http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sodium-glucose Co-transporter 2 Inhibitors: a New Path for Heart Failure Treatment
Jaewon Oh,이승현,Chan Joo Lee,Seok-Min Kang 대한심장학회 2021 Korean Circulation Journal Vol.51 No.5
Results from cardiovascular outcome trials (CVOT) with 5 different sodium-glucose co-transporter 2 inhibitors (SGLT2i; empagliflozin, canagliflozin, dapagliflozin, ertugliflozin, sotagliflozin), initially developed for their glucose-lowering effect by blocking tubular glucose reabsorption in kidney, have been shown to decrease the risk of heart failure hospitalization (HFH) across a range of patients with and without atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Following these CVOT results, SGLT2i (dapagliflozin, empagliflozin, sotagliflozin) also were reported to reduce HFH and cardiovascular death in patients with heart failure with reduced ejection fraction (HFrEF), regardless of existence or absence of T2DM. Ongoing studies have been conducted to evaluate the clinical benefit of SGLT2i (empagliflozin, dapagliflozin) in patients with heart failure with preserved ejection fraction (HFpEF). Although SGLT2i brought us to the entrance of a new era for prevention of HF incidence and worsening of HF, the search for pivotal mechanism of SGLT2i to improve our pharmacological armamentarium should continue in order to protect every HF patient from fatal progression of HF disease. In this review, we summarized the updated clinical evidences on SGLT2i (rather than basic and translational evidence) for reduction of HF risk in T2DM patients and favorable clinical outcomes in both HFrEF and HFpEF patients.
Jae Won Oh,Il-Wook Cho,류미이,송진동 한국진공학회 2015 Applied Science and Convergence Technology Vol.24 No.3
InP/InGaP quantum structures (QSs) were grown on GaAs (001) substrates by a migrationenhanced molecular beam epitaxy method. Temperature-dependent photoluminescence (PL) and emission wavelength-dependent time-resolved PL (TRPL) were performed to investigate the optical properties of InP/InGaP QSs as a function of migration enhanced epitaxy (MEE) growth cycles from 2 to 8. One cycle for the growth of InP QS consists of 2-s In and 2-s P supply with an interruption time of 10 s after each source supply. As the MEE growth cycle increases from 2 to 8, the PL peak is redshifted and exhibited different (larger, comparable, or smaller) bandgap shrinkages with increasing temperature compared to that of bulk InP. The PL decay becomes faster with increasing MEE cycles while the PL decay time increases with increasing emission wavelength. These PL and TRPL results are attributed to the different QS density and size/shape caused by the MEE repetition cycles. Therefore, the size and density of InP QSs can be controlled by changing the MEE growth cycles.
Influence of Crystallization Temperature on the Optical Properties of MAPbBr₃ Single Crystals
Jaewon Oh,Won Yeob Jeong,Seo Yun Lee,Bom Lee,Mee-Yi Ryu 한국진공학회(ASCT) 2020 Applied Science and Convergence Technology Vol.29 No.1
Optical properties of methylammonium lead bromide (MAPbBr₃) perovskite single crystals grown using a seed-induced inverse temperature crystallization method were studied using photoluminescence (PL) and time-resolved PL measurements. Crystallization rate was observed to be faster with an increasing crystallization temperature. The highest crystal quality was recorded for a sample crystallized at 85°C, and it exhibited the strongest X-ray diffraction peaks and PL intensity. The PL spectra for all samples crystallized at room temperature showed an asymmetric shape with a shoulder in the low energy side; this can be attributed to a photon recycling effect caused by re-emission inside the single crystal. We confirmed that the structural and optical properties of MAPbBr₃ single crystals can be manipulated by modifying the crystallization temperature.
Blinking Heart : Pneumopericardium
( Jae Won Oh ),( Chi Young Shim ),( Ho Youn Won ),( Byeong Keuk Kim ),( Seok Min Kang ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
A 56-year-old man presented with chest discomfort on emergency room. He had stroke 8 years ago and right upper lobectomy (lung cancer, adenocarcinoma) with lymph node dissection 2 weeks ago. Electrocardiogram revealed normal sinus rhythm without any ischemic signs but chest radiograph showed pleural effusion at right lobe and pneumopericardium at left heart border (Figure 1). Computed tomography (CT) showed pneumopericardium at anterior side but no sign of bronchopericardial fistula (Figure 2). Two-dimensional transthoracic echocardiogram was visible only in diastolic phase (Figure 3) but hindered by trapped pericardial air in systolic phase (Figure 4). It could be ``blinking heart sign` in echocardiogram of pneumopericardium, especially in early phase at parasternal long view and parasternal short view. We could not find any compromised-hemodynamic sign and remarkable abnormality. Chest tube was inserted for drainage of right pleural effusion and pleural fluid analysis revealed chylothorax. So we presumed that pneumopericaridum resulted from the sequela of post lung cancer operation. During conservative care with chest tube drainage and intermittent nasal oxygen therapy, his symptoms did not aggravate and his vital signs were stable. After improvement in pleural effusion and pneumopericardium, chest tube was removed. The patient was discharged in good condition and has subsequently done well.