정신분열병 환자에서 신체미세기형에 관한 연구

주은정,정성훈,맹소진,윤세창,김종훈,김철응,신영민,김용식,Joo, Eun-Jeong,Jeong, Seong Hoon,Maeng, So Jin,Yoon, Se Chang,Kim, Jong Hoon,Kim, Chul Eung,Shin, Youngmin,Kim, Yong Sik 대한생물정신의학회 2002 생물정신의학 Vol.9 No.2

Object and Method:Minor physical anomalies(MPAs) are frequently seen in patients with schizophrenia. MPAs are considered to arise from the anomalous development of ectoderm-originated tissues in the developing fetus. Since the central nervous system originates from ectoderm, MPAs can be regarded as externally observable and objective indicators of the aberrant development which might have taken place in the central nervous system. To investigate whether MPAs are more frequent in schizophrenic patients, the frequencies of MPAs were compared between schizophrenic patients and normal controls. Total 245 schizophrenic patients diagnosed with DSM-IV(male : 158, female : 87), and 418 normal control subjects(male : 216, female : 202) were included in this study. The MPAs were measured using the modified Waldrop scale with fifteen items in six bodily regions; head, eye, ear, mouth, hand, and foot. Result:The total scores of Waldrop scale were $4.40{\pm}1.93$($mean{\pm}standard$ deviation) in patients and $3.43{\pm}1.68$ in controls for females, and for males, $4.58{\pm}1.75$ in patients and $4.28{\pm}1.59$ in controls. For females, the excess of MPAs in schizophrenic patients was statistically significant(t-test : p<0.001). For males, schizophrenic patients also showed more MPAs than normal controls, but this tendency did not reach statistical significance (t-test : p=0.094). When the modified Waldrop total scores excluding head circumference were compared, the total scores in schizophrenic patients were significantly higher for both male and female subjects(t-test : male p<0.001, female p=0.001). The individual anomaly items included in Waldrop scale were also investigated. The items of epicanthus, hypertelorism, malformed ears, syndactylia were significantly more frequent in schizophrenic patients. In contrast, the items of adherent ear lobes, asymmetric ears, furrowed tongue, curved fifth finger, single palmar crease and big gap between toes did not show any differences in frequency between schizophrenic patients and normal controls. Since a lot of statistical analyses showed different results between male and female subjects, it seems to be necessary to consider gender as an important controlling variable for the analysis, however only the item of head circumference showed statistically significant gender-related difference according to log-linear analysis. Conclusion:With a relatively large sample size, the frequencies of MPAs enlisted in Waldrop scale were compared between schizophrenic patients and normal controls in this study. MPAs were more frequently seen in schizophrenic patients and, especially, several specific items in the Waldrop scale showed prominent excess in schizophrenic patients. Although definite conclusions cannot be drawn due to the inherent limitation of the study using Waldrop scale, these results seem to support the possibility that aberrant neurodevelopmental process might be involved in the pathogenesis of schizophrenia in some of the patients.

사료내 ${\beta}$-glucanase 활성 강화 고역가 복합효소제 첨가급여가 착유우의 유생산 및 체세포수 변화에 미치는 영향

주은정,정수진,윤병선,남기택,최일신,안종호,황성구,Joo, Eun-Jung,Jeong, Su-Jin,Yoon, Byung-Seon,Nam, Ki-Taek,Choi, Il-Shin,Ahn, Jong-Ho,Hwang, Seong-Gu 한국유기농업학회 2004 韓國有機農業學會誌 Vol.12 No.2

In recent years, many researches are actively undertaken for environmental-friendly animal production according to the increased understanding about food safety because of the outbreak of various diseases such as mad cow disease, Foot and mouth disease and Poultry Influenza virus. However, high quality(higher safety)- animal production may not be successful without increasing of disease resistance of animal and the improvement of feeding environment. To increase the disease resistance is able to be accomplished by stimulating the immune function. The present study was undertaken to investigate the effects of enzyme mixture reinforced with ${\beta}$-glucanase activity which degrade polysaccharide to release ${\beta}$-glucan known as stimulator of immune function on the change of milk production and somatic cell count. After 12weeks of experimental feeding, milk production tended to be increased and somatic cell count was decreased from average $227{\times}10^4$ to $37.1{\times}10^4$. Milk protein and solid-fat content were tended to increase but milk fat showed decreasing tendency by the feeding of enzyme mixture. All together, it has been suggest6d that the improvement of high quality milk production may be possible through the dietary addition of immune modulating enzyme mixture in lactating dairy cows.

해저터널의 그라우팅 최적 설계를 위한 수치해석적 연구

주은정,김용기,신종호,권오엽,Joo, Eun-Jung,Kim, Yong-Kye,Shin, Jong-Ho,Kwon, Oh-Yeob 한국터널지하공간학회 2010 한국터널지하공간학회논문집 Vol.12 No.5

대부분의 터널은 시간이 지남에 따라 유입량 증가, 작용수압의 변화 등 지하수의 영향을 받는다. 이러한 수리영향에 대응하기 위하여 터널 시공 시 지하수의 유입과 라이닝의 간극수압을 줄이기 위한 그라우팅을 적용한다. 본 연구에서는 효과적인 그라우팅을 위해 수치 해석결과를 바탕으로 다양한 그라우팅 조건에 대한 영향을 분석하였다. 그라우팅 영향 특성을 분석하기 위하여 그라우팅의 상대 투수계수 해석, 그라우팅의 두께, 그라우팅의 거리 등을 영향요소로 다르게 하였다. 해석결과는 지반하중, 수압, 라이닝 위치에 따른 수압, 라이닝 주변 수압분포, 유입량으로 나누어서 고찰하였다. 라이닝의 작용하는 지반 하중은 모든 조건에서 거의 동일했으며, 라이닝에 작용하는 수압은 그라우팅의 투수계수가 감소할수록, 두께가 증가할수록, 그라우팅 영역 거리가 가까울수록 감소하였다 유입량은 그라우팅 투수계수가 작을수록 감소하며, 그라우팅 두께와는 반비례한다. 본 그라우팅 영향 평가를 활용하여 지반 조건에 따른 그라우팅의 효과적인 적용을 할 수 있다. In the long-term, most tunnels suffer from the increase in ground water inflow and in pore water pressure on the lining. To reduce such hydraulic effect, generally grouting methods are adopted. In this paper effective grouting design is proposed based on numerical simulation. To investigate the optimal grouting layout, factors such as relative permeability, grouting thickness, and distance from the lining are considered. The results are analysed in terms of pore water pressure, inflow rate, and earth pressure. It is revealed that the pore water pressure has increased with a decrease in grout permeability, an increase in grouting thickness and an increase in grouting distance. Meanwhile the inflow rate has decreased with a decrease in grout permeability and is inversely proportional to grouting thickness. Effective grouting design guideline are proposed based on this study.

사료내 β-glucanase활성 강화 고역가 복합효소제 첨가급여가 착유우의 유생산 및 체세포수 변화에 미치는 영향

주은정 ( Joo Eun-jung ),정수진,윤병선 ( Yoon Byung-seon ),남기택 ( Nam Ki-taek ),최일신 ( Choi Il-shin ),안종호 ( Ahn Jong-ho ),황성구 ( Hwang Seong-gu ) 한국유기농업학회 2004 韓國有機農業學會誌 Vol.12 No.2

In recent years, many researches are actively undertaken for environmental-friendly animal production according to the increased understanding about food safety because of the outbreak of various diseases such as mad cow disease, Foot and mouth disease and Poultry Influenza virus. However, high quality(higher safety)- animal production may not be successful without increasing of disease resistance of animal and the improvement of feeding environment. To increase the disease resistance is able to be accomplished by stimulating the immune function. The present study was undertaken to investigate the effects of enzyme mixture reinforced with β-glucanase activity which degrade polysaccharide to release β-glucan known as stimulator of immune function on the change of milk production and somatic cell count. After 12weeks of experimental feeding, milk production tended to be increased and somatic cell count was decreased from average 227×10⁴ to 37.1×10⁴. Milk protein and solid-fat content were tended to increase but milk fat showed decreasing tendency by the feeding of enzyme mixture. All together, it has been suggested that the improvement of high quality milk production may be possible through the dietary addition of immune modulating enzyme mixture in lactating dairy cows.

운영중 다목적 복층터널의 부력영향 검토

김호종,김현아,주은정,신종호,Kim, Ho-jong,Kim, Hyeon-ah,Joo, Eun-jung,Shin, Jong-ho 한국터널지하공간학회 2015 한국터널지하공간학회논문집 Vol.17 No.6

지하수위 아래에 건설되는 복층터널은 비교적 대단면이며 비배수 터널로 건설되는 특징을 가지고 있다. 지하수위 하부에 위치하는 터널은 지하수로 인해 발생하는 부력으로부터 터널의 안정성 확보방안이 필요하다. 일반적으로 터널 라이닝과 지반사이의 경계면에서의 결합력은 부력에 대해 충분한 안정성을 발휘한다. 그러나 장기적인 시간이 경과하면 구조물의 열화로 인하여 결합력이 감소할 수 있다. 본 연구에서는 장기적인 관점에서 부력으로 인한 복층터널의 영향을 조사하였다. 그 결과 부력으로 인해 터널 하단부분에서 변형과 라이닝에 작용하는 응력이 증가하였다. 본 연구로부터 운영중 터널의 라이닝과 지반사이의 결합력을 유지시킬 수 있는 방안이 필요함을 알 수 있다. Double-deck tunnels beneath the groundwater table have relatively large volume and commonly constructed as watertight tunnels. In this case, it requires to secure stability of the tunnels for buoyant force. Generally the contact force between lining and ground is sufficient to resist the buoyant force. However in the long-term the contact force could be reduced because of structural deterioration. In this study the effect of long-term buoyant force acting on the double-deck tunnel is investigated. The results has shown that the buoyant force has increased invert deformation and stress. It is indicated that the contact resilience between lining and ground needs to be kept during tunnel operation.

라이닝-지반 수리상호작용이 해저터널에 미치는 영향

신종호,박동인,주은정,Shin, Jong-Ho,Park, Dong-In,Joo, Eun-Jung 한국터널지하공간학회 2008 한국터널지하공간학회논문집 Vol.10 No.1

라이닝 작용수압과 유입량은 지하수 수위 아래 혹은 하 해저터널 설계시 중요하게 고려되어야할 수리요소이다. 이 요소들은 수심, 심도, 수리경계조건의 영향을 받는다. 본 논문에서는 각 설계요소가 라이닝하중과 유입량에 미치는 영향을 수치해석적 도구를 이용하여 살펴보았다. 수심영향해석은 심도 30 m에 건설된 마제형 터널에 대하여 수심과 라이닝/지반 상대투수계수 비를 다양하게 변화시켜 조사하였고, 심도영향 해석은 수심 60 m의 터널에 대하여 심도 및 라이닝/지반 상대투수계수 비를 변화시켜 해석하였다. 해석결과 수리경계조건과 상관없이 수심 및 심도가 증가함에 따라 지반하중이 증가하였다. 이는 배수터널은 침투력의 영향으로, 비배수 터널은 정수압의 영향으로 수두가 증가함에 따라 지반하중이 증가함을 보여준 것이다. 수심, 심도의 증가에 따라 유입량은 선형적으로 증가하였으며, 라이닝/지반 상대투수계수비와 유입량관계는 펼쳐진 S자 곡선(stretched S-curve)형태로 나타남을 확인하였다. One of the most important design concerns for undersea tunnels is to establish design water load and flow rate. These are greatly dependent on the hydraulic factors such as water head, cover depth, hydraulic boundary conditions. In this paper, the influence of the hydraulic design factors on the ground loading and the inflow rate was investigated using the coupled finite element method. A horse shoe-shaped tunnel constructed 30 m below sea bottom was adopted to evaluate the water head effect considering various water depth for varying hydraulic conditions and relative permeability between lining and ground. The effect of cover depth was analysed for varying cover depth with the water depth of 60 m. The results were considered in terms of pore water pressure, ground loading and flow rate. Ground loading increases with an increase in water head and cover depth without depending on hydraulic boundary conditions. This points out that in leaking tunnels an increase in water depth increases seepage force which consequently increases ground loading. Furthermore, it is identified that an increase in water head and cover depth increases the rate of inflow and a decrease in the permeability ratio reduces the rate of inflow considerably.

고수압 조건하의 해저터널 라이닝에 작용하는 하중특성

신종호(Shin Jong Ho),박동인(Park Dong In),주은정(Joo Eun Jung) 대한토목학회 2006 대한토목학회 학술대회 Vol.2006 No.10

해저터널의 수리영향 평가 및 제어

신종호(Shin Jong Ho),주은정(Joo Eun Jung),채성은(Chae Sung Eun) 대한토목학회 2009 대한토목학회 학술대회 Vol.2009 No.10

라이닝 작용수압과 터널내로의 유입량의 상관관계 실험적 연구

신종호(Shin Jong Ho),주은정(Joo Eun Jung) 대한토목학회 2007 대한토목학회 학술대회 Vol.2007 No.10

더미 안테나를 사용한 모노폴 안테나 보정계수 추출

안형배(Heung-Bae Ahn),주은정(Eun-Jung Joo),이황재(Hwang-Jae Rhee),강대현(Dae-Hyun Kang),이종악(Jong-Arc Lee) 대한전자공학회 2001 대한전자공학회 학술대회 Vol.2001 No.6