Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants

Che´rif Rabhi,Guillaume Arcile,Le´on Cariel,Christine Lenoir,Je´rome Bignon,Joanna Wdzieczak-Bakala,Jamal Ouazzani 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.9

The three ayurvedic medicinal plants, Withania somnifera, Emblica officinalis, and Bacopa monnieri, were extracted by high-pressure static extraction using the Zippertex® technology. The extracts were mixed to reach quantifiable amounts of active compounds identified by high-pressure liquid chromatography-mass spectrometry (HPLC-MS) analysis. The mixture of extracts was incubated with resting cells of the fungus Beauveria bassiana ATCC 7159. The fermentation promoted the fluidization of the starting dense mixture, while HPLC monitoring evidenced the disappearance of glucogallin from E. officinalis extract and the concomitant increase in gallic acid content. Topical exposure of the chick embryo chorioallantoic membrane (CAM) to the nonfermented extract led to the extensive necrosis and destruction of the treated membrane. However, the fermented extract was shown to be free of any toxicity. Furthermore, compared with the untreated CAM, the fermented sample reduced CAM vascularization, suggesting its antiangiogenic potency. The innocuity of the fermented extract was demonstrated using the in vivo LD50 test, the morphological examination of internal organs of treated rats, as well as the evaluation of blood biomarkers of liver damage (aspartate aminotransferase and alanine aminotransferase). The fermented extract was developed as a nutraceutical antiangiogenic treatment of age-related macular degeneration and commercialized in an oral form named Ethnodyne-Visio™.

제주 우수 수영 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe the annual effect of training of periodically anaerobic and erobic motor ability for Che-Ju representive team of elementary, middle and high school athletes, first the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events, second individually fitness scientific analysis. prescription. proper management of athlete will be necessary to apply.

제주 우수 육상경기 선수들의 년중 훈련효과 분석 및 처방

김철원,임상용,김승곤,오만원,김성찬,이창준,남사웅,이세형,류재청 濟州大學敎 體育科學硏究所 1996 체육과학연구 Vol.2 No.-

The study was undertaken to analysis, evaluate, and prescribe t h e annual effect of training of periodically anaerobic and aerobic motor ability for Che-Ju representive team of elementary, middle and high school athletes. first. the performance can be obtained when it was prescribed proper training after analysis of physical fitness by each events. second, individually fitness. scientific analysis. prescription. proper management of athlete will be necessary to apply. In addition to physiology aspect, it is essential to consider sport biomechanics. sport psychology when we prescribe specific events and necessary approach in demension coach-athlete-researcher for individual.

의료소비자의 관계혜태 지각이 관계의 질 및 행동의도에 미치는 영향

허철선(Che이-Seon Heo),유광우(Kwang-Woo Yoo) 한국무역연구원 2014 무역연구 Vol.10 No.1

Medical institutions are important to develop and maintain enduring relationship with medical service conswners. So, this research aims to find out the effect of medical service conswners perception of relational benefits on relationship quality and behavioral intention. On the basis of the literature review, the research model is established. This research has been done through the survey utilizing medical service consumers in Gangwondo, and the effective 368 questionnaires are tested for the research model. The main findings are as follows. First, among 5 key dimensions of relational benefits, psychological, customization, economic, and information benefits except social benefits have significant effects on relationship satisfaction. Also, medical institutions type and medical service consumers type as moderating variables are included concurrently, and the significant differences are found in other 4 benefits except relationship between social benefits and relationship satisfaction. Second, relationship satisfaction relates positively to relationship commitment and behavioral intention. But the normative commitment, one of 3 key dimensions of relationship commitment, has no significant effects on recommendation to others. Third, the revisit intention has significant effect on recommendation to others. Finally, the findings reveal that the overall goodness fit index of the model is comparatively good and model set in this research is significant. At the end of the research, managerial implications, limitations and future research directions are suggested.

의료 화상을 위한 전처리 필터들의 특성에 관한 연구

강명아,최종주,정종필,정채영,정남채 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

There has been no fixed rule of pre-processing course required to do image processing that it was barely possible to find the proper pre-processing course, only to process with experience till now. In this paper, lots of application method of pre-processing algorithm, only available by the non-typified and experiential method, shall quantify and the algorithm method of algorithm according to the rule shall calculate the frequency of the value of each pixel gray level and the histogrm of the image. And then average it to all pixel number and finally set a high-ranking or optional % standardized by the average value in teh standard value. The result of a experiment showed the Median filter is superior to the Mean filter in all image of the smoothing filter. The sobel filter extracted feature. The laplacian filter presented sectional feature which not showed in original image.

정신지체인의 이직 영향 요인에 관한 연구

이채식 한국장애인고용촉진공단 고용개발원 2005 장애와 고용 Vol.15 No.1

The purpose of this study is pactically examine for the factors which number of seperation of people with mental retardation by the variables which related to factors of seperation was divided general characteristics, conceptual skills, social skills, vocational skills, social supports. Here is summary of the important study findings. Firstly, the differences which number of the seperation by the general characteristics of people with mental retardation are found. The each variables which number of the seperationthe lower are found. Those are the older age, the disability level 2, the type of housing which the boarding house, the lower or higher average monthly wage, the type of vocational rehabilitation program which the pre-employment is the public vocational training, the existence of jod coach. Secondly, In order to examine the factors of the number experience seperation of people with mental retardation, the hierarchical logistic regression analysis is used. The each variables whice number of the experience seperation the lower are found. Those are the higher daily living ability, the better vocational living attitudes, the better vocational activity characters. This study findings have several practical implications. Firstly, the vocational rehabilitation services in pre-employment for workers with mental retardation have to be run with a focus on the occupational skills. Secondly, the vocational rehabilitation programs focused on the actual(company) work tasks. 본 연구는 정신지체인의 이직경험횟수에 영향을 주는 요인을 살펴보기 위해서 이직요인과 관련된 변인을 일반적 특성, 개념적 기술, 사회적 기술, 직업적 기술, 사회적 지지로 구분하여 이직경험횟수에 영향을 주는 요인을 분석해 보았다. 주요한 연구결과를 요약하면 다음과 같다. 첫째, 정신지체인의 일반적 특성에 따른 이직경험횟수의 차이는 연령이 높을수록, 장애등급이 2급일수록, 주거형태가 기숙사일수록, 직종이 단순생산직일수록, 평균임금이 낮거나 높을수록, 입사전 직업재활프로그램 유형이 공공직업훈련일수록, 작업지도원이 배치되어 있을수록 이직경험횟수가 각각의 변인에서 낮게 나타났다. 둘째, 정신지체인의 이직경험횟수에 영향을 미치는 요인을 밝히기 위해 다중회귀분석을 실시한 결과, 직업생활태도와 직업생활태도와 직업적 행동특성이 좋을수록 이직경험횟수가 낮은 것으로 나타났다. 이상의 연구결과를 통하여 얻을 수 있는 실천적 함으로는 첫째, 정신지체근로자의 이직을 최소화하기 위한 취업 이전의 직업재활서비스는 직업적 기술 중심의 프로그램이 운영되어야 하고, 둘째, 현장(사업체) 직무중심의 직업재활 프로그램이 제공되어야 한다. 이와 같은 결과에서 보면 현장의 직무중심의 직업재활이 중요함을 알 수 있다.

OSS 게이트웨이의 보안 요구사항

안치홍,석승학,성열옥,한근희,정자욱 공주대학교 생산기술연구소 2002 論文集 Vol.10 No.-

OSS systems that are represented by the carrier preselection and number portability services con no longer be operated by themselves in their own domains since the freedom and various changes in electronic commerce require the interconnections between the heterogeneous OSS systems. However, since the cost of direct internonnections of OSS systems is so enormous we must consider the use of OSS gateways to interconnect heterogeneous OSS systems. In this research, we analyze the security weakness for interconnecting OSS systems throught gateways and suggest the security requirements for the OSS gateway.

방언 연구의 의의에 대하여

정제문 順天大學校 師範大學 附屬 科學敎育硏究所 1996 科學과 敎育 Vol.4 No.-

In introductory remarks, we seldom meet with argumentations about the purpose of dialectology. They are usually centered upon the usefulness of dialect data for the description of language development from the viewpoint of the historical comparative linguistics. Aside from the topics so far, the writer in this paper aims to discuss the significance of studying dialects in the age of local autonomy especially from an epistemological point of view. As a result of his investigation over dialect phenomena, he insists that dialects should be educated as a means of expelling the evil motto of 'both-sides wrong' from our society.

신발 힐의 높이에 따른 보행자세의 운동역학적 분석

류재청,안성규 濟州大學敎 體育科學硏究所 1997 체육과학연구 Vol.3 No.-

This study was conducted to discover the maost desirable height for shoe heels. An analysis of human kinematics and gaits according to different kinds of shoe heel heights was carried out. Walking, which is related to the locomotor and nervous systems, is different from running. It has some unique characteristics such as the double-supporing phase and the pelvis-centered smooth connections with tension and flexion which can make it possible to walk comfortably. The specific goals of this study are as follows: 1. To analyze the variables of gait cycles with respect to shoe heel height. 2. To analyze the variables of linear kinematics with respect to shoe heel height. 3. To analyze the variables of anguiar kinematics with respect to shoe heel height. 4. To discover the ideal heel height to promote a comfortable walking style. Limits of this study: 1. The processes of BSP and Yeadon-kwon were used. 2. The shoe heel heights investigated were 1. 0 cm(ie: bare foot) 2. 3cm 3. 5cm 4. 7cm 3. The equipment used in this experiment comprised of : a Panasonic VCR: VCR analyzer and analysis program: a Kwon "3D Mothion Anaysis" package. 4. The subjects of this experiment were 3 female collage students who are not used to wearing high heeled shoes: all are aerobics instuctors. with an exellent sense of equilibrium. The model of the human body is defined as a rigid body system connected by 19 jonts(for the purpose of this experiment the nose included as an imaginative joint to give precise direction). In order to reduce any displacement which may occur during didgitization. Iandmarkers were attatched to each of the 19 body segments of each subject. The subject were then asked to walk firstly in bare feet and then wearing shoes with a 3cm, 5cm, and then 7cm heel. A video camera zoom lens was used to record the subjects' walking patterns(RTD-LTO-LTD-RTO-RTD) for one complete gait cycle and the direction of the subject was defined wsing X and Y axes. After the digitization and interpolation of all frames the linear and angular variables which are necessary for the study were calculated. The results of this study are as follows: 1. The time taken to complete one gait cycle increases or decreases by a negligable amount as heel heights vary. It appears that the higher the heel is, the longer the length of each stride will be and the greater the horizontal displacement at the center of the body. 2. When a higher heel is worn vetical displacement is increased during the initial phaze of each gait cycle however when a lower heel is worn. vertical displacement is increased in the final phaze of the gait cycle. 3. The average horizontal speed of each phase increases, regardless of the height of the heel. 4. The vertical speed decreases. regardless of heel height in any gait cycle, the speed decreases with each consecutive phaze eg: in a cycle consisting of :RTD-LTO-LTD-RTO-RTD. the initial phaze from RTD to LTO will the fastest movement in the cycle. the speed will decrease with each concecutive phaze in the cycle. The second phaze of the gait (LTO to LTD) will be slower than the first, and the the final phaze (LTD to RTO to RTD) being the slowest in the cycle. (Overall. the rate of decrease in speed in the last the last phaze of any gait cycle is always slower than the decrease of the first two phazes. therefore we can put the last two phazes together to make one final phaze (LTD-RTO-RTD) as the decrease in speed is so small.) 5. For each motion variable, the difference in tension and flextion of lower body joints is not apparent, using any heel height. The tension and flextion in the shank and thigh is negligable with a 5cm or 7cm heel. The tension and flextion is the most apparent when using a 3cm heel. 6. The walking speed changes little according to heel height alterations. The common outcome is that there is a slow increase in speed after the LTO phase, so that when supporting body weight on the right foot, it is very hard to move on to a new 'centered' body weight position. No problem appears when using a 3cm-heel. however when walking bare foot. there is more pressure on L5 and on S1 than with a 3cm-heel. this is because walking is a forward-motion and the center of the body is left behind when walking bare foot. In conclusion, it is the 3cm-heeled shoe that is the most suitable height to promote a comfortable forward walking motion.

Micro-sociology의 건축적 적용에 관한 연구

林采震 홍익대학교 산업기술연구소 1994 産業技術 Vol.4 No.-

Based on the theory of sociometry, which initiated by Moreno, this study explore the possibility of expanding the theory into utilization in architectural planning. Because the main concern of the study is human behaviors in the institution setting. the patient area of a hospital has been chosen. After observations of the patient area (i.e single two-persons fur- six- and larger ward) some of the findings are as follows. 1) Social interactions are most frequent within the ward 2) Inter -ward interactions are influcened by distance and 3) Gender and social background in the group significantly interfere the interactions. The study, therefore, concludes that the size of ward and the characteristics of group significantly affects the human behaviors.