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Review : Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
( Seung Hoi Koo ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the peripheral tissues in humans, and could cause severe metabolic disorders by inducing accumulation of lipid in the liver, resulting in the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD, which is characterized by increased fat depots in the liver, could precede more severe diseases such as non-alcoholic steatohepatitis (NASH), cirrhosis, and in some cases hepatocellular carcinoma. Accumulation of lipid in the liver can be traced by increased uptake of free fatty acids into the liver, impaired fatty acid beta oxidation, or the increased incidence of de novo lipogenesis. In this review, I would like to focus on the roles of individual pathways that contribute to the hepatic steatosis as a precursor for the NAFLD. ((Iin Mol Hepatol 2013;19:210-215)
구승회(Koo, Seung Hoi) 새한영어영문학회 2018 새한영어영문학 Vol.60 No.4
This paper explores the derivation of coordinate constructions in English within the framework of Optimality Theory (OT). In the literature of the generative grammar, many inviolable constraints, such as Law of the Coordination of Likes (LCL), Coordinate Constituent Constraint (CCC), etc., have been put forward to accommodate various types of the coordinate constructions in English. However, such rule-based approaches are not sufficient to deal with the nature of the coordinate constructions properly. In this paper, we postulate the ranking of the violable constraints to account for the coordinate constructions in a unified manner. The proposed OT-based approach could also reveal the nature of the coordinate constructions in English without resort to any rule-based constraints like LCL and CCC.
An Analytical Approach for AGV Fleet Size Determination
Koo, Pyung-Hoi,Song, Jun-Yeob,Lee, Seung-Woo 한국경영과학회 1998 한국경영과학회 학술대회논문집 Vol.- No.1
As manufacturing systems are growing in size and complexity, material flow control has become one of the key issues for system efficiency. This paper addresses a design problem involved in automated guided vehicle systems (AGVS). Of the AGVS design issues, the determination of the AGVS fleet size is the basic and important issue. Existing non-simulation approaches in determining AGV fleet size have not considered stochastic features of AGVS. This paper presents an analytical model for determining the AGV fleet size in which the stochastic characteristics are taken into consideration.