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Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention
Byoung-won Park,Seong Soon Kwon,Min Ho Lee,Do Hoi Kim,Min Su Hyon,Duk Won Bang 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1
Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). Methods: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. Results: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. Conclusion: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.
다양한 운동형태의 일회성 운동에 따른 혈액성분 및 혈장량 변화에 대한 연구
김도윤,김원현,김광회 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
Acute Blood Compositions change were determined in 18 Healthy college aged-men completing three counterbalanced running trial at different exercise intensities: trial 1 at 50%LT, trial 2 at 100% LT intensity and 150%LT intensity. For each trial, blood samples were collected at pre-exercise(baseline), immediately post-exercise(PE), 24 hours(24h) and 48 hours post-exercise. Serum samples were analyzed for Hematocrit(Hct), Red Blood Cell(RBC), White Blood cell(WBC), Hemoglobin(Hb), and plasma Volume Change(PVC). In addition, capillary blood samples were collected for analysis of blood lactate concentrations during incremental test to determine LT. All samples were compared to pre-exercise(baseline). In assessing the blood compositions change variables, significant difference was determined in chages of Hct, RBC, Hb at various intensities over time. However, there was no significant difference in WBC, PVC at any intensity. Consequently, there was significant difference between the 150%LT and the 50%LT for the blood compositions change. I thought that the 50%LT and the 100%LT which was used the exercise protocol with 400 calories consumption didn't support the stimulation enough to response during the exercise even though 150%LT stimulated subjects to get less response than previous studies.
준비운동과 정리운동이 수영에서의 혈액내 젖산농도 및 심박수에 미치는 영향
김원현,김광회,김도윤 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
The purpose of this study is to examine the effect of warming up in swimming on Lactate Density which makes man be exhausted. And this study is to analyze the effect of cooling down in removing Lactate and the relation with heartrate. The test was practiced in the swimming pool of H University and 14 university students, who has two years experience in swimming and are healthy, were selected for this study. Seven students were warming up and cooling down group and seven were other group. Warming up and cooling down was done 15minutes. This exercise was done 5minutes swimming and 1minutes rest during twenty minutes. The measurement of Lactate and heartrate was conducted stable period, right after warming period and exercise period of body per 5minutes (3times). Just after exercise, cooling down and restoration period per 5minutes (3times), the measurement was conducted. And after cooling down(after 35minutes), the measurement was practiced. The average and standard deviation were conducted on each analysis part. The average difference between groups was analyzed by Two-way ANOVA. The difference in group was examined by Bonferroni test at the p<.05 level of significant. The results as follows 1. Warming up 1). Just after warming up, each group's lactate amount in blood has significant change (P<.05). 2). Just after warming up, lOminutes exercise, 15minutes exercise and 20minutes, each group's heartrate has significant change.(p<.001, p<.01, p<.05, p<.01) 3). All groups have significant change on the lactate and heartrate through exercise (p<.05, p<.01, p<.001). 2. Cooling down 1). After cooling down, each group's lactate amount in blood has no significant change. 2). Each group's heartrate has significant change just after cooling down after 5minutes and 10 minutes(p<.01, p<.05). 3). All groups have significant change on the lactate and heartrate through restoration period(p<.05, p<.01, p<.001).
Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor
Do, Hyun-Jin,Song, Hyuk,Yang, Heung-Mo,Kim, Dong-Ku,Kim, Nam-Hyung,Kim, Jin-Hoi,Cha, Kwang-Yul,Chung, Hyung-Min,Kim, Jae-Hwan Elsevier 2006 FEBS letters Vol.580 No.7
<P><B>Abstract</B></P><P>We investigated nuclear localization signal (NLS) determinants within the AT-hook and ETS DNA-binding domains of murine Elf3 (mElf3), a member of the subfamily of epithelium-specific ETS transcription factors. Deletion mutants containing the AT-hook, ETS domain or both localized strictly in the nucleus, suggesting that these individual domains contain independent NLS motif(s). Within the AT-hook domain, four basic residues (<SUP>244</SUP>KRKR<SUP>247</SUP>) were critical for strong NLS activity, and two potent bipartite NLS motifs (236–252 and 249–267) were sufficient for nuclear import of mElf3, although less efficient than the full domain. In addition, one stretch of basic residues (<SUP>318</SUP>KKK<SUP>320</SUP>) within the ETS domain appears to be essential for mElf3 nuclear localization. Taken together, mElf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport.</P>
Do, Hyun-Jin,Lee, Won-Young,Lim, Hye-Young,Oh, Jong-Hyun,Kim, Dong-Ku,Kim, Jin-Hoi,Kim, Teoan,Kim, Jae-Hwan Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of cellular biochemistry Vol.106 No.6
<P>The core embryonic stem cell transcription factors Oct4, Sox2, and Nanog are expressed in germ cell tumors (GCTs) and have been proposed to play a regulatory role in tumorigenesis. However, little is known about the mechanism of regulation of tumorigenesis by the complicated network of these proteins. Nanog is a novel homeobox-containing transcription factor that is expressed in pluripotent cells as well as GCTs. To understand the molecular and functional role of human NANOG (hNANOG) in germ cells, mutagenesis of the C-terminal domain (CD) of hNANOG and transient transfection assays in NCCIT human embryonic carcinoma cells were carried out to identify critical transactivation motifs. We divided the CD into three putative functional subdomains, CD1, tryptophan-repeat (WR) subdomain, and CD2. WR subdomain and CD2 independently contained transcriptional potential and, in combination, had a synergistic effect on transcriptional activity, while CD1 was transcriptionally inactive. The glutamine (Q) motif in WR subdomain, and multiple acidic residues in CD2 were required for maximal and synergistic transcriptional activation by the hNANOG CD. The results of the current study contribute to a better understanding of the complicated molecular machinery of stem cell transcription factors and their role in unregulated proliferation in germ cell tumorigenesis. J. Cell. Biochem. 106: 1079–1089, 2009. © 2009 Wiley-Liss, Inc.</P>