그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

고혈압 환자에서 경동맥 신전성의 변화

허영선,김학진,송영빈,안지현,임성훈,이왕수,김상욱,김태호,김치정,류왕성,유언호 중앙대학교 의과대학 의과학연구소 2000 中央醫大誌 Vol.25 No.3

海雲台 海濱變形에 관한 硏究

閔丙亨,姜龍太,朴雲龍,金嘉也 동아대학교 공과대학 부설 한국자원개발연구소 1984 硏究報告 Vol.8 No.1

This study has been carried out to determine the values of bed-sand scale and time scale which are difficult at hydraulic model tests on the HAE UN DAE beach after performing a marine investigation required to establish a protection method about the deformation of HAE UN DAE beach by using hydraulic model test. The amount of topography deformation of HAE UN DAE beach has also been obtained by the two dimensional movable bed hydraulic model test in a quantitative way.

지단백 대사 기전에 대한 문헌 고찰

김태운,박태곤 부산대학교 과학교육연구소 2006 교사교육연구 Vol.45 No.-

Atherosclerosis, along with the resultant coronary artery disease (CAD), is a leading cause of mortality in industrialized countries. Lipoproteins (LP) are generally classified according to their density. Triglycerides are mainly transported in chylomicrons and very low density LP (VLDL), cholesterol is mainly transported in low density LP (LDL) and high density LP (HDL). The metabolism of LP is controlled by their apolipoproteins, by specific receptors, enzymes, and transfer proteins. Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an activated form of apo E. The LDL receptor therefore mediates the uptake of intermediate density lipoprotein (IDL) and LDL by the liver, and it also facilitates uptake of LDL by other tissues. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase (LCAT). Cholesterol ester accumulating in HDL can then follow a number of different fates: uptake in the liver in HDL containing apolipoprotein (particle uptake) by LDL receptors, selective uptake of HDL cholesterol ester in liver or other tissues involving scavenger receptor B1 (SRBI), or transfer to triglyceride-rich lipoproteins as a result of the activity of cholesterol ester transfer protein (CETP), with subsequent uptake of triglyceride-rich lipoprotein remnants in the liver. CETP promotes the transfer of cholesterol esters (CE) from antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs. A deficiency of CETP is associated with increased HDL levels and decreased LDL levels, a profile that is typically antiatherogenic. Recently, another key molecule involved in this pathway was identified, scavenger receptor BI ; this mediates the selective uptake of HDL cholesterol esters in the liver and thus constitutes a pathway of reverse cholesterol transport parallel to that mediated by CETP. Thus, the remodeling of human HDL by CETP, involving CE;-TG interchange, followed by the action of hepatic lipase (HL), leads to the enhanced uptake of HDL CE by cellular SR-BI. These observations suggest that in animals such as humans in which both the selective uptake and CETP pathways are active, the two pathways could operate in a synergistic fashion to enhance reverse cholesterol transport. In conclusion, a major challenge will be to determine if manipulation of RCT pathway by targeting molecules such CEPT, LCAT, HL, or SRBI can be used for therapeutic benefit.

12주간의 우리춤 체조가 폐경기여성의 신체조성과 혈중지질에 미치는 영향

김순경,김태운 釜山大學校 附設 體育科學硏究所 2009 體育科學硏究所 論文集 Vol.25 No.2

본 연구는 45-55세의 폐경기여성 9명을 대상으로 12주간의 우리춤 체조(1회 60분, 주3회)을 실시하고 신체조성과 혈중지질에 미치는 영향을 살펴본 결과는 다음과 같다. 12주간의 우리춤 체조 전후의 신체조성의 변화에서 체중은 우리춤 체조 전 검사에서 58.17+_4.04kg, 우리춤 체조 후 56.39+_3.40kg으로 유의(p<.01)하게 감소하였으며, 체지방률은 우리춤 체조 전 검사에서 30.22+_2.22%, 우리춤 체조 후 28.22+_1.39%로 유의(p<.05)하게 감소하였으며, 제지방량은 우리춤 체조 전 검사에서 40.28+-1.89kg은 우리춤 체조 후 40.94+-2.32kg으로 증가하였으나 통계적으로는 유의한 차이가 나타나지 않았다. 혈중지질의 변화에서 T-C는 186.22 +- 13.28mg/dl에서 185.89 +- 35.23mg/dl(0.18%)로 유의(p<.05)하게 감소하였고, HDL-C는 59.11 +- 8.64mg/dl에서 60.33 +- 12.87mg/dl(2.07%)로 유의(p<.05)하게 증가하엿으며, LDL-C는 117.44 +- 15.46mg/dl에서 116.67 +- 30.05 mg/dl(0.67%)로 유의(p<.05)하게 감소하였으며, TG도 95.67 +- 33.82mg/dl에서 79.00 +- 17.99mg/dl(21.10%)로 감소하였다. 결론적으로 12주간의 우리춤 체조가 폐경기 여성의 신체조성 및 혈청지질에 긍적적인 효과를 보였다.

大學 男女 球技選手들의 最大無機的 Power

김태운,유재충,안덕균,선우섭,이한,손두욱,박충서 慶熙大學校 社會體育硏究所 1994 體育科學論叢 Vol.- No.7

The purpose of the present research is to compare characteristics of maximal anaerobic power observed in different types of sports and player's sex differences. We have reached the following conclusions from the results we obtained by measuring maximal anaerobic power and blood lactate concentration of 60 elite university male and female players during the exercise of bicycle ergometer: 1. As to absolute and relative values of maximal anaerobic power, male players are higher in the order of rugby and handball, whereas female players are higher in the order of hockey and soccer, but no significant differences are observed between types of sports. 2. Male players are noticably higher in absolute values of maximal anaerobic power(p<0.001), but relative value is very simi1ar to that of female players. 3. It is estimated that the fact, that female players show obvious higher mean anaerobic power(p<0.001) during the 3,4KP excercise is due to sex differences in ocdurrence work load of maximal anaerobic power. 4. Comparison of blood lactate concentration at each work load in different types of sports and player's sex differences show an increase in proportion to mean anaerobic power. The results given above clearly show the differences between the type of sports such as rugby and hockey requiring power and speed, and the type of sports such as handball and soccer requiring edurance.

Salmonella sp.의 신속한 동정을 위한 증진배양의 개선에 관한 연구

김기태,김태우,옥순학,이영호,백운화 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.6

식품 및 생활폐수내의 존재하는 Salmonella spp.에 대한 효율적이고 신속한 동정을 위한 증진배야업을 개발하고자 하였다. 본 연구에 사용된 균주인 S. enteritidis 생육을 촉진시키기 위한 방법으로 cAMP 및 yeast extract를 사용하였는데 전자인 경우는 배지내의 농도가 10 mM 이상일 때 10^-3 cfu/ml의 균수로 7시간 배양후 균수가 control보다 약5배의 증가를 보였으며 후자인 경우는 0.6% 첨가시 10배의 증가를 보였다. 다른 균주들에 대한 선택적인 성장효과를 보기위하여 selenite broth와 bile salts를 사용하였고 이때 사용된 균주는 Staphylococcus aureus, Pesudomonas aeruginosa, Lactobacillus plantarum 및 Escherichia coli이었고 bile salts의 농도가 0.1%일때 네 가지 균주의 증식에 대한 억제 효과가 있었다. 두 단계의 증진배양법으로서 1차 증진배양에서는 selenite broth에 0.6% yeast extract를 첨가한 것으로 2차 증진배양에서는 0.1% bile salts를 첨가한 것으로 하였는데 타균과의 혼합배양에서 Salmonella의 초기균수가 10^0.3일 때 14시간 증진배양으로 10^8.5 cfu/ml까지 증식을 보였으며 초기균수가 1 cfu/100 ml인 경우는 10시간의 1차 증진배양과 6시간의 증진배양으로 약 10^7의 증식속도를 나타내었다. The development of an enrichment method for the rapid and effective identification of Salmonella spp. in sewage or food was studied. As a growth factor for Salmonella, 10 mM cyclic adenosine monophosphate (cAMP) in trypticase soy broth with 0.6% yeast extract (TSBYE) increased cell number five-folds and 0.6% yeast extract in selenite broth increased cell number ten-folds of control. Bile salts in slenite broth was tested for the selection of S. enteritidis in a mixture with Staphylococcus aureus, Pesudomonas aeruginosa, Lactobacillus plantarum and Escherichia coli. The latter four strains were effectively inhibited at 0.1% bile salt. A two-step culture method was used to enrich Salmonella spp.; a primary-enrichment and secondary-enrichment culture. At a primary-enrichment step, selenite broth with 0.6% yeast extract and 10 mM cAMP was used, and at a secondary-enrichment step, -0.1% bile salt was additionally used. Culture times of a primary-enrichment and a secondary-enrichment step were 8 hr and 6 hr, respectively. In this procedure, cell number increased from 10^0.3 to 10^8.5 with inhibition of other strains within 14 hr. In the case of an initial cell concentrarion as low as 10^-2 cfu/ml, a cell number increased to 10^7 cfu/ml by using a 10 hr primary-enrichment and 6 hr secondary-enrichment procedure.

남성 건강검진 수진자에서 간기능 장애 및 비알코올성 지방간과 대사 증후군과의 관련성

최태성,유재영,김진석,장은철,박주언,김병익 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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비만치료의 원리와 대책

김태운 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.1

The increasing prevalence of obesity and its concomitant health risks justify widespread efforts toward prevention. This review has considered in detail the potential ability of physical activity, dietary, and lifestyle modification interventions to reduce the prevalence of obesity. ......

인터넷 웹을 기반으로 한 공정규명과 공정제어 교육 시스템

김태언,이범석 경희대학교 산학협력기술연구원 2002 산학협력기술연구논문집 Vol.8 No.-

As the computer systems are developed rapidly, the area of the engineering softwares are also expanded. Most of these engineering softwares are the high-priced commercial softwares for the exactness of the results. However, the commercial softwares are too expensive for some users. especially undergraduate students. In this study, the engineering software for the chemical process control is made of the JAVA language in a web environment. Then the virtual experiment of the process control can be executed free of charge using this software. This software is worked on the internet and shows how to identify a unknown process system and how to tune the control parameters to operate the process system. The numerical examples are presented to illustrate the virtual experiment for the process control using the software made in this study.