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문상호 ( Mun Sang Ho ),이수정 ( Lee Su Jeong ),송헌호 ( Song Heon Ho ),박영이 ( Park Yeong I ),김봉수 ( Kim Bong Su ),최영희 ( Choe Yeong Hui ),박영의 ( Park Yeong Ui ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Carcinoid tumor is the most commen tumor of appendix. Metastases from the appendecial carcinoid tumor is rare, and the prognosis of metastatic appendecial carcinoid tumors are closely related to the histologic findings. Atypical, aggressive metastatic car
최문영 ( Choe Mun Yeong ),송현주 ( Song Hyeon Ju ),김미연 ( Kim Mi Yeon ),이영숙 ( Lee Yeong Sug ),김승정 ( Kim Seung Jeong ),최규복 ( Choe Gyu Bog ),윤견일 ( Yun Gyeon Il ),강덕희 ( Kang Deog Hui ),박기덕 ( Park Gi Deog ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.2
Baclofen, a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), is used for the treatment of muscle spasm, intractable hiccups and multiple sclerosis. It is mostly excreted by glomerular filtration with a clearance that is proportional to creatinine clearance. Early hemodialysis is a treatment of the choice for baclofen-induced neurologic complication in renal failure patients. We experienced a 57-year-old hemodialysis patient with right arm muscle spasm who developed baclofen-associated encephalopathy by a single dose of oral baclofen (10 mg). He admitted to the hospital with the symptom of stuporous mental status with no specific focal neurologic signs. Brain CT imaging and blood biochemistry showed no specific abnormality. EEG revealed the typical metabolic encephalopathy findings, such as triphasic wave and frontal lobe syndrome with delta wave. After daily hemodialysis for 3 days, there was a complete recovery of an altered mentality. After one month later, the follow-up EEG showed normal finding with the resolution of abnormal waves. We report this case with a review of relevant literature. Baclofen should be used carefully, and rather recommended not to be administered in patients with renal failure. (Korean J Nephrol 2004;23(2):353-357)
일평균기온 특성에 따른 통일한국의 지역별 벼 생육기간 분포
최돈향 ( Choe Don Hyang ),김보경 ( Kim Bo Gyeong ),신문식 ( Sin Mun Sig ),남정권 ( Nam Jeong Gwon ),정진일 ( Jeong Jin Il ),김기영 ( Kim Gi Yeong ),오명규 ( O Myeong Gyu ),하기용 ( Ha Gi Yong ),고재권 ( Go Jae Gwon ),이재길 ( Lee 한국농림기상학회 2003 한국농림기상학회지 Vol.5 No.3
N/A This study was conducted to examine rice growth duration by analyzing agricultural climatic conditions at different latitudes in unified Korea. The climatic conditions of nine sites from Wunggi (latitude 42N) to Jeju (latitude 31N) were examined in this study. The rice growth duration of various cropping patterns was determined by analyzing consecutive days when effective daily mean air temperature was suitable for rice growth from the first seeding date to the last maturing date. The rice growth duration in Wunggi located in North Korea was available 138 days for machine transplanting, 115 days for direct seeding on dry paddy cultivation, and 97 days for direct seeding on a flooded surface with cultivation after seeding. On the other hand, the rice growth duration in Kwangju (latitude 35N) located in South Korea was 195 days for machine transplanting, 180 days for direct seeding on dry paddy cultivation, and 170 days for direct seeding on a flooded surface cultivation after seeding.
한국 전통간장 제조시 맥아첨가방법이 간장의 성분과 식미에 미치는 영향
최광수 ( Choe Gwang Su ),권광일 ( Kwon Gwang Il ),이종구 ( Lee Jong Gu ),이륜경 ( Lee Lyun Gyeong ),최종동 ( Choe Jong Dong ),유문균 ( Yu Mun Gyun ),임무혁 ( Im Mu Hyeog ),김기주 ( Kim Gi Ju ),홍영표 ( Hong Yeong Pyo ),안영순 ( An 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.3
Methods of adding barley malt as source of carbohydrates and enzymes in the production of kanjang in order to improve it`s tastes and qualities were investigated. Soybean meju, soybean-malt meju and soybean meju cum malt wat mashed with 20% salt brine in the ratio of 1 : 3 respectively, matured and analyzed the chemical compositions of the soy sauce mash samples for 150 days of maturing. Organoleptic evaluations for the matured soy sauce samples were done. The higher total nitrogen. TCA soluble nitrogen, O.D. at 500 nm, pure extract and lactic acid content could be observed with the toy sauce mash made of soybean-malt meju than those of contrail one from the beginning of the mashing throughout to the whole maturing period of 150 days. The higher the content of malt in the soybean-malt meju, the higher those content in the mash. But the lower content of those compositions in the soy sauce mash made of soybean meju cum malt than those in the contrast was found. The highest scores in all the sensory characteristics including 7.56 points, which were significantly different from that of contrast soy sauce 5% level, in overall palatability were obtained by the soy sauce made of soybean-malt meju added with 30% malt in the organoleptic evaluations.
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간암 조기진단을 위한 개인별 간암 발생 예측 모형의 유용성에 관한 전향적 연구
최종원 ( Choe Jong Won ),한광협 ( Han Gwang Hyeob ),정재연 ( Jeong Jae Yeon ),홍성필 ( Hong Seong Pil ),전재윤 ( Jeon Jae Yun ),문영명 ( Mun Yeong Myeong ),명성민 ( Myeong Seong Min ),송기준 ( Song Gi Jun ),김동기 ( Kim Dong Gi 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
조산 예측을 위한 IGFBP-1 (Insulin-like Growth Factor-binding Protein-1)의 유용성에 대한 연구
최준식 ( Choe Jun Sig ),양재혁 ( Yang Jae Hyeog ),류현미 ( Ryu Hyun Mee ),김문영 ( Kim Mun Yeong ),한정렬 ( Han Jeong Lyeol ),안현경 ( Ahn Hyun Kyung ),신중식 ( Sin Jung Sig ),김주오 ( Kim Ju O ),문명진 ( Moon Myoung Jin ),정진훈 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.7
목적 : 조기 자궁 진통은 제태 기간 37주 이전에 자궁 수축이 일어나는 것을 의미하며, 조산의 대부분의 원인이다. 본 연구의 목적은 조기 양막 파수가 없는 산모에서 자궁 경부의 IGFBP-1 (phosphorylated isoform)을 측정하여, phIGFBP-1의 수치 증가와 조산과의 연관성을 보고자 하였다. 연구 방법 : 환자는 2002년 4월부터 2002년 12월까지 삼성제일병원 산부인과에서 조기 자궁 진통으로 진단 받은 57명의 산모를 대상으로 하였으며, 대조군은 환자군과 제태 기간이 유사한 무증상의 산모 30명을 대상으로 하였다. 소독된 경 (speculum)을 사용하여 자궁 경부 염증에 대한 검사 및 dacron swab을 이용하여 phIGFBP-1의 정성 및 정량 분석을 하였다. 이때 nitrazine test를 사용하여 조기 양막 파수가 있는 경우를 제외하였다. phIGFBP-1의 정성 분석은 Medix Biochemica사의 rapid strip test를 사용하였다. 결과 : 조산은 환자군에서 7예가 있었으며, 대조군에서는 한예도 발생하지 않았다 (p=0.037) (Table 2). phIGFBP-1의 정성 분석상 양성이 30예, 음성이 39예이었다. 평균 phIGFBP-1 농도가 양성인 군이 63.5±81.2 g/L, 음성인 군이 1.2±3.7 g/L로 양성인 군이 통계적으로 의미 있게 높았다 (P<0.0001) (Fig. 1). 그러나 이 두 군간의 조산의 발생 빈도는 통계적인 차이를 보이지 않았다 (Table 3). phIGFBP-1의 정량 분석은 양성군에서 83.8±86.5 g/L, 음성군에서 2.1±5.0 g/L로 양성군에서 통계적으로 유의하게 phIGFBP-1의 높은 농도를 보였다 (Table 4). 본 연구 결과에 의하면 phIGFBP-1 검사 kit의 민감도 18.5%, 특이도 59.6%, 위양성률 40.3%, 위음성율 28.6%, 양성예측치 16.7%, 음성예측치 94.9%의 결론을 얻을 수 있었다. 결론 : phIGFBP-1 kit는 검사 결과 산정까지도 단시간에 이루어지며, 검사 방법 및 판독 또한 용이하여 향후 조산 예측의 한 도구로 도움을 줄 수 있으리라 생각된다. 비록 민감도와 특이도가 낮으나 본 연구에서 보인 phIGFBP-1의 높은 음성예측치는 조기 자궁 수축이 있는 산모에 대한 과잉 치료를 예방에 기여할 수 있고, 잠재적인 자궁 수축 억제제의 부작용 또한 낮출 수 있으리라 기대된다. 앞으로 많은 수의 연구가 축적되면 좀 더 낳은 결과가 나오리라 생각된다. Objective : This study is performed to assess whether detection of phosphorylated insulin like growth factor binding protein-1 (phIGFBP-1) in cervical secretions by a bed side test could be used to prediction preterm delivery in patient with regular uterine contraction. Methods : In our prospective study, 42 women between 20.2 and 36.4 weeks gestation with regular, persistent contraction (2-3/min for 30 min). and 27 women between 22.0 and 37.0 weeks of gestation without symptoms of preterm labor were assessed for presence of cervical phIGFBP-1. Dacron swabs were applied to the cervix and assayed in 5min by using immunochromatography, actim partus test (Medix Biochemica). Results : Of the 42 patients with regular uterine contractions, 22 had a positive actim partus test and 20 had a negative test. Among the 22 patients with positive test, 5 delivered preterm and other 17 patients delivered term (<37 weeks). Among the the 20 women with a negative test, 2 delivered preterm (NS). The mean concentration of phIGFBP-1 in 22 positive patients is 83.8±86.5 ㎍/L and that in 20 negative patients is 2.1±5.0 ㎍/L (P<0.0001) (Table 4). Sensitivity, specificity, false positive, false negative, positive predictive, and negative predictive values were 18.5, 59.6, 40.3, 28.6, 16.7, and 94.9%, respectively. Conclusion : The absence of cervical phIGFBP-1 is seems to be a valuable test in excluding preterm delivery in patients who have regular uterine contractions. The high negative predictive value in this study may enable physicians to prevent over treatment of patients with uterine contractions. Therefore, many unwanted side-effects and complications of potentially hazardous tocolytic therapy can be prevented.
좌우 기관지 모두에서 발견된 생선등뼈로 인한 폐쇄성 폐렴
최유진 ( Choe Yu Jin ),황원민 ( Hwang Won Min ),나문준 ( Na Mun Jun ),이원영 ( Lee Won Yeong ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Foreign body aspiration occurs rarely in adults. Aspiration of foreign bodies into tracheobronchial tree commonly occurs by accident, and in most cases they get removed without delay. Sometimes, however, small foreign bodies that lodge in the peripheral a