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이정호,이기철,최미 인제대학교 1998 仁濟醫學 Vol.19 No.2
Clozapine은 기존의 항정신병약물과 달리 추체외로 부작용이 적고 음성증상에 효과적이기 때문에 그 사용이 증가하고 있는 추세이다. 반면에 치명적인 무과립구증 등의 부작용 때문에 엄격한 관리 지침과 제한된 적응증이 요구된다. 이런 관점에서 clozapine을 어떤 이유에서든 과량 복용하는 경우에는 심각한 문제가 대두될 수 있다. 저자들은 국내에서 아직까지 보고된 바 없는 clozapine으로 자살 기도를 한 여자 환자에서 급성 중독의 증상을 치험한 바 문헌고찰과 함께 보고한다. There is a increasing tendency to use clozapine which have low extrapyramidal symptom side effects and effectiveness on the negative symptoms of schizophrenia as compared with conventional antipsychotics. But there is need for strict managements of monitoring and limited indications for the prevention of serious side effect such as fatal agranulocytosis. According to that point, the overdose of clozapine is a serious problem for any reason. We report a case of acute toxicity induced by clozapine overdose in suicidal atempted 23-year-old female with review of the literature.
이정호,이기철,최영민,전성일 인제대학교 1996 仁濟醫學 Vol.17 No.4
주정 의존 환자 및 배우자를 대상으로 이들의 인격 특징과 특성이 어떤 관계를 보이는지 알아 보고자, 45명의 주정 의존 환자와 15명의 배우자에게 16 Personality Factor Questionnaire를 실시하였다. 주정 의존 환자들은 그들의 배우자보다 자아 강도가 약하고, 소심하고, 사변성을 보이며, 자책감을 많이 느끼는 인격 특징을 보이며, 인격 특성은 강한 불안과 높은 진보성이 결여된 창의력을 보임을 알수 있었다. The authors administered the Korean-standardized Cattell's 16 Personality Factors Questionnaire to the 45 patients with alcohol dependence and to their 18 spouses. In first stratum source traits, the patients with alcohol dependence showed more significant C-factor(low ego strength), H-factor(shyness), M-factor(Autia), and O-factor (guilt pronness) than those of their spouse. In second stratum source traits, the patients with alcohol dependence showed more significant ANX-factor (high anxiety) and CRE-factor (high creativity) than those of their spouse. The above findings suggest that the patients with alcohol dependence have intense anxiety and creativity that are not progressive. Also, they have personality characteristics such as low ego strength, boldness, autia, guilt-proneness.
유전학의 시선으로 본 사람과 언어 : 한국인과 동북아시아의 인족과 언어
이정호 부산대학교 인문학연구소 2008 코기토 Vol.- No.64
Genetic gaze that regards peoples and languages of Homo sapiens in a special way is dependent upon the multi-disciplinary context constructed not only by many fields of the modern life science, especially population genetics, but also by those of the humanities and social science. Firstly, it gives due attention to the human history recorded in the human DNA and genome, which can be decoded by the molecular experiments. The genetic gaze regards an ethnic group as a population of individuals who, in general, outbreed each other, but display variable marriage patterns either locally or historically. Every ethnic group has worldwide and local migration-settlement history. Languages differentiate by way of geographical divergence between two isolating human populations. However, language replacement often occurs by mobile ethnic groups like nomads. In the genetic gaze, language capability is a polygenic trait that has been adopted by the species of Homo sapiens. From the integrative perspective based upon the recent archaeological findings, the hypothesis proposed by a great linguist of the Altai language family, and the human migration-settlement history and population genetics of the Northeast Asia, the people and language of Korea are likely to have derived from the population who spoke the proto-Altaic language during the Neolithic culture about 7~8000 years ago, the first in the whole Northeast Asia. They have migrated to and settled in the plain located in the southern part of the Great Hsinganring Mountains that runs from the northeast to the southwest, ranging from the eastern Mongolia to the Inner Mongol and Western Liaoning region in China. This genetic gaze that may provide more definitive clues to the genetic and linguistic relationships among the peoples and languages in the Northeast Asia, including Korean and Manchus, encourages more systematic multi- disciplinary approaches based on human population genetics in the near future.