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반복자연유산 환자에서 Antithrombin III 결핍증에 대한 연구
남윤성,차광렬,김남근,강명서,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Kim, Nam-Keun,Kang, Myung-Seo,Oh, Do-Yeon 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.4
Objective : To analyze the antithrombin II deficiency in patients with recurrent spontaneous abortion. Material and Method: The blood samples were tested by chromogenic assay to evaluate the activity of antithrombin III. Results: There was only one case of antithrombin III deficiency. This patient experienced one neonatal death after delivery and one FDIU (fetal death in utero). And also this patient showed a lupus anticoagulant and the prolongation of PTT. Conclusions: Women with recurrent miscarriage who have no obvious identified cause should consider hematologic screening. Antithrombin III deficiency could be a cause of recurrent spontaneous abortion. But the incidence is very rare in Korean patients.
남윤성,김남근,이수만,강명서,오도연,차광렬,Nam, Yoon-Sung,Kim, Nam-Keun,Lee, Su-Man,Kang, Myung-Seo,Oh, Do-Yeon,Cha, Kwang-Yul 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.3
Objective : To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. Material and Method: Factor XII was analyzed by clotting method. Results: Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT. Conclusions: It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.
Homocysteine 과다증과 관련된 반복 자연유산에서 Methylenetetrahydrofolate Reductase돌연변이에 대한 분석
남윤성,최종순,하권수,이지원,오도연,Nam, Yoon-Sung,Choi, Jong-Soon,Ha, Kwon-Soo,Lee, Zee-Won,Oh, Do-Yeon 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. Material and Method: The blood sample of habitual aborter with high fasting homocysteine level was tested by PCR - RFLP method. Results: The patient was found to be a homozygosity for MTHFR gene mutation that was confirmed by the finding which is consistent with the mutation at the nucleotide 677 C to T, corresponding to Ala to Val. Conclusions: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the MTHFR mutation should be examined in the workup of recurrent spontaneous abortion showing hyperhomocysteinemia.
남윤성,김남근,강명서,오도연,차광열,Nam, Yoon-Sung,Kim, Nam-Keun,Kang, Myung-Seo,Oh, Do-Yeon,Cha, Kwang-Yul 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.2
Objective: To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. Material and Method: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. Results: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. Conclusion: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
소아 용혈성요독증후군에서 ADAMTS13 활성도의 변화
이초애,김남근,장문주,이준호,정해일,이선주,박혜원,오도연,Lee, Cho-Ae,Kim, Nam-Keun,Jang, Moon-Ju,Lee, Jun-Ho,Cheong, Hae-Il,Lee, Sun-Ju,Park, Hye-Won,Oh, Do-Yeon 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2
Purpose : HUS usually occurs in children after infection with shiga toxin-producing microorganism(D+HUS). In contrast, non-postdiarrheal(D-) HUS occurs at any age and has a high rate of relapse and a poor prognosis. The clinical presentation of D-HUS is similar to that of thrombotic thrombocytopenic purpura(TTP). Recently severe deficiencies of ADAMTS13 were reported not only in TTP and D- HUS but also in D+ HUS during their acute phase. The purpose of the study is to evaluate the plasma ADAMTS13 activity in D+ and D-HUS. Methods : Nineteen children with HUS(D+ HUS 12 and D- HUS 7) were enrolled. The assays of plasma ADAMTS13 activity were performed during the acute stage in the D+ HUS and at various stages of relapsing courses in the D- HUS patients by multimer assay, based on electrophoresis. Results : The median plasma activity of ADAMTS13 in D+ HUS and D- HUS were 80.9%(37.8-132.4%) and 53.9%(1.0-94.1%), respectively, which were not statistically significantly different from control(86.4%, 34.2-112.3%)(P>0.05). One boy with D- HUS had severe deficiency of ADAMTS13(1.0%). His platelet count was normalized temporarily by fresh frozen plasma infusion. Conclusion : We have demonstrated that there is no significant difference of the plasma ADAMTS13 activity between D+ HUS, D- HUS and control. We detected severe deficiency of ADAMTS13 in one boy who presented with relapsing episodes of D- HUS. ADAMTS13 deficiency should be considered in the subgroup of D- HUS especially with early onset and recurrent courses. Plasma therapy can be beneficial in this subgroup.
불임환자와 반복자연유산 환자에서 루프스 항응고인자와 항카디오리핀 항체에 대한 연구
남윤성,차광렬,백진영,김남근,강명서,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Baek, Jin-Young,Kim, Nam-Keun,Kang, Myung-Seo,Oh, Do-Yeon 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.1
Objective : To report the prevalence of lupus anticoagulants and anticardiolipin antibodies in patients with recurrent spontaneous abortion and infertility. Material and Method: Lupus anticoagulants and anticardiolipin antibodies were analyzed by Diluted Russell's Viper Venom Test (DRVVT) and solid phase enzyme immunoassay, respectively. Results : In 200 patients with infertility, there were 6 cases (3%) with positive lupus anticoagulants or anticardiolipin antibodies. Of these, 3 patients (1.5%) showed positive lupus anticoagulants and anticardiolipin antibodies, respectively. In 120 patients with recurrent spontaneous abortion, there were 13 cases (10.8%) of positive lupus anticoagulants or anticardiolipin antibodies. Of these, one patient (1%) showed lupus anticoagulants and 12 patients (10%) showed anticardiolipin antibodies. But in two groups, there was no cases with positive lupus anticoagulants and anticardiolipin antibodies. Conclusion: Lupus anticoagulants and anticardiolipin antibodies are definite cause of recurrent spontaneous abortion. There has been a speculation that they might be associated with infertility and repeated IVF failures. But it was found that the role of lupus anticoagulants and anticardiolipin antibodies in these cases are not clear.
반복자연유산 환자에서 Homocysteine과 Methylenetetrahydrofolate Reductase 돌연변이의 상관관계에 대한 분석
남윤성,차광렬,김남근,강명서,김세현,오도연,Nam, Yoon-Sung,Cha, Kwang-Yul,Kim, Nam-Keun,Kang, Myung-Seo,Kim, Se-Hyun,Oh, Do-Yeon 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.3
Objective : To analyze the interrelationship between homocysteine and methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: Homocysteine and MTHFR mutation were tested by fluorescent polarizing immunoassay and PCR-RFLP method, respectively. Results: In patients with homocysteine level less than 5 ?mol/L, there was no case of normal group but there were four cases of heterozygosity and one case of homozygosity. In patients with homocysteine level 5$\sim$10 ? mol/L, the number of normal, heterozygosity and homozygosity group were eleven, eighteen and eight, respectively. In patients with homocysteine level $10{\sim}15$ ? mol/L, the number of normal, heterozygosity and homozygosity group were four, one and one, respectively. In patients with homocysteine level more than 15 ? mol/L, there was no case of normal and heterozygosity group but there were two cases of homozygosity. Conclusions: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. And there was a significant relationship between homocysteine and MTHFR mutation.
Dermatophagoides pteronyssinus와 Lipopolysaccharide 자극에 의한 수지상세포의 IL-12 분비
김형윤 ( Hyoung Yun Kim ),한만용 ( Man Yong Han ),서지영 ( Ji Yeong Seo ),조효진 ( Hyo Jin Cho ),김남근 ( Nam Keun Kim ),오도연 ( Do Yeon Oh ),황성규 ( Seong Gyu Hwang ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
Backgound: Epidemiological studies have provided indirect evidence that exposure to less invasive microbials enhances the development of allergic diseases. Nonetheless, our understanding of the mechanisms that underlie this apparent symbiosis between microbes and allergen remains incomplete. Objective: The purpose of our study was to evaluate the response of Dermatophagoides pteronyssinus (Der p) on Lipopolysaccharide (LPS) pulsed Dendritic cells (DCs). Method: Peripheral blood monocyte-derived DCs were obtained from 11 healthy donors. The monocyte-derived DCs were cultured with the LPS and Der p. Then, the costimulatory molecule expression and IL-12 production were evaluated. Result: Der p-activated monocyte-derived DCs did not induce the costimulatory molecule expression and IL-12 production. In contrast, LPS-activated monocyte-derived DCs were found to produce IL-12 in a concentration-dependent manner and to increase their expression of CD80 and CD86. However, there was no differences between ``LPS pulsed DCs`` and ``LPS and Der p copulsed DCs`` in the amount of IL-12 produced. Conclusion: In healthy adults, LPS-induced IL-12 production was not impaired by Der p. (Korean J Asthma Allergy Clin Immunol 2006;26:200-205)
만성면역혈소판감소자색반에서의 Anti-D immunoglobulin 치료
김혜정 ( Hye Jeong Kim ),정윤진 ( Yun Jin Jung ),황의남 ( Eui Nam Hwang ),김영훈 ( Young Hoon Kim ),최진성 ( Jin Sung Choi ),남승현 ( Seung Hyun Nam ),김봉석 ( Bong Seog Kim ),오도연 ( Do Yeon Oh ),윤성수 ( Sung Soo Yoon ),박선양 대한내과학회 2008 대한내과학회지 Vol.74 No.2
목적: 성인 만성 면역혈소판감소자색반 환자에서 anti-D 면역글로불린을 투여하여 혈소판 상승에 대한 효과와 부작용을 확인하고자 본 연구를 시행하였다. 방법: 이전 치료에 반응을 하지 않거나 재발한 전체 14명의 성인 만성 면역혈소판감소자색반 환자를 대상으로 하였다. 14명 환자가 스테로이드 요법을 받았고, 10명의 환자는 비장절제술을 시행 받았다. Anti-D 면역글로불린의 주입량은 50~70 μg/kg이었으며 단 한번 주입하여 반응을 확인하였고, 치료 반응의 평가는 혈소판 및 혈색소 수치를 추적 검사하였다. 결과: 치료 반응이 확인된 경우는 전체 환자의 36% 인 5명이었고, 혈소판 상승이 지속된 기간은 평균 7일이었으며 심각한 합병증은 없었다. 결론: 본 연구에서는 성인의 만성 면역혈소판감소자색 반증에서 Fc 수용체 차단제인 anti-D 면역글로불린을 이용한 치료가 임상적 유용성이 있는 것으로 나타났다. Background/Aims: Immune thrombocytopenic purpura (ITP) is an autoimmune disease that is mediated by anti-platelet antibodies. Based on the pathogenesis of ITP we evaluated the efficacy of intravenous anti-D immunoglobulin for adult chronic ITP. Methods: Fourteen patients (4 without splenectomy and 10 with splenectomy) with refractory chronic ITP were treated with 50-70μg/kg of intravenous anti-D immunoglobulin only once. Treatment effects were evaluated by measuring the platelet counts and hemoglobin levels. Results: Five patients (36%) showed a response; improvement in the platelet count lasted for on average 7 days (range: 2~24 days). There were no serious adverse effects. Conclusion: Anti-D immunoglobulin, which is associated with an Fc receptor blockade, appeared to be safe and effective for the treatment of adults with chronic ITP. Further studies are needed to confirm these findings and define further potentially effective treatment protocols with intravenous anti-D immunoglobulin. (Korean J Med 74:176-180, 2008)