http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
최승임,최흔,박성연,곽이경,송제은,신소연,백지현,신현일,오홍상,김용찬,염준섭,한진희,김민재 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.1
Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can cause relapse of malaria. The only drug currently used for eliminating hypnozoites is primaquine. The antimalarial properties of primaquine are dependent on the production of oxidized metabolites by the cytochrome P450 isoenzyme 2D6 (CYP2D6). Reduced primaquine metabolism may be related to P. vivax relapses. We describe a case of 4 episodes of recurrence of vivax malaria in a patient with decreased CYP2D6 function. The patient was 52-year-old male with body weight of 52 kg. He received total gastrectomy and splenectomy 7 months before the first episode and was under chemotherapy for the gastric cancer. The first episode occurred in March 2019 and each episode had intervals of 34, 41, and 97 days, respectively. At the first and second episodes, primaquine was administered as 15 mg for 14 days. The primaquine dose was increased with 30 mg for 14 days at the third and fourth episodes. Seven gene sequences of P. vivax were analyzed and revealed totally identical for all the 4 samples. The CYP2D6 genotype was analyzed and intermediate metabolizer phenotype with decreased function was identified.
감염 동맥류로 인한 척추 골수염으로 오인한 베체트병 1예
손효주,최승임,정경화,정민선,이인철,홍석찬,정용필 대한내과학회 2018 대한내과학회지 Vol.93 No.2
Behçet’s disease is a systemic vasculitis of unknown etiology characterized by recurrent oral and genital ulcers and uveitis. The vascular involvement of Behçet’s disease affects arteries, veins, and blood vessels of all sizes, and it can include venous or arterial thrombosis and arterial aneurysms. There are only a few reports of an aortic aneurysm invading a vertebral body in a patient with Behçet’s disease. Here, we report the case of a 45-year-old man who was initially diagnosed with vertebral invasion of a mycotic aneurysm. He underwent vascular surgery and received empirical antibiotics, but all cultures were negative. However, he had persistent, recurrent deep vein thrombosis and elevated inflammatory markers. After reviewing the pathology, a final diagnosis of Behçet’s disease was made. He was successfully treated with corticosteroids. This report presents a rare case of Behçet’s disease mimicking vertebral invasion of a mycotic aneurysm. 감염 동맥류의 이차적인 척추 침범 또는 척추골수염으로인한 척추 주변 조직의 염증성 변화의 가능성을 의심하였으나, 임상 경과 및 증상, 병리 조직을 토대로 최종적으로 베체트병에 의한 복부대동맥류 및 척추체의 손상으로 진단한 증례를 경험하여 보고한다.