머신러닝 기법을 활용한 치매 예측 모델과 상업적 활용 전략: 웨어러블 기기의 수면 및 활동 데이터를 기반으로

조영은,우종필,김중안 한국경영정보학회 2024 Information systems review Vol.26 No.2

본 연구는 웨어러블 기기에서 수집된 라이프로그 데이터를 활용하여 고령화 사회에서 증가하고 있는 치매를 조기에 진단하여 관리할 수 있는 예측 모델을 개발하고, 이를 기반으로 한 상업적 활용 전략을 제안하는 것을 목표로 하였다. 이 연구는 전문의의 병리진단을 기반으로 한 60~80대 174명의 대상자로부터 수집된 12,184개의 라이프로그 정보(수면 및 활동 정보)와 치매 진단 데이터를 활용하였다. 연구 과정에서 수면과 활동 데이터를 포함하는 다차원적인 데이터셋을 표준화 하였고 다양한 머신러닝 알고리즘으로 분석하였으며, 가장 높은 ROC-AUC점수를 보여준 랜덤 포레스트 모델이 가장 우수한 성능을 보였다. 또한 ablation test를 통해 수면과 관련된 변수들과 활동과 관련 변수들의 제외가 모델 예측력에 미치는 영향을 평가하였고, 이러한 변수들이 모델의 예측력에 유의미한 영향력을 가지고 있음을 확인하였다. 마지막으로, 개발된 모델의 상업적 활용 전략의 가능성을 탐구함으로써, 치매 예방 시스템의 상업적 확산을 위한 새로운 방향을 제안하였다. This study aimed to propose early diagnosis and management of dementia, which is increasing in aging societies, and suggest commercial utilization strategies by leveraging digital healthcare technologies, particularly lifelog data collected from wearable devices. By introducing new approaches to dementia prevention and management, this study sought to contribute to the field of dementia prediction and prevention. The research utilized 12,184 pieces of lifelog information (sleep and activity data) and dementia diagnosis data collected from 174 individuals aged between 60 and 80, based on medical pathological diagnoses. During the research process, a multidimensional dataset including sleep and activity data was standardized, and various machine learning algorithms were analyzed, with the random forest model showing the highest ROC-AUC score, indicating superior performance. Furthermore, an ablation test was conducted to evaluate the impact of excluding variables related to sleep and activity on the model's predictive power, confirming that regular sleep and activity have a significant influence on dementia prevention. Lastly, by exploring the potential for commercial utilization strategies of the developed model, the study proposed new directions for the commercial spread of dementia prevention systems.

Bioactive Polyglycolic Acid (PGA) or Polylactic Acid (PLA) Polymers on Extracellular Matrix Mineralization in Osteoblast-like Mc3T3-E1 Cells

조영은,김혜진,김용하,최재원,김연정,김갑중,김진수,최식영,권인숙 한국영양학회 2006 Nutritional Sciences Vol.9 No.4

Porous matrices of bioactive polymers such as polyglycolic acid (PGA) or polylactic acid (PLA) can be used as scaffolds in bone tissue growth during bone repair process. These polymers are highly porous and serve as a template for the growth and organization of new bone tissues. We evaluated the effect of PGA and PLA polymers on osteoblastic MC3T3-E1 cell extracellular mineralization. MC3T3-E1 cells were cultured in a time-dependent manner -1, 15, 25d as appropriate - for the period of bone formation stages in one of the five culture circumstances, such as normal osteogenic differentiation medium, PGA-plated, fetal bovine serum (FBS)-plated, PGA/FBS-coplated, and PLA-plated. For the evaluation of bone formation, minerals (Ca, Mg, Mn) and alkaline phosphatase activity, a marker for osteoblast differentiation, were measured. Alizarin Red staining was used for the measurement of extracellular matrix Ca deposit. During the culture period, PGA-plated one was reabsorbed into the medium more easily and faster than the PLA-plated one. At day 15, at the middle stage of bone formation, cellular Ca and Mg levels showed higher tendency in PGA- or PLA-plated treatments compared to non-plated control and at day 25, at the early late stage of bone formation, all three cellular Ca, Mg or Mn levels showed higher tendency as in order of PGA-related treatments and PLA-plated treatments, compared to control even without significance. Medium Ca, Mg or Mn levels didn’t show any consistent tendency. Cellular ALP activity was higher in the PGA- or PLA-plated treatments compare to normal osteogenic medium treatment. PGA-plated and PGA/FBS-plated treatments showed better Ca deposits than other treatments by measurement of Alizarin Red staining, although PLA-plated treatment also showed reasonable Ca deposit. The results of the present study suggest that biodegradable material, PGA and also with less extent for PLA, can be used as a biomaterial for better extracellular matrix mineralization in osteoblastic MC3T3-E1 cells

감나무 외

조영은,권유미,송재실 새가정사 1982 새가정 Vol.- No.-

생활습관병 예방 프로젝트 4 실천리스트 - 몸과 마음 함께 쉬어야 휴식이다

조영은,Jo, Yeong-Eun 한국건강관리협회 2013 건강소식 Vol.37 No.10

삶의 피로가 지속되는 일상, 어떻게 하면 온전한 휴식을 얻을 수 있을까? '이번 주말에는 아무것도 하지 않고 쉬기만 할 거야'하고 마음먹어보지만, 여전히 나를 괴롭히는 복잡한 생각들에 시달리며 평온한 휴식에서 멀어지곤 한다. 심리학에서 지혜를 얻어 지친 마음을 달래는 법, 마음의 휴식을 얻을 수 있는 방법을 알아보자.

구치부 교합지지 상실과 수직고경 감소를 동반한 부분 무치악 환자에서 교합평면 회복을 통한 완전구강회복 증례

조영은,이성복,이석원,최조셉준석 大韓齒科補綴學會 2022 대한치과보철학회지 Vol.60 No.3

The loss of posterior occlusal support leads to further complications such as collapsed occlusal plane and reduced vertical dimension, and it may cause problems such as facial appearance change, reduced chewing efficiency, and temporomandibular joint disorders. In such case, it is necessary to re-establish occlusal plane and vertical dimension properly through accurate diagnosis and predictable treatment plan. This case report presents a 71-year-old female, whose occlusal plane was collapsed and posterior restorative space was insufficient. To perform a patient-friendly full mouth rehabilitation, proper vertical dimension and occlusal plane were decided by evaluation of interocclusal space at her physiologic mandibular rest position, swallowing, pronunciation, facial appearance, and the average length of anterior teeth. And then, the fixed provisional restorations were fabricated with the new occlusal position, and evaluated for 5 months with checking adaptation of masticatory muscles and any kind of clinical symptoms occurs or not. After confirmation of functional stability and esthetic satisfaction with the newly established occlusion, final definitive restorations were fabricated and inserted in the mouth. Through the above process, the treatment result was functionally and aesthetically satisfactory. 구치부 교합지지가 상실되면 수직교합고경이 감소되면서 대합치의 점진적인 정출과 전치부 치아들의 전방 돌출을 초래하게 되고 결국 교합평면이 붕괴됨과 아울러 안모의 변화, 저작 효율 저하, 그리고 측두하악관절 장애 등의 문제가 발생할 수 있다. 이 경우, 정확한 진단 과 예지성 있는 치료계획 수립을 통한 교합평면 재설정 및 수직고경 회복이 필요하다. 본 증례는 71세 여성 환자로, 교합 평면이 붕괴되고 구치부 보철 수복 공간이 부족하여, 수직고경 거상을 동반한 완전구강회복을 계획하였다. 생리적 하악안정위, 연하, 발음, 안모, 전치부 평균 길이 등을 평가하는 임상적 과정을 통해 적절한 수직고경 및 3차원적 교합평면을 재설정하여 임시보철물을 제작하였고, 약 5개월 간 임시 보철물 상태로 악관절 및 저작근의 적응 여부를 관찰하고 교합을 안정화하였다. 기능적, 심미적 임상증상이 없음을 확인한 후 최종 보철 수복하였다. 이러한 환자친화적 완전구강회복 과정을 수행하여 기능 및 심미적으로 만족스러운 결과를 얻었기에 이를 보고하고자 한다.

불면증에 대한 스트레스와 인지과정의 통합 모형 검증

조영은,권정혜 한국임상심리학회 2012 Korean Journal of Clinical Psychology Vol.31 No.1

The purposes of this study were to prove the validity of the integrated model of insomnia including cognitive process and stress, and to examine the mediating effects of thought suppression on the relationships of stress, dysfunctional beliefs and attitudes about sleep, cognitive arousal and insomnia. The study included 423 subjects from the general population aged 20-59(males=183, females=240). For this study, DBAS- 16(Dysfunctional Beliefs and Attitudes about Sleep Scale-16), DHS-Revised(The Daily Hassle Scale-Revised Version), WBSI(White Bear Suppression Inventory), PSAS(Pre-Sleep Arousal Scale), and ISI(Insomnia Severity Index) were carried out. The data were statistically analyzed using structural equation modeling(SEM). The results of the study validated the integrated model of insomnia including stress and cognitive process. This study also showed that thought suppression had a significant role in the cognitive process contributing to insomnia. The specific results of the study were as follows. The mediating effect of thought suppression was significant on 1) the path from stress to insomnia via cognitive arousal, and 2) the path from dysfunctional beliefs about sleep to insomnia via cognitive arousal.

Bioaccumulation and time trends of brominated flame retardants in marine mammals from Korean coastal waters

조영은,정윤선,문효방 환경독성보건학회 2019 한국독성학회 심포지움 및 학술발표회 Vol.2019 No.10

Biomonitoring of legacy and emerging contaminants using marine mammals from Korean coastal waters

조영은,정윤선,목소리,박겸준,문효방 환경독성보건학회 2019 한국독성학회 심포지움 및 학술발표회 Vol.2019 No.10

중소기업의 R&BD형 기술사업화 성과에 대한 연구

조영은,송영화,박선영 한국기술혁신학회 2016 한국기술혁신학회 학술대회 발표논문집 Vol.2016 No.10

INTERNOISE 2016 참관기

조영은 한국소음진동공학회 2016 소음 진동 Vol.26 No.6