Extranodal natural killer/T-cell lymphoma with long-term survival and repeated relapses: does it indicate the presence of indolent subtype?

Seok Jin Kim,Yong Park,Byung Soo Kim,Insun Kim,Young Hye Ko,Won Seog Kim 대한혈액학회 2012 Blood Research Vol.47 No.3

Background Extranodal natural killer (NK)/T-cell lymphoma is a subtype of lymphoma that is derived from NK cells. It is considered as an aggressive form of non-Hodgkin’s lymphoma because of frequent relapses and resistance to treatment. Relapsed NK/T-cell lymphoma often follows a fulminant course that is refractory to conventional chemotherapy treatment. Methods Several patients with extranodal NK/T-cell lymphoma showed long-term survival in spite of frequent relapses. Thus, the medical records of patients diagnosed with extranodal NK/T-cell lymphoma from 1995 to 2007 were reviewed and assessed. Results Of the 140 cases reviewed, 6 were selected (4.29%). Each of these patients had a minimum of 3 relapses or disease progression during the follow-up period, and their median overall survival was 66 months (range, 42-89 months). They were grouped according to the atypical clinical behavior observed: (1) repeated relapses or progression (≥3 times) during follow-up; and (2) long-term survival of more than 40 months, as the longest overall survival median was previously considered at approximately 40 months. The clinicopathological and laboratory characteristics of these patients were similar to those of other extranodal NK/T-cell lymphoma patients. However, 5 of the studied cases involved relatively lower expression of the proliferation-related antigen Ki-67 (<40-50%), indicating less proliferative activity. Clinically, they showed delayed relapse for at least 20 months after the initial complete remission. Conclusion Our observations suggest that the clinical behavior of some extranodal NK/T-cell lymphoma patients differs from the typical clinical course.

Cellular Features of the Fronds and Turions in Spirodela polyrhiza

Kim, InSun Korean Society of Microscopy 2013 Applied microscopy Vol.43 No.4

Structural aspects of highly reduced vegetative organs in the aquatic Spirodela polyrhiza were examined using scanning and transmission electron microscopy. The study focused mainly on young and mature fronds with turions and their cellular features were compared. Mature fronds were composed of thin-walled chlorenchyma with highly vacuolated cells; most of which were frequently occupied by either tanniferous deposits or various crystals. Fronds of photoautotrophic offspring were produced from the meristematic region of the reproductive pockets within mother fronds, where they remained until separation. Moderate degrees of wall ingrowth and plasmalemma proliferation were detected briefly in the epidermis of daughter fronds during early development. Vascular tissues were generally much reduced, but air chambers were well-established in fronds. Chloroplasts having grana with several thylakoids were distributed throughout the plant, but starch grains were encountered frequently in the mesophyll chloroplasts of younger fronds and initial stage of the turion. Their cytoplasm was dense with small vacuoles in most cases. Further, big starch grains, up to several microns, occupying most of the plastid volume were formed in the turion prior to sink for overwintering. Plasmodesmata were numerous in the examined tissues, except mature turions, suggesting a symplastic pathway of the metabolites within body.

Temperature Dependence and Impedance Characteristics of Hybrid Solar Cells Based on Poly(phenylene vinylene): ZnO Nanoparticles With Added Surfactants

Kim, Jun Young,Kim, Jaehoon,Amsden, Jason J.,Roh, Jeongkyun,Park, Insun,Yoon, Do Y.,Kim, Hyeok,Lee, Chang Hee IEEE 2017 IEEE journal of photovoltaics Vol.7 No.4

<P>A recent study has shown that the use of a semiconducting surfactant in hybrid bulk heterojunction solar cells based on poly[ 2-methoxy-5-(3',7'-dimethyloctyloxyl)-1,4-phenylene vinylene] and zinc oxide significantly increases their performance. To further study the mechanism underlying the improved performance resulting from the addition of a semiconducting surfactant, we compared the temperature and light intensity dependence of the current voltage characteristics and impedance spectra of devices that used no surfactant, an insulating oleic acid (OA) surfactant, or a semiconducting 2-(2-ethylhexyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de] isoquinoline-6,7-dicarboxylic acid (BQ) surfactant. The temperature and light intensity dependence data enabled us to extract the activation energy for different devices, and we measured the junction resistance through impedance spectroscopy. The device that used BQ had significantly lower activation energy (9-12 meV) than that without surfactant or oleic acid (17-21 meV), thus indicating improved charge transport and consequently an increased short-circuit current. Furthermore, the impedance characteristics showed that the injection resistance, when the BQ surfactant was used, was lower than that when no surfactant or oleic acid was used. These experiments provide further evidence that the use of semiconducting surfactants is essential to improvethe performance of hybrid bulk heterojunction solar cells.</P>

임신 35주 조기 분만 후 동반된 융모상피암 1예

김성건,김옥경,한지운,서동주,김인선,강재성 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.2

정상임신과 연관되어 발생하는 융모상피암은 매우 드물다. 정상임신과 연관된 융모상피암의 경우 그 진단이 늦어 병이 진행된 후 발견된 경우가 많으므로 그 예후가 불량하다. 따라서 분만시 태반에 대한 주의 깊은 검사와 추적이 필요하며, 일단 진단이 되면 적극적인 치료를 요한다. 저자들은 임신 35주에 제왕절개한 환자에서 3개월 후 심한 질 출혈로 응급자궁적출술하여 조직검사상 융모상피암으로 진단되어 복합항암화학요법을 시행한 증례를 문헌 고찰과 함께 보고하는 바이다. Choriocarcinoma associated with a normal pregnancy is very rare. In choraiocarcinoma associated with a normal pregnancy, diagnosis is late, and prognosis may be poor due to widespread metastases. So at delivery, careful examinations for abnormal placentas are needed, and if diagnosis is confirmed, intensive care is needed. We present a case of choriocarcinoma arising from placenta at 35th week of pregnancy and 3 months later, requiring emergency hysterectomy due to severe vaginal bleeding and combination chemotherapy (EMA CO) with review of literatures.

Structural Differentiation of the Connective Stalk in Spirodela polyrhiza (L.) Schleiden

Kim, InSun Korean Society of Microscopy 2016 Applied microscopy Vol.46 No.2

Structural differentiation of the connective stalk in giant duckweed, Spirodela polyrhiza, was examined to reveal the anatomical and ultrastructural characteristics within reduced shoot. The study focuses primarily on structural features of the connective stalk (CT), which connect offspring to their mother fronds. Photoautotrophic offspring fronds remained connected by stalks to mother fronds in the reproductive pockets until separation. The CT originated from the meristematic region of the abaxial frond and joined the fronds laterally with two abscission layers. The most notable features of the CT were polymorphic mitochondria, random occurrences of fibrillar structures in intercellular spaces, and great variability in cell wall thickness. Vascular tissues in CTs were highly reduced, demonstrating only a central vascular strand. Grana with 2 to 4 thylakoids and starch grains were found in the chloroplasts. A chlorophyll assay indicated high chlorophyll concentrations in daughter fronds and low concentrations in CTs. The frond and CT, while physically connected to each other, functioned independently. Despite great reduction in S. polyrhiza, the CT has proven to be very efficient for separating offspring from the mother frond, which lends to its capacity for rapid vegetative reproduction. The ultrastructural aspects of CTs in S. polyrhiza were characterized for the first time in this study.

Intraoperative consultation for ovarian tumors

Kim, Insun Yeungnam University College of Medicine 2019 Yeungnam University Journal of Medicine Vol.36 No.3

The primary function of intraoperative frozen consultation is to provide an as accurate and prompt diagnosis as possible during surgery and to guide the surgeon in further management. However, the evaluation of frozen section (FS) is sometimes difficult because of suboptimal tissue quality and frozen artifacts compared with routinely processed tissue section. The pathologist responsible for the FS diagnosis requires experience and good judgment. Ovarian tumors are a heterogeneous group of tumors including primary surface epithelial tumors, germ cell tumors and sex cord-stromal tumors, secondary tumors, and other groups of tumors of uncertain histogenesis or nonspecific stroma. Intraoperative FS is a very important and reliable tool that guides the surgical management of ovarian tumors. In this review, the diagnostic key points for the pathologist and the implication of the FS diagnosis on the operator's decisions are discussed.

Chrysanthemum Boreale Inhibits A2E-Induced ARPE-19 Cell Damage

InSun Yu,Dong Hee Kim,Mina K. Kim,Min Jung Kim 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Intraoperative consultation for ovarian tumors

Insun Kim 영남대학교 의과대학 2019 Yeungnam University Journal of Medicine Vol.36 No.3

The primary function of intraoperative frozen consultation is to provide an as accurate and prompt diagnosis as possible during surgery and to guide the surgeon in further management. However, the evaluation of frozen section (FS) is sometimes difficult because of suboptimal tissue quality and frozen artifacts compared with routinely processed tissue section. The pathologist responsible for the FS diagnosis requires experience and good judgment. Ovarian tumors are a heterogeneous group of tumors including primary surface epithelial tumors, germ cell tumors and sex cord-stromal tumors, secondary tumors, and other groups of tumors of uncertain histogenesis or nonspecific stroma. Intraoperative FS is a very important and reliable tool that guides the surgical management of ovarian tumors. In this review, the diagnostic key points for the pathologist and the implication of the FS diagnosis on the operator’s decisions are discussed.

Morphological Features of Pollen Grains in Portulaca

Kim, InSun Korean Society of Microscopy 2013 Applied microscopy Vol.43 No.2

The morphological features of pollen grains collected from the broad-leaved and cylindrical-leaved Portulaca species of the Hawaiian Islands were investigated. The variation in size and surface pattern were examined using scanning electron microscopy and statistical analysis. Pollens of the Portulaca were apolar grains of monads exhibiting apertures, colpi, and relatively thin echini. Of particular interest was the differing size of pollen grains among the species studied. Pollens of the broad-leaved Portulaca were considerable in size with a length of about $73{\sim}86{\mu}m$, while the cylindrical-leaved Portulaca tended to have smaller pollen grains ranging from 50~65 in diameter. The smallest pollens were found in cultivar 2 having an average of $43{\mu}m$. The pollen was intectate, and the exine surface appeared granulous, having sculptured elements of spinules and puncta. Two types of puncta were discerned; one forming an operculum, and the other, a simple perforation. Numerous spinules and small puncta were found throughout the cylindrical-leaved Portulaca. In the present study, morphological features of pollen grains from ten Hawaiian Portulaca species, including endemic and unknown taxa, revealed the aforementioned pattern of variation. This paper aim to provide morphological information that could be of phylogenetic value within the Hawaiian Portulaca.

Structural Changes of Adhesive Discs during Attachment of Boston Ivy

Kim, InSun Korean Society of Microscopy 2014 Applied microscopy Vol.44 No.4

This study investigates the developmental pattern of adhesive discs (ADs) to highlight the ontogeny and structural changes that occur during the growth of Boston ivy. Initiation to postmortem features of ADs were examined through light and scanning electron microscopy. The study also reveals a new finding of the dislocation of peripheral tissues of adaxial origin. Four phases of attachment are suggested with regards to its climbing behavior: 1) pre-attachment, 2) upon attachment, 3) after attachment, and 4) final attachment. During initiation, several ADs originate from tendril primordia without epidermal differentiation. However, different growth rates in the epidermis results in completely different ADs. ADs were discerned by size, shape, and color during expansion, but cells in the adaxial surface remained alive longer than the other side. Upon contact, the ADs demonstrate simultaneous growth and deterioration, but once attachment is established the latter process subdues to final stages. Epidermal transformation, adhesive secretion, cellular disruption, and mechanical stress were essential for the self-clinging nature of Boston ivy. The post-attachment sequence is also believed to be critical in achieving maximum mechanical strength to provide extensive support. The developmental process of ADs is prompted by tactile stimulation but in a highly organized and systematic manner.