세종대 북원의 팽창과 황희 - 황희의 국방활동을 중심으로 -

이주희(Lee, Ju-Hui) 효원사학회 2020 역사와 세계 Vol.- No.57

황희(1363~1452)는 여말 선초의 격변기에 국가의 동량으로서 4대 임금을 모셨던 인물이다. 그러한 그의 청렴성에 대한 논란이 있다. 본 논문은 황희에게 만일 공직자 윤리에 부정적인 면이 있었다면 그럼에도 불구하고 세종이 그를 심복처럼 의지한 이유를 살폈다. 즉 재상인 그가 이끌어간 세종대의 시대적 상황을 살피고 재상으로서 황희가 국방 분야에서 어떠한 역할을 했는지에 대해 알아보았다. 세종대는 국제적 긴장이 고조된 시기였다. 세종은 백성을 살폈고, 그것이 가능하려면 황희가 필요했다. 北狄(몽골)이 언제 조선을 침공해 올지도 모르는 상황에서 축성 등의 대규모 토목공사가 필요했지만 그것 때문에 나라가 기울어지는 것은 막아야 했다. 황희는 국가에 해를 끼치지 않는 것을 전제로 국방책을 입안하고 밀고나갔다. 1428년 황희는 현실에 맞추어 북방의 방어체계를 개선했고, 1432년부터 4군 6진 개척을 배후에서 지휘했다. 그러한 가운데도 황희는 많은 추문에 휘말렸고, 세종은 거듭 황희를 보호했다. 청렴한 국정을 운영하는 것도 중요하지만 北狄(몽골)의 침공으로 나라가 망하면 무슨 소용이 있겠는가. 어려운 시기였기에 세종에게 황희의 혐의는 더 중요하지 않았다. 설사 황희가 부정을 저질렀다고 해도 난국을 타개하고 해쳐나갈 인물을 내친다는 것은 어려웠다. 세종에게 청렴하기만 하고 능력이 없는 인물은 필요가 없었다. 어느 특정 인물이 유학적인 소양이 높더라도 냉혹한 현실을 다루는데 서툴다면 어디에 쓰겠는가. 오히려 나라를 지키는 일에는 야수와 날카로운 시선과 바위와 같은 인내심이 필요했다. 세종은 황희의 아들들이 자기 자식들의 물건을 훔쳐 나누어 가진 이 사건을 보고 굉장히 불쾌했을 것이다. 그것은 존엄에 위해를 가하는 대역죄였다. 하지만 이 사건을 적당한 선에서 봉합했다. 戰雲이 감도는 시기에 세종에게 황희는 없어서는 안 되는 漢元帝때의 ‘史丹’과 같은 존재였으며 충직한 명재상이었다. Hwang Hui (1363-1452) served four kings as a pillar of the state during the turbulent period of the late Goryeo Dynasty and the early Joseon Dynasty. There is a controversy about his integrity. This paper examined Hwang Hee"s reasons why Sejong relied on him like a henchman, nevertheless, if there were any negatives to the ethics of public officials. In other words, we looked at the times of King Sejong"s reign, led by his father-in-law, and found out what role Hwang Hee played in the defense sector as prime minister. The Sejong era was a time of heightened international tension. Sejong looked at the people and needed Hwang Hui to make it possible. At a time when Mongolia might invade Joseon, large-scale civil engineering projects such as the construction of the fortress were needed, but the country had to be prevented from tilting due to it. Hwang Hee drafted and pushed ahead with the defense plan on the condition that it would not harm the nation. In 1428, Hwang Hui improved the defense system of the north in line with the reality, and from 1432 he led the development of the sixth division of the fourth division. In the meantime, Hwang-Hui was embroiled in many scandals, and King Sejong repeatedly protected her. It is also important to run clean state affairs, but what good is it if the country collapses due to the invasion of Mongolia? Hwang Hui"s charges were not more important to Sejong because it was a difficult time. Even if Hwang Hee was dishonest, it was difficult to break the impasse and make a person who would harm him. There was no need for a person who was only clean and incapable of Sejong. Even if a certain person has a high level of studying abroad, what would he use if he is not good at dealing with the harsh reality? Rather, defending the country required patience, such as wild beasts, sharp eyes, and rocks. Sejong must have been very upset to see the incident in which Hwang Hee"s sons stole and shared their children"s belongings. It was a high-handed crime of inflicting harm on dignity. However, the case was sealed to a moderate extent. In times of war, Hwang Hui was an indispensable "Stan" of the Han Dynasty and a loyal master.

Identification of a novel mutation in a patient with pseudohypoparathyroidism type Ia

Lee, Ye Seung,Kim, Hui Kwon,Kim, Hye Rim,Lee, Jong Yoon,Choi, Joong Wan,Bae, Eun Ju,Oh, Phil Soo,Park, Won Il,Ki, Chang Seok,Lee, Hong Jin The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.5

Pseudohypoparathyroidism type Ia (PHP Ia) is a disorder characterized by multiform hormonal resistance including parathyroid hormone (PTH) resistance and Albright hereditary osteodystrophy (AHO). It is caused by heterozygous inactivating mutations within the Gs alpha-encoding GNAS exons. A 9-year-old boy presented with clinical and laboratory abnormalities including hypocalcemia, hyperphosphatemia, PTH resistance, multihormone resistance and AHO (round face, short stature, obesity, brachydactyly and osteoma cutis) which were typical of PHP Ia. He had a history of repeated convulsive episodes that started from the age of 2 months. A cranial computed tomography scan showed bilateral calcifications in the basal ganglia and his intelligence quotient testing indicated mild mental retardation. Family history revealed that the patient's maternal relatives, including his grandmother and 2 of his mother's siblings, had features suggestive of AHO. Sequencing of the GNAS gene of the patient identified a heterozygous nonsense mutation within exon 11 (c.637 C>T). The C>T transversion results in an amino acid substitution from Gln to stop codon at codon 213 ($p.Gln213^*$). To our knowledge, this is a novel mutation in GNAS.

The benzodiazepine anesthetic midazolam prevents hyperglycemia‐induced microvascular leakage in the retinas of diabetic mice

Lee, Yeon-Ju,Kim, Minsoo,Lee, Jee-Yeon,Jung, Se-Hui,Jeon, Hye-Yoon,Lee, Seung Ah,Kang, Seongsik,Han, Eun-Taek,Park, Won Sun,Hong, Seok-Ho,Kim, Young-Myeong,Ha, Kwon-Soo Federation of American Society for Experimental Bi 2018 The FASEB Journal Vol.32 No.11

Software-based Performance Analysis of a Pseudolite Time Synchronization Method Depending on the Clock Source

Lee, Ju Hyun,Hwang, Soyoung,Yu, Dong-Hui,Park, Chansik,Lee, Sang Jeong The Institute of Positioning 2014 Journal of Positioning, Navigation, and Timing Vol.3 No.4

A pseudolite is used as a GPS backup system, and is also used for the purpose of indoor navigation and correction information transmission. It is installed on the ground, and transmits signals that are similar to those of a GPS satellite. In addition, in recent years, studies on the improvement of positioning accuracy using the pseudorange measurement of a pseudolite have been performed. As for the effect of the time synchronization error between a pseudolite and a GPS satellite, a time synchronization error of 1 us generally induces a pseudorange error of 300 m; and to achieve meter-level positioning, ns-level time synchronization between a pseudolite and a GPS satellite is required. Therefore, for the operation of a pseudolite, a time synchronization algorithm between a GPS satellite and a pseudolite is essential. In this study, for the time synchronization of a pseudolite, "a pseudolite time synchronization method using the time source of UTC (KRIS)" and "a time synchronization method using a GPS timing receiver" were introduced; and the time synchronization performance depending on the pseudolite time source and reference time source was evaluated by designing a software-based pseudolite time synchronization performance evaluation simulation platform.

The Korean Social Life, Health and Aging Project-Health Examination Cohort

Ju-Mi Lee,Won Joon Lee,Hyeon Chang Kim,Wungrak Choi,Jina Lee,Kiho Sung,Sang Hui Chu,Yeong-Ran Park,Yoosik Youm 한국역학회 2014 Epidemiology and Health Vol.36 No.-

The Korean Social Life, Health, and Aging Project (KSHAP) is a population-based longitudinal study of health determinants among elderly Koreans. The target population of the KSHAP are people aged 60 years or older and their spouses living in a rural community of Korea. A complete enumeration survey was conducted in the first wave of the KSHAP on 94.7% (814 of 860) of the target population between December 2011 and July 2012. The KSHAP-Health Examination (KSHAP-HE) cohort consists of 698 people who completed additional health examinations at a public health center (n=533) or at their home (n=165). Face-to-face questionnaires were used to interview participants on their demographics, social network characteristics, medical history, health behaviors, cognitive function, and depression symptoms. Health center examinations included anthropometric measures, body impedance analysis, resting blood pressure measurement, radial artery tonometry, bone densitometry, the timed up-and-go test, and fasting blood analysis. However, only anthropometric measures, blood pressure measurement, and non-fasting blood analysis were available for home health examinations. Collaboration is encouraged and access to the KSHAP baseline data will be available via the website of the Korean Social Science Data Archive (http://www.kossda.or.kr).

Effect of the Red Ginseng against PM2.5-induced Pulmonary Dysfunction in BALB/C Mice

Ju Hui Kim,Jong Min Kim,Hyo Lim Lee,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Han Su Lee,Ho Jin Heo 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle

Lee, Hyo Min,Ok, Seong-Ho,Sung, Hui-Jin,Eun, So Young,Kim, Hye Jung,Lee, Soo Hee,Kang, Sebin,Shin, Il-Woo,Lee, Heon Keun,Chung, Young-Kyun,Choi, Mun-Jeoung,Bae, Sung Il,Sohn, Ju-Tae Canadian Science Publishing 2013 Canadian journal of physiology and pharmacology Vol.91 No.4

<P> Mepivacaine is an aminoamide local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. This study investigated the arachidonic acid metabolic pathways involved in mepivacaine-induced contraction, and elucidated the associated cellular mechanism with a particular focus on extracellular signal-regulated kinase (ERK) in endothelium-denuded rat aorta. Isolated rat thoracic aortic rings were suspended for isometric tension recording. Cumulative mepivacaine concentration-response curves were generated in the presence or absence of the following inhibitors: quinacrine dihydrochloride, nordihydroguaiaretic acid, phenidone, AA-861, indomethacin, NS-398, SC-560, fluconazole, PD 98059, and verapamil. Mepivacaine-induced ERK phosphorylation, 5-lipoxygenase (5-LOX) expression, and cyclooxygenase (COX)-2 expression in rat aortic smooth muscle cells were detected by Western blot analysis in the presence or absence of inhibitors. Mepivacaine produced tonic contraction in isolated endothelium-denuded rat aorta. Quinacrine dihydrochloride, nordihydroguaiaretic acid, phenidone, AA-861, NS-398, PD 98059, and verapamil attenuated mepivacaine-induced contraction in a concentration-dependent manner. However, fluconazole had no effect on mepivacaine-induced contraction. PD 98059, quinacrine dihydrochloride, nordihydroguaiaretic acid, AA-861, phenidone, and indomethacin attenuated mepivacaine-induced ERK phosphorylation. Mepivacaine upregulated 5-LOX and COX-2 expression. These results suggest that mepivacaine-induced contraction involves ERK activation, which is primarily mediated by the 5-LOX pathway and in part by the COX-2 pathway. </P>

A New Record of the Varunid Crab, Varuna yui (Decapoda: Varunidae), from Korea

Lee, Sang-Hui,Jeong, Jin-Hyeop,Kim, Ju-Yeon,Lee, Seok-Hyun The Korean Society of Systematic Zoology 2022 Animal Systematics, Evolution and Diversity Vol.38 No.1

The varunid crab, Varuna yui Hwang & Takeda, 1986, is known as widely distributed in the Southeast Asian region. Three specimens of varunid crabs were collected near the estuary of the river from Korea and identified as V. yui. Varuna yui could be distinguished from the other congeneric species, V. litterata (Fabricius, 1798), by having a more extended mesial lobe on the distal region of the male first gonopod. In this paper, morphological diagnosis and illustrations of the newly collected V. yui are provided. The specimens examined herein were deposited in the National Marine Biodiversity Institute of Korea and Nakdonggang National Institute of Biological Resources.

Essential Role of Transglutaminase 2 in Vascular Endothelial Growth Factor–Induced Vascular Leakage in the Retina of Diabetic Mice

Lee, Yeon-Ju,Jung, Se-Hui,Kim, Su-Hyeon,Kim, Min-Soo,Lee, Sungeun,Hwang, JongYun,Kim, Soo-Youl,Kim, Young-Myeong,Ha, Kwon-Soo American Diabetes Association 2016 Diabetes Vol.65 No.8

<P>Diabetic retinopathy is predominantly caused by vascular endothelial growth factor (VEGF)-induced vascular leakage; however, the underlying mechanism is unclear. Here we designed an in vivo transglutaminase (TGase) activity assay in mouse retina and demonstrated that hyperglycemia induced vascular leakage by activating TGase2 in diabetic retina. VEGF elevated TGase2 activity through sequential elevation of intracellular Ca2+ and reactive oxygen species (ROS) concentrations in endothelial cells. The TGase inhibitors cystamine and monodansylcadaverin or TGase2 small interfering RNA (siRNA) prevented VEGF-induced stress fiber formation and vascular endothelial (VE)-cadherin disruption, which play a critical role in modulating endothelial permeability. Intravitreal injection of two TGase inhibitors or TGase2 siRNA successfully inhibited hyperglycemia-induced TGase activation and microvascular leakage in the retinas of diabetic mice. C-peptide or ROS scavengers also inhibited TGase activation in diabetic mouse retinas. The role of TGase2 in VEGF-induced vascular leakage was further supported using diabetic TGase2(-/-) mice. Thus, our findings suggest that ROS-mediated activation of TGase2 plays a key role in VEGF-induced vascular leakage by stimulating stress fiber formation and VE-cadherin disruption.</P>

Investigating Vegetative Growth of Phalaenopsis Orchids under Different Light Intensity and Photoperiodic Conditions

Ju Hui Lee,Hyo Beom Lee,Hyo Jin Kim,Seong Kwang An,Ki Sun Kim 한국원예학회 2017 한국원예학회 학술발표요지 Vol.2017 No.5