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원발성 비장 혈관성 병변: 40증례의 임상병리학적, 면역조직화학적 소견과 영상의학 소견과의 비교 분석
허주령,고영화,이희진,최가원,권귀영,김은주 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.5
Background : Primary splenic vascular lesions include the tumor and the inflammatory condition. A primary splenic vascular tumor is rare but is the most common tumor of the benign primary splenic tumors. Methods : We describe the clinicopathological, radiological, and immunophenotypical findings of 40 cases of primary vascular lesions identified at our hospital from 1996 to 2009. Results : The patients included 18 men and 22 women, aged 12 to 74 years, with a mean of 43.3-years and median of 40-years. They comprised 14 hemangiomas (35%), 13 lymphangiomas (32.5%), three hamartomas (7.5%), three littoral cell angiomas (7.5%), three sclerosing angiomatoid nodular transformations (SANT, 7.5%) and four angiosarcomas (10%). The majority of the patients (65%) were asymptomatic. Some of the patients (32.5%) complained of abdominal pain, and 2.5% of the patients presented with fever. Metastases were identified in 75% of the patients with an angiosarcoma at the initial work-up. One angiosarcoma patient died of the disease despite adjuvant chemoradiotherapy. The radiological findings for hamartoma, littoral cell angioma, and SANT were nonspecific. Microscopically, six types of vascular lesions showed classic morphological and immunophenotypical features of their type. Conclusions : One should be aware of rare splenic vascular lesions when radiological findings are nonspecific. Histomorphological and immunophenotypical features are helpful for the differential diagnosis.
Epidemiologic overview of malignant lymphoma
허주령 대한혈액학회 2012 Blood Research Vol.47 No.2
Malignant lymphoma encompasses a wide variety of distinct disease entities. It is generally more common in developed countries and less common in developing countries. The East Asia region has one of the lowest incidence rates of malignant lymphoma. The incidence of malignant lymphoma around the world has been increasing at a rate of 3-4% over the last 4 decades, while some stabilization has been observed in developed countries in recent years. The reasons behind this lymphoma epidemic are poorly understood, although improving diagnostic accuracy, the recent AIDS epidemic, an aging world population and the increasing adoption of cancer-causing behaviors are suggested as contributing factors. Etiologies of malignant lymphoma include infectious agents, immunodeficiency, autoimmune disease, exposure to certain organic chemicals, and pharmaceuticals. The distribution of many subtypes exhibit marked geographic variations. Compared to the West, T/natural killer (NK) cell lymphomas (T/NK-cell lymphoma) and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are relatively more common, whereas other B-cell lymphomas, particularly follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, are less common in Asia. Some subtypes of T/NK-cell lymphomas defined by Epstein-Barr virus association are predominantly Asian diseases, if not exclusively so. Both ethnic and environmental factors play roles in such diversity. In this review, we discuss the geographic distribution and etiology of malignant lymphoma, as well as the trend.
김용만,남주현,김재익,김영탁,목정은,김경진,허주령 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.2
Embryonal carcinoma is an uncommon neoplasm of germ cell origin which usually arise in the ovary. Embryonal carcinoma is closely related to endodermal sinus tumor(EST) and was seperated from this grup of tumor by Kurman and Norris. In addition to the charicteristic histological and immunohistological features, embryonal carcinoma was reported to have a prognosis which is better than EST. We experienced one case of embryonal carcinoma of the ovary and report with a brief review of the literature.
피부 원발성 CD 30 양성 림프구증식 질환 1예 : 림프종양 구진증과 악성 림프종의 중간형 Borderline case
장성은,허주령,문기찬,성경제,최지호,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3
Primary cutaneous CD30-positive large cell lymphoma and lymphomatoid papulosis; both entities are characterized by CD30-positive large atypical cells predominantly of T cell origin. We report a borderline case between CD30-positive large cell lymphoma and lymphomatoid papulosis in a 57-year-old woman presenting as a spontaneous disappearing and recurrent solitary erosive nodule on the right upper eyelid. Histopathological findings of two biopsies from each lesion showed mixed CD30-positive large atypical cells, many eosinophils and neutrophils histologically. The nodule disappeared after chemotherapy and subsequent radiotherapy. She is well without recurrence for a follow-up of 9 months.