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( Jia Cheng ),( Na Sun ),( Xin Zhao ),( Li Niu ),( Mei Qin Song ),( Yao Gui Sun ),( Jun Bing Jiang ),( Jian Hua Guo2 ),( Yuan Sheng Bai ),( Jun Ping He ),( Hong Quan Li ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8
Seventeen compounds derived from traditional Chinese medicines (TCMs) were tested for their antiviral activity against porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. Visualization with the cytopathologic effect (CPE) assay and the 3-(4, 5-dimethyithiazol- 2-yl)-2,5-diphenyltetrazolium bromide test were used to determine the 50% cytotoxic concentration (CC50) and 50% effective concentration (EC50) in cultured Marc-145 cells. Among the tested compounds, chlorogenic acid and scutellarin showed potential anti-PRRSV activity. The EC50 values were 270.8 ± 14.6 μg/ml and 28.21 ± 26.0 μg/ml and the selectivity indexes were >5.54 and 35.5, respectively. The time-of-addition and virucidal assay indicated that the anti-PRRSV activity of the two compounds could be due to their inhibiting the early stage of virus replication and/or inactivating the virus directly. The inhibition of the virus attachment was not observed in the adsorption inhibition assay. The inhibition ratios of chlorogenic acid and scutellarin were, respectively, 90.8% and 61.1% at the maximum non-cytotoxic concentrations. The results have provided a basis for further exploration of their antiviral properties and mechanisms in vivo. We believe that the chlorogenic acid and scutellarin have a great potential to be developed as new anti-PRRSV drugs for clinical application.
A Parallel Method of Deep Packet Inspection based on Message-Passing Interface
Jia-xing Qu,Guo-yin Zhang,Xi-zhong Wang,Jia-hui Liu,Da-hua Song 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.12
With the increasing number of cores in multicore processors, it is challenging task how to take advantage of powerful parallel computing for the deep packet inspection. This paper introduces the deep packet inspection with a parallel method which exploits the message-passing interface (MPI). The parallel procedure includes the master thread and the slave thread. The master assigns the data packet to the slave. The slave executes the string matching with rules for inspecting. Both the master and the slave communicate by using MPI functions. The experimental results show that the parallel method is suitable for the trend of the increasing number of cores in multicore processors. Moreover, when the number of threads is equal to the number of cores in multicore processors, the performance arrives at the maximum throughput.
Context Effects in Lexical Ambiguity Processing in Chinese: A Meta-Analysis
Jia Guo,Hua Shu,Ping Li 서울대학교 인지과학연구소 2007 Journal of Cognitive Science Vol.8 No.1
Context effects in lexical ambiguity processing have been extensively examined in various languages including Chinese. A meta-analysis was performed on seven studies conducted in Chinese in order to determine how the Chinese data as a whole agree or disagree with previous findings in other languages. All seven studies reviewed in our analysis used the priming technique to determine the degree of activation of alternative meanings of an ambiguous word in sentence context. The analysis reveals a small but consistent effect of context on lexical access: the contextually appropriate interpretation of a word consistently shows greater priming than the inappropriate interpretation. We further show that sentence contexts interact closely with the meaning frequency of an ambiguous word. We also identify variables in these studies such as length of context and timing of presentation that could influence the strength of the context effect.
Modified GMDH networks for oilfield production prediction
Jia Guo,Wei Huang,Qiong Mao,Xudong Wang,Xinying Wang,Tao Song 한국자원공학회 2018 Geosystem engineering Vol.21 No.4
The self-organizing Group Method of Data Handling (GMDH) functional network is effective in predicting oilfield production. During operation the division of data sample depending on artificial classification cannot lead to global optimum in great probability and the variables are probably eliminated early in the iterative process in traditional GMDH algorithm. Recent years, GMDH model has been improved through many artificial intelligent models, but few people take the optimization of the model structure into account. In this paper, different training and testing set grouping and the effects of variables transmission were studied. The modified GMDH algorithm was optimized using the original variables preservation method and the random sample method, which was applied to the oilfield production forecasting simulation. The results of the modified GMDH algorithm, the traditional GMDH algorithm, ANNs and the empirical equations for predicting annual oil production were compared. The simulative results indicated that the modified GMDH model was the best tool for data-fitting with lowest error (RMSE = 13.9440, MAPE = 0.1121 and SI = 0.0378) and highest accuracy (R = 0.9984).
Jia, Wenbin,Zhu, Xiaoping,Zhang, Wei,Cheng, Jianbo,Guo, Cuihua,Jia, Zhihai Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.12
This experiment was designed to evaluate the effects of source of supplemental zinc (Zn) on performance, nutrient digestibility and plasma mineral profile in Cashmere goats during the cashmere fiber growing period. Twenty-seven Liao Ning Cashmere wether goats (9-10 month of age; initial BW = 19.31${\pm}$0.32 kg) were fed a basal diet (containing 22.3 mg Zn/kg DM) with no supplemental Zn (control) or 20 mg of supplemental Zn/kg of DM from Zn sulfate ($ZnSO_{4}$) or Zn methionine (ZnMet) for 60 days including a 10-day metabolism trial. Average daily gain (ADG) (p<0.05) and gain:feed (G/F) (p<0.05) were increased by Zn supplementation, but no differences were noted between Zn sources (p>0.05). The length and diameter of cashmere fiber did not differ among treatments (p>0.05). Zn supplementation had no influence on digestibility of DM, CP, EE and NDF (p>0.05). However, ADF digestibility in the group supplemented with ZnMet was significantly higher than in other treatments (p<0.05). Plasma Zn was increased (p<0.05) and Cu tended to be decreased (p = 0.057) by Zn supplementation, but no differences were found between Zn sources (p>0.05). Plasma alkaline phosphatase activity (AKP) was improved by Zn supplementation (p<0.05) and was higher in the $ZnSO_{4}$ than the ZnMet group (p<0.05). Zn retention was increased (p<0.05) and apparent absorption rate was decreased (p<0.05) by Zn supplementation. The results indicate that supplementation of 20 mg Zn/kg DM either as $ZnSO_{4}$ or ZnMet in the basal diet containing 22.3 mg Zn/kg DM can improve growth performance in Cashmere goats, and effectiveness of the two sources is similar on performance measurements.
Jia Yang,Jiajia Hao,Chen Tang,Yaxin Guo,Mingxin Guo,Zhipeng Li,Shuzheng Liu,Hui Yu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Although many hydrogels have been applied to wearable sensors, it is still challenging to simultaneouslyrealize hydrogels with optical transparency, superior mechanical properties, excellent sensing performance,and anti-freezing by using inexpensive raw materials and an easy preparation process. Herein,using ethylene glycol/H2O (EG/ H2O) as a solvent, poly(vinyl alcohol)/EG organohydrogel (PVA/EGOHG) was prepared by a simple heating and frozen-thawing method. Owing to the multifunctionalityof EG (i.e., physical cross-linker, anti-freezer and co-solvent), PVA/EG OHG demonstrated excellent integratedproperties, including high strength, high toughness, and anti-freezing performances. Besides, PVA/EG OHG also showed low friction, self-cleaning, and frost resistance properties. After the introduction ofLiCl, ionically conductive PVA/EG @LiCl organohydrogel was served as a self-cleaning strain sensor, whichcould be long-term stable to detect the motions of human under room and low temperatures. The studyprovides to further understanding of the organohydrogel, which will help us design next-generationhigh-performance organohydrogels.
Efficient Greedy Algorithms for Influence Maximization in Social Networks
( Jia Guo Lv ),( Jing Feng Guo ),( Hui Xiao Ren ) 한국정보처리학회 2014 Journal of information processing systems Vol.10 No.3
Influence maximization is an important problem of finding a small subset of nodes in a social network, such that by targeting this set, one will maximize the expected spread of influence in the network. To improve the efficiency of algorithm KK_Greedy proposed by Kempe et al., we propose two improved algorithms, Lv_NewGreedy and Lv_CELF. By combining all of advantages of these two algorithms, we propose a mixed algorithm Lv_MixedGreedy. We conducted experiments on two synthetically datasets and show that our improved algorithms have a matching influence with their benchmark algorithms, while being faster than them.
Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4
Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.