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Kim, Yong-Guy,Lee, Jin-Hyung,Kim, Chang-Jin,Lee, Jae-Chan,Ju, Yoon Jung,Cho, Moo Hwan,Lee, Jintae Springer-Verlag 2012 Applied microbiology and biotechnology Vol.96 No.6
<P>Members of the actinomycetes family are a rich source of bioactive compounds including diverse antibiotics. This study sought to identify novel and non-toxic biofilm inhibitors from the actinomycetes library for reducing the biofilm formation of Pseudomonas aeruginosa PAO1. After the screening of 4104 actinomycetes strains, we found that the culture spent medium (1?%, v/v) of Streptomyces sp. BFI 230 and Kribbella sp. BFI 1562 inhibited P. aeruginosa biofilm formation by 90?% without affecting the growth of planktonic P. aeruginosa cells, while the spent media enhanced the swarming motility of P. aeruginosa. Global transcriptome analyses revealed that the spent medium of Streptomyces sp. BFI 230 induced expression of phenazine, pyoverdine, pyochelin synthesis genes, and iron uptake genes in P. aeruginosa. The addition of exogenous iron restored the biofilm formation and swarming motility of P. aeruginosa in the presence of the spent medium of Streptomyces sp. BFI 230, which suggests that the Streptomyces sp. BFI 230 strain interfered iron acquisition in P. aeruginosa. Experiments on solvent extraction, heat treatment, and proteinase K treatment suggested that hydrophilic compound(s), possibly extracellular peptides or proteins from Streptomyces sp. BFI 230 cause the biofilm reduction of P. aeruginosa. Together, this study indicates that actinomycetes strains have an ability to control the biofilm of P. aeruginosa.</P>
A study on reliability assessment of a decay heat removal system for a sodium-cooled fast reactor
Kim, Jintae,Jae, Moosung Elsevier 2018 Annals of nuclear energy Vol.120 No.-
<P><B>Abstract</B></P> <P>Probabilistic risk assessment is expected to play a major role in the design and regulation framework for future reactors. Since the safety of a sodium-cooled fast reactor largely depends on the reliability of a decay heat removal system, which adopts a passive safety feature, it is necessary to assess the reliability of this system in order to conduct probabilistic risk assessment. Currently existing reliability assessment methodology is based on the probability of component failures and human errors. However, this design does not work as a passive safety system consisting of active components that do not need any external input to operate. In this study, a methodology for evaluating the reliability of a passive safety system that includes functional failure is proposed. The Prototype Gen-IV Sodium-cooled Fast Reactor that is currently under development in Korea was selected as the reference reactor, and the functional reliability of the decay heat removal system in the reactor was calculated by uncertainty propagation of the system parameters that can affect system failure. Sensitivity analysis was also performed to determine which parameters have crucial effects on system failure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The reliability of a decay heat removal system which is the passive system of a sodium-cooled fast reactor has been assessed using the functional failure concept. </LI> <LI> Latin hypercube sampling in conjunction with partial rank correlation coefficient method has been utilized for sensitivity analysis. </LI> <LI> Control rod drive line and reactor vessel expansion reactivity coefficient is/has been identified to have the greatest influence on the functional reliability of the decay heat removal system in the unprotected loss of heat sink accident. </LI> </UL> </P>
김형두,김종진,김윤화,홍은경,안승혜,박용구,박영희,이주희,원남희,서진태,지현숙,양문호,이중달 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1983 東西醫學硏究所 論文集 Vol.2 No.1
Twelve consecutive cases of chondrosarcoma and its histologic variants are analyzed histopathologically and include seven cases of ordinary(classic) type, two cases of mesenchymal type, one case of clear cell type and two cases of peripheral secondary type arising from one of multiple osteochondromas. One of seven classic chondrosarcomas is classified as dedifferentiated chondrosarcoma, which recurred locally five years after initial surgical removal. Histologic features of the variants are described in details, and differential points on histologic findings and clinical manifestation as well are discussed.
Jintae Jeong,Yurry Um,Mok Hur,Yeonbok Kim,Dawoon Jeong,Chansik Jung,Seongcheol Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05
Background : ‘baek-chul’(White atractylodes rhizome) widely used in traditional herbal remedies in Asia. A. Japonica and A. Macrocephala are used as ‘baek-chul’ in Japanese Pharmacopoeia but only A. Macrocephala is used as ‘baek-chul’ in Chinese Pharmacopoeia. Based on morphologic observation A. japonica has small infloresence diameter, white flowers and gynodioecism, whereas A. macrocephala has large inflorescence diameter, red flowers ,monoecism and developed rhizomes. but The distinction of these isn't easy. SSRs are very useful molecular markers for species identification. In this study, genetic diversity and identification between A. Japonica and A. Macrocephala were confirmed by SSR marker. Methods and Results : DNAs were extracted from leaf tissue of A. Japonica, A. Macrocephala and A. Japonica × A. Macrocephala (Breeding varieties, ‘Dachul’) using DNeasy plant Mini Kit (Qiagen, Hilen, Germany). these plants cultivated from RDA(Eumseong) and used for PCR amplification. The relative concentration of the extracted DNA was estimated Nano Drop ND-1000 (NanoDrop Technologies, Wilmington, De, USA) And final DNA concentration was adjusted to 5.5ng/μL. In this study 8 primer pairs were tested on 4 A. Japonica, 4 A. Macrocephala, 2 ‘Dachul’. These primers showed high polymorphism among and within four populations of A. macrocephala.(Zheng et al.). We detected interspecific and intraspecific SSR polymorphism by 3 primer pairs. Conclusion : The results showed that these markers were found to be useful for diversity analysis as they distinguished among Atractylodes spp. and also A.Macrocephala. This work is intended to serve as the basis for the breeding of new varieties in white atractylodes rhizome.
Flow-enhanced electrochemical immunosensors on centrifugal microfluidic platforms.
Kim, Tae-Hyeong,Abi-Samra, Kameel,Sunkara, Vijaya,Park, Dong-Kyu,Amasia, Mary,Kim, Nahui,Kim, Jintae,Kim, Hanshin,Madou, Marc,Cho, Yoon-Kyoung Royal Society of Chemistry 2013 Lab on a chip Vol.13 No.18
<P>We present a novel fully integrated centrifugal microfluidic device with features for target antigen capture from biological samples, via a bead-based enzyme-linked immune-sorbent assay, and flow-enhanced electrochemical detection. The limit of detection (LOD) of our device for the C-reactive protein (CRP) was determined to be 4.9 pg mL(-1), a 17-fold improvement over quantification by optical density. The complete sample-to-answer protocol of our device is fully automated and takes less than 20 min. Overall, the presented microfluidic disc adds to the comparatively small number of fully integrated microfluidic-based platforms that utilize electrochemical detection and exemplifies how electrochemical detection can be enhanced by flow to successfully detect very low levels of biomarkers (e.g. pg mL(-1)).</P>
Jintae Park,Sora Baek,Gowun Kim,Seung-Joo Nam,Ji Hyun Kim 대한재활의학회 2022 Annals of Rehabilitation Medicine Vol.46 No.5
Objective To investigate esophageal motility disorders in patients with esophageal residual barium on chest x-rays after videofluoroscopic swallowing studies (VFSS) through high-resolution esophageal manometry (HREM).Methods We reviewed the records of 432 patients who underwent VFSS from September 2019 to May 2021, and 85 patients (19.7%) with large residual barium (diameter ≥1 cm) were included. As a result of HREM, motility disorders were classified as major or minor motility disorders according. Esophagogastroduodenoscopy and chest computed tomography results available were also reviewed.Results Among 85 patients with large residual barium in the esophagus, 16 patients (18.8%) underwent HREM. Abnormal esophageal motilities were identified in 68.8% patient: three patients (18.8%) had major motility disorders—achalasia (n=1), esophagogastric junction (EGJ) outflow obstruction (n=2)—and eight patients (50%) had minor motility disorders—ineffective esophageal motility (n=7), fragmented peristalsis (n=1). In those with normal esophageal motility, three patients of esophageal structure disorders (18.8%)—esophageal cancer (n=1), cardiogenic dysphagia (n=1), slight narrowing without obstruction of EGJ (n=1)—and two patients (12.5%) with chronic atrophic gastritis (n=2) were confirmed.Conclusion Esophageal motility disorders were identified in 68.8% of 16 patients with large esophageal residual barium with three patients in the major and eight patients in the minor categories. Residual barium in the esophagus was not rare and can be a sign of significant esophageal motility disorders.
A New Filter-Bank Multicarrier System: The Linearly Processed FBMC System
Kim, Jintae,Park, Yosub,Weon, Sungwoo,Jeong, Jinkyo,Choi, Sooyong,Hong, Daesik IEEE 2018 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.17 No.7
<P>In this paper, we propose a linearly processed filter-bank multicarrier (LP-FBMC) system which employs faster than Nyquist signaling to remove residual intrinsic interferences. We represent the FBMC transceiver in a matrix form and then apply singular value decomposition-based linear transformation in order to convert the overlapped FBMC data into parallel independent interference-free data. This interference-free characteristic of the proposed LP-FBMC system enables the use of conventional multiple antenna configurations. Performance evaluations show that out-of-band emission performance of the proposed LP-FBMC system is superior to those of conventional quadrature amplitude-based FBMC (FBMC-QAM) and orthogonal frequency division multiplexing systems. Furthermore, the proposed LP-FBMC system outperforms the conventional FBMC-QAM in terms of bit error rate performance when high order modulation is employed under time-varying channel and multiuser uplink environment.</P>