I>. ZNF509L binds to the <I>p21/CDKN1A</I> promoter either alone or by interacting with MIZ-1 to recruit the co-activator p300 to activate <I>p21/CDKN1A</I> transcription. In contrast, ZNF509S1 binds to the distal <I>RB</I> promoter to interact and interfere with the MIZF repressor, resulting in derepression and transcription of <I>RB</I>. Immunohistochemical analysis revealed that ZNF509 is highly expressed in normal epithelial cells, but was completely repressed in tumor tissues of the colon, lung and skin, indicating a possible role as a tumor suppressor.</P>