Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats

Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*

"덕은 가르쳐질 수 있는가?"라는 물음의 도덕교육적 함의

김상돈 ( Sang Don Kim ) 한국윤리교육학회 2009 윤리교육연구 Vol.0 No.20

소크라테스는 『프로타고라스』와 『메논』에서 "덕은 가르쳐질 수 있는가?"라는 물음을 제시한다. 프로타고라스와 메논은 미묘한 차이가 있기는 하지만 모두 덕은 가르쳐질 수 있다고 주장한다. 하지만 소크라테스는 덕의 교육가능성과 덕의 지식가능성을 논리적으로 연결시키면서 만약 프로타고라스와 메논이 덕의 지식가능성을 입증하지 못한다면 그들은 부당 전제의 오류를 범하게 되는 것임을 주장한다. 왜냐하면 덕의 교육가능성은 덕의 지식가능성에 의존하기 때문이다. 덕의 지식가능성에 대한 논의는 "덕이란 무엇인가?"라는 물음에 관한 논쟁으로 이어진다. 그러나 두 대화편 모두에서 덕의 본질에 대한 최종적인 결론은 발견되지 않는다. 따라서 덕의 교육가능성 역시 미해결의 과제로 남게 된다. 소피스트의 상대주의적 관점을 비판하고 이성에 근거한 객관적인 지식을 추구한 것으로 알려진 소크라테스가 덕의 지식가능성과 교육가능성에 대해 확신하지 않았다는 점은 다소 의아한 것이다. 그렇다면 프로타고라스, 메논과의 논쟁에서 보여준 소크라테스의 의구심은 어떤 의미로 해석될 수 있는가? 본 논문은 덕의 교육가능성에 대한 물음과 논쟁을 분석하여 그것에 담긴 도덕교육적 함의를 탐색한다. This study is focused on Socratic question, "Can be virtue teachable", in Protagoras and Meno. In Protagoras, Protagoras insists that he can teach virtue, in particular, civic virtue, and he know what it is. But Socrates presents some questions to him. According to Socrates, we cannot have a conviction about the possibility, if we don`t have the knowledge about what virtue is. Similarly in Meno, Meno also ask a question to Socrates. The teachability of virtue and the possibility as knowledge of virtue are correlated. Socrates examines two theses. But the conclusion is disappointed. Socrates still open the question those two possibilities. This means that he, too, has not a cogent argument on what virtue is. Socrates`s hesitation shows a lot of implications about moral education. Can we teach morals? What is the moral that we intend to teach. Is it the same as Socratic virtue? Or, Is it different with ancient Greek virtue. Greek, arete, can it be interpreted as virtue, modern language? We can find the answer about these questions, by distinguishing and moral. Virtue can be totally reduced into moral. It has some different logical structure. Here, we can find the true meaning of virtue ethics. In moral education, moral virtue and moral principle or moral rule have competed each other. Nevertheless, without principle, virtue cannot be justified as contents of moral education, because teaching is possible by principle. Moral principle, moral rule, and moral knowledge cannot be separated in concept. Contrarily, moral knowledge with virtue is ineffective in moral education.

장이간 이뇨제 남용중인 특발성 또는 자가획득 부종간의 병태생리의 차이

민경환(Kyung Hwan Min),김호중(Ho Jung Kim),유준호(Jun Ho Ryu),한상웅(Sang Woong Han),강석우(Seok Woo Kang),문중돈(Jung Don Mun) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1

N/A Patients suffering from idiopathic or self-induced edema are uniformly characterized by chronic use of furosemide, which leads to vicious cycle of edema. Among chronic furosemide users who don't have any other specific edema forming diseases, 9 patients from the outpatient clinic(OC) and 6 patients examined at the emergency room(ER) used it mainly for weight reduction and for cyclical edema, respectively. All of the ER group patients were presented with severe hypokalemia(2.04±0.2mEq/L; range 1.3 to 2.7 mEq/L) and alkalosis(748±0.01; range 7.44 to 7.51) but none from the OC group showed such results. Other baseline parameters including Plasma renin activity(PRA) and aldosterone level on recumbency, and FEn₂were similar in both groups. In contrast, daily working hours(6.1±0.5 vs 10±0.6hr, p<0.01), average body weight gain between AM and PM(0.4±0.1 vs 0.9±0.lkg, p<0.01), peak weight gain interval(9±0.8 vs 5±0.1day, p<0.05), PRA(7.6±1.5 vs 23.5±7.2ng/ml/h, p<0.05) and aldosterone level(22.1±4.2 vs 64.8±10.4 ng/dl, p<0.01) on ambulation, and FEk. on normokalemia(ll±2A vs 36±7.7%, p<0.01) were statistically different between the two groups. In comparison to the OC group, both the amout of urine(617±39 vs 358±26ml, p<0.01) and the percent change of PRA(-14±4 vs -3±2%, p<0.05) and al-dosterone level(-17±5 vs -4±3%, p<0.05) after saline loading(lL over 1hr, IV) following ambulation were smaller in the Elt group. Moat of the ER group patients(5/6) required aldosterone antagonist (spironolactone) added to K(+) supplement, but all of the OC group patients were managed to maintain an edema-free status with conservative treatment. In conclusion, patients with idiopathic edema seem to have more fluid transudation out of intravascular space during orthostasis with a prominent degree of deranged renin-aldosterone axis and K(+) metabolism than those with self-induced edema.

Reproductive Cycle of the Female Grey Mullet, Mugil cephalus, on the Coast of Jeju Island, Korea

Kim, Sung Jun,Lee, Young Don,Yeo, In Kyo,Baek, Hea Ja,Kim, Hyung Bae,Nagae, Masaki,Soyano, Kiyoshi,Hara, Akihiko 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

숭어의 생식주기를 밝히기 위해 2002년 2월부터 2003년 3월까지 제주도 동남부 연안에서 채집하였고, 난모세포의 발달과정을 조직학적 방법으로 관찰하였다. 난모세포의 발달과정은 GSI 변화와 밀접하였다. GSI는 9월에 급격히 증가하여 12월에 최고 값을 나타내었다. 난소의 조직학적 관찰결과, 염색인기와 주변인기의 난모세포는 연중 관찰되었으며, 8월에는 일부에서 난황을 포함하는 난모세포가 관찰되었다. 대부분의 난모세포가 10월과 12월에는 난황구가 단계의 난모세포로 발달했다. 10월과 12월에 난황구기 난모세포들을 가진 개체의 출현이 가장 높았으며, 잔존여포와 퇴화 난모세포는 2월부터 관찰되었다. 숭어의 주산란기는 11월에서 1월이고, 난군동기발달형의 난소를 가지며 외양으로 이동하여 산란하는 어류에 속한다.

Cytotoxicity induced by the mixture components of nickel and poly aromatic hydrocarbons

Kim, Injeong,Lee, Yeseul,Kim, Sang Don Springer-Verlag 2019 Environmental geochemistry and health Vol. No.

Effect of Korea Ginseng Extract on the Recovery of Heart Rate after Exercise and the Aerobic Capacity in Old Men

Kim,Tai Ho,Kim, Chun,Rhee, Sang Don 中央大學校 醫科大學 1979 中央醫大雜誌 Vol.4 No.1

Long Photoperiod Affects Gonadal Development in Olive Flounder Paralichthys olivaceus

Kim, Byeong-Hoon,Lee, Chi-Hoon,Hur, Sang-Woo,Hur, Sung-Pyo,Kim, Dae-Hwan,Suh, Hae-Lip,Kim, Sung-Yeon,Lee, Young-Don The Korean Society of Developmental Biology 2013 발생과 생식 Vol.17 No.3

To effects of sex maturation in olive flounder by regulating long photoperiod, gonadal development and GTH mRNA expression in the pituitary were investigated. Photoperiod was treated natural photoperiod and long photoperiod (15L:9D) conditions from September 2011 to March 2012. The results showed that natural photoperiodic group showed a higher gonadosomatic index (GSI) than long photoperiodic group during the spawning season (March 2012). The histological analysis of ovarian tissue showed that natural photoperiod group of ovaries contained vitellogenic oocytes, but long photoperiod group of ovaries mainly contained perinucleolus staged oocyte and oil-drop staged oocytes. The FSH mRNA of olive flounder, under natural photoperiod group, showed a significantly higher expression but no significant difference under long photoperiod group. The $LH{\beta}$ mRNA showed a significantly higher expression only under natural photoperiod group. These results may suggest that long photoperiodic information regulates secretion of pituitary FSH and LH and maintain early growing stage of gonadal development in this species.

Pseudolite Antenna Calibration Algorithm using a Multi-Antenna Receiver

Kim, Chong-Won,Jeon, Sang-Hoon,Kim, Ghang-Ho,Kee, Chang-Don,Lee, Taik-Jin,So, Hyoung-Min The Korean Society for Aeronautical and Space Scie 2012 International Journal of Aeronautical and Space Sc Vol.13 No.2

The need for position information in indoor environments has been growing lately. Several indoor navigation systems have been studied. Among them, pseudolite-based indoor positioning systems are one of the best systems to obtain precise position measurements. However, the installation of such systems is very difficult because the calibration of pseudolite antenna position is complicated. For precise calibration, the use of carrier phase measurements is necessary, and whenever carrier phase measurements are considered, problems with cycle ambiguity appear. In this paper, a new approach to calibrate the positions of pseudolite antennas is proposed. By using a multi-antenna, the ambiguity can be eliminated, epoch by epoch, for every single carrier phase measurement. Moreover, the number of calibration points can be reduced down to 3 by use of measurements collected at unknown positions. Using the proposed methods, the process of the collection of carrier phase measurements becomes considerably simple and convenient. Simulation results are presented to verify the proposed algorithms.

Possible Involvement of Photoperiodic Regulation in Reproductive Endocrine System of Female Olive Flounder Paralichthys olivaceus

Kim, Hyun Chul,Lee, Chi Hoon,Hur, Sung Pyu,Kim, Byeong Hoon,Park, Jun Young,Lee, Young Don The Korean Society of Developmental Biology 2015 발생과 생식 Vol.19 No.1

This study investigated possible involvement of photoperiodic regulation in reproductive endocrine system of female olive flounder. To investigate the influence on brain-pituitary axis in endocrine system by regulating photoperiod, compared expression level of Kisspeptin and sbGnRH mRNA in brain and FSH-${\beta}$, LH-${\beta}$ and GH mRNA in pituitary before and after spawning. Photoperiod was treated natural photoperiod and long photoperiod (15L:9D) conditions from Aug. 2013 to Jun. 2014. Continuous long photoperiod treatment from Aug. (post-spawning phase) was inhibited gonadal development of female olive flounder. In natural photoperiod group, the Kiss2 expression level a significant declined in Mar. (spawning period). And also, FSH-${\beta}$, LH-${\beta}$ and GH mRNA expression levels were increasing at this period. However, in long photoperiod group, hypothalamic Kiss2, FSH-${\beta}$, LH-${\beta}$ and GH mRNA expression levels did not show any significant fluctuation. These results suggest that expression of hypothalamic Kiss2, GtH and GH in the pituitary would change in response to photoperiod and their possible involvement of photoperiodic regulation in reproductive endocrine system of the BPG axis.

Magnetic Black Holes Are Also Unstable

Sang Pyo Kim,Don Page 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1

Most black holes are known to be unstable to emitting Hawking radiation (in asymptotically at spacetime). If the black holes are non-extreme, they have positive temperature and emit thermally. If they are extremal rotating black holes, they still spontaneously emit particles like gravitons and photons. If they are extremal electrically charged black holes, they are unstable to emitting electrons or positrons. The only exception would be extreme magnetically charged black holes if there do not exist any magnetic monopoles for them to emit. However, here we show that even in this case, vacuum polarization causes all magnetic black holes to be unstable to emitting smaller magnetic black holes.