서혜부탈장 수술 후 급성요폐 예방을 위한 알파차단제의 효과

함영일(Young Il Hahm),이진석(Jin Suk Lee),임성진(Sung Jin Lim),박경서(Kyung Seo Park),조영삼(Young Sam Cho),주관중(Kwan Joong Joo),권칠훈(Chil Hoon Kwon),박흥재(Heung Jae Park) 대한비뇨기종양학회 2009 대한비뇨기종양학회지 Vol.7 No.2

궤양성 대장염 환자와 혈액투석 환자 및 정상대조군의 다면적 인성검사 ( MMPI ) 특성 비교

김홍주(Hong Joo Kim),조영중(Young Joong Cho),이숭환(Soong Hwan Lee),한동수(Dong Soo Han),손주현(Joo Hyun Sohn),김호중(Ho Joong Kim),박경남(Kyung Nam Park),조연규(Yun Gyoo Cho) 대한내과학회 1998 대한내과학회지 Vol.54 No.2

N/A Objectives: For many years, inflammatory bowel disease has been thought to have a strong psychosomatic component, but recent prospective studies show no evidence of correlation between various psychologic factors and the disease activity. However, chronic renal disease still places unique stresses on the hemodialysis patients, with consequent emotional reactions. The aims of this study are to investigate the psychologic factors of ulcerative colitis and hemodialysis patients using MMPI scales, which are objective psychological test, thus give aid to psychological understanding of these patients. Methods: We investigated 23 ulcerative colitis patients in remission followed at outpatient department of Hanyang University Hospital and 35 patients receiving hemodialysis between June, 1994 and August, 1995. Twenty students were selected for normal control group. We utilized T-score of each MMPI scale for analyzing characteristics of each group and regard T-score over 70 or below 40 as abnormal. Results: The average T-scores of each MMPI scale in ulcerative colitis, hemodialysis patients 8r normal control group were within normal range between 40 and 70, except for T-score of Es scale in hemodialysis patient group(34.5). The results of comparison between each MMPI scale of two patients & normal control group were as follows. 1) L scale was significantly elevated in ulcerative colitis & hemodialysis patients group compared with that of normal control group. F scale was significantly elevated in hemodialysis patients compared with that of ulcerative colitis patients & normal control group (p<0.01). 2) Hs(p<0.01), D, Pt(p<0.05) and Sc(p<0.01) scales were significantly elevated in hemodialysis patients compared with those of ulcerative colitis patients normal control group. 3) Es scale was significantly lower in hemodialysis patients compared with that of ulcerative colitis patients & normal control group(p<0.01). Conclusion: The result presented in this study reflects emotional disturbances, functional impairment, stressful life condition, excessive hypochondriacal thinking, depressed mood and egocentrie tendency of hemodialysis patients campared with ulcerative colitis patients & normal control group. This result also reflects the projective tendency, hostility, difficulty in rapport formation, psychologic disturbance, obssesive and rigid personality, anxiety and retiredness of hemodialysis patients compared with ulcerative colitis patients & normal control group. On the other hand, we can't find any statistically significant differences between ulcerative colitis and normal control group.

변형된 Steinmann 핀과 긴장대 강선을 이용한 상완골 근위부 골절의 치료

정수태(Soo-Tai Chung),김현철(Hyun-Chul Kim),유정현(Jeong-Hyun Yoo),조영중(Young-Joong Cho) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.1

목적: 상완골 근위부 전위형 골절에서 변형된 Steinmann 핀과 긴장대 강선을 이용한 내고정의 유용성과 결과를 분석하고자 하였다. 대상 및 방법: 1998년 9월부터 2002년 2월 사이에 상완골 근위부 전위형 골절로 변형된 Steinmann 핀과 긴장대 강선으로 내고정술을 시행받고 평균 24.9 (6-39)개월 추시된 13예를 대상으로 하였다. 남자가 6명, 여자가 7명, 평균 연령은 58.1 (39-81)세였다. Neer의 평가 기준으로 임상결과를 측정하였다. 결과: 임상적 결과는 우수가 9예, 만족이 4예였으며, 모든 예에서 방사선학적 골유합을 얻었다. 상완골두의 무혈성 괴사 또는 금속 실패와 같은 합병증은 발생하지 않았으며, Steimann 핀의 근위부 자극으로 인한 충돌 증후군을 2예에서 보였으나 골유합 달성 후 내 고정물의 조기 제거로 좋은 결과를 얻을 수 있었다. 결론: 변형된 Steinmann 핀과 긴장대 강선을 이용한 내고정술은 수술부위 연부 조직의 손상이 적어 합병증의 빈도가 낮으며, 비교적 견고한 고정을 얻을 수 있어 조기 재활치료를 가능하게 하는 방법이다. Purpose: The purpose of this study was to evalulate the usefulness of internal fixation with two modified Steinmann pins and tension band wiring in displaced proximal humeral fracture. Materials and Methods: Thirteen cases of displaced proximal humeral fracture were surgically treated with modified Steinmann pins and tension band wiring and followed for an average 24.9 (6-39) months. Male to female ratio was 6 to 7. Average age was 58.1 (39-81) years. Results were assessed using Neer's evaluation criteria. Results: Excellent results were noted in 9 cases and satisfactory results in 4 cases. All cases obtained radiological union. There was no complication such as avascular necrosis of humeral head or metal failure. Two cases showed impingement syndrome of the proximal portions of Steinmann pins, which were managed by early removal of the metal after union. Conclusion: Internal fixation using modified Steinmann pins and tension band wiring for proximal humeral fracture minimizes perioperative soft tissue damage, has a low risk of complications, and enables early rehabilitation by rendering relatively rigid fixation.

최종당화산물이 혈관평활근세포 증식에 미치는 영향 및 그 기전

송진영,임성희,서지영,조영중,유형준,박성우,임자혜 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:혈관평활근세포의 증식은 죽상경화증의 주된 변화로 당뇨병과 동반된 죽상경화증에서도 관찰된다. 최종당화산물(AGE)은 NO와 결합함으로써 이의 혈관평활근세포 증식 억제 작용을 차단한다고 알려져 있으나. 혈관평활근세포에도 최종당솨산물에 대한 수용체가 발견되었음에도 불구하고 최종당화산물이 혈관평활근세포의 증식에 직접 미치는 영향 및 기전에 대하여는 잘 알려져 있지 않다. 본 연구에서는 최종당화산물이 백서 대동맥에서 분리 배양한 혈관평활근세포 증식에 미치는 영향 및 그 기전을 알아 보고자 하였다. 방법:혈관평활근세포는 male Sprague­Dawley 백서의 대동맥에서 분리하여 10% FBS­DMEM 내에서 배양하였고, 세포 증식 실험은 24­well plate에 well당 1×10⁴세포를 0.1% FBS­DMEM(with or without AGE­BSA, anti­AGE antibody, MAP kinase inhibitor, antioxidants)내에서 배양하여 48시간후 MTT assay로 세포 증식을 측정하였다. 결과:AGE­BSA를 2.5, 5.0㎍/mL 농도로 첨가한 경우 혈과평활근세포 수는 AGE­BSA를 가하지 않은 대조군에 비해 1.5, 1.6배 증가되었다. 이러한 AGE­BSA에 의한 혈관평활근세포 증식 촉진 효과는 anti­AGE antibody(100㎍/mL), MAP kinase 억제제인 PD98509(50μM)및 항산화제인 N­acetylcysteine(1μM)이나 butylated hydroxyanisole(10μM)에 의해 차단되었다. 결론:이러한 결과는 AGE가 혈관평활근세포에서 산화 스트레스의 변화를 초래하고 MAP kinase 경로를 통해 혈관평활근세포의 증식 및 죽상경화증의 발생에 기여할 가능성을 뒷받침한다. Background : Diabetes mellitus is an epidemiologically proven risk factor for atherosclerosis. Advanced glycation end products (AGE) have been implicated in the pathogenesis of many diabetic vascular complications. AGE not only change the physicochemical properties of proteins, but also AGE on the vascular smooth muscle cells (VSMCs) have not been fully explained despite of presence of an AGE-receptor on the VSMCs. Methods : In order to test whether AGE promotes atherosclerosis by stimulation of the growth promoting signal transduction pathways in the VSMCs, the proliferation of rat aortic VSMCs cultured in the presence of AGE-BSA with/without anti-AGE antibodies, the MAP kinase inhibitor and antioxidants was measured. The VSMCs (1x10^4 cells in 24-well plates) isolated from the aorta of Sprague-Dawley rats were incubated for 48 hours and the proliferation was assessed by a MTT assay. Results : AGE-BSA increased the proliferation of rat aortic VSMCs by 1.5~1.6 fold at the ㎍/mL level. The stimulatory effect of AGE-BSA (5㎍/mL) was blocked by the anti-AGE antibodies (100 ㎍/mL). PD98059 at 50? inhibited the AGE-BSA-induced VSMC proliferative response of the VSMCs to AGE. AGE-BSA-induced VSMC proliferation was also attenuated by N-acetylcysteine (1?) and butylated hydroxyanisole (10?), implying that increased intracellular oxidative stress might be also involved in the proliferative response to AGE. Conclusion : These results suggest AGE play a role in diabetic atherosclerosis by stimulating of the growth promoting signal transduction pathways in the VSMCs (J Kor Diabetes 26:91~99, 2002).

스트렙토조토신-유발 당뇨병 백서에서 Melatonin의 항산화효과

유형준,문도호,안명수,정홍배,윤광식,안병진,신진,정안철,조영중,남홍우 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.1

Backround: An increase in oxidative stress has been suggested to play major roles in the complications of diabetes. The bulk of the experimental data favors enhanced free radicals in diabetes and antioxidant defense mechanisms may be reduced in diabetes. Melatonin, the major secretory product of the pineal gland has been shown to be a potent and specific hydroxyl radical scavenger. The purpose of our study was to determine the antioxidative effeet of melatonin in streptozotocin-induced diabetic rats. Methods: Sprague-Dawley rats weighing 200-240 g were divided into 3 groups: normal controls(n-7), diabetic contmls(n-9), melatonin-treated diabetic animals(n-9). Diabetes was induced by intraperitoneal injection of streptozotoein(55 mg/kg body weight) and melatonin(6 mg/kg body weight) was orally administered for 20 days. At day 20 after streptozotocin administration, blood was collected for the assay of glucose, albumin and cholesterol. Erythrocyte membrane lipid peroxidation was determined by malonyldialdehyde(MDA) reactivity. Results: 1) The MDA resctivity of erytbrocyte membrane in melatonin-treated diabetic animals (meanstandard deviation: 5.52+-1.52nmol/ml packed cells) were lower(p$lt;0.05) than that in diabetic controls(7.68+-1.16nmol/mL packed cells). But, there was no significant difference between melatonin-treated diabetic animals and normal contls(4.93+-1.19 nmol/mL packed cells). 2) There were no significant differences of blood glucose and body weight between diabetic controls and melatonin-treated diabetic animals. Conclusion: These results show the antioxidative effect of melatonin in streptozotocin-induced diabetic rats. Further clinical and long-term experimental studies are needed to assess the effect of melatonin on development and progression of diabetic complications. (J Kor Soc Endocrinol 13:45-51, 1998)

당뇨병 환자의 생활사건과 관련된 스트레스의 양과 당뇨병 관리의 연관성

김현규,유재명,박성우,최경애,임성희,임정원,유형준,김두만,최문기,조영중,정유선,서승오,최철수 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.3

Background: The life events which diabetic patients experience has an influence on conduct and communication pattern that is essential to control diabetes. The psychosocial life events which patients experienced in recently, as well as in the past has an important meanings in the process of the plan, implementation and evaluation of diabetic control. However, the most researches on this issues are scanty. Thus, we evaluated the relation of diabetic control to stress amounts associated with the life event which diabetic patients experience for the past one year. Methods: In this study, 81 diabetic patients admitted to H hospital from March, 1999 to February 2000 were examined in stress amounts associated with life events, blood sugar, HbA1C, duration, complication, family history, treatment to inspect the hypothesis that stress experiences for recent 1 year are related to diabetic control. The 'Life Psychosocial Event Scale' invented by Lee was used. To examine the hypothesis that diabetic control may be influenced by the amount of stress, we investigated the difference of the means between the two groups (upper 30% of patients vs. lower 30% of patients) by T-test. Results: The mean age was 56.9±15.1 years and the mean duration of diabetes was 8.9±7 years. Fasting plasma glucose (FPG) was 200.3±71.0 mg/dL, PP2 was 292.9±87.2 mg/dL, HbA_(1C) was 10.5±2.6%, complication was 0.8±0.9. The age showed negative correlation with stress amounts. The other variables did not show significant correlation with stress amounts. Thus, our study indicated that the hypothesis that stress experiences for recent 1 year are related to diabetic control was rejected. However, considering the perception-phenomenological approach on stress, if we study the relationship between stress with diabetic control inclusively, it seems that we can recognize such relationship. Conclusion: To address relation between stress with diabetic control inclusively, we need to consider stress factors in diversified aspects more than only one. Therefore, we must investigate how do patients perceive and cope with stress inclusively, because the crisis of life is influenced on the stress coping skill of patients. The study on this issue must be continued to identified the key factors associated with stress in diabetes.