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조직학적으로 확진한 결핵성 복막염 환자의 복수 Adenosine deaminase ( ADA ) 활성도에 관한 연구
배선우(Seon Woo Bae),진춘조(Choon Jo Jin),심영학(Young Hak Shim),신계철(Kye Chul Shin),권상옥(Sang Ok Kwon),김남동(Nam Dong Kim),차신웅(Shin Woong Cha),이광훈(Kwang Hoon Lee),장우익(Woo Ick Jang) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A Recent investigations have suggested that the measurement of ADA activities in various body fluids is useful in the diagnosis of tuberculous effusion. In this study, ascitic fluid ADA activities were measured in 18 cases of tuberculous peritonitis, 18 cases of malignant ascites and 33 cases of liver cirrhosis with ascites. The results obtained were as fallows: 1) The mean ADA activity in tuberculous peritonitis was 184.96±27.55U/L, in malignant ascites 22.35±3.10U/L and in liver cirrhosis 7.37±0.61U/L. 2) The ADA activity in tuberculous effusion was significantly higher than in the rest of the groups(p<0.001). 3) The malignant effusion show no significant difference with transudative effusion(p>0.05). 4) As a screening test for tuberculous peritonitis, the ADA activities above 50-70U/L had a sensitivity and specificity of 100%. In conclusion, the measurement of ascitic fluid ADA activity may be a simple and reliable screening test for the diagnosis of tuberculous peritonitis.
김준호(Jun Ho Kim),박형석(Hyung Seok Park),진춘조(Choon Jo Jin),공수정(Sue Jung Kong),최의광(Eui Kwang Choi),민미심(Mee Sim Min),이경영(Kyung Young Lee),윤상애(Sang Ae Yoon) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
Enteric endometriosis usually takes the form of asymptomatic, small, superficial, serosal implants encountered incidently at l,>parotomy for another disease. When symptoms occur from enteric endornetriosis, they are usually due to intestinal obstruction. Intestinal endometriosis frequently, but not always manifests a temporal relationship between the onset of abdominal pain and the interval before or during menstruaticin. Primary endometriosis of the ileum is of particular concern due to the high incidence of the srnall bowel obstruction. Surgery is the usual form of treatment for mural endometriosis causing intestinal obstruction. We experienced an unusua1 case of ileal endometriosis associated with small bowel obstruction in a 22-year o]d women, who was admitted to our hospital complaning of cramping low abdominal pain, vomiting and obstipation. Surgical resection was performed for the management of intestinal obstruction. We present this case with a review of literatures. (Korean J Gasti-oenterol 1995;27; 879 - 883)
대장 종양에서의 Sonic Hedgehog 단백의 발현
한혜승 ( Hye Seung Han ),이선영 ( Sun Young Lee ),성무경 ( Moo Kyung Seong ),김정환 ( Jeong Hwan Kim ),성인경 ( In Kyung Sung ),박형석 ( Hyung Seok Park ),진춘조 ( Choon Jo Jin ),황태숙 ( Tae Sook Hwang ) 대한장연구학회 2008 Intestinal Research Vol.6 No.1
Background/Aims: Dysregulation of the hedgehog pathway has been implicated in regeneration and carcinogenesis, leading to the expression of the sonic hedgehog (Shh) protein in gastrointestinal neoplasms. The expression of Shh in colon neoplasms and paired normal colonic mucosa was therefore investigated. Methods: Forty-four colon cancers and 73 colon adenomas that were removed by surgical colectomy or colon polypectomy between August 2005 and August 2006 were included. Colorectal neoplasms and the adjacent normal colon tissue were examined by immunohistochemistry using rabbit polyclonal Shh antibody. Results: Expression of Shh was up-regulated in adenomas and adenocarcinomas of the colon compared to normal colon tissues (p<0.001). The degree of Shh expression was not associated with the size, shape, or, location of the tumor, or as the age and gender of the patient. In normal colonic epithelium, Shh was expressed at the apex of the crypts and in a few basally-located cells. Conclusions: Higher levels of Shh expression in colonic adenoma and adenocarcinoma suggest that Shh is required during epithelial proliferation in the colon. Hedgehog signaling is likely to be associated with early tumorigenesis in colonic neoplasms. (Intest Res 2008;6:19-24)
권상옥(Sang Ok Kwon),이광훈(Kwang Hoon Lee),장우익(Woo Ik Jang),조한선(Han Seon Cho),차신웅(Sin Woong Cha),민병철(Byoung Chul Min),진춘조(Choon Jo Jin) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
Pregnancy is rarely encountered in women with cirrhosis since cirrhosis is less common in women and usually developes after the childbearing years. Additionally, cirrhosis in young women is often accompanied by severe menstrual irregularities and infertility with disturbance of estrogen metabo- lism. The managernent of the liver disease in pregnant patients is the sarne as that of normal people. Studies have shown that while pregnancy may result in a normal healthy infant, the risk of variceal hemorrhage is high, especially in the second and third trimesters. Cirrhosis seems to have an adverse effect on fetal outcome with a high incidence of stillbirths and prematurity in pregnant women. We report our experience of three episodes of pregnancy in two cases of liver cirrhosis and ascites with brief review of literatures.
Helicobacter pylori 감염에 의한 위염의 병리조직학적 양상 및 박멸치료 후의 호전
조영일(Young Il Jo),박형석(Hyung Seok Park),송기호(Ki Ho Song),인행환(Haeng Hwan In),윤성욱(Seong Yuk Youn),김예리(Yei Lee Kim),이재동(Jae Dong Lee),진춘조(Choon Jo Jin),윤상애(Sang Ae Yoon) 대한내과학회 1998 대한내과학회지 Vol.54 No.2
N/A body and fundus. A signi6cant, positive correlation was noted between HP score and the score for inflammation, for activity, and for mucus depletion. After eradication of HP infection, significant improvement in activity, chronic inflammation, and mucus depletion was detected in responders with a successful HP eradication; the activity return to normal in follow-up, and chronic inflammation and mucus depletion was decreased significally in severity in responders(p<0.05%). No significant reduction in severity of gastritis and mucus depletion was detected in the non-responders with persistent HP infection following anti-HP triple therapy. Conclusion: The eradication of HP results in a rapid, significant histopathological improvement in the gastritis scores and epithelial damage in gastric mucosa.