마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향

김동희,이규재,최주봉,이영미,윤양숙,김정례,장병수,양용석 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD. 아토피성 피부염은 주로 천식과 비염 등을 동반하는, 주위에서 흔히 볼 수 있는 만성 염증성 피부질환으로 유전학적, 환경적, 면역학적 요인이 복잡하게 연관되어 발병한다. 해수에 포함된 마그네슘염은 피부에 작용하여 피부장벽을 보호하는 것으로 알려지고 그에 대한 면역학적인 연구와 조직학적 연구는 아직 부족한 실정이다. 이번 연구에서는 피부염을 인위적으로 일으키는 hapten 형성물질인 DNCB를 hairless mice에 도포하여 아토피 피부염 동물 모델로 만든 후, 마그네슘이 다량 함유된 해양 미네랄수를 처리한 후 피부장벽에 미치는 영향을 관찰하였다. DNCB로 피부염을 유발한 hairless mice에 해양미네랄수를 국소적으로 도포하였을 때 유의한 피부수분함량이 증가와 경피수분손실의 감소를 확인하였다 (p<0.01). 피부측정에서 피부거칠기(skin roughness, p<0.05)와 스케일생성 (skin scaliness, p<0.01)은 실험군에서 유의한 개선효과를 나타내었으며 조직학적 검사에서도 피부손상지수의 유의한 감소 (p<0.01)와 비만세포와 (p<0.01) 호산구의 감소(p<0.05) 소견을 보였고 또한 혈청 IgE의 감소를 관찰할 수 있었다(p<0.01). 이상과 같이 마그네슘이 다량 함유된 해양 미네랄수 도포는 피부장벽의 손상을 줄이고 피부수분손실을 효과적으로 줄임으로 아토피성 피부염 증상 유발을 억제할수 있음을 확인하였다. 현재까지 아토피성 피부염의 관리를 위하여 세라마이드나 식물성 오일의 보습제가 주로 활용되고 있는 상황에서 부가적인 피부장벽의 보호를 위하여 탈염 해양 미네랄수의 활용이 가능할 것으로 판단되며 장기적으로 아토피 피부염치료의 대체, 혹은 보조적 물질로 활용될 수 있을 것으로 기대된다.

A Research on the Construction of golf Course and Its Surrounding Area in China from the Perspective of “Ecology-Production-Life” Space

Haolong Xu(Haolong Xu),Fengli Sun(Fengli Sun) 동북아경상학회 2022 동북아경상연구 Vol.3 No.2

Purpose - This paper aims to analyze and provide solutions to the current problems of golf courses and surrounding land in China, guided by the concept of “ecology-production-living” space and using scientific and objective analysis while selecting appropriate indicators. This paper hopes to optimize the utilization value of golf courses and their surrounding space in China and provide a new and feasible basis and method for the rational development and popularization of golf in China based on the country’s actual situation. Design/Methodology/Approach - Combining with domestic and foreign theories and research, this paper analyzed the “ecology-production-life” space problems in golf course and its surrounding area, and draws a series of corresponding conclusions or strategies. Findings - This paper studies the strategic measures for the sustainable development of Chinese golf from the perspective of “ecology-production-life” space are obtained. Research Implications - In terms of the managerial implication of this paper, this study provides a new feasible basis and method for the rational development and popularization of golf in China. It also has certain practical significance for realizing the rural revitalization strategy.

Improving primary sludge dewaterability by oxidative conditioning process with ferrous ion-activated peroxymonosulfate

Xu Zhou,Wenbiao Jin,Lan Wang,Wanqing Ding,Chuan Chen,Xijun Xu,Renjie Tu,Song-fang Han,Xiaochi Feng,Duu-Jong Lee 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.9

Enhancement of sludge dewaterability is key for sludge management and disposal of wastewater treatment plants (WWTP). In this study, the Fe2+-peroxymonosulfate (PMS) conditioning approach was first used to oxidize the primary sludge from the primary sedimentation tank of a full scale WWTP. The combination of Fe2+ (0.05-0.5 g/g TSS) and PMS (0.05-0.5 g/g TSS) could significantly improve the dewaterability of primary sludge. The optimal addition amount of Fe2+ and PMS was 0.1 g/g TSS and 0.25 g/g TSS, respectively, under which the capillary suction time (CST) and specific resistance to filtration (SRF) of the sludge was reduced by 79% and 95%. The physicochemical properties (particle size, zeta potential, EPS composition) of the primary sludge before and after oxidative conditioning were measured. Results showed that sulfate radicals generated from Fe2+-PMS system effectively reduced organic matter in different EPS fractions, further destroying sludge floc cells. Then the bound water in the sludge flocs was released, thereby improving the sludge dewaterability. The microscopic morphology also indicated that the sludge flocs have a blocky structure with tight texture before conditioning. After conditioning, the sludge flocs become smaller, and many irregular pores are formed on the surface, which facilitates the passage of internal moisture. Economic analysis showed that Fe2++PMS conditioning is more economical than the traditional Fenton method.

Keynote Speakers of the Participation Countries : Study on the Chinese Cities Tourism Center Positioning

( Xu Feng ) 한국관광산업학회 2004 국제관광학술대회 Vol.- No.-

Self-Updating One-Time Password Mutual Authentication Protocol for Ad Hoc Network

( Feng Xu ),( Xin Lv ),( Qi Zhou ),( Xuan Liu ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.5

As a new type of wireless network, Ad hoc network does not depend on any pre-founded infrastructure, and it has no centralized control unit. The computation and transmission capability of each node are limited. In this paper, a self-updating one-time password mutual authentication protocol for Ad hoc network is proposed. The most significant feature is that a hash chain can update by itself smoothly and securely through capturing the secure bit of the tip. The updating process does not need any additional protocol or re-initialization process and can be continued indefinitely to give rise to an infinite length hash chain, that is, the times of authentication is unlimited without reconstructing a new hash chain. Besides, two random variable are added into the messages interacted during the mutual authentication, enabling the protocol to resist man-in-the-middle attack. Also, the user`s identity information is introduced into the seed of hash chain, so the scheme achieves anonymity and traceability at the same time.

Literature Review on Tourism Destination Management

Xu, Feng-Zeng,Nie, Su-Min,Kim, Sang-Ho 한국관광산업학회 2006 Tourism Research Vol.22 No.-

Topology Optimization Method of Lattice Structures Based on a Genetic Algorithm

Feng Ruo-qiang,Liu Feng-cheng,Xu Wei-jia,Liu Yang 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.3

A two-stage topology optimization method of lattice structures based on a genetic algorithm is proposed. The first stage is the form-finding analysis of lattice structures, and the optimal initial shape was achieved with the numerical inverse hanging method. The second stage is the topology optimization of single-layer lattice structures, which can be realized by changing the mesh size and the tube configurations to minimize the total weight of steel tubes subject to the design requirements. The mesh configuration optimization is realized through the adjustment of the nodal horizontal co-ordinates and the removal of tubes with lower stress. The maximum displacement of the structure, the maximum stress of the circular steel tubes, and the nonlinear buckling load are the state variables, and a genetic algorithm (GA) is the optimization algorithm. Different stress-limiting values used to delete the tubes were discussed. The numerical examples show that the two-stage topology optimization method for lattice structures proposed in this paper is correct and efficient. Furthermore, the forms of the optimized structure are rich, and the structure is lightweight and efficient.

Inter regional diffusion of policy innovation in China A comparative case study

Xu-Feng Zhu 서울대학교행정대학원 2017 Asian Journal of Political Science Vol.25 No.3

Classic theoretical research on the diffusion of policy innovation is usually based on decentralized democratic regimes. However, in authoritarian centralized countries such as China, questions such as, ‘What are the driving forces and the structural dynamics behind local government policy innovation and inter-regional diffusion?’ and ‘How do the governmental structural factors lead to the different patterns of diffusion of policy innovation across local governments?’ are interesting research topics. The theoretical framework proposed in this study highlights the roles of the contingent vertical and horizontal governmental relations in innovation diffusion. I extract two key properties: vertical mandatory intervention from the central government and horizontal political competition among peer governments. This research uses four models to develop a new typology of the interregional diffusion of policy innovation in China: (1) the enlightenment model, (2) the championship model, (3) the designation model, and (4) the recognition model. A comparative case study is conducted in this research, with four policy cases showing that China has developed diversified mechanisms to encourage local governments to perform policy innovation and inter-regional diffusion.

Alum sludge conditioning with ferrous iron/peroxymonosulfate oxidation: Characterization and mechanism

Xu Zhou,Wenbiao Jin,Lan Wang,Lin Che,Chuan Chen,Shao-feng Li,Xue-Ting Wang,Renjie Tu,Song-fang Han,Xiaochi Feng,Nan-Qi Ren 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.4

Alum sludge produced by drinking water plants needs to be conditioned and dewatered before final disposal. In this study, a novel ferrous iron/peroxymonosulfate (PMS) oxidation process was employed to enhance alum sludge dewaterability. The effect of oxidative sulfate radicals generated by Fe2+ activated HSO5  on alum sludge was studied. The results showed that the optimal conditioning conditions for addition of Fe2+ and PMS were 0.5 g/g and 0.1 g/g TSS, respectively. Meanwhile, the capillary suction time (CST) and specific resistance to filtration (SRF) of alum sludge was reduced by 66% and 88%. Also found was that the absolute value of the zeta potential increased and the particle size decreased in alum sludge after Fe2+-PMS conditioning, which indicated that oxidative sulfate radicals destroyed the floc structure of alum sludge and smaller particles were generated. At the same time, the water contained in sludge flocs was released and enhanced sludge dewaterability, while leaching of aluminum ions also characterized decomposition of alum sludge.

A RuO2IrO2 electrocatalyst with an optimal composition and novel microstructure for oxygen evolving in the single cell

Feng Ye,Yanpeng Cao,Weiwei Han,Yakun Yang,Yuancheng Feng,Peng Liu,Chao Xu,Xiaoze Du,양우철,Liu Guicheng 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.3

A highly active RuO2IrO2 electrocatalyst was developed via dip-coating/calcination method for oxygen evolution reaction (OER). The catalyst on Ti substrate with a 7/3 molar ratio between Ru and Ir showed the highest electrocatalytic activity for OER among composite samples in different molar ratios. Moreover, the properties of RuO2IrO2 grown on carbon paper were evaluated by proton exchange membrane water electrolysis single cell. Compared with the micron-particle structure of RuO2IrO2 catalyst on the Ti substrate, the catalyst grown on the carbon paper showed a novel nano dendrite shape and can be used directly as the gas diffusion electrode. Owing to the large surface area of the catalyst, the nano dendrite-shaped RuO2IrO2 catalyst exhibits excellent OER performance in the single cell. Furthermore, a cell voltage of 2.50 V is achieved under 200mA cm2 at 30 oC by using the optimal composition RuO2IrO2 (Ru : Ir=7/3) and the commercial 20% Pt/C as anode and cathode, respectively.