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서로 다른 가교제를 이용하여 제조한 온도 및 pH 민감성 하이드로겔의 특성
한영아,손성옥,지병철 한국섬유공학회 2002 한국섬유공학회지 Vol.39 No.5
Poly(N-isopropyl acrylamide)(PNIPAAm) and its copolymer hydrogels crosslinked withN,N'-methylenebisacrylamide(MBAAm) and poly(ethylene glycol) diacrylate(PEGDA) were prepared and their characteristics including swelling/deswelling behaviors were investigated. The hydrogel, with lower gelation rate and higher transmittance was prepared when PEGDA was used as a crosslinking agent. The volume phase transition temperature of PNIPAAm hydrogel was not affected seriously by the concentration of monomer and crosslinking agent, whereas, that of copolymer hydrogel was increased up to 5$0^{\circ}C$ by incorporating a small amount of SMA. In the case of copolymer hydrogel, higher volume phase transition temperature was obtained when PEGDA was used as a crosslinking agent, suggesting the chain length of the crosslinking agent has a significant effect on the volume phase transition temperature of P(NIPAAm-co-SMA) hydrogel. The pH dependence of the hydrogel was observed when PEGDA was used as a crosslinking agent as well as MBAAm. Larger pores were found at the surface of the hydrogel crosslinked with PEGDA, suggesting that the surface morphology has a close relation to the water contents and the volume phase transitions of PNIPAAm and P(N IPAAm-co-SMA) hydrogel.
Poly(ethylene glycol) Diacrylate로 가교된 Poly(N-isopropyl acrylamide-co-sodium methacrylate) 하이드로겔
한영아,최진현 한국생체재료학회 2003 생체재료학회지 Vol.7 No.2
Poly[N-isopropyl acrylamide (NIPAAm)-co-sodium methacrylate (SMA)] hydrogels crosslinked with poly(ethylene glycol) diacrylate (PEGDA) were prepared and their characteristics including volume phase transition behaviors were investigated. In the course of hydrogel preparation, transmittance fell off more stiffly at lower SMA feed ratio. In contrast, higher concentration of PEGDA decreased the transmittance. Gelation was slow-downed as the chain length of PEGDA increased. Notably, the water content of hydrogel crosslinked with PEGDA was enhanced up to 70% after deswelling had occurred. The water contents of the hydrogels also showed the pH dependence. The morphology of the freeze-dried hydrogel revealed a close relationship with the water content of the hydrogel, suggesting that the chain length of a crosslinking agent had a significant effect on the pore size. The gelation times and the water contents of poly(NIPAAm-co-SMA) hydrogels before/after the volume phase transition can be controlled by changing SMA feed ratio, crosslinking agent concentration, and the chain length of crosslinking agent.
그림일기를 활용한 언어중재가 언어발달지체 아동의 화용언어능력에 미치는 영향
한영은(Young-Eun Han),이효진(Hyo-Jin Lee),정한진(Hanjin Jeong),서경희(Kyoung-Hee Sehr) 한국의료정보교육협회 2019 보건의료생명과학논문지 Vol.7 No.2
본 연구는 언어발달지체 아동에게 필요한 화용언어 능력을 높이기 위해 그림일기를 중재에 활용했을 때 긍정적인 효과가 있는지 알아보았다. 연구대상은 만 5세 언어발달지체 남자 아동이었고 단일대상 연구 설계로 연구가 진행되었다. 중재 기간은 총 26회기로 기초선 1회기, 중재 24회기, 사후평가 1회기였으며 한 회기는 40분씩 중재하였다. 중재 결과, 언어발달지체 아동에게 그림일기를 활용하면 화용언어능력 증진에 긍정적인 영향을 미치는 것을 확인할 수 있었다. The purpose of this study is to find out the effects of language Intervention using picture diary on pragmatic language ability of children with delayed language development. The study was conducted as a single case study and design for a child aged 5 years old with delayed language development. The Intervention period was conducted for a total of 26 sessions. Pre-evaluation was carried out in the first session, Intervention was carried out over the 24sessions and post-evaluation in the final session. It takes 40 minutes for each session. As a result of this study, language Intervention using picture diary had a positive effect on children with delayed language development.
Current status of proton therapy techniques for lung cancer
한영이 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.4
Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while minimizing the dose to normal tissues. The state-of-the-art intensity modulated proton therapy is now prevailing as a major treatment technique in proton facilities worldwide, but still faces many challenges in being applied to the lung. Thus, in this article, the current status of proton therapy technique is reviewed and issues regarding the relevant uncertainty in proton therapy in the lung are summarized.
세기변조 방사선치료의 환자 치료 전 선량보증에 대한 고찰
한영이,Han, Youngyih 한국의학물리학회 2013 의학물리 Vol.24 No.4
본 논문은 현재 세기변조 방사선 치료를 시행 시에 일반적으로 사용 되고 있는 환자 치료 전 품질보증의 방법 중, 2차원 선량분포를 측정하여 품질을 보증하는 방법들에 관한 이슈들을 최근 3~4년 간 발표된 논문들을 중심으로 살펴보고, 향후 품질보증 방법의 개선방향에 대하여 조명해 보고자 하였다. This review paper deals with the current statues of pre-treatment quality assurance conducted for Intensity modulated radiation therapy. Focusing on the issues relevant to two-dimensional verification of absorbed dose distribution, review was made for the papers published during the last 3~4 years. Lastly, the future development direction was projected.