Impact of attachment, temperament and parenting on human development

홍유라,박재선 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.12

The purpose of this review is to present the basic concepts of attachment theory and temperament traits and to discuss the integration of these concepts into parenting practices. Attachment is a basic human need for a close and intimate relationship between infants and their caregivers. Responsive and contingent parenting produces securely attached children who show more curiosity, selfreliance,and independence. Securely attached children also tend to become more resilient and competent adults. In contrast, those who do not experience a secure attachment with their caregivers may have difficulty getting along with others and be unable to develop a sense of confidence or trust in others. Children who are slow to adjust or are shy or irritable are likely to experience conflict with their parents and are likely to receive less parental acceptance or encouragement,which can make the children feel inadequate or unworthy. However,the influence of children’s temperament or other attributes may be mitigated if parents adjust their caregiving behaviors to better fit the needs of the particular child. Reflecting on these arguments and our childhood relationships with our own parents can help us develop the skills needed to provide effective guidance and nurturance.

고용량 Ara-C를 기조로 한 소아 급성골수성백혈병 환아의 치료

홍유라,이보영,이정현,강지혜,박재선,김미향 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

목적: 급성골수성백혈병 환아들에 대한 치료성적을 향상시키기 위화여 단일기관에서 진료한 환아들의 임상적 특징, 치료 성적을 분석하였다. 방법 : 1991년 8월부터 2001년 9월까지 고신대학교 복음병원에서 치료받은 급성골수성백혈병 환아 16례의 말초혈액소견, 골수검사소견, 치료, 사인, 관해율과 생존율을 후향적으로 분석하였다. 결과 : 1. 급성골수성백혈병 소아 12례 중 8례에서 변형 Capizzi-Denver 항암요법(고용량 Ara-C, Adriamycin, L-asparaginase, Etoposide, Thioguanine, Dexamethasone)을, 4명에서는 "DCTER 항암요법" (Dexamethasone, Cytarabine, Thioguanine, Etoposide, Rubdomycin)으로 치료하였다. 2. 치료를 받았던 환아 12명 중 9명에서 관해되어 관해율은 75%(9/12)였으며 6년 무사고 생존율은 19%(3/16)이나 일단 관해된 환자에서 6년 이상 재발없이 관해를 유지했던 환자의 비율은 25%(n=12. 3 in CCR) 였다. 3. 변형 Cappizzi요법을 받았던 8명의 환아만을 대상으로 보면 관해율은 100%였으며 6년 무재발 생존율은 37.5%(3/8)였다. 4. 사망한 13례의 주된 사인은 치료 전 진행된 암에 의한 DIC 1례, 치료 전 뇌출혈 1례, 진단 즉시 치료거부 2명, 치료 중 종양용해증후군 1례, 카테타 심장삽관 중 심정지 1례, 치료 중 자의 중단 1례, 관해 후 재발 2례, 관해 후 패혈증 2례, 말초자가 조혈모세포이식 과정에서 수혈 후 폐부종 1례, 장염 1례였다. 결론 : 치료 초기부터 고용량 Ara-C를 사용하는 "변형 Capizzi-Denver요법"의 관해율, 치료독성은 기존 치료법들과 비슷한 수준이며, 생존 환자가 적어 치료 성적의 비교가 곤란하나 향후 더 많은 환자를 대상으로 한 연구가 요망된다. Purpose: To improve the survival of children with acute myelocytic leukemia(AML), retrospective evaluation of treatment results was made in a single institution. Methods: From August 1991 to September 2001, 16 children with AML diagnosed at Kosin University Collage of Medicine were analysed in terms of remission, survival and cause of death. Twelve of the 16 patients were applicable to an induction and postremission chemotherapy with "modified Capizzi-Denver regimen" (Cytarabine, Adriamycin, Dexamethasone, L-asparaginase, Etoposide, Thioguanine) or "DCTER regimen" (Dexamethasone. Cytarabine, Thioguanine, Etoposide, Rubdomyein) Results: 6-year event free survival by Kaplan Meier estimation was 19%. 9 of 12 treated patients responded to the induction therapy and the probability of remaining in first remission was 33%. All patients in "modified Capizzi-Denver regimen" remitted (8/8) and 3 of them have been survived more than 6 years. Conclusion: Although the number of patients was small, some of the patients with AML achieved long term survival with "modified Capizzi-Denver regimen without severe toxicity and need study with more patients.

초극소 저체중 출생아에서 발생한 기관 삽관 후 기관지 천공

홍유라 대한신생아학회 2012 Neonatal medicine Vol.19 No.3

Bronchial injury is a rare and serious complication of endotracheal intubation in neonates. Bronchial perforation following tracheal intubation causes a high-volume air leak mimicking pneumothorax and pneumomediastinum, and it may result in intraventricular hemorrhage, mediastinitis and sepsis. I report my experience of diagnosing a main bronchial perforation in an extremely low birth weight infant, who had a high-volume air leak following tracheal intubation, which persisted after chest tube insertion.

초극소 저체중 출생아에서 cytomegalovirus 패혈증 이후에 나타난 중추성 요붕증

홍유라 대한신생아학회 2012 Neonatal medicine Vol.19 No.3

I report a case of extremely low birth weight infant, who presented central diabetes insipidus associated with cytomegalovirus infection. His brain magnetic resonance imaging showed a flattened pituitary gland, and demonstrated a lack of posterior pituitary hyperintensity. It successfully managed with oral desmopressin (Minirin®) and persisted beyond the resolving of symptomatic cytomegalovirus infection.

고용량 Ara-C를 기초로 한 소아 급성골수성백혈병 환아의 치료

홍유라,이보영,이정현,강지혜,박재선,김미향 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1

Purpose : To improve the survival of children with acute myelocytic leukemia (AML), retrospective evaluation of treatment results was made in a single institution. Methods : From August 1991 to September 2001, 16 children with AML diagnosed at Kosin University College of Medicine were analysed in terms of remission, survival and cause of death. Twelve of the 16 patients were applicable to an induction and postremission chemotherapy with "modified Capizzi-Denver regimen" (Cytarabine, Adriamycin, Dexamethasone, L-asparaginase, Etoposie, Thioguanine) or "DCTER regimen" (Dexamethasone, Cytarabine, Thioguanine, Etoposide, Rubdomycin). Results : 6-year event free survival by Kaplan Mejer estimation was 19%. 9 of 12 treated patients responded to the induction therapy and the probability of remaining in first remission was 33%. All patients in "modified Capizzi-Denver regimen" remitted (8/8) and 3 of them have been survived more than 6 years. Conclusion : Although the number of patients was small, some of the patients with AML achieved long term survival with "modified Capizzi-Denver regimen" without severe toxicity and need study with more patients.

Clostridium difficile B 독소 유전자 직접검출법에 의한 항생제 연관 설사증과 위막성 대장염의 진단

홍유라,정석훈,김경보,이상호,최경현,박선자,박무인,전병찬 대한감염학회 2003 Infection and Chemotherapy Vol.35 No.5

Statins as a possible factor affecting fluoroquinolone resistance of coagulase-negative Staphylococcus in the conjunctiva: a case-control study

홍유라,Oh Chi Eun,이상준 고신대학교(의대) 고신대학교 의과대학 학술지 2024 고신대학교 의과대학 학술지 Vol.39 No.2

Background: Conjunctival bacterial flora is a common cause of endophthalmitis after ophthalmic procedures. This study investigated the conjunctival bacterial flora, especially coagulase-negative Staphylococcus (CoNS), and their antibiotic sensitivity in patients who underwent ophthalmic procedures. Factors related to fluoroquinolone resistance were also investigated.Methods: In total, 167 samples were analyzed from 135 patients who underwent cataract surgery or intravitreal injection at Kosin University Gospel Hospital between April 14, 2014, and September 29, 2016. Bacterial identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry or VITEK 2 equipment. Antibiotic sensitivity tests were performed using an AST-P600 card with VITEK 2 equipment. Clinical information was extracted from patients’ medical records. Sixty-eight individuals with conjunctival flora containing CoNS were classified into the fluoroquinolone-sensitive and fluoroquinolone-resistant CoNS groups, and their characteristics were compared. Results: A total of 192 isolates of Gram-positive bacteria were identified, including Staphylococcus epidermidis (33.3%), Corynebacterium spp. (18.8%), and CoNS other than S. epidermidis (9.2%). Of the 106 CoNS isolates, 68.9%, 69.8%, and 58.5% were sensitive to ciprofloxacin, levofloxacin, and norfloxacin, respectively. In patients with CoNS, statin use within 3 months before sample collection was significantly associated with fluoroquinolone resistance (p=0.016). Statin use was a significant risk factor for fluoroquinolone resistance in multivariate logistic regression analysis (odds ratio, 4.86; 95% confidence interval, 1.25–18.91; p=0.022).Conclusions: CoNS, including S. epidermidis, was the most common conjunctival bacterial flora, with a fluoroquinolone sensitivity rate ranging from 58.5% to 69.8% in patients undergoing ophthalmic procedures. Statin use was a significant risk factor for fluoroquinolone resistance.

피부 백혈병을 동반한 선천성 급성 골수성 백혈병 1례

홍유라,김미향 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Congenital leukemia is a rare disease developing within the first 4 to 6 weeks of life. Specific cutaneous leukemic infiltrates occur in 25% to 30% of infants with congenital leukemia and usually appear as firm blue, red, or purple nodules in a generalized distribution. We report a male term leukemic patient who presented with multiple skin nodules of reddish to purple color on the trunk and extremities. Skin biopsy revealed hematopoietic cells and acute monoblastic leukemia(M5 in FAB) was diagnosed by subsequent bone marrow aspiration. The skin lesion was completely disappeared after one cycle of chemotherapy with cytarabine, daunorubicin, etoposide, and dexamethasone, while the fraction of blasts remain unchanged.

초극소 저체중 출생아에서 회음부 궤양을 동반한 혈관종 치료경험 1례

홍유라 고신대학교 의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Hemangiomas represent the most common benign tumor of infancy, with ulceration its most frequent complication. I experienced a case who was extremely very low birth weight infant(born at 25 weeks gestation, 670 g) and had a ulcerated perineal hemangioma. Ulcerated hemangiomas in the perineal area are usually very painful and distressing for the infant and secondary infection is common. But no one uniformly effective treatment modality was found and their potential side effects in infant are not known. Without specific therapeutic modalities(corticosteroids, interferon alfa-2a and flashlamp pulsed-dye laser), I treated with local wound care(occlusive dressings) and management of infection. After 8 weeks of treatment, the ulcer was healed.

Reliability and validity of free software for the analysis of locomotor activity in mice

홍유라,문은수 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.1

Background: Kinovea software that tracking semi-automatically the motion in video screen has been used to study motion-related tasks in several studies. However, the validation of this software in open field test to assess locomotor activity have not been studied yet. Therefore, this study aimed to examine the reliability and validity of this software in analyzing locomotor activities. Methods: Thirty male Institute Cancer Research mice were subjected in this study. The results examined by this software and the classical method were compared. Test-retest reliability and inter-rater reliability were analyzed with Pearson's correlation coefficient and intraclass correlation coefficient (ICC). The validity of this software was analyzed with Pearson's correlation coefficient. Results: This software showed good test-retest reliability (ICC=0.997, 95% confidence interval [CI]=0.975- 0.994, p<0.001). This software also showed good inter-rater reliability (ICC=0.987, 95% CI=0.973-0.994, p<0.001). Furthermore, in three analyses for the validity of this software, there were significant correlations between two methods (Pearson's correlation coefficient=0.928-0.972, p<0.001). In addition, this software showed good reliability and validity in the analysis locomotor activity according to time interval. Conclusion: This study showed that this software in analyzing drug-induced locomotor activity has good reliability and validity. This software can be effectively used in animal study using the analysis of locomotor activity.