放射線照射에 의한 濟州産 鹽乾옥돔의 貯藏性向上에 관한 硏究

金洙賢,鄭昌朝,趙韓玉,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

濟州産 鹽乾옥돔(yellow sea bream ; Branchiostegus japonicus japonicus)을 Vinyl 眞空包裝 0, 0.5, 1.0, 1.5 및 2.0Mrad 水準으로 放射線 照射후 室溫과 冷藏으로 60日間 貯藏하여 鹽乾옥돔의 理化學的變化 및 官能檢査를 수행하였다. 貯藏期間中 總菌數는 放射線 照射水準이 높아짐에 따라 抑制되고 있었으며, 放射線照射와 冷藏處理가 더욱 效果的이었다. TMA의 增加率은 高線量水準에서 적었으며 2.0Mrad水準은 도리어 貯藏初期에 비하여 末期에 이르러 TMA의 含量을 減少시켰다. TMAO의 減少率은 貯藏條件에 관계없이 照射後 20日傾부터는 急激한 減少現象을 나타내었다. Total nitrogen의 減少는 無照射區에서 가장 컸으며, 照射水準이 높아짐에 따라 變化의 폭은 적었다. VBN含量은 各 處理區 모두 D30에서 顯著한 增加를 보이고 있었으며, 放射線處理에 따라 多少 抑制되었다. 放射線照査와 室溫貯藏區에서는 20日까지, 放射線照査 및 冷藏處理區에서는 40日까지 鹽乾옥돔의 鮮度를 유지시킬 수가 있었다. 組織變化, 總菌數, 腐敗 등 要因을 考慮할 때 鹽乾옥돔의 貯藏性向上을 위해서는 1.0Mrad가 適正水準으로 推定되었다. Salted dry yellow sea bream were vaccum packed in a plastic bags and irradiated at differents levels (0.0.5, 1.0, 1.5 and 20 Mrad) using ?? source. The irradiated samples were stored at room temperature and 5℃. Physical and chemical properties were examined during storage. The total bacterial count was depressed according to level of irradiation applied. It was noted that cold storage after irrdiation was more effective than room temperature. TMA contents slowly increased with higher dosage rates up to 1.5 Mrad but there was a gradual decrease of TMA at the 2.0 Mrad level.It was observed that there was a rapid decrease of TMAO 20 days after irradiation irrespective of storage temperature. The reduction of total nitrogen content was highest in the control but to a lesser degree when irradiation was applied. VBN content increased in all treatments 30 days after irradiation but it was also noted that there was a tendency toward depression of VBN by irradiation. The shelf life of salted dry sea bream was extended by 20 days with irradiation plus room temperature, and by 40 days with irradiation plus cold storage. To extend shelf life of salted dry sea bream, the most effective dosage rate was 1.0 Mrad based on tenderness, bacterial count and rancidity.

放射線照射에 의한 柑橘貯藏에 관한 硏究

鄭昌朝,趙漢玉,金洙賢,金在河 제주대학교 방사능이용연구소 1985 연구보고 Vol.1 No.-

柑橘의 貯藏性 向上을 爲한 ?? 線 照射가 濟州産 溫洲柑橘에 미치는 影響을 調査하였다. 溫洲柑橘 4個 系統을 10,000Ci, ?? 線源을 利用 0, 50, 100, 150Krad水準으로 照射하여 92日間 半地下式 貯藏庫에 貯藏, 調査한 結果를 要約하면 아래와 같다. 1. 貯藏終了時까지의 柑橘 累積腐敗率은 中生系인 米澤(T₂) 74.32%, 早生溫洲(T₁) 69.67%, 中晩生系林溫洲(T₃) 61.79%와 晩生系 靑島(T₄)가 64.33%였다. 反面 서울地域의 腐敗率은 D-72에서 T₁; 28%, T₃; 25% 및 T₄; 24%로 濟州地域에 比해 越等히 낮았다. 柑橘의 腐敗는 貯藏初期에 徐徐히 增加하나 照射後 59日부터는 急激히 上昇하기 始作하였다. 腐敗率과 柑橘系統 사이에는 高度의 相關關係가 있었으며 貯藏性은 T₃와 T₄가 가장 우수하였다 ??. 高放射線 照射水準(100, 150Krad)은 貯藏中期까지 柑橘貯藏에 效果가 있었으나 照射 76日 以後에는 對照區와 差가 없었다. 2. 放射線 照射는 貯藏期間中 柑橘의 酸度를 減少 시켰으며 平均 酸度는 T₁; 1.01%, T₃; 1.01%, T₄; 0.84% 및 T₂; 0.77%로 柑橘系統 및 照射線量間에는 高度(P<0.01)의 有意差가 認定되었다. 3. 모든 處理區에서 還元糖과 全糖含量은 增加하고 있었으나 統計的 有意性은 없었고 50Krad照射區에서만은 對照區에 比해 有意的(P<0.01)으로 減少하고 있었다. 糖度는 T₁,T₄가 T₂, T₃에 比하여 높았으며 高線量水準(100, 150Krad)에서 Control에 比해 有意的인 減少가 있었다(P<0.01). Ascorbine 酸含量은 모든 處理區에서 貯藏時期가 經過됨에 따라 減少하였으며 高照射線量水準에서 對照區에 比해 有意的인 減少가 있었다(P<0.01). A study was conducted to evaluate the effect of ?? irradiation on the preservation of Satsuma mandarin in Cheju Island. Four varieties (S. m. early, S. m. Komezawa, S. m. Hayashi and S. m. Aoshima) were irradiated using 10,000 Ci, ?? ray with dosages of 0, 50, 100 and 150Krad. During 92 days of storage the effects of irradiation on mandarin properties were as follows; 1. At the end of storage period the accumulated fruit rotting percentage were S. m. Komezawa (T₂); 74.32%, S. m. early (T₁); 69.67%, S. m. aoshima (T₄); 64.33% and S. m. Hayashi (T₃); 61.79%. The rottings steadily increased from the early stage of storage and rapid spoilage continued after 59 days of irradiation. A high correlation existed between fruit rotting and varieties (T₃; Y=0.78x-15.30, T₄; Y=0.79x-12.29, T₁; Y=0.93x-9.01 and T₂; Y=0.79x-13.49). High dosages (100 and 150 Krad) improved fruit preservation during the mid storage stage. However 76 days after high dose irradiation there was no significant difference a rotting between irradiated fruit and the control. 2. Irradiation decreased acidity of fruit during storage (P<0.01). The mean acidities of examined varieties were T₁; 1.01%, T₃; 1.01%, T₄; 0.84% and T₂; 0.77%. A significant differences were observed in acidity between varieties and dosages (P<0.01). 3. With one exception in all treatments, the increase in free and total sugar content was not statistically significant. The exception was the 50 Krad treatment where the total sugar content decreased. T₁and T₄showed slightly higher value of Brix than T₂and T₃and were significantly (P<0.01) decreased by higher dosage. The ascorbic acid content in all treatments decreased with length of storage and also decreased significantly with a higher dosage.

放射線 照射에 依한 濟州産 염乾옥돔의 貯藏性性向上에 관한 硏究

金在河,金洙賢,鄭昌朝,趙漢玉 제주대학교 1984 논문집 Vol.18 No.-

濟州道 鹽乾옥돔(yellow sea bream; Branchiostegus japonicus japonicus)을 Vinyl 眞空包裝 0, 0.5, 1.0, 1.5 및 2.0 Mrad 水準으로 放射線 照射후 室溫과 冷藏으로 60日間 貯藏하여 鹽乾옥돔의 理化學的 變化 및 官能檢査를 수행하였다. 貯藏期間中 總菌數는 放射線 照射水準이 높아짐에 따라 抑制되고 있었으며, 放射線照射와 冷藏處理가 더욱 效果的이었다. TMA의 增加率은 高線量水準에서 적었으며 2.0Mrad 水準은 도리어 貯藏初期에 비하여 末期에 이르러 TMA의 含量을 減少시켰다. TMAO의 減少率은 貯藏條件에 관계없이 照射後 20日傾부터는 急激한 減少現象을 나타내었다. Total nitrogen의 減少는 無照射區에서 가장 컸으며, 照射水準이 높아짐에 따라 變化의 폭은 적었다. VBN含量은 各處理區 모두 D30 에서 顯著한 增加를 보이고 있었으며, 放射線處理에 따라 多少 抑制되었다. 放射線照射와 室溫貯藏區에서는 20日까지, 放射線照射 및 冷藏處理區에서는 40日까지 鹽乾옥돔의 鮮度를 유지시킬수가 있었다. 組織軟化, 總菌數, 腐敗 등 要因을 考廬할때 鹽乾옥돔의 貯藏性向上을 위해서는 1.0Mrad가 適正水準으로 推定되었다. Salted dry yellow sea bream were vaccum packed in a plastic bags and irradiated at differents levels (0, 0.5, 1.0, 1.5 and 2.0 Mrad) using ??Co source. The irradiated samples were stored at room temperature 5℃. Physical and chemical properties were examined during storage. The total bacterial count was depressed according to level of irradiation applied. It was noted that cold storage after irrdiation was more effective than room temperature. TMA contents slowly increased with higher dosage rates up to 1.5 Mrad but there was a gradual decrease of TMA at the 2.0 Mrad level. It was observed that there was a rapid decrease of TMAO 20 days after irradiation irrespective of storage temperature. The reduction of total nitrogen content was highest in the control but to a lesser degree when irradiation was applied. VBN content increased in all treatments 30 days after irradiation but it was also noted that there was a tendency toward depression of VBN by irradiation. The shelf life of salted dry sea bream was extended by 20 days with irradiation plus room temperature, and by 40days with irradiation plus cold storage. To extend shelf life of salted dry sea bream, the most effective dosage rate was 1.0 Mrad based on tenderness, bacterial count and rancidity.

VHDL 언어를 이용한 Analyzer의 설계 및 구현

하수철,김충석 大田大學校 1988 論文集 Vol.7 No.2

This paper designs and implements an analyzer in the environment to support VHDL(VHSIC Hardware Description Language) standardized by IEEE. The VHDL analyzer accepts the source text for syntactic and semantic validity aginst the language definition In so doing,it builds an intermediate representation of the source at the VHDL designs library, which forms the basis for later manipulation of VHDL designs by other utilities. The intermediate representation is presented in the form of a file which comtains the attributes for the identifiers in the source text. The implementation in this paper is written with C language using Lex and Yacc on the XENIX system.

세 가지의 서로 다른 동소성 방광대치술 후 상부요로 변화와 대사성산증의 발생

이진형,김청수,안한종 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.12

후천성 면역 결핍증 환자의 혀에 발생한 거대세포바이러스(CMV : cytomegalovirus) 감염

송노헌,이종호,정필훈,김명진,김수경,남일우,김종원,백세미,홍삼표 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

전립선암의 병리학적 병기 예측인자에 대한 고찰

안한종,최은호,김정균,홍범식,정태규,박형근,김청수,박태한,공경엽 大韓泌尿器科學會 1997 Korean Journal of Urology Vol.38 No.12

Report of the Second Asian Prostate Cancer (A-CaP) Study Meeting

Kim, Choung-Soo,Lee, Ji Youl,Chung, Byung Ha,Kim, Wun-Jae,Fai, Ng Chi,Hakim, Lukman,Umbas, Rainy,Ong, Teng Aik,Lim, Jasmine,Letran, Jason L.,Chiong, Edmund,Wu, Tong-lin,Lojanapiwat, Bannakij,Tü,rk Asian Pacific Prostate Society 2017 Prostate international Vol.5 No.3

<P>The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The study was launched in December 2015 in Tokyo, Japan, and the participating countries and regions engaged in preparations for the study during the course of 2016, including patient registration and creation of databases for the purpose of the study. The Second A-CaP Meeting was held on September 8, 2016 in Seoul, Korea, with the participation of members and collaborators from 12 countries and regions. Under the study, each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognostic investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. At the Second Meeting, participating countries and regions discussed the status of preparations and discussed various issues that are being faced. These issues include technical challenges in creating databases, promoting participation in each country or region, clarifying issues relating to data input, addressing institutional issues such as institutional review board requirements, and the need for dedicated data managers. The meeting was positioned as an opportunity to share information and address outstanding issues prior to the initiation of the study. In addition to A-CaP-specific discussions, a series of special lectures was also delivered as a means of providing international perspectives on the latest developments in prostate cancer and the use of databases and registration studies around the world.</P>

A Deep Belief Network and Dempster-Shafer-Based Multiclassifier for the Pathology Stage of Prostate Cancer

Kim, Jae Kwon,Choi, Mun Joo,Lee, Jong Sik,Hong, Jun Hyuk,Kim, Choung-Soo,Seo, Seong Il,Jeong, Chang Wook,Byun, Seok-Soo,Koo, Kyo Chul,Chung, Byung Ha,Park, Yong Hyun,Lee, Ji Youl,Choi, In Young Hindawi 2018 Journal of healthcare engineering Vol.2018 No.-

<P><B>Object</B></P><P> Pathologic prediction of prostate cancer can be made by predicting the patient's prostate metastasis prior to surgery based on biopsy information. Because biopsy variables associated with pathology have uncertainty regarding individual patient differences, a method for classification according to these variables is needed. </P><P><B>Method</B></P><P> We propose a deep belief network and Dempster-Shafer- (DBN-DS-) based multiclassifier for the pathologic prediction of prostate cancer. The DBN-DS learns prostate-specific antigen (PSA), Gleason score, and clinical T stage variable information using three DBNs. Uncertainty regarding the predicted output was removed from the DBN and combined with information from DS to make a correct decision. </P><P><B>Result</B></P><P> The new method was validated on pathology data from 6342 patients with prostate cancer. The pathology stages consisted of organ-confined disease (OCD; 3892 patients) and non-organ-confined disease (NOCD; 2453 patients). The results showed that the accuracy of the proposed DBN-DS was 81.27%, which is higher than the 64.14% of the Partin table. </P><P><B>Conclusion</B></P><P> The proposed DBN-DS is more effective than other methods in predicting pathology stage. The performance is high because of the linear combination using the results of pathology-related features. The proposed method may be effective in decision support for prostate cancer treatment.</P>

Primary Tumor Characteristics Are Important Prognostic Factors for Sorafenib-Treated Patients with Metastatic Renal Cell Carcinoma: A Retrospective Multicenter Study

Kim, Sung Han,Kim, Sohee,Nam, Byung-Ho,Lee, Sang Eun,Kim, Choung-Soo,Seo, Ill Young,Kim, Tae Nam,Hong, Sung-Hoo,Kwon, Tae Gyun,Seo, Seong Il,Joo, Kwan Joong,Song, Kanghyon,Kwak, Cheol,Chung, Jinsoo Hindawi Publishing Corporation 2017 BioMed research international Vol.2017 No.-

<P>We aimed to identify prognostic factors associated with progression-free survival (PFS) and overall survival (OS) in metastatic renal cell carcinoma (mRCC) patients treated with sorafenib. We investigated 177 patients, including 116 who received sorafenib as first-line therapy, using the Cox regression model. During a median follow-up period of 19.2 months, the PFS and OS were 6.4 and 32.6 months among all patients and 7.4 months and undetermined for first-line sorafenib-treated patients, respectively. Clinical T3-4 stage (hazard ratio [HR] 2.56) and a primary tumor size >7 cm (HR 0.34) were significant prognostic factors for PFS among all patients, as were tumor size >7 cm (HR 0.12), collecting system invasion (HR 5.67), and tumor necrosis (HR 4.11) for OS (<I>p</I> < 0.05). In first-line sorafenib-treated patients, ≥4 metastatic lesions (HR 28.57), clinical T3-4 stage (HR 4.34), collecting system invasion (univariate analysis HR 2.11; multivariate analysis HR 0.07), lymphovascular invasion (HR 13.35), and tumor necrosis (HR 6.69) were significant prognosticators of PFS, as were bone metastasis (HR 5.49) and clinical T3-4 stages (HR 4.1) for OS (<I>p</I> < 0.05). Our study thus identified a number of primary tumor-related characteristics as important prognostic factors in sorafenib-treated mRCC patients.</P>