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TC1(C8orf4) is a novel endothelial inflammatory regulator enhancing NF-kappaB activity.
Kim, Jungtae,Kim, Yunlim,Kim, Hyun-Taek,Kim, Dong Wook,Ha, Yunhi,Kim, Jihun,Kim, Cheol-Hee,Lee, Inchul,Song, Kyuyoung Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.6
<P>Endothelial inflammation is regulated by a complex molecular mechanism. TC1(C8orf4) is a novel regulator implicated in cancer and inflammation. It is a small protein conserved well among vertebrates. In zebrafish embryos, it is mostly expressed in angio-hematopoietic system and the overexpression induces edema. In human aortic endothelial cells and umbilical vein endothelial cells, TC1 transfection up-regulates key inflammatory cytokines, enzymes, and adhesion proteins including IL-6, IL-1alpha, COX-2, CXCL1, CCL5, CCL2, IL-8, ICAM1, VCAM1, and E-selectin, while TC1 knockdown down-regulates them. TC1 also enhances inflammatory parameters such as monocyte-endothelial adhesion and endothelial monolayer permeability. TC1 is up-regulated by IL-1beta, TNF-alpha, LPS, and phorbol ester, and the up-regulation is inhibited by I-kappaB-kinase inhibitors. TC1, in turn, enhances the nuclear translocation of RelA and the DNA binding activity, suggesting a biological role of amplifying NF-kappaB signaling via a positive feedback. Our findings suggest that TC1 is a novel endothelial inflammatory regulator that might be implicated in inflammatory vascular diseases.</P>
A Smart Bench Press Machine: Automatic Weight Control Sensitive to User Tiredness
Kim, Jihun,Jo, Han-jin,Kim, Kiyoung,Ji, Hae-geun,Kim, Jaehyo The International Promotion Agency of Culture Tech 2019 International Journal of Advanced Culture Technolo Vol.7 No.1
In order to provide a safe free-weight-training environment to people without workout trainers, we suggest a smart bench press machine with an automatic weight control system sensitive to user tiredness. Physical weight plates on the machine are replaced with a hydraulic cylinder as a press load and the cylinder knob is coupled with a step motor to change its tensile force automatically in-between lifting exercises. Three subjects participated to verify the usability of the smart bench press machine. They were asked to lift a 6-RM press load 10 times with 3 different lifting conditions: 1) no assistance, 2) a human assistance, and 3) the automatic weight control. All subjects were not able to complete the 10 sets without assistance due to tiredness, but they finished the full sets under the two assistive conditions. Average lifting speeds under the automatic weight control condition showed the most consistent level. Normalized quasi-tension data based on surface electromyogram signals of both Pectoralis Majors revealed that the subjects maintained the target muscle activation level above 50% but not more than 80% throughout the 10 sets. Therefore, the smart bench press machine is expected to both keep pace with the lifting exercise and reduce risk of injuries due to excessive muscle tensions.
Semantic Signature: Comparative Interpretation of Gene Expression on a Semantic Space
Kim, Jihun,Kim, Keewon,Kim, Ju Han Hindawi Publishing Corporation 2016 Computational and mathematical methods in medicine Vol.2016 No.-
<P><I>Background</I>. Interpretation of microarray data remains challenging because biological meaning should be extracted from enormous numeric matrices and be presented explicitly. Moreover, huge public repositories of microarray dataset are ready to be exploited for comparative analysis. This study aimed to provide a platform where essential implication of a microarray experiment could be visually expressed and various microarray datasets could be intuitively compared.<I> Results</I>. On the semantic space, gene sets from Molecular Signature Database (MSigDB) were plotted as landmarks and their relative distances were calculated by Lin's semantic similarity measure. By formal concept analysis, a microarray dataset was transformed into a concept lattice with gene clusters as objects and Gene Ontology terms as attributes. Concepts of a lattice were located on the semantic space reflecting semantic distance from landmarks and edges between concepts were drawn; consequently, a specific geographic pattern could be observed from a microarray dataset. We termed a distinctive geography shared by microarray datasets of the same category as “semantic signature.”<I> Conclusions</I>. “Semantic space,” a map of biological entities, could serve as a universal platform for comparative microarray analysis. When microarray data were displayed on the semantic space as concept lattices, “semantic signature,” characteristic geography for a microarray experiment, could be discovered.</P>
A Smart Bench Press Machine : Automatic Weight Control Sensitive to User Tiredness
Jihun Kim,Han-jin Jo,Kiyoung Kim,Hae-geun Ji,Jaehyo Kim 국제문화기술진흥원 2019 International Journal of Advanced Culture Technolo Vol.7 No.1
In order to provide a safe free-weight-training environment to people without workout trainers, we suggest a smart bench press machine with an automatic weight control system sensitive to user tiredness. Physical weight plates on the machine are replaced with a hydraulic cylinder as a press load and the cylinder knob is coupled with a step motor to change its tensile force automatically in-between lifting exercises. Three subjects participated to verify the usability of the smart bench press machine. They were asked to lift a 6-RM press load 10 times with 3 different lifting conditions: 1) no assistance, 2) a human assistance, and 3) the automatic weight control. All subjects were not able to complete the 10 sets without assistance due to tiredness, but they finished the full sets under the two assistive conditions. Average lifting speeds under the automatic weight control condition showed the most consistent level. Normalized quasi-tension data based on surface electromyogram signals of both Pectoralis Majors revealed that the subjects maintained the target muscle activation level above 50% but not more than 80% throughout the 10 sets. Therefore, the smart bench press machine is expected to both keep pace with the lifting exercise and reduce risk of injuries due to excessive muscle tensions.
Jihun Kim,Byongjun Lee,Sangwook Han,Jeong-Hoon Shin,Taekyun Kim,Sangtae Kim,Younghwan Moon IEEE 2013 IEEE transactions on smart grid Vol.4 No.1
<P>Recent technological achievement in areas of distributed computing, networking, high speed communications and digital control, as well as the availability of accurate GPS time source, are rapidly becoming the enabling factors for the development of a new generation of real time power grid monitoring tools. KDN (Korea electric power Date Network Co.) R&D department with KERI, Korea University and LSIS has embarked on long term research and development work in the field of wide area systems specifically applied to the power transmission grid in Korea. Primary focus will be on wide area measurement and monitoring, analysis, assessment technique and tools aimed at preventing the propagation of power grid instabilities. Of special interest are voltage stability and small signal stability. This project aligns with KEPCO (the Korea Electric Power Company). In this paper, case studies performed with the use of the developed system are presented.</P>
Kim, Mijung,Park, Jihun,Ji, Sangyoon,Shin, Sung-Ho,Kim, So-Yun,Kim, Young-Cheon,Kim, Ju-Young,Park, Jang-Ung The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.18
<P>Here we demonstrate fully-integrated, bezel-less transistor arrays using stretchable origami substrates and foldable conducting interconnects. Reversible folding of these arrays is enabled by origami substrates which are composed of rigid support fixtures and foldable elastic joints. In addition, hybrid structures of thin metal films and metallic nanowires worked as foldable interconnects which are located on the elastomeric joints.</P>