複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.

Prostaglandin E₂의 子宮內 投與가 家兎의 卵集機能에 미치는 影響에 關한 實驗的 硏究

崔鏡淑,羅重烈,李壽鍾 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

Prostaglandin E₂의 子宮內 投與가 家兎의 卵巢機能에 미치는 影響에 關한 實驗的 硏究

崔鏡淑,羅重烈,李壽鍾 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

The effects of intra-uterine administration of Prostaglandin-E₂on the ovary and plasma steroid hormones were studied. Pseudopregnancy was induced in seven rabbits by the injection of 50㎍ of ethinyl estradiol and 100IU of hCG subcutaneously. And these seven pseudopregnant rabbits served as control group. In the prostaglandin-E₂ was implanted in uterus on Day seven under laparotomy and uterine incision with pentothal anesthesia. The plasma estrogen and progesterone level was determined by radioimmunoassay with three days interval in both control and prostaglandin=E₂ treated group. The uterus and ovaries were submitted to histologic study on Day 30. The following results were obtained; 1. Serum progesterone level in intra-uterine prostaglandin-E₂-implanted pseudopregnant rabbits was decreased at 14th day of pseudopregnancy, while the progesterone level of normal pseudopregnant rabbits was decreased from 15th day of pseudopregnancy and returned to normal values by 18th day. 2. Serum estrogen levels of pseudopregnant rabbit was higher than pretreatment state and returned to normal value by 30th day, while, in prostaglandin-E₂treated group, the serum estrogen values was decreased at 11th and 18th day below the level of pretreatment state and it was more decreased at 28th day. 3. The corpus luteum regresses from 15th day in control group, but in prostaglandin-E₂ Treated group, the corpus luteum was indistinct. The numbers of follicles in control group were 4-5 in number, while, in prostaglandin-E₂treated group, they were increased to 7-11 in number. The endometrium was papillary secretory patterns in control group, while, in prostaglandin-E₂ treated group, the endometrium was shown to have proliferative patterns.

급성 중독 환자에 대한 역학적 고찰 : 서울과 지방의 비교

김성중,김인병,최성욱,김경수,이영수,Choi, Jong Moo 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Study objective: To compare patients with acute poisoning between urban and rural areas Design: Retrospective chart review of 217 patients with acute poisoning Setting: Two University Hospital EDs Methods: patients were divided into two groups according to hospital. The group A was 109 patients who came to ED of Asan Medical Center and the group B was patients who came to ED of Ajou University Hospital from June 1994 to February 1995. We analysed the age and sex distributions, poisoning substances. causes of poisoning and the past history of psychiatric problems in patients of the two groups. Results: Total number of patients with acute poisoning were 109 in the group A and 108 in the group B. Female was more prevalent than male in the group A and male was more than female in the group B. There was a significant difference in sex distribution between two groups. The mean age of the group A was 27.7 years which was significantly different from the mean age of the group B, 33.7 years. The age incidences in both group were highest in 2nd decade. The accidental poisoning cases were 37% in the group A and 31% in the group B. The rates of committed suicide were 7% in the group A and 22% in the group B. The most common agent of poisoning was therapeutic drug in the group A and agricultural or industrial chemical in the group B. The overall mortality was 5% in the group A and 15% in the group B. Conclusion: There were significant differences in age and sex distributions. poisoning substances, causes of poisoning and the past history of psychiatric problems between two groups.

DEA 첨가 금속 Alkoxide를 사용한 PZT 박막의 제조 및 특성 평가

윤화중,임무열,구경완,최명진 충남대학교 기초과학연구소 1994 忠南科學硏究誌 Vol.21 No.1

Lead acetate trihydrate, zirconium iso-propoxide and titanium iso-propoxide used for the starting material to fabricate PZT coating solution. Iso-metoxy-ethanol used for the solvent of the starting material. Adding diethanolamine formed the chelate compound and prevented the hydrosis of coating solution. The coating sol solution is changed to M-O-M structure polymer gel by adding H_2O, and the polymer gel has the more strong bonding force. The cross-sectional SEM micrograph of PZT thin film showed that the metal of lower electrode was silicated with SiO_2 of buffer layer. The SIMS depth profile for PZT thin film indicated that the metal of lower electrode and silicon was diffused up to the upper part of PZT thin film. For the X-RD data of PZT thin film, the thin film on Pt substrate and with Ti buffer layer had strong perovskite phase. The PZT thin films measured by Sawyer-Tower circuit showed feroelectric characteristic representating D-E hysterisis curve. The remanent polarization and coercive field of the film was 1.92 C/㎠ and 33.3kV/㎝. I-V characteristic curve showed that the leakage currents and break down voltages of PZT thin films on Ni/SiO_2/Si, Ti/SiO_2/Si, Pt/SiO_2/Si substrate was 1.43 × 10 exp (-10) A/㎠, 1.19×10 exp (-10) A/㎠, 2.28×10 exp (-10) A/㎠ and 0.334 MV/㎝, 0.33 MV/㎝, 0.11 MV/㎝ each. C-V curve indicated dielectric constant 57 The resistance antiresonance frequency of PZT film was 612 ㎒, and the resistance was 14 ㏀ at that frequency.

Yamaguchi index에 의한 파라쿼트 중독 환자의 예후 결정

김인병,최성욱,김성중,김경수,이영수 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Study objective: To evaluate the significance of Yamaguchi index as a predictor of outcome in patients with acute paraquat poisoning Design: Retrospective chart review Setting: Two university Hospital EDs Methods: We reviewed the medical records of 47 patients with acute paraquat poisoning(18 survived and 29 died). The Eq1 was defined as : Eq1=[K+] x [HCO₃] / 0.088[Cre] mEq L¹ The patient's data were plotted as calculated Eq1 values(y-axis) against interval of time from ingestion to admission (T) (x-axis). The study patients were divided into three groups. Group A consisted of patients with Eq1> 1500-399LogT; Group B consisted of patients with Eq1: 930-399LogT < Eq1 ≤ 1500-399LogT; Group C consisted of patients with Eq1 ≤ 930-399LogT. Results: There was a significant difference among three groups (A, B and C) as far as prognosis was concerned(P<0.01). In group A, all patients survived(survival rate 100%). In group B, six of 13 patients survived(survival rate 46%). In group C, none of patients survived Isurvival rate 0%). Conclusion: Yamaguchi index is a significant predictor of outcome in patients with acute paraquat poisoning

CW Laser Annealing 과정중 SOS 상의 시간적 온도변화 측정에 관한 연구

고년규,윤희중,유동선,최원국,문경순 연세대학교 대학원 1987 延世論叢 Vol.23 No.1

The purpose of this experiment is to demonstrate the new method of TSRTM during CW Ar laser annealing using a He-Ne laser probe beam. Optical interference phenomena by a small changes of refractive index of Si, which is induced by the temperature change during short time laser annealing on the Si wafer surface, was used. The samples, SOS(Silicon on Sapphire), used in this work were epi. <100> Si grown on a <1012> insulator sapphire substrate with 2.0μm thickness. From the experimental temperature dependent equation of the refraction of index of Si with respect to the probe beam(λ=6328 Å) in furnace experiment, n(T)=3.98+7×10-4T (℃), the temperature on the destructtve or constructive interference was calculated. Incident Ar laser beam whose power ranges from 1.8W to 2.8W was irradiated and the effect of temperature rise of Si wafer on the elliptical spot whose major and minor axis is 200μm, 15μm respectively is investigated by the He-Ne laser probe beam which is focused 30μm. The annealing time ranges from 8 msec~250 msec to 500 msec~20 sec was adopted to estimate that the first constructive interference is occurred at least total irradiated power density 5.46×102Jㆍsec/cm2, and it is inferred that more than 180msec is needed for the first constructive interference when the total incident energy is 2.8 W. For the longtime annealing, about more than 1 sec, the interference pattern was coincided with the result produced by the furnace experiment. It is investigated from the space-resolved temperature gradient that the irradiated laser beam was focused in center.

고유함수전개법을 이용한 비대칭 유전체 원주공진기의 공진특성해석

류원열,민경호,장중호,전오곤,이창화,최현철 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

The resonant frequency of the dielectric rod resonator which is surrounded by cylindrical cavity can be calculated very exactly by using eigenfunction expansion method in the concept of electric and magnetic wall from the symmetry. But if the supporter is put in the cavity, the symmetry disappears. Thus this method has some errors. In this paper, the resonant frequency of the asymmetric dielectric rod resonator was calculated by using the eigenfunction expansion method. Also, the effect of the supporter was discussed. Then we found that the resonant frequency was more affected in the case of TM mode than TE or Hybrid modes as the length of the supporter was longer.

Effects of angiotensin receptor blocker at discharge in patients with heart failure with reduced ejection fraction: Korean Acute Heart Failure (KorAHF) registry

Choi, Ki Hong,Lee, Ga Yeon,Choi, Jin-Oh,Jeon, Eun-Seok,Lee, Hae-Young,Cho, Hyun-Jai,Lee, Sang Eun,Kim, Min-Seok,Kim, Jae-Joong,Hwang, Kyung-Kuk,Chae, Shung Chull,Baek, Sang Hong,Kang, Seok-Min,Choi, D Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.257 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>After introduction of up-titration strategy, there are limited data on comparison between the effects of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) in patients with heart failure with reduced ejection fraction (HFrEF). The study sought to investigate the association between treatment with ARB at discharge and clinical outcomes in patients with HFrEF compared with treatment with ACEI or no renin angiotensin system blocker (RASB).</P> <P><B>Methods</B></P> <P>The KorAHF registry is a prospective multicenter cohort and included patients who were hospitalized for acute heart failure (AHF). We studied 3005 patients with HFrEF (<40%), and divided into ARB (<I>n</I> =1190), ACEI (<I>n</I> =1090), and no RASB (<I>n</I> =725) groups. Propensity score matching was performed.</P> <P><B>Results</B></P> <P>All-cause death occurred in 346 patients (29.1%) in the ARB group, 315 patients (28.9%) in the ACEI group, and 305 (42.1%) in the no RASB group. After propensity score matching (ARB vs. ACEI, 827 pairs), there was no significant difference between the two groups in the rate of death (HR 0.91, 95% CI 0.76–1.09, <I>p</I> =0.32). All-cause death was significantly lower in the ARB group than in the no RASB group (ARB vs. no RASB, 538 pairs, HR 0.69, 95% CI 0.56–0.83, <I>p</I> <0.001). The ARB group had a significantly lower discontinuation rate than the ACEI group (20.8% vs. 33.6%, <I>p</I> <0.001).</P> <P><B>Conclusions</B></P> <P>For treatment of AHF with reduced EF after hospitalization, ARB at discharge shows a mortality benefit comparable to that of ACEI. In addition, tolerability of medication was greater for ARB than for ACEI.</P>