No Association of Insulin-like Growth Factor Gene Polymorphisms with Survival in Patients with Colorectal Cancer

조윤영,김종광,채의수,손상균,강병욱,문준호,전성우,박준석,박진영,최규석 대한암학회 2011 Cancer Research and Treatment Vol.43 No.3

Purpose Insulin-like growth factors (IGF) regulate a wide range of biological functions including cell proliferation, differentiation, and apoptosis through paracrine and autocrine mechanisms. Accordingly, the present study analyzed polymorphisms of IGF genes and their impact on the prognosis for patients with colorectal cancer. Materials and Methods Four hundred and two consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in the present study. The genomic DNA was extracted from fresh colorectal tissue and 8 polymorphisms of IGF genes determined using a real-time polymerase chain reaction genotyping assay. Results Pathologic stages after surgery were as follows: stage 0/I (n=85, 21.1%), stage II (n=147,36.6%), stage III (n=145, 36.1%), and stage IV (n=25, 6.2%). Multivariate survival analysis including stage, age, site of disease, and carcinoembryonic antigen level showed that the progressionfree survival for patients with the IGF2 +1280 GG genotype was slightly better than for the patients with the combined IGF2 +1280 AA and AG genotype (p=0.056), although there was no significant difference in the overall survival. However, the other polymorphisms were not associated with survival. Conclusion None of the 8 IGF1 or IGF2 gene polymorphisms investigated in this study were found to be independent prognostic markers for Korean patients with surgically resected colorectal cancer.

세계화와 남북한관계의 변화 : 국제갈등해소론관점에서

조윤영 성균관대학교 사회과학연구소 2001 社會科學 Vol.40 No.1

This paper intends to examine the changing relationship between South and North Korea in the era of globalization. Conflict resolution approach is adopted to analyze the South-North Korean relationship. In the recent decades, there have been fundamental changes in the nature and scope of international politics. The extent of the changes go well beyond the mere end of the Cold War and reconciliation between the superpowers. As of yet, the world is still at a stage of transformation where competing forces and dynamics operates at different levels of interactions. Although the superpower rivalry has ended, the world is not a more peaceful place. New conflict formations are replacing the old ones and new threats are emerging. This phenomena is one of the feature of globalization process. Korean conflict still remains locked in a Cold War framework and appears to be far from any immediate resolution despite the South-North Korean summit in 2000. Thus, the question for inter-Korean relations in the globalization era is how to transform the nature of their relationship from one of confrontation into one of peaceful coexistence, and finally, peaceful reunification. This study will address this question by examining the history of the Korean negotiation process since 1971, with the application of conflict resolution approach. This approach emphasizes the stage of prenegotitation, high quality agreement, negotiation strategies and tactics, and implementation. This study concludes that the conflict resolution approach has more explanatory power with respect to the resolution of contentious issues through negotiations. Finally this paper attempts to bridge the gap between the theory and practice of conflict resolution by outlining practical implications for North- South Korean negotiations.

르포 - 치열한 극복의 현장 후쿠시마

조윤영,Jo, Yun-Yeong 한국원자력산업회의 2018 원자력산업 Vol.38 No.3

사례 1 : 가정복지 케이스웍 사례연구

조윤영 어린이재단 (구 한국복지재단) 1988 사회복지관 사례연구 Vol.4 No.-

Performance Evaluation of the Serum Thyroglobulin Assays With Immunochemiluminometric Assay and Immunoradiometric Assay for Differentiated Thyroid Cancer

조윤영,천세종,이수연,정재훈,박형두,김선욱 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.5

Background: Measurement of postoperative serum thyroglobulin (Tg) is important for detecting persistent or recurrent differentiated thyroid cancer. We evaluated the analytic performance of the DxI 800 assay (Beckman Coulter, USA) for serum Tg and anti-thyroglobulin antibodies (TgAbs) in comparison with that of the GAMMA-10 assay (Shinjin Medics Inc., Korea) for serum Tg and RIA-MAT 280 assay (Stratec, Germany) for TgAb. Methods: We prospectively collected blood samples from 99 patients thyroidectomized for thyroid cancer. The functional sensitivity was investigated in standards and human serum. Precision and linearity were evaluated according to the guidelines of the Clinical and Laboratory Standards Institute. The correlation between the two assays was assessed in samples with different Tg ranges. Results: The functional sensitivity of the DxI 800 assay for serum Tg was between 0.0313 and 0.0625 ng/mL. The total CV was 3.9-5.6% for serum Tg and 5.3-6.9% for serum TgAb. The coefficient of determination (R2) was 1.0 and 0.99 for serum Tg and TgAb, respectively. The cut-offs for serum TgAb were 4.0 IU/mL (DxI 800) and 60.0 IU/mL (RIA-MAT 280), and the overall agreement was 68.7%. The correlation between the two assays was excellent; the correlation coefficient was 0.99 and 0.88 for serum Tg and TgAb, respectively. Conclusions: The DxI 800 is a sensitive assay for serum Tg and TgAb, and the results correlated well with those from the immunoradiometric assays (IRMA). This assay has several advantages over the IRMA and could be considered an alternative test for Tg measurement.

다문화 청소년 국가정체성과 자아존중감 종단적 변화양상 및 영향요인 : 잠재전이분석을 적용하여

조윤영 다문화아동청소년연구원 2023 다문화아동청소년연구 Vol.8 No.2

본 연구는 다문화 청소년의 국가정체성과 자아존중감의 잠재집단을 분석하고 시간 변화에 따른 전이양상과 영향 요인을 살펴보았다. 자료는 한국 다문화 청소년 패널 자료 중 3차년도와 5차년도를 사용하였고, 잠재전이분석(latent transition analysis: LTA)법을 통해 이루어졌으며 연구 결과는 다음과 같다. 첫째, 초6 시기의 국가정체성과 자아존중감은 3개의 잠재집단(높은 집단, 중간 집단, 낮은 집단)이 도출되었고, 중1 시기의 국가정체성과 자아존중감도 3개의 잠재집단(높은 집단, 중간 집단, 낮은 집단)이 나타났다. 둘째, 잠재집단의 전이 양상은 초6 시기 낮은 집단은 중2 시기의 중간집단과 낮은 집단으로 전이 되었고, 초6 시기의 높은 집단은 중2 시기의 낮은 집단과 높은 집단으로 전이 되었다. 초6 시기의 중간집단은 중2 시기의 중간집단과 낮은 집단으로 전이되는 가능성을 보였다. 셋째, 영향 요인의 분석한 결과, 초6 시기에서 중2 시기로의 전이에는 친구관계, 자아탄력성, 우울이 유의한 것으로 나타났고, 집단 별로 차이를 보였다. 이러한 결과는 다문화 청소년의 국가정체성과 자아존중감의 종단적 전이과정을 설명하고, 다문화 청소년의 성장과 발달을 돕기 위한 교육정책에 중요한 자료로 활용될 수 있을 것이다.

보육보조금의 효과 분석: 영아기본보조금을 중심으로

조윤영,Cho, Yoon Young 한국개발연구원 2007 韓國 開發 硏究 Vol.29 No.3

보육보조금은 일반적으로 여성의 노동시장참여를 용이하게 해주려는 것과 아동이 양질의 보육 및 교육 환경에서 돌보아지는 것을 돕는 목표로 지급된다. 본 연구는 보육시설을 이용하는 영아가구에 보육료를 지원하는 영아기본보조금의 효과를 살펴봄으로써 영아기본보조금이 그 정책목표를 달성하고 있는지 검토한다. 기본보조금이 2006년 민간보육시설에만 도입되었고 유아는 제외하고 영아에게만 지급된다는 준실험적(Quasi-Experiment) 설정을 이용하여 시설 측면과 가구 측면의 효과를 분석한다. 분석 결과, 보조금으로 인해 영아의 이용비중이 높은 보육시설에서는 교사의 처우 및 시설환경이 개선되는 등의 효과가 나타났으나 여성의 노동공급에는 거의 영향을 미치지 않았고, 수요자의 보육만족도에도 부정적 영향을 미친 것으로 나타났다. This paper evaluates the effects of the Basic Subsidy Program provided to families with infants cared for in private day care centers. There has been a discrepancy in the price and quality level between public and private day care centers. Public day care centers which receive government support in their labor costs are able to maintain relatively higher quality at lower price than their private counterparts, while the majority of children are cared for at private day care centers. To reduce the gap of the price and quality of care between public and private day care centers by improving the quality and decreasing the price of private day care centers, the Basic Subsidy Program was introduced in 2006 to the private day care centers. The subsidies mainly aim to improve the quality and the accessibility of child care, and encourage mothers' labor supply. For this purpose, the provision of the Basic Subsidy Program imposed prerequisites to the care providers including minimum wage and four major insurances for teachers, and child-staff ratio. I examine whether the subsidies improve the quality of care, help mothers balancing work and family, and increase satisfaction with child care from mothers' perspective. Since the outcome variables that measure the quality of care are difficult to obtain, I instead use the input variables for quality production. Child-staff ratio, teachers' welfare, and care environment are considered. The relationship between these variables and the introduction of subsidies is examined. The 2004 National Survey of Child Care and Education and the 2004 National Survey of Day Care Centers are used for the base data set. To reflect the outcomes after the Basic Subsidy Program, equivalent data sets for households and care providers are constructed by the KDI Data Analysis Unit. Using these nationally representative data sets, information regarding child care is collected. The findings show that the subsidies contribute to the quality of care improving the input variables of quality production. The welfare of teachers is improved, and the child-staff ratio significantly decreases. As a result, the usage of private day care centers greatly increases even though the price level rarely changes. However, mothers' satisfaction with child care are rarely affected by the subsidies. Although the subsidies with no eligibility criteria enlarge the recipients, the actual effects to increase maternal labor supply or to improve satisfaction is limited. Given this findings, I suggest some modifications of subsidies to raise the effectiveness of the subsidy program.

보육보조금의 효과 분석: 영아기본보조금을 중심으로

조윤영 한국개발연구원 2008 KDI Journal of Economic Policy (KDI JEP) Vol.- No.s

This paper evaluates the effects of the Basic Subsidy Program provided to families with infants cared for in private day care centers. There has been a discrepancy in the price and quality level between public and private day care centers. Public day care centers which receive government support in their labor costs are able to maintain relatively higher quality at lower price than their private counterparts, while the majority of children are cared for at private day care centers. To reduce the gap of the price and quality of care between public and private day care centers by improving the quality and decreasing the price of private day care centers, the Basic Subsidy Program was introduced in 2006 to the private day care centers. The subsidies mainly aim to improve the quality and the accessibility of child care, and encourage mothers' labor supply. For this purpose, the provision of the Basic Subsidy Program imposed prerequisites to the care providers including minimum wage and four major insurances for teachers, and child-staff ratio. I examine whether the subsidies improve the quality of care, help mothers balancing work and family, and increase satisfaction with child care from mothers' perspective. Since the outcome variables that measure the quality of care are difficult to obtain, I instead use the input variables for quality production. Child-staff ratio, teachers' welfare, and care environment are considered. The relationship between these variables and the introduction of subsidies is examined. The 2004 National Survey of Child Care and Education and the 2004 National Survey of Day Care Centers are used for the base data set. To reflect the outcomes after the Basic Subsidy Program, equivalent data sets for households and care providers are constructed by the KDI Data Analysis Unit. Using these nationally representative data sets, information regarding child care is collected. The findings show that the subsidies contribute to the quality of care improving the input variables of quality production. The welfare of teachers is improved, and the child-staff ratio significantly decreases. As a result, the usage of private day care centers greatly increases even though the price level rarely changes. However, mothers' satisfaction with child care are rarely affected by the subsidies. Although the subsidies with no eligibility criteria enlarge the recipients, the actual effects to increase maternal labor supply or to improve satisfaction is limited. Given this findings, I suggest some modifications of subsidies to raise the effectiveness of the subsidy program.

산부인과 영역의 의료분쟁에 관한 판례분석

조윤영 연세대학교 대학원 2000 원우론집 Vol.32 No.-

한국의 외교안보전략과 이명박 정부의 정책방향과 과제

조윤영 평화문제연구소 2008 統一問題硏究 Vol.20 No.2

When Presidnt Lee Myung-bak came to the office, his governmentpursues for the "advancement of Korea" as a core national strategy basedon the governing philosophy of pragmatism. With regard to nationalstrategies for security and foreign policy, Korean government plans to implement a total of 47 policy agendas including 10 core ones such as the strengthening the US-ROK alliances, dismantlement of Nuclear program in the North, multilateral cooperation in Asia, and contributing program for international society. These national strategies try to differentiate from those policies from previous governments and hope to provide more fruitful outcomes including US-ROK relations and other major foreign policy issues. This paper attempts to analyze South Korea``s national strategies for security and foreign policy. Four major analytical areas were taken to be more close examination such as US-ROK alliance, national policy to the North, multilateral cooperation in East Asia, and participation of major international peace activities. This paper also suggests policy recommendations for effective and successful implementations of national strategy of security and foreign policy.