Estimating population density of Nicrophorus quadripunctatus (Coleoptera: Silphidae) in Korea

Kim Do‐Sung,Cho Young‐Bok,Han Yong‐Gu 한국곤충학회 2020 Entomological Research Vol.50 No.11

Estimating the population density of organisms is of great concern to ecologists and much effort has been put into making accurate assessment of population levels in nature. We evaluated the trapping web (TW) method for the determination of the density of species of burying beetles. We found eight and six species of burying beetles at Beopjusa and Ssanggok‐ri areas, respectively. Most of the species population comprised Nicrophorus quadripunctatus, with densities of 65 and 195 per ha for Beopjusa and Ssanggok‐ri areas, respectively. Moreover, the flight intercept trap (FIT) method from 2003 to 2007 also revealed the same trend: Beopjusa temple (2928) to Ssanggok‐ri (5835). However, the differences in number of individuals were probably due to the differences in the methods and the length of the trapping period. The populations of N. quadripunctatus exist as metapopulations, making accurate assessment of the population densities extremely difficult. We hypothesized that the TW method could accurately estimate population densities extrapolated from patch population size per area.

Rebuilding a Support System for Vulnerable Populations in Disasters - Lessons from USA and Japan -

Sung Soo Byun,Do Hyeong Kim,Jae Eun Lee,Jeong Il Na,Seong Cho,Ga Hee Kim 위기관리 이론과 실천 2018 Crisisonomy Vol.14 No.5

재난약자 및 재난 특성에 따라 여성가족부, 보건복지부, 행정안전부 등 소관 부처에 따라 개별적 정책 수립 및 지원이 이루어지고 있다. 또한 재난발생시 대응 및 복구 과정에서의 재난약자에 대한 지원 대책도 갖추고 있지 않다. 이에 이 연구는 재난약자에 대한 지원체계 개선 방안 제시를 목적으로 하고 있다. 또한 연구 목적 달성을 위해, 미국, 일본 등 재난관리 선진국의 재난약자 보호 및 지원을 위한 제도 및 체계를 비교분석하여 그 시사점을 찾고자 한다. 연구의 목적을 달성하기 위해, 이 연구는 우리나라의 재난약자 지원 현황을 분석하였으며, 외국의 재난약자 지원체계 사례를 분석하여 시사점 을 도출하였다. 이 연구는 해외사례에서 도출된 시사점을 바탕으로 우리나라의 재난약자 지원체계 개선을 위한 3가지 방안을 제시하였다. 첫째 법령체계 개선과 관련하여 재난약자 관련 대상 및 업무의 명확화와 지방자치단체의 재난약자 지원 관련 조례의 개선을 제시하였다. 둘째, 재난약자 피해경감을 위하여, 재난약자 신속 대피지원 강화, 재난약자 지원을 위한 공공 및 민간 조직간 협력 강화 등이 요구된다. 셋째, 노인, 장애인, 영유아 등에 따라 주관하는 부처 및 부서가 다르기 때문에 통합적 지원체계 구축에는 어려움이 있다. 이에 재난약자 지원체계는 재난약자 지원관련 계획 수립 및 교육은 각 개별기관에서 진행하며, 지원에 필요한 인력⋅예산⋅장비 등은 총괄기관에서 담당하는 방향으로 구축하는 것이 효율적일 것으로 판단된다. The policy design and implementation processes for vulnerable populations in disasters are scattered across various governmental agencies in Korea including the Ministry of Gender Equality and Family, the Ministry of Health and Welfare and the Ministry of Public Administration and Security, depending on the type of the vulnerable and the nature of the disaster. Moreover, there is no effective strategy to assist the vulnerable during the processes of disaster response and recovery. Therefore, this study aims to improve the support system for the victims of disasters in Korea by analyzing and comparing the U.S. and Japanese systems of protecting and supporting the vulnerable. Based on the lessons from the two countries, we analyze the current status of disaster support system in Korea and draw implications for policymakers and practitioners in Korea. In conclusion, the study suggests several measures to improve the support system for the vulnerable in Korea, including legal reform, organizational reconstruction, and clear identification of tasks and responsibilities among relevant government agencies.

STRUCTURAL AND FUNCTIONAL DIVERSITIES OF CALMODULIN ISOFORMS IN SOYBEAN

Cho, Moo Je,Lee, Sang Hyung,Kim, Jong Chul,Huh, Won Do,Hwang, Inhwan Plant molecular biology and biotechnology research 1994 Proceedings the 2nd Korean-Germany joint symposium Vol.1994 No.-

Real-Life Experience of Sofosbuvir and Ribavirin for Genotype 2 HCV Infected Korean Patients: A Multicenter Cohort Study

( Sung Won Lee ),( Hae Lim Lee ),( Nam Ik Han ),( Hee Yeon Kim ),( Chang Wook Kim ),( Chan Ran You ),( Sang Wook Choi ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We have evaluated the efficacy and safety of the sofosbuvir (SOF) and weight-based ribavirin (RBV) therapy in genotype 2 hepatitis C virus (HCV) infected Korean patients in real clinical settings. Methods: A total of 323 patients who received SOF plus RBV between May 2016 and February 2017 at the liver unit of the Catholic University of Korea were consecutively recruited and analyzed. Patients with chronic hepatitis and cirrhosis underwent 12 weeks and 16 weeks of antiviral therapy, respectively. The primary endpoint was sustained virologic response 12 weeks after the end of treatment (SVR12). Results: The mean age was 61.6±11.8 years and 36% of the patients were male. 238 (73.7%) patients had chronic hepatitis, 78 (24.1%) compensated cirrhosis, and 7 (2.2%) decompensated cirrhosis. 17 (5.3%) patients had a history of hepatocellular carcinoma treatment. 52 (16.1%) patients were treatment experienced (7 non-responders, 33 prior relapse, and 12 intolerable to interferon based treatment). 95.1% (293/308) of the patients achieved undetectable HCV RNA at week 4, 99.6% (255/256) end of treatment response and 96.6% (141/146) SVR12. No difference was observed according to age, previous treatment experience, viral load and cirrhosis (P>0.05). Overall, the SOF plus RBV regimen was well-tolerated but 4 patient discontinued treatment due to possible drug-related side effects. The most frequently observed adverse event was anemia and 15.9% (47/296), 5.4% (16/296) of the patients experienced grade 2 and grade 3 anemia, respectively. The doses of RBV were reduced to median 825mg and 577mg daily in grade 2 and 3 anemia groups, respectively but the SVR12 were 100% in both groups. Conclusions: Sofosbuvir and ribavirin regimen resulted in a high SVR rate and was tolerable in genotype 2 HCV infected Korean patients in real clinical practice.

Predominant Lactic Acid Bacteria from Salted Sea Food

Cho. Gyu-sung,Bae. Chae-Yun,Do. Hyung-Ki,Shin. Hyeun-Kil 한국축산식품학회 2005 심포지움 및 학술발표회 Vol.- No.36

Lactic acid bacteria are dominant microflora in many kinds of fermented foods. In this study, dominant microflora, especially lactic acid bacteria were isolated from salted sea food, and we determined physiological characteristics, and assayed specific property such as bacteriocin activity. The population of lactic acid bacteria as well as aerobic mesophilic counts was at the level of 10⁷ cfu /g. Total 17 strains of LAB were isolated from salted sea food sample. The phenotypic characteristics of these strains were determined followed by Bergey s Manual. And genotypic and bacteriocin activity were tested by Schillinger and Lucke⁽⁷⁾.

Conditioning with 10 Gy Total Body Irradiation, Cyclophosphamide, and Fludarabine without ATG Is Associated with Improved Outcome of Cord Blood Transplantation in Children with Acute Leukemia

Cho Hee Won,주희영,Hyun Ju Kyung,Lee Ji won,Sung Ki Woong,Koo Hong Hoe,Lim Do Hoon,Yoo Keon Hee 대한의학회 2021 Journal of Korean medical science Vol.36 No.19

Background: The optimal conditioning regimen in cord blood transplantation (CBT) needs to be determined. This study aimed to identify the impact of conditioning regimen on the outcome of CBT in children with acute leukemia. Methods: Medical records of patients with acute leukemia who received CBT were retrospectively reviewed. Results: A total of 71 patients were allocated into 2 groups; patients who received total body irradiation 10 Gy, cyclophosphamide 120 mg/kg, and fludarabine 75 mg/m2 were named as the TCF group (n = 18), while the non-TCF group (n = 53) included patients conditioned with regimens other than the TCF regimen. All patients in the TCF group were successfully engrafted, while 22.6% in the non-TCF group (n = 12) failed to achieve donor-origin hematopoiesis (P = 0.028). The incidence of cytomegalovirus diseases was 5.6% in the TCF group and 30.2% in the non-TCF group (P = 0.029). The 5-year overall survival rates of the TCF and non-TCF groups were 77.8% and 44.2%, respectively (P = 0.017). Conclusion: Patients conditioned with the TCF regimen achieved better engraftment and survival rates, less suffering from cytomegalovirus disease. Our data suggest that the TCF regimen is a preferred option for CBT in children with acute leukemia.

Prognostic significance of nuclear factor of activated T-cells 5 expression in non–small cell lung cancer patients who underwent surgical resection

Cho, Hyun Jin,Yun, Hwan-Jung,Yang, Hee Chul,Kim, Soo Jin,Kang, Shin Kwang,Che, Chengri,Lee, Sang Do,Kang, Min-Woong Academic Press [etc.] 2018 The Journal of surgical research Vol.226 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Nuclear factor of activated T-cells 5 (NFAT5) is known to be correlated with migration or invasion of tumor cells based on previous <I>in vitro</I> studies. The aim of this study was to analyze the relationship between NFAT5 expression and clinical prognosis in non–small cell lung cancer (NSCLC) patients who underwent surgical resection.</P> <P><B>Materials and methods</B></P> <P>A total of 92 NSCLC patients who underwent surgical resection were enrolled. The tissue microarray core was obtained from surgically resected tumor specimens. NFAT5 expression was evaluated by immunohistochemistry. Relationships of NFAT5 expression with disease recurrence, overall survival, and disease-free survival (DFS) were analyzed.</P> <P><B>Results</B></P> <P>The mean age of 92 patients was 63.7 y. The median follow-up duration was 63.3 mo. Fifty-one (55%) patients exhibited positive expression of NFAT5. Disease recurrence in the NFAT5-positive group was significantly (<I>P</I> = 0.022) higher than that in the NFAT5-negative group. NFAT5-positive expression (odds ratio: 2.632, 95% confidence interval: 1.071-6.465, <I>P</I> = 0.035) and pathologic <I>N</I> stage (<I>N</I>1-2 <I>versus N</I>0; odds ratio: 3.174, 95% confidence interval: 1.241-8.123, <I>P</I> = 0.016) were independent and significant risk factors for disease recurrence. DFS of the NFAT5-positive group was significantly worse than that of the NFAT5-negative group (89.7 <I>versus</I> 48.7 mo, <I>P</I> = 0.011). A multivariate analysis identified NFAT5 expression (<I>P</I> < 0.029) as a significant independent risk factor for DFS of patients with postoperative pathologic T and <I>N</I> stages (<I>P</I> < 0.001 and <I>P</I> = 0.017, respectively).</P> <P><B>Conclusions</B></P> <P>NFAT5 expression is a useful prognostic biomarker for NSCLC patients who underwent surgical resection.</P>

Continuing besifovir dipivoxil maleate versus switching from tenofovir disoproxil fumarate for treatment of chronic hepatitis B: Results of 192-week phase 3 trial

( Do Seon Song ),( Won Kim ),( Sang Hoon Ahn ),( Hyung Joon Yim ),( Jae Young Jang ),( Young Oh Kweon ),( Yong Kyun Cho ),( Yoon Jun Kim ),( Gun Young Hong ),( Dong Joon Kim ),( Young Kul Jung ),( Joo 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.2

Background/Aims: Besifovir dipivoxil maleate (BSV), an acyclic nucleotide phosphonate, shows potent antiviral activity against hepatitis B virus. Our previous 48-week trial revealed that BSV has comparable antiviral efficacy to tenofovir disoproxil fumarate (TDF) and better safety profiles in terms of improved renal and bone safety. This extension study evaluated the prolonged efficacy and safety of BSV in treatment-naive chronic hepatitis B patients. Methods: Patients continued to participate in an open-label BSV study after an initial 48-week double-blind comparison of BSV and TDF treatment. The antiviral efficacy and drug safety was evaluated up to 192 weeks in two groups: patients continuing BSV treatment (BSV-BSV) and patients switching from TDF to BSV after 48 weeks (TDF-BSV). Results: Among 197 patients receiving randomized treatments, 170 (86%) entered the open-label phase and 152 (77%) entered the 192-week extension study. Virological response rates over 192 weeks were 92.50% and 93.06% in the BSV-BSV and TDF-BSV groups, respectively (P=0.90). Hepatitis B envelop antigen seroconversion and alanine aminotransferase normalization rates were similar between the groups (P=0.75 and P=0.36, respectively). There were no drug-resistant mutations to BSV. Bone mineral density and renal function were well preserved in the BSV-BSV group, whereas these initially worsened then recovered after switching therapy in the TDF-BSV group. Conclusions: BSV maintained potent antiviral efficacy after 192 weeks and showed no evidence of drug resistance. BSV was safe, well tolerated, and effective in patients who switched from TDF to BSV. Trial Registration Number: NCT01937806 (date: 10 Sep 2013). (Clin Mol Hepatol 2021;27:346-359)

Comparison of four immunohistochemical tests and FISH for measuring Her2 expression in gastric carcinomas

Cho, Eun Yoon,Srivastava, Amitabh,Park, Kyeongmee,Kim, Jiyun,Lee, Min Hyeong,Do, Ingu,Lee, Jeeyun,Kim, Kyoung-Mee,Sohn, Tae Sung,Kang, Won Ki,Kim, Sung Elsevier Science B.V., Amsterdam 2012 Pathology Vol.44 No.3

Synthesis and characterization of fluorene-based copolymers containing siloxane or distilbene moieties on their main chain

Cho, Hoon-Je,Park, Moo-Jin,Hwang, Do-Hoon,Ahn, Taek,Hong, Ji-Won,Lee, Jonghee,Cho, Nam Sung,Shim, Hong-Ku Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of polymer science Part A, Polymer chemist Vol.47 No.6

<P>Two novel types of polyfluorene copolymers containing siloxane linkages or distilbene moieties on their main-chains were synthesized by Ni(0)-mediated Yamamoto coupling polymerization. These polymers, designated P2Silo05, P2Silo15, PF-P02, and PF-P05 were prepared by copolymerization between 2,7-dibromo-9,9′-dihexylfluorene and bis(bromobenzene)-terminated disiloxane monomer (for P2Silo05 and P2Silo15) or dibromodistilbene monomer (for PF-P02 and PF-P05). All of the polymers were highly soluble in common organic solvents such as chloroform, toluene, and p-xylene. The glass transition temperatures of the polymers were between 92 and 113 °C, and the decomposition temperatures for a 5% weight loss (T<SUB>d</SUB>) were above 420 °C for all of the polymers, demonstrating high thermal stability. The molecular weight (M<SUB>w</SUB>) of the polymers ranged from 4.2 × 10<SUP>4</SUP> to 8.8 × 10<SUP>4</SUP>. The blue shift of the maximum in the UV-visible absorption was greater in polymers with a higher molar percentage of siloxane linkages or distilbene moieties than in homo poly (dihexylfluorene) (PDHF). However, the photoluminescence spectra of the polymers were similar to those of PDHF in terms of the onsets and patterns. Single-layer light-emitting diodes were fabricated with a configuration of ITO/PEDOT:PSS/polymers/Ca/Al. The maximum electroluminescence emission wavelengths of the polymers were 425–450 nm, corresponding to pure blue light. The CIE co-ordinates of the polyfluorenes containing siloxane linkages or distilbene moieties ranged from (0.21, 0.21) to (0.17, 0.10), indicating deeper blue light than that of PDHF {CIE co-ordinates of (0.25, 0.29)}, with P2Silo15 giving the deepest blue-light {CIE co-ordinates of (0.17, 0.10)}. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 1595–1608, 2009</P> <B>Graphic Abstract</B> <P>We have synthesized two types of polyfluorene copolymers containing siloxane linkages or distilbene moieties on their main-chains. To the best of our knowledge, P2Silo05 and P2Silo15 are the first polyfluorene copolymers that contain siloxane linkages on their main-chains. Interestingly, the CIE coordinates of the polyfluorenes containing siloxane linkages or distilbene moieties ranged from (0.21, 0.21) to (0.17, 0.10), indicating a deeper blue light emission than that of PDHF {CIE coordinates of (0.25, 0.29)}. <img src='wiley_img/0887624X-2009-47-6-POLA23259-gra001.gif' alt='wiley_img/0887624X-2009-47-6-POLA23259-gra001'> </P>