수유 요인에 따른 유치열의 치면별 우식패턴

임경욱,이광희,라지영,안소연,김윤희 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

연구목적은 모유 또는 분유 섭취 시 나타나는 유치열의 치면별 우식패턴에 차이가 없으며 수유기간에 따른 차이도 없다는 가설을 검증하는 것이었다. 익산시, 청주시, 울산광역시의 36-71 개 월 어린이 815명을 대상으로 구강검사로 치면별 우식경험도를 조사하고, 보호자들을 대상으로 설문지 조사법으로 모유와 분유 중에서 생후 1년간 주로 수유한 것과 수유 기간을 조사하였다. 모유군과 분유군 간 우식경험유치면수(dmf)의 차이는 유의하지 않았다. 모유군에서 분유군보다 우식경험도가 더 높았던 유치군은 상악 유전치이었고, 유치면군은 상악 유전치 협설면과 인접면이었으며, 유치는 상악 유절치와 상하악 제2유구치이었고, 유치면은 상악 유중절치의 협면과 원섬면, 상악 유측절치의 협설면, 인접면, 상악 제2유구치의 설면, 인접면, 교합면, 하악 제2유구치의 협면, 원심면이었다. 모유군에서 수유기간이 증가함에 따라 우식경험유치면수가 증가한 유치군은 상악 유전치와 상악 유구치이었고, 유치면군은 상악 유전치의 인접면, 상악 유구치의 협설면, 인접면, 교합면, 하악 유구치의 인접면이었으며, 유치는 상악 유전치, 상악 유구치, 하악 제 2유구치이었고, 유치면에서는 상악 유전치의 인접면, 상악 제 1유구치의 협설면, 인접면, 교합면, 상악 제 2유구치의 협면, 하악 제 2유구치의 근심면이었다. 분유군에서는 수유기간 3년 이상에서 우식경험유치면수가 증가하였으나 차이가 유의하지 않았다. 수유와 관련되어 발생하는 상악 유절치의 중증 유아기 우식증은 분유를 수유하는 경우보다 모유를 수유하는 경우에 더 많이 발생하였다. 모유 수유를 2년 이상 하는 경우에는 상악 유절치의 우식 예방을 위한 조치가 필요하다. The purpose of this study was to investigate the tooth surface caries patterns in the primary dentition according to breast or bottle feeding. The subjects of study were 815 children, 36 to 71 months old, in Iksan, Cheongju and Ulsan cities. The caregivers of the children were asked which they fed between the breast milk and the infant formula during the 1st year after birth and the duration of feeding. There was no significant difference in dmfs between the breast milk group and the infant formula group(significance level 0.05, same below). Tooth groups, tooth surface groups, teeth, and tooth surfaces which had significantly higher dmfs in the breast milk group than in the infant formula group were upper anterior teethttooth groups), upper incisors' buccal and proximal surfacesttooth surface groups), upper incisors and upper second molars (teeth), upper central incisors' buccal and distal surfaces, upper lateral incisors' buccolingual and proximal surfaces, upper 2nd molars' lingual. proximal. and occlusal surfaces, and lower 2nd molars' buccal and distal surfaces. In the breast milk group, tooth groups, tooth surface groups, teeth, and tooth surfaces which dmfs significantly increased as the duration of the feeding increased were upper anterior teeth and upper molars (tooth groups), upper anterior teeth's proximal surfaces, upper molars' buccolingual, proximal, and occlusal surfaces, lower molars' proximal surfacesttooth surface groups), upper anterior teeth, upper molars, lower 2nd molars (teeth), upper anterior teeth's proximal surfaces, upper 1st molars' buccolingual, proximal. and occlusal surfaces, upper 2nd molars' buccal surfaces, and lower 2nd molars' mesial surfaces (tooth surfaces). In the infant formula group, dmfs increased after 3 years of feeding, but the difference was not significant. Caries prevention is necessary in case of breastfeeding more than two years.

3관능성 BPA-3MA를 기질로한 광중합형 치면열구전색재의 물성 연구

박경준,김경남,안광덕,김광만,한동근,전호욱 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The BPA-3MA(bisphenol-A trimethacrylate) in which one of two hydroxy group was substituted by methacrylate was synthesized by reaction of Bis-GMA with methacryloyl chloride. To investigate the possibility to apply BPA-3MA as matrix of composite resin or pit and fissure sealant, BPA-3MA(3MA) or Bis-GMA(GMA) as matrix, TEGDMA as diluent, CQ as photosensitizer, EDMAB as photoinitiator and 5㎛ pyrogenic silica as filler were used for making experimental sealants. In addition, these experimental sealants were compared to a commercial Concise L/C White sealant(CLW, 3M Co, U.S.A.) for flexural strength, diametral tensile strength, amount of abrasion, surface hardness, water sorption and solubility, and degree of conversion. The flexural strength of CLW was the highest value but there was not significant difference with 3MA. Diametral tensile strength of all 3 groups were similar(p>0.05) and the amounts of abrasion of 3MA and GMA were less than that of CLW(p<0.05). The surface hardness of 3MA was higher than that of GMA(p<0.05) but similar to that of CLW. The water sorption of 3MA was less than that of GMA and CLW(p<0.05) and the solubilities of 3MA and CLW were than that of GMA(p<0.05). GMA and CLW were relatively polymerized well as compared to 3MA. From these results, pit and fissure sealant using trifunctional BPA-3MA as matrix had superior physical and mechanical properties to existing Bis-GMA sealant. Furthermore, it will be possible to develop composite resin having superior properties to existing composite resin.

가족성 정신분열병 환자에서 임상 특성의 가족내 연관성

최경숙,이유상,장용이,조은영,전현옥,김창현,김상욱,홍경수 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods : Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ² -test and Spearman's correlation. Results : Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoidsubtype (χ²=7.623, P=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ² =3.850, p=0.0497, df=1). Among single symptom items in DIGS, only 'auditory hallucination' showed significant concordance rate ( χ² =5.503, P=0.019, df=1). Factor analysis for symptoms items in the Rrawiecka Rating Scale indicated three symptom dimensions ; negative, psychotic and affective, Psychotic (P =0.442, P=0.003) and affective dimension scores (p =0.427, P=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion : Familial factors, Possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-para-noid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome, It supports their use in the delineation of homogeneous subgroups for future genetic studies.

Long-term outcomes after stent insertion in patients with early and late hepatic vein outflow obstruction after living donor liver transplantation

Kyeong Sik Kim,Ji Soo Lee,Gyu Sung Choi,Choon Hyuck David Kwon,Jae-Won Cho,Suk-Koo Lee,Kwang Bo Park,Sung Ki Cho,Sung Wook Shin,Jong Man Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.6

Purpose: The purpose of this study was to describe the long-term effects of stenting in patients with hepatic venous outflow obstruction (HVOO), who underwent living donor liver transplantation (LDLT). Methods: Between January 2000 and December 2009, 622 adult patients underwent LDLT at our hospital, and of these patients, 21 (3.3%) were diagnosed with HVOO; among these patients, 17 underwent stenting. The patients were divided into early or late groups according to the time of their HVOO diagnoses (cutoff: 60 days after liver transplantation). Results: The median follow-up period was 54.2 months (range, 0.5–192.4 months). Stent insertion was successful in 8 of 10 patients in the early group and 6 of 7 in the late group. The 5-year primary patency rates were 46% and 20%, respectively. In both groups, patients with recurrent HVOO at the beginning showed kinking confirmed by venography. Patients who carried their stents for more than 3 years maintained long-term patency. There was no significant difference in spleen size between groups; however, when the groups were compared according to whether they maintained patency, spleens tended to be smaller in the patency-maintained group. Conclusion: Unlike stenosis, if kinking is confirmed on venography, stenting is not feasible in the long term for patients with LDLT.

Comparison of immunogenicity and reactogenicity of split versus subunit influenza vaccine in Korean children aged 6-35 months

Kim, Yun Kyung,Eun, Byung Wook,Kim, Nam Hee,Kang, Eun Kyeong,Lee, Byung Sub,Kim, Dong Ho,Lim, Jung Sub Informa Healthcare 2013 Scandinavian journal of infectious diseases Vol.45 No.6

<P><I>Background</I>: Studies comparing the immunogenicity and reactogenicity of trivalent inactivated subunit (SU) and split (SPL) vaccines in children in Asia are limited. In 2008, we assessed the safety and immunogenicity of SU and SPL influenza vaccines in Korean children aged 6-35 months. <I>Methods</I>: We studied 2 non-randomized cohorts of children who received either SU or SPL vaccine in an open-label non-stratified controlled trial at 6 hospitals in Korea. We measured antibody titers with a hemagglutination-inhibition assay at baseline and 30 days after the first or second flu shot. The primary goal was the determination of vaccine immunogenicity according to the European Union Committee of Human Medicinal Products licensing criteria. <I>Results</I>: Out of a total of 106 participants aged 6-35 months, 47 received the SPL vaccine and 59 the SU vaccine. After vaccination, 41 (87.2%), 40 (85.1%), and 33 (70.2%) of the 47 subjects in the SPL group had titers ≥ 1:40 against H1N1, H3N2, and B, respectively. In the SU group, 42 (71.2%), 34 (57.6%), and 22 (37.3%) of 59 subjects had titers ≥ 1:40 against H1N1, H3N2, and B, respectively. The post-vaccination geometric mean titers of H1N1, H3N2, and B (SPL vs SU) were 119.1, 99.8, and 61.4 vs 75.4, 51.2, and 24.1, respectively. There were no serious vaccine-related adverse events. There were no differences between the SPL and SU vaccines with respect to adverse events. <I>Conclusions</I>: The immunogenicity of the SPL vaccine appears to be better than that of the SU vaccine in children aged 6-35 months in Korea.</P>

Translocation of DNA and protein through a sequentially polymerized polyurea nanopore

Kim, Hyung-Jun,Choi, Ui-Jin,Kim, Hyein,Lee, Kidan,Park, Kyeong-Beom,Kim, Hyun-Mi,Kwak, Dong-Kyu,Chi, Seung-Wook,Lee, Jin Seok,Kim, Ki-Bum The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.2

<P>Here, we investigated the translocation of biomolecules, such as DNA and protein, through a sequentially polymerized polyurea nanopore, with a thin (<10 nm) polymer membrane of uniform thickness. The polyurea membrane was synthesized by molecular layer deposition using <I>p</I>-phenylenediisocyanate (PDI) and <I>p</I>-phenylenediamine (PDA) as sequential precursors. The membrane exhibited a hydrophobic surface with a highly negative surface charge density (−51 mC m<SUP>−2</SUP> at pH 8). It was particularly noted that the high surface charge density of the membrane resulted in a highly developed electro-osmotic flow which, in turn, strongly influenced the capture probability of biomolecules, depending on the balance between the electro-osmotic and electrophoretic forces. For instance, the capture frequency of negatively charged DNA was demonstrated to be quite low, since these two forces more or less cancelled each other, whereas that of positively charged MDM2 was much higher, since these two forces were additive. We also identified that the mean translocation time of MDM2 through the polyurea nanopore was 26.1 ± 3.7 μs while that of the SiN nanopore was 14.2 ± 2.0 μs, hence suggesting that the enhanced electrostatic interaction between positively charged MDM2 and the negatively charged pore surface affects the translocation speed.</P>

Evaluation of immunogenicity of the 2008-2009 seasonal influenza vaccines by microneutralization test

Kim, Seung Youn,Kim, Yun Kyung,Eun, Byung Wook,Kim, Nam Hee,Kang, Eun Kyeong,Lee, Byong Sop,Lim, Jung Sub,Lee, Jun Ah,Kim, Dong Ho The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.12

Purpose: For evaluating the immunogenicity of an influenza vaccine, the microneutralization (MN) test has a higher sensitivity and specificity as compared to the hemagglutination inhibition (HI) test. However, the MN test is more time consuming and is difficult to standardize. We performed the MN test to determine its usefulness as an alternative or complementary test to the HI test for evaluating the immunogenicity of influenza vaccines. Methods: We compared the MN test with the HI test using 50 paired samples taken from a previous clinical study (2008-2009) in Korean children under 18 years of age. Results: The linear correlation coefficients of the 2 tests for H3N2, H1N1, and influenza B were 0.69, 0.70, and 0.66, respectively. We identified a high index of coincidence between the 2 tests. For an influenza vaccine, the postvaccination seroprotection rates and seroconversion rates determined by the MN test were 78.0% and 96.0%, 90% and 42.0%, and 42.0% and 48.0% for H3N2, H1N1, and influenza B, respectively. Geometric mean titer fold increases of H3N2, H1N1, and influenza B were 2.89, 5.04, and 4.29, respectively, and were 2.5-fold higher. We obtained good results in the evaluation of the immunogenicity of the 2008-2009 seasonal influenza vaccines. Conclusion: We found that the MN test was as effective as the HI test. Therefore, we suggest that the MN test can be used as an alternative or complementary test to the HI test for evaluating the immunogenicity of influenza vaccines.

Plotter-assisted integration of wearable all-solid-state micro-supercapacitors

Kim, Sung-Wook,Kang, Kyeong-Nam,Min, Jin-Wook,Jang, Ji-Hyun Elsevier 2018 Nano energy Vol.50 No.-

<P><B>Abstract</B></P> <P>We introduce the use of xurography as a facile plotter-assisted integration technique for an all-solid-state flexible micro-supercapacitors (mSCs), which is cost-effective and time-saving, by which 162 mSCs can be simultaneously produced on an A4 sized PET film. 3D-graphene networks (3DGNs) grown on a SiO<SUB>2</SUB> template exhibited large surface area and outstanding electrical conductivity as active materials for mSCs due to the interconnected 3D structure. By simply mixing SWNTs and Ag NWs with 3DGNs, an excellent specific areal capacitance of 19 mF cm<SUP>−2</SUP> was obtained from an as-prepared 3DGN/SWNT/AgNW mSC on a flexible substrate and 84% of the initial capacitance was maintained after 10,000 cycles. The device exhibited stable electrochemical performances under various deformation conditions. The subsequent transfer onto a textile further allowed the fabrication of a wearable particle detector, which confirmed a practical application of a mSC with good performance integrated via a plotter-assisted technique.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A facile plotter-assisted integration technique for an all-solid-state flexible mSC is introduced. </LI> <LI> The 3DGN/SWNT/AgNW showed an excellent capacitance of 19 mF cm-2 and 84% of the initial was maintained after 10,000 cycles. </LI> <LI> The subsequent transfer onto a textile allowed for the fabrication of a wearable particle detector. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Xurography, a facile plotter-assisted integration technique, allows for the cost effective and time saving fabrication of an all-solid-state flexible mSC, by which 162 mSCs can be simultaneously produced on an A4 size flexible PET film. When the plotter-assisted-integrated supercapacitor was transferred onto the fabric, it had a highly stable electrochemical performance as an energy storage device, which is promising for practical applications of wearable electronic devices.</P> <P>[DISPLAY OMISSION]</P>

Early life stress, resilience and emotional dysregulation in major depressive disorder with comorbid borderline personality disorder

Kim, Min-Kyeong,Kim, Jong-Sun,Park, Hae-In,Choi, Sun-Woo,Oh, Wook-Jin,Seok, Jeong-Ho Elsevier 2018 Journal of affective disorders Vol.236 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Borderline personality disorder (BPD) show different course and treatment compared to major depressive disorder (MDD). Early life stress may increase BPD onset; however, resilience may play a protective role against the development of psychopathology. The goal of this study was to compare the early life stress, resilience, and the clinical characteristics of emotional dysregulation in patients with MDD with and without comorbid BPD.</P> <P><B>Methods</B></P> <P>Thirty patients with both BPD and MDD, 25 patients with MDD alone, and 25 age- and sex- matched healthy controls, participated in this study. Analysis of variance was used to compare the early life stress, resilience, and emotional dysregulation among groups. Also, multivariate logistic regression models were used to identify the relationship of the early life stress and resilience domains with BPD comorbidity within MDD patients.</P> <P><B>Results</B></P> <P>The domains of emotional abuse and self-regulation ability were significantly associated with BPD comorbidity and BPD severity. In emotional dysregulation, difficulty scores of impulsivity, coping strategies, and emotion clarity domains were significantly increased in patients with both BPD and MDD compared to patients with MDD alone.</P> <P><B>Limitations</B></P> <P>The relatively small sample size may contribute to reduce statistical power of investigation.</P> <P><B>Conclusions</B></P> <P>Emotional abuse experiences in early life, and deficits in self-regulation, are significantly associated with comorbid BPD in patients with MDD. A comprehensive evaluation including early life stress, resilience and emotion regulation ability may help to identify comorbid BPD in patients with MDD and develop treatment strategies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Major depressive disorder may coexist with borderline personality disorder. </LI> <LI> Comorbid borderline personality disorder involves worse clinical course and lower treatment response. </LI> <LI> Assessment of comorbid borderline personality is necessary for depressive patients. </LI> <LI> Child emotional abuse may contribute to develop borderline personality disorder. </LI> <LI> Deficits in emotion regulation are significantly associated with borderline personality. </LI> </UL> </P>

Frequency and Characteristics of Interval Colorectal Cancer in Actual Clinical Practice: A KASID Multicenter Study

( Kyeong Ok Kim ),( Kyu Chan Huh ),( Sung Pil Hong ),( Won Hee Kim ),( Hyuk Yoon ),( Sang Wook Kim ),( Yeon Soo Kim ),( Jong Ha Park ),( Jun Lee ),( Bum Jae Lee ),( Young Sook Park ) 대한간학회 2018 Gut and Liver Vol.12 No.5

Background/Aims: The aims of the present study were to determine the frequency of interval colorectal cancers (CRCs) after surveillance colonoscopy and to compare the clinicopathologic features and survival outcomes with those of noninterval CRCs. Methods: From January 2003 to December 2013, 66,016 follow-up colonoscopies for 38,412 patients performed within recommended time were reviewed retrospectively based on data from 11 tertiary hospitals in South Korea. To compare clinicopathologic features and survival rates for interval CRC, 106 patients with non-interval CRC matched in age and gender were included. Results: Among the 66,016 colonoscopies performed within the surveillance period, 63 cases (63/66,016) of interval CRC were detected, and 53 were finally included in the analysis. The mean age was 69.9±8.8 years, and the male to female ratio was 1.94:1. Although the occurrence rate of cancer in the right side colon was higher than that of non-interval CRC, interval CRCs were predominantly left sided. Other clinicopathologic features and overall survival were not significantly different between the two groups. Missed lesion was suspected to be the most common cause (29 cases, 54.7%). Conclusions: The frequency of interval CRC among patients who had undergone a surveillance colonoscopy was 0.095%. While sharing some similar clinical features and survival outcomes, interval CRCs in Korea developed more often in males and on the left side in contrast to results from Western studies. (Gut Liver 2018;12:537-543)