청소년기는 과연 조작되었는가?

최윤진 한국청소년학회 1999 21세기 청소년 포럼 Vol.10 No.-

Analysis of Positive Patch Test Allergens in Allergic Contact Dermatitis Patients with Atopic Dermatitis

최윤진,변지연,최유원,노주영,최해영 대한피부과학회 2023 Annals of Dermatology Vol.35 No.4

Background: There has been debate regarding whether patients with atopic dermatitis (AD) have an altered frequency of contact allergen sensitization. Increased exposure to topical medications and moisturizers as well as impaired skin barrier function increase the risk of contact sensitization, whereas the Th2-skewed inf lammatory pathway of AD is associated with a reduced risk. Objective: This retrospective study was performed to determine the characteristics of contact sensitization in allergic contact dermatitis (ACD) patients with a current or past history of AD. Methods: A clinical record review was conducted for patients referred to Ewha Womans University Medical Center, for patch tests between March 2017 and March 2021. We com- pared the rates of contact sensitization between ACD patients with and without AD. Results: In total, 515 patch test results were reviewed and divided into the AD group (n=53) and non-AD group (n=462). The AD group showed decreased any-allergen positivity (1+, 2+, or 3+) (56.6%) compared to the non-AD group (72.9%) (p =0.013). The positivity rate for budesonide was significantly higher in the AD group (p =0.011), while the prevalence of a positive result for balsam of Peru was higher in the non-AD group (p =0.036). Nickel sulfate, cobalt chloride, and potassium dichromate were the most common sensitized allergens in both groups. Conclusion: Our study shows a decreased prevalence of contact sensitization in AD patients compared to non-AD patients. Clinicians should be aware of the risk of corticosteroid aller- gies in ACD patients with history of AD.

국내 판례로 확인한 약물 발진에 관련된 법적 분쟁에 대한 고찰

최윤진,김경욱,변지연,최유원,노주영,최혜영 대한피부과학회 2023 대한피부과학회지 Vol.61 No.3

Background: Both medicolegal disputes and the incidence of cutaneous drug eruptions are increasing in Korea. We were unable to find research that surveyed the legal disputes involving drug eruption cases

Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker

최윤진,김나영,이혜승,박선미,박지현,윤혁,신철민,박영수,김진욱,이동호 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.4

Background: The human leucine-rich repeat-containing G-protein coupled receptor (LGR) 5 and CD44 are one of the candidates for the marker of gastric cancer stem cells. We compared the expressions of two genes among control, dysplasia and cancer groups. Methods: We compared the mRNA expression of LGR5, CD44 and CD44v8-10 and immunohistochemistry (IHC) of LGR5 and CD44 in gastric antral mucosa of 45 controls, 36 patient with gastric dysplasia, and 39 patients with early gastric cancer. Additionally, IHC of LGR5 in gastric body mucosa was analyzed. Normal mucosa adjacent to dysplastic or cancer lesions was used for the quantitative real-time–PCR and IHC. Results: Immunoreactivity of LGR5 in base of antral mucosa was higher in non-cancerous tissues of cancer than those of control (P =0.006), whereas the expression of LGR5 mRNA was not different among the three groups. Immunostaining of LGR5 was much stronger in the antrum than in the body of stomach (P < 0.001). Although there was no difference in antral immunointensity of LGR5 according to the severity of intestinal metaplasia, stronger immunostaining was found in the body with an aggravation of intestinal metaplasia (P trend < 0.001). The expression of CD44v8-10 mRNA was higher in cancer patients than control subjects and patients with dysplasia (P = 0.018 and 0.009) while the expression of CD44 mRNA was higher in the control groups than the others. Conclusions: IHC of LGR5 in crypt base and CD44 may be used for gastric CSC markers. LGR5 expression may be associated with the developing of corporal intestinal metaplasia. The expression of CD44v8-10 mRNA would be more suitable for gastric cancer stem cell marker than CD44 or LGR5 mRNA.

청소년 시민참여와 비형식교육

최윤진 한국시민청소년청년학회(구 한국시민청소년학회) 2011 시민청소년학연구 Vol.2 No.1

근래에 나타나는 주요 사회 변화 양상은 삶의 양식의 개별화와 분절화, 그리고 위험사회 요소의 증가 현상 등을 들 수 있는데, 이것은 청소년들로 하여 금 다양하고 복합적인 정체성을 형성해 나가는데 많은 영향을 주고 있으며, 교 육에 있어서 변화와 새로운 패러다임을 요청하고 있는데 즉, 보다 개방적이고 학습자 중심적이며 다양한 경험이 가능한 학습의 장을 제공해 줄 수 있는 비형 식 교육의 필요성을 증대시키고 있다고 볼 수 있다. 또한 탈 근대적 성격을 보여주는 오늘날, 시민성의 개념도 변화하고 있다 고 볼 수 있는데 즉 기성 사회에 순응하고 정치적 책임과 권리를 수행하는 시민 상에서 한 걸음 더 나아가서 자신이 속한 경제, 사회 문화 각 공동체적 삶에서 적절한 역할과 지위를 행사하며 때로는 비판적이고 또 능동적으로 참여하며 공 동체에 기여하는 적극적 시민상을 의미하는 새로운 시민성이 요구되고 있다. 청소년들이 이러한 적극적 시민으로 성장하기 위해서는 형식교육과 비형식교 육이 결합된 보다 복합적인 교육의 장이 요구되고 있다. 비형식 교육의 개념은 1960년대 후반부터 제기되었고 당시에는 형식교 육의 기회를 놓친 성인들을 위한 보충교육이나 저개발 국가의 학교교육의 부실 함을 보완할 구호 교육적 성격이 주요했었던 것에 반해서 21세기에 들어서면 서 평생교육 이념에 근거해 참여적 시민 양성을 위한 교육의 장으로 그 중요성 이 새롭게 제기되고 있다. 이 연구에서는 비형식교육의 몇 가지 주요 특성을 분 석하면서 비형식교육이 기존 형식교육의 한계로 지적되었던 권위적 통제방식, 타율적 학습과정, 고정적이고 결과중심의 교육과정 등의 문제를 보완할 수 있 는 대안적 가능성을 보여주고 있음을 밝혀보고자 하였다. 그러나 결론적으로 형식교육과 비형식교육 중 하나를 선택해야 하는 이 분법적 접근은 적절치 않으며, 적극적 시민성을 청소년들에게 함양시키기 위해 서는 두 가지 교육의 장이 균형있게 같이 제공되어야 함을 주장한 바 있다.

장애인편의시설의 유니버설디자인 적용 및 확대 방안에 관한 연구

최윤진,박병은 한국상품문화디자인학회 2017 상품문화디자인학연구 Vol.48 No.-

본 연구는 장애인편의시설이 장애인 전용이라는 제한성에서 벗어나 노인, 아동 등 일상생활에서 가능한 많은 사람들이 보 편적으로 사용할 수 있는 유니버설디자인의 적용을 통해 누구나 차별없이 동등하게 이용할 수 방안을 제안하기 위해 진행 되었다. 본 연구는 선행연구와 문헌연구를 통해 장애인편의시설과 유니버설디자인의 이론적 개념을 정립하고, 장애인편의 시설과 관련한 법률 및 유니버설디자인 관련 조례 현황을 분석하여 현재 유니버설디자인이 적용되는 영역을 살펴보았으며, 실제 유니버설디자인의 적용 및 확대가 필요한 ‘정보에 자유롭게 접근할 수 있는 권리’의 사례를 제안하였다. 최근 「발달장 애인의 권리보장 및 지원에 관한 법률」과 「한국수화언어법」이 시행됨에 따라서 물리적 공간뿐만 아니라 정보접근의 확대 를 위한 유니버설디자인의 적용도 충분히 고려되어야 하지만 유니버설디자인 및 장애인편의시설에 관한 선행연구에 있어 서 대다수가 물리적 환경의 실태조사와 개선방안에 집중되어 있었다. 또한 장애인편의시설의 경우, 실제 이용 여부 보다는 설비가 구축되어 있는지 없는지가 주요 조사내용이었다. 이에 일부 정보접근에 대한 유니버설디자인의 적용 가능성을 제안 하였고, 장애인의 요구를 수용하고 환경을 개선해 나가는 과정에서 장애인만 고려하는 것이 아닌 다수의 사람들이 편리하 고, 안전하게 이용할 수 있는 환경을 구축하는데 가장 효과적인 접근이 유니버설디자인의 원칙을 적용하고 확대하는 것임 을 제안한다. This study was intended to present the measures applying the universal design that could allow the 'convenience facilities for the disabled' to transcend their traditional function of serving the disabled and increase their accessibility to many people, including the elderly, children, etc., in everyday life so as to be used equitably by anyone without discrimination. In this study, we established the theoretical concept of the convenience facilities for the disabled and that of universal design based on preceding studies and literature study and examined the area applying the universal design by analyzing the laws related to convenience facilities for the disabled and ordinances associated with universal design. Moreover, we propose the cases of the 'right to have unrestrained access to information' which required application and expansion of universal design. The majority of the preceding studies on universal design and convenience facilities for the disabled focused on actual conditions of physical environment and improvement measures despite the need to give full consideration to application of universal design vital for expansion of access to information, as well as physical space, amid recent enforcement of the Act on the Protection of Rights and Support for People with Developmental Disabilities and Korean Sign Language Law. In addition, most preceding studies on convenience facilities for the disabled placed the focus on investigation on whether facilities were established, rather than actual use.In this study, thus, we presented the applicability of universal design for access to some information and suggested that the application of principles of universal design would constitute the most effective approach to building an environment enabling convenient and safe use by many people, rather than limiting the consideration to the needs of the disabled, in the course of accommodation to the requirements of the disabled and efforts for improvement of environment.

Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean

최윤진,Dong Ho Lee,한경도 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6

Background/Aims: In Korea, the incidence of colorectal cancer (CRC) and nonalcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC. Methods: Data from the National Health Insurance Corporation 2009 to 2012 were analyzed. NAFLD disease was defined as a fatty liver index > 60 in the absence of alcohol consumption of ≥ 30 g/day. Results: NAFLD was identified in 2,543,649 (11.8%) of 21,592,374 participants. CRC was identified in 19,785 (0.8%) of participants with NAFLD (fatty liver index ≥ 60) and in 80,871 (0.6%) participants without NAFLD (fatty liver index < 30). Multivariate logistic regression analysis demonstrated an independent association between NAFLD and CRC after adjusting for other confounders (hazard ratio, 1.13; odds ratio, 1.12 to 1.15). In subgroup analyses, fatty liver index ≥ 60 was associated with CRC regardless of body mass index, but the association was more prominent in persons with a normal index. NAFLD, in the absence of diabetes, hypertension, or dyslipidemia, was more highly associated with CRC than when one or more of these conditions are present. Conclusions: CRC should be considered as a possibility in patients with fatty liver index ≥ 60, even in the absence of obesity or other metabolic syndromes.

[94-02] 소년교정기관에서의 상과 벌 -비행청소년 교정프로그램의 실태와 개선방안 연구-

최윤진 한국청소년정책연구원 1994 한국청소년정책연구원 연구보고서 Vol.- No.-

새로운 칼륨 경쟁적 위산분비 차단제

최윤진 대한소화기학회 2022 대한소화기학회지 Vol.80 No.6

Proton pump inhibitors (PPIs) have several limitations to their efficacy including insufficient acid suppression, slow onset of action, and variable efficacy among patients due to CYP2C19 metabolism. Potassium-competitive acid blockers inhibit H+-K+-ATPase in a reversible and K+-competitive manner, are novel acid suppressive drugs with rapid onset of action, meal independence, and prolonged control of intragastric acidity compared to PPIs. Potassium-competitive acid blockers exhibited non-inferior therapeutic efficacies on reflux esophagitis, gastric ulcers, and Helicobacter pylori eradication. The review is focused on the unmet needs across the acid-related diseases and recent updates on clinical studies using vonoprazan and tegoprazan.

특집1 : 포스트모더니즘과 교육철학적 대응 / 제도교육의 재조명 - 푸코와 료따르의 이론을 중심으로 -

최윤진 한국교육철학학회 1993 교육철학연구 Vol.11 No.-

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