혈장 중 theophyline 분석법 확립 및 약동학적 연구

김형기,권준택,염윤기 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

..

Glutaraldehyde의 농도 및 pH에 따른 항균효과 및 결체조직에 미치는 자극에 관한 비교연구

윤형석,김용기 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

The purpose of this study was to compare the antmicrobial and irritational effects of various glutaraldehyde groups under defferent concentrations along with pH levels on two species of microorganisma,S.aureus and S. sanguis, and dorsal connective tissue of 16 Sprague Dawley rats. The results can be summarized as follows: 1.The intensity of antimicrobial effects on two tested species increased as the concentration of glutaraldehyed got higher. 2.Buffered groups demonstrated stronger antimicrobial effects over unbufferde groups under all tested concentrations and showed statistically significant differences(<0.05) except 10% S. sanguis group. 3.The results of connective tissue reaction study showed the general increased in severity of tissue irritation and in the diffusion of fixed tissue layer. 4.No apparent histological differences could be found in the degree of tissue irritation between buffered and unbuffered glutaraldehyde groups. 5.The overall picture of histological ovservation demonstrated the decrease of inflammatory response with time and no notably different findings bwtween experimental groups were indicated after 4 weeks of test periods.

부분적 무치증을 동반한 법랑질 형성부전 환자의 치험례

윤형석,김용기 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.2

Enamel hypoplasia may be defined as an incomplete formation of the organic enamel matrix of teeth can be derived from a variety of local and systemic factors. A 9-year-old female patient with a chief complaint of abnormal crown shape with partial anodontia came to the clinic for complete rehabilitation. Family history revealed the presence of notched central incisors in her brother and VDRL was performed to rule out congenital syphilis which responded positively in this case. Functional orthodontic appliance were delivered to increase vertical dimension and hypoplastic teeth were restored either stainless steel crown or composite resin restoration. Congenital missing and extracted areas were recovered by delivering upper and lower removable acrylic partial dentures.

골다공증 척추 골절에서 전방 감압술 및 기기 이용 전방 유합술

하기용,류승준,윤형문 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

Fluoxetine 정제의 생물학적 동등성 시험

김형기,권준택,염윤기 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The bioequivalence of generic fluoxetine tablet(Myungin Pharmaceutical Co.) to the fluoxetine tablet(Prozac^(ⓡ)), Lilly Korea Co.) as a reference drug. Single dose of 60 mg fluoxetine was administered to 24 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 72 hours and plasma concentration of fluoxetine was measured by well validated HPLC. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of fluoxetine is bioequivalent with the reference, both formulations in 60 mg tablet.

혈장 중 theophylline 분석법 확립 및 약동학적 연구

김형기,권준택,염윤기 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

배경 및 목적 : 치료적 약물농도 모니터링이나 약물 상호작용연구에 활용할 수 있는 빠르고 간단한 혈중 theophylline의 분석방법을 확립한다. 재료 및 방법 : 표준 혈장시료에 1N HCl 100 ㎕를 첨가하고 내부 표준물질 7-(β-hydroxy-propyl) theophylline (50 ㎍/ml) 50 ㎕를 첨가한후 diethyl ether를 이용하여 추출한 후 질소기류하에서 건조하여 이동상으로 재용해한 후 C18 reverse-phase column에 주입하여 280 nm의 자외선파장에서 HPLC system을 이용하여 검출하였다. 표준 혈장시료를 이용하여 일내- 일간 정밀성과 정확성, 회수율, 단기, 장기 안정성 및 냉해동 안정성을 평가하여 분석방법을 검증하였다. 결과 : 최소검출농도는 0.1 ㎍/ml로 10 ㎍/ml의 농도까지 직선성을 관찰할 수 있었으며 일내- 일간 정밀성과 정확성, 회수율 및 단기, 장기 안정성 및 냉해동 안정성 모두 CV%가 10 % 이내로 분석방법을 확립하였다. 결론 : 본 실험결과 theophylline의 치료적 약물농도 모니터링 및 약물상호작용에 관련된 연구에 활용할 수 있는 빠르고 간단한 분석방법을 확립하였다.

Simvastatin 정제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.

Cefixime 경구제제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic cefixime(Pofixim^(®), Kwangmyung Pharmaceutical Co.) capsule to the cefixime capsule(Suprax^(®), Dong-A Pharmaceutical Co.) as a reference drug. Single dose of 100 mg cefixime was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 14 hours and plasma concentration of cefixime was measured by well validated reverse phase high-performance liquid chromatography. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of cefixime can be declared bioequivalent with the reference, both formulations in 100 mg capsule.

乾癬治療를 위한 자외선 B照射와 光化學療法(PUVA)의 비교 연구

朴允基,金瀅壹 연세대학교 대학원 1985 延世論叢 Vol.21 No.5

Abstract Thirty nine patients with stable plaque type psoriasis were treated with the combination therapy of mineral oil plus UV-B or oral methoxsalen plus longwave UV light (PUVA) therapy. The mean number of treatment, average exposure dose, and accumulated exposure dose of each group needed for achieving each grade were evaluated according to the lesion site. Average exposure time and accumulated exposure time were also calculated. No difference was found between these croups in the number of exposure for clearing of over 95% of the lesions. But, for the exposure time, mineral oil plus UV-B treated group took much lese than the PUVA treated group. Based on these findings and considering the general advantages of UV-B phototherapy, the combination therapy of mineral oil plus UV-B can be recommended as a useful method for the treatment of psoriasis.

3D-CT를 이용한 골격성 III급 개방교합자의 악교정 수술 전, 후 설골 및 상기도의 변화

이윤섭,백형선,이기준,유형석 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.2

본 연구는 골격성 III급 개방교합자의 악교정 수술 전, 후 설골과 상기도의 변화를 3D-CT를 이용하여 관찰하고 이를 정상교합자와 비교하기 위하여 시행하였다. 전치부 개방교합을 동반한 골격성 III급 부정교합으로 진단되어 악교정 수술을 받은 환자 중 12명을 선정 후, 3D-CT를 통해 설골과 상기도의 3차원 입체영상을 분석하여, 악교정 수술 전, 후의 설골의 위치 변화 및 상기도의 부피 변화를 살펴보고, 이의 결과를 정상교합자 10명과 비교하였다. 설골은 골격성 III급 개방교합군에서 악교정 수술 전에 정상교합군의 설골에 비해 전방에 위치하고 있었고 악교정 수술 후 설골은 후, 상방으로 변화하였으나 유의성은 관찰되지 않았다. Hyoid plane과 mandibular plane이 이루는 각은 악교정 수술 전의 골격성 III급 개방교합군이 정상교합군보다 큰 값을 나타내었고, 악교정 수술 후에는 그 차이가 더욱 증가하였다. 골격성 III급 개방교합군의 상기도 부피는 정상교합자보다 작으며 이는, 악교정수술 후에 더욱 감소하였다. 3차원 영상 분석 결과, 골격성 III급 개방교합자의 상기도는 정상교합자에 비해 좁으며, 하악골 후퇴술 이후 더욱 감소하기 때문에 이는 수술적 개선의 안정성에 영향을 줄 수 있음을 알 수 있었다. Objective: The purpose of this study was to investigate the structural changes of the hyoid bone and upper airway after orthognathic surgery for skeletal class III anterior open bite patients, and make comparisons with normal occlusion. Methods: Pre- and post-operative computed tomography (CT) examinations were performed on 12 skeletal class III anterior open bite patients who were treated with mandibular setback osteotomy. Using the V-works 4.0 program, 3-dimensional images of the total skull, mandible, hyoid bone, and upper airway were evaluated. Results: In the Class III openbite group, the hyoid bone were all positioned anteriorly, compared to the Normal group (p < 0.05). The angle between the hyoid plane and mandibular plane in the Class III openbite group before surgery was greater than in the Normal group (p < 0.05), and the difference increased after surgery (p < 0.01). In the Class III openbite group, the volume of the upper airway decreased after surgery (p < 0.001) and the volume of the upper airway was smaller than the Normal group before and after surgery (p < 0.001). Conclusions: The narrow upper airway space in skeletal Class III openbite patients decreased after mandibular setback osteotomy. This may affect the post-surgical stability.