제4발표 : 안전한 방사선치료를 위한 리스크 관리

한영이 대한방사선방어학회 2019 대한방사선방어학회 학술발표회 논문요약집 Vol.2019 No.11

Current status of proton therapy techniques for lung cancer

한영이 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.4

Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while minimizing the dose to normal tissues. The state-of-the-art intensity modulated proton therapy is now prevailing as a major treatment technique in proton facilities worldwide, but still faces many challenges in being applied to the lung. Thus, in this article, the current status of proton therapy technique is reviewed and issues regarding the relevant uncertainty in proton therapy in the lung are summarized.

The Impact of Tissue Inhomogeneity Corrections in the Treatment of Prostate Cancer with Intensity-Modulated Radiation Therapy

한영이,박원,허승재,Han Youngyih,Park Won,Huh Seung Jae Korean Society of Medical Physics 2004 의학물리 Vol.15 No.3

목적: 전립선암의 세기조절 방사선 치료 시, 조직의 밀도보정 여부가 선량분포에 끼치는 영향을 연구한다. 재료 및 방법: 5명의 전립선 암 환자에 대하여 6 MV와 10 MV의 광자선에 대하여 각각 치료계획을 수립하였다. 각각 의 계획에서 7개의 조사선이 설정되었고, 선량계산 시에는 체조직의 밀도의 불균일성을 무시하였다. 선량 처방점인 회전중심점에서의 흡수선량과 계획표적용적(PTV)의 최대선량, 최소선량, 평균선량과 처방점선량의 95% 이상의 받는 부피(V>$_{p95%}$) 등을 측정하였다. 직장과 방광 내에서의 최대선량, 최소선량, 최방선량의 50%, 75%, 90% 이상을 받는 부피를 측정하였다. 동일한 조건에서 조직의 밀도 불균일성을 포함하여 선량분포를 재계산하고, 측정한 모든 물리량을 재 측정하였다. 결과: 밀도보정을 함으로써, 처방점에서의 흡수 선량은 6 MV에서 평균 4.9% 10 MV에서는 평균 4% 감소하였다. V>$_{p95%}$는 6 MV와 10 MV에서 각각 0.8%와 0.9% 감소하였다. PTV의 평균 흡수 선량은 6 MV와 10 MV에서 각각 4.2% 와 3.4% 감소하였다. 직장과 방광에서의 흡수선량은 약 l~2%의 차이를 보였다 결론: 전립선암의 세기변조 방사선치료시에 밀도보정을 무시하는 것은 표적에는 고려할 만한 선량의 차이를 유발하며, 주위의 위험장기에 미치는 영향은 미미하다. Purpose: To investigate the effects of tissue inhomogeneity corrections on the dose delivered to prostate cancer patients treated with Intensity-Modulated Radiation Therapy (IMRT). Methods and Materials: For five prostate cancer patients, IMRT treatment plans were generated using 6 MV or 10 MV X-rays. In each plan, seven equally spaced ports of photon beams were directed to the isocenter, neglecting the tissue heterogeneity in the body. The dose at the isocenter, mean dose, maximum dose, minimum dose and volume that received more than 95% of the isocenter dose in the planning target volume ( $V_{p>95%}$) were measured. The maximum doses to the rectum and the bladder, and the volumes that received more than 50, 75 and 90% of the prescribed dose were measured. Treatment plans were then recomputed using tissue inhomogeneity correction maintaining the intensity profiles and monitor units of each port. The prescription point dose and other dosimetric parameters were remeasured. Results: The inhomogeneity correction reduced the prescription point dose by an average 4.9 and 4.0% with 6 and 10 MV X-rays, respectively. The average reductions of the $V_{p>95%}$ were 0.8 and 0.9% with the 6 and 10 MV X-rays, respectively. The mean doses in the PTV were reduced by an average of 4.2 and 3.4% with the 6 and 10 MV X-rays, respectively. The irradiated volume parameters in the rectum and bladder were less decreased; less than 2.1 % (1.2%) of the reduction in the rectum (bladder). The average reductions in the mean dose were 1.0 and 0.5% in the rectum and bladder, respectively. Conclusions: Neglect of tissue inhomogeneity in the IMRT treatment of prostate cancer gives rise to a notable overestimation of the dose delivered to the target, whereas the impact of tissue inhomogeneity correction to the surrounding critical organs is less significant.

세기변조 방사선치료의 환자 치료 전 선량보증에 대한 고찰

한영이,Han, Youngyih 한국의학물리학회 2013 의학물리 Vol.24 No.4

본 논문은 현재 세기변조 방사선 치료를 시행 시에 일반적으로 사용 되고 있는 환자 치료 전 품질보증의 방법 중, 2차원 선량분포를 측정하여 품질을 보증하는 방법들에 관한 이슈들을 최근 3~4년 간 발표된 논문들을 중심으로 살펴보고, 향후 품질보증 방법의 개선방향에 대하여 조명해 보고자 하였다. This review paper deals with the current statues of pre-treatment quality assurance conducted for Intensity modulated radiation therapy. Focusing on the issues relevant to two-dimensional verification of absorbed dose distribution, review was made for the papers published during the last 3~4 years. Lastly, the future development direction was projected.

개인맞춤형 신항원 암백신 후보 예측을 위한 인공지능 플랫폼

한영만 대한산업공학회 2021 ie 매거진 Vol.28 No.3

간호관리학 교과목 학습성과 평가를 위한 CEA의 적용 가능성 고찰

한영인(Han, Young In) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.5

본 연구는 간호관리학 교과목 학습성과 평가에 CEA(Course embedded assessment)을 적용하기 위한 문헌연구로 시행하였다. 선행연구과 미국대학평가사 무국의 자료를 통해 CEA의 개념, 장․단점, 단계, 적용 시 주의사항 등을 고찰하였으며, 이를 근거로 간호관리학 교과목 학습성과 평가체계에 적합한 CEA모형과 세부지침을 제시하였다. 이를 근거로 간호관리학 교과목 학습성과 평가를 위한 CEA 평가체계와 세부지침을 제시하였다. 결론적으로 CEA 단계별 간호관리학 교과목 학습성과 평가체계를 구축한다면 일관성 있는 간호관리학 교과목 학습성과 평가체계를 통해 간호관리역량 향상과 지속적인 간호관리학 교과목 학습성과 질적개선에 기여할 것으로 사료된다. The purse of this study was to suggest possibility of adaptation of course embedded assessment for course outcome in nursing management through literature review. The course outcome in nursing management through literature & Office of Assessment web site reference review on concept, advantage, disadvantage, process, measure, tool and precaution. This study was confirmed by the Nursing Management subjects the possibility of learning outcomes assessment in the CEA program evaluation system. In conclusion, if you build a Nursing Management course learning outcomes assessment system is believed to contribute to the consistent quality of nursing education and continuing education courses to evaluate for improvement in nursing management capabilities.

복합문제 표준화환자의 통합시뮬레이션 실습 참여체험

한영인 한국간호시뮬레이션학회 2017 한국간호시뮬레이션학회지 Vol.5 No.1

Purpose: This study aimed to understand the meanings and nature of the lived experience of participating in integrated simulation practice of standardized patients with complex problems. Methods: The hermeneutic phenomenological human science approach developed by van Manen was adopted in-depth interviews and observations were conducted with 6 standardized patients’ and recorded with their consent. The data were collected over two months, from March 1, to April 30, 2016. The statements were analyzed and revealed five essential themes of the standardized patients with complex problems. Results: The essential themes of outcomes consisted of <Conflict between the virtual and real world>, <Inadequate and surprise nursing interventions>, <Limitations of the standardized patient role>, <Identified with the standardized patient>, and <Rewarding patient role>. Conclusion: The standardized patients who participated in this study had difficulty in carrying out the role of the patient, and they said that the nursing students felt that they were rewarding because they were helpful.

戴震의 氣一元論的 自然主義 특성에 대한 연구

한영 한중철학회 2001 한중철학 Vol.7 No.-

마이크로-나노버블 및 일반버블 산기장치 시스템의 산소전달효율 비교 연구

한영립 ( Young Rip Han ),최영익 ( Young Ik Choi ),윤태경 ( Tae Kyung Yoon ),이강춘 ( Gang Choon Lee ),정병길 ( Byung Gil Jung ) 한국수처리학회 2011 한국수처리학회지 Vol.19 No.5

The main objective of this study was to evaluate the comparative analysis of oxygen transfer efficiencies between MNB(Micro-nano bubble) and CB(conventional bubble) diffuser systems for application of wastewater treatment processes such as flotation, aeration, water reclamation and so on. The bubble size of the MNB diffuser system was shown to be below 0.5 ㎛, and a proper air flowrate was 1.0 L/min. When the proposed MNB system compared with the CB diffuser system, the overall oxygen transfer coefficient (KLa), standard oxygen transfer rate (N) and volumetric oxygen transfer rate (VOTR) values were 11.67 (13.18), 11.80 (13.08) and 3.23 (13.14) times higher for influent (effluent) dyeing wastewater in the same initial conditions at air flow rate (1.0 L/min) under standard conditions (20℃, 1 atm), respectively. Therefore, the MNB diffuser system is expected to be much better effective technology on water and wastewater treatment processes.

Tweety-homolog (Ttyh ) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain

한영은,권재,원종하,안희영,장민우,우준성,이제선,박민구,윤보은,이승은,황은미,정재영,박형주,오수진,이창준 한국뇌신경과학회 2019 Experimental Neurobiology Vol.28 No.2

In the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Cl-- and osmolytes- efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed as the pore-forming VRAC which is activated by low cytoplasmic ionic strength but not by swelling, the molecular identity of the pore-forming swellingdependent VRAC (VRACswell) remains unclear. Here we identify and characterize Tweety-homologs (TTYH1, TTYH2, TTYH3) as the major VRACswell in astrocytes. Gene-silencing of all Ttyh1/2/3 eliminated hypo-osmotic-solution-induced Cl- conductance (ICl,swell) in cultured and hippocampal astrocytes. When heterologously expressed in HEK293T or CHO-K1 cells, each TTYH isoform showed a significant ICl,swell with similar aquaporin-4 dependency, pharmacological properties and glutamate permeability as ICl,swell observed in native astrocytes. Mutagenesis-based structure-activity analysis revealed that positively charged arginine residue at 165 in TTYH1 and 164 in TTYH2 is critical for the formation of the channel-pore. Our results demonstrate that TTYH family confers the bona fide VRACswell in the brain.